만삭아에 발생한 괴사성 장염

김대연,김성철,김경모,김애란,김기수,피수영,김인구,Kim, Dae-Yeon,Kim, Seong-Chul,Kim, Kyung-Mo,Kim, Ellen Ai-Rhan,Kim, Ki-Soo,Pi, Soo-Young,Kim, In-Koo 대한소아외과학회 2003 소아외과 Vol.9 No.1

Necrotizing Enterocolitis (NEC) is usually a disease of premature infants, but occasionally it affects the term neonate. Twenty-five infants with NEC were treated at Asan Medical Center between January 2000 and December 2002, and 13 of them were term infants. In each case, the diagnosis of NEC was established by a clinical illness fulfilling the Bell's stage II or III NEC as modified by Walsh or by surgical findings. There were six males and seven females. The birth weight was from 1,960 to 3,700 g. The age at diagnosis was from 1 to 40 days. Four patients had congenital heart disease: one of who had hypothyroidism and cleft palate. Abdominal distension was present in all, and bloody stools in four. One patient had history of hypoglycemia, three had Rota viral infection. Eight patients had leucopoenia (<$5.0{\times}10^9/L$), seven had thrombocytopenia (<$100{\times}10^9/L$), and three severe thrombocytopenia (<$50{\times}10^9/L$). Laparotomy was required in 10 of the 13 patients. Indications for operation in the acute phase were failure to respond to aggressive medical therapy in five, and perforation in three patients. There were two late phase operations for intestinal stricture and fistula. There were no operative complications. Ten of thirteen patients survived (76.9%). Two patients died of septic complication. There was a delayed death due to heart failure. There was a significant difference in survival according to platelet count ($50{\times}10^9/L$) (p<0.05). Congenital heart disease and Rota viral infection are associated with NEC in term infants and thrombocytopenia and leucopoenia may be surgical indications.

방과 후 학교 체육프로그램 참여에 따른 학교생활 및 학업만족에 관한 연구

김대연,최명수 대구경북체육학회 2018 체육연구 Vol.14 No.1

The purpose of this study was to investigate the effect of middle school students' school life and academic satisfaction on the after - school physical activity. Through this, I tried to improve the student life and the immersion in the study. According to the results of the study, first, it was found that the students who participated in the after - school physical activities had a significant influence on the academic satisfaction of the students. This is directly related to school life. School life behaviors are essentially altruistic behaviors, conscientious behavior, participative behavior, and polite behaviors, which are essential for young people to learn. These factors are thought to be able to be learned naturally through physical education rather than through physical education through physical education.

Deoxyribonucleoside의 보호와 di-p-Methoxytrityl기의 제거에 대한 Alcohol류의 효과

이상직,송병수,김대연 嶺南大學校附設 基礎科學硏究所 1984 基礎科學硏究 Vol.4 No.-

5'-O-Dimethoxytritylthymidine and N-benzoyl-5'-O-dimethoxytrityldeoxyade-nosine were synthesized from the corresponding deoxynucleosides and some factors influencing their yields were also investigated. To remove the dimethoxytrityl group from 5'-O-Dimethoxytritylthymidine and N-benzoyl-5'-O-dimethoxytrityldeoxyadenosine, ZnBr₂/CH₃NO₂, ZnBr₂/CH₃NO₂in the presence of alcohols, and CH₃COOH/CH₃NO₂systems were employed. The rates of the detritylation as well as the extent of side reaction in these systems were estimated and the effect of alcohols on the reactions was discussed.

Cyclophosphamide투여에 의한 모발의 초미형태학적 변화

김대연,김중길,임정교,손태중 慶北大學校 醫科大學 1995 慶北醫大誌 Vol.36 No.2

목적 : 핵단백합성억제제인 cyclophosphamide를 장기투여 했을 때 탈모가 일어난다. 그래서cyclophosphamide가 모낭에 일으키는 손상을 형태학적으로 규명하고자 본 연구를 시행하였다. 대상 및 방법 : 체중 250∼300gm의 Sprague-Dawley계 숫쥐에 cyclophosphamide, 4㎎/㎏를 1일1회씩 매일 복강내 주사하면서 1주부터 6주째까지 피부를 광학 및 전자현미경적으로 검색하였다. 결과 : 광학현미경으로, 모간의 염좌·모구의 축소·모기질의 위축이 cyclophosphamide투여 1주일째부터 경미하게 나타나서 그 변화는 4주째에 뚜렷하게 발견되었다. 전자현미경적으로는 모유두 세포의 숫적감소, 모기질세포의 위축성변화, 모의 불규칙한 trichohyaline과립형성으로 인한 모의 염좌, 내측모근초의 전반적인 위축 및 전자밀도의 증가, 외측모근초의 글리코겐과립 소실 및 세포간격의 증가 등이 약제 투여기간이 계속됨에 뚜렷하게 발견되었다. 그러나 모기질의 기저세포는 큰 변화가 없었고 6주째 투여에서 기저세포 핵의 heterochromatine이 불규칙한 배열을 보여주었다. 결론 : 이상의 소견으로 보아 cyclophosphamide 투여에 의한 모낭의 상해는 모기질 세포의 위축 및 성장장해가 가장 중요한 요인이라고 여겨지며 이로 인해 모발의 위축 및 불규칙한 성장으로 생장기 탈모가 일어난다고 생각된다. The author studied the effects of Cyclophosphamide, a potent inhibitor of nucleoprotein synthesis, to investigate the morphologic evidence of destructive actions to the hair follicles. Sprague-Dawley rats were received 4 ㎎ of cyclophosphamide per ㎏ of body weight daily for 1 to 6 weeks, intraperitoneally, and examined light and electron microscpically. Light microscopically, ditortion and constriction of the hair shafts, diminished diameter of the hair bulbs, and atrophy of the hair matrix were developed from 1 week, which was more prominent in second weeks and they were progressed after that time. Hairs were frequently fractured due to constriction of the hair shafts. Electron microscopically, cells of the hair pulp were decreased in number, and cells of the hair matrix atrophied. Degenerative changes of the cellular organelles participating in growth and development of the hairs were noted, such as disordered formation of trichohyaline granules, diffuse atrophy and increased electron density of the inner root sheath, and loss of the glycogen and intercellular edema of the outer root sheath. But basal cells of the matrix relatively showed minor changes. From the above results, cyclophosphamide may specifically alter the matrix cells of the hair follicles and induces anagen hair losses, which may be reversible at al small dosage when the drug is discontinued, because basal cells of the matrix show monor changes.

산화막 증착을 통한 이중스크린 3D 프로젝션 디스플레이 스크린용 산란형 편광필름의 편광유지도 개선

김대연,서종욱 한국반도체디스플레이기술학회 2012 반도체디스플레이기술학회지 Vol.11 No.4

Keeping the polarization direction of the projection light unchanged is of crucial importance for high quality of images on a double-screen 3D projection display system. It has been found that the deposition of oxide layers on the surfaces of scattering polarizer film results in an improvement of polarization maintenance property of the film. The secondary image formed on the front screen by the light scattered from the rear screen decreases by 30% through the application of oxide layers on both surfaces of the screen. Since the oxide layer can also be used as an anti-reflection (AR) coating of the film, this method is very effective for the projection display applications.

韓國 老人福祉制度와 敎育에 관한 硏究

金大淵 弘益大學校 1983 弘大論叢 Vol.15 No.1

The Purpose of this study is to Review Historical Background and Development of the welfare System of the Aged as well as to find out the present Conditions and problem,s and to provide Some implications for the Establshment of policy Directions and Tasks of the Aged welfare System in Korea. The Results of the Study are Summarized as follous; ① The policy of the Aged welfare System should be Established on the Basis of filial Piety and Respect for the Old which are deeply Settled Traditionally in Korea. And it is inevitable to take in to Account Short comings of the Advanced Countries, and Also our good merits in order to set up feasible counter plans. ② The implementation of the Aged welfare policy should be Closely integrated to the Economic growth for the Balanced Development. ③ It is Desirable to Utilize welfare Resources to the maximum for the 「productive welfare」 wiping out Such negative Conceptions as welfare is just Consuming investment. ④ The Aged weflare System should cover good conditions of pysical Existence and cultural life as well as Economic. Social, and mental Area. Thus it should Enhance Social Activies and Roles of the Aged. ⑤ It is necessary to carry out Researches with Special References to Senility Phenomena of the Ages in terms of Life long Education. ⑥ It goes without Saying that pertinent Social Conditions should be provided for the Aged to find their lives worth Living Based on "good image of we Aged" Preparing for the future.

소아의 미분화(태생) 간육종

김대연,김기홍,정성은,이성철,박귀원,김우기,Kim, Dae-Yeon,Kim, Ki-Hong,Jung, Sung-Eun,Lee, Seong-Cheol,Park, Kwi-Won,Kim, Woo-Ki 대한소아외과학회 1999 소아외과 Vol.5 No.1

Undifferentiated (embryonal) sarcoma is a rare malignancy of the liver in children and young adults. Seven cases of undifferentiated (embryonal) sarcoma of the liver pathologically verified at Seoul National University Children's Hospital between 1986 and 1999 were retrospectively analyzed. There were three girls and four boys, and their mean age at diagnosis was 12.1 years (range 7-13 years). Six patients presented with an abdominal mass or pain, and one with weight loss. Tumor size ranged from $8.0{\times}8.0$ cm to $15.0{\times}15.0$ cm. Four tumors were located in the right lobe, two in the left lobe and one in both. One patient died during chemotherapy. Initial complete resection was accomplished in three patients. Two patients underwent complete resection after chemotherapy. Five patients with complete resection survived without evidence of disease for 8, 11, 13, 28, and 84 months. A patient with partial resection and chemotherapy died of sepsis during chemotherapy 19 months after complete surgical resection. Adjuvant chemotherapy and radiotherapy were performed in all patients after complete surgical resection. In conclusion, though undifferntiated (embryonal) sarcoma of the liver is highly malignant, the combination therapy of surgery, chemotherapy and radiotherapy appears to result in a favorable prognosis.

소아 응급 환자의 초기 치료

김대연 대한외과학회 2009 대한외과학회 학술대회 초록집 Vol.2009 No.5

2000年代 社會變化와 새마을敎育 프로그램 開發方向 硏究

金大淵 弘益大學校 敎育硏究所 1987 敎育硏究論叢 Vol.- No.3

미세아의 외과적 문제점들

김대연,김성철,김애란,김기수,피수영,김인구,Kim, Dae-Yeon,Kim, Seong-Chul,Kim, Ellen Ai-Rhan,Kim, Ki-Soo,Pi, Soo-Young,Kim, In-Koo 대한소아외과학회 2006 소아외과 Vol.12 No.1

Recent advances in neonatal management have resulted in a dramatic increase in survival of very low birth weight infants. These critically ill infants, however, continue to pose significant challenges in management and ethics. There is little information on the outcome of the micropremie (birth weight less than 800 g) that require surgery. The records of 171 micropremies treated over a 15 year period (beginning in 1989) at Asan Medical Center was reviewed retrospectively. Forty-one (24.0 %) infants required surgical interventions by pediatric surgeons. There were 90 boys and 81 girls. The smallest infant, weighed 396g at birth, had esophageal atresia and died before surgery. The smallest survivor, birth weight 645 g, received anenterostomy for necrotizing enterocolitis at the weight of 590 g. The gestational age of the group rangedfrom 21 to 36 weeks. The most common surgical problem was inguinal hernia. There were 20 inguinal hernias, and repairs were performed on17 infants. Excluding 2 cases, hernia repair was performed at the time of discharge. There was only one recurrence of adirect inguinal hernia. Necrotizing enterocolitis developed in 17 patients, 11 were operated upon, two had peritoneal drainages, and 9 had enterostomies. Five of 11 surgical infants died after operation and three of the nonsurgical infants died of various complications. Although micropremies have potentially high risks of serious complications and death, the outcome can improve with careful surgical observation and judgment.