http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
카르보닐화합물에 대한 유기티타늄화합물의 화학선택성에 대한 연구
이근설,김희정 상명대학교 기초과학연구소 1992 기초과학연구 Vol.6 No.-
카르보음이온 화학은 탄소-탄소 결합을 형성하는 유기합성분야에서 가장 중요한 부분중의 하나이다. 고전적인 카르보음이온, 예를 들어 알킬리튬 또는 Grignard 시약은 카르보닐화합물에 대해 높은 반응성을 나타내는 반면 낮은 선택성을 갖는다. 반면에 RTiX3로 표현되는 유기티타늄 화합물은 카르보닐 화합물에 대해 화학적이고 입체적인 선택성이 높은 것으로 알려졌다. 본 연구에서는 trichlorophenyltitanium을 합성하여 이것의 카르보닐 화합물에 대한 반응성을 본 결과 다른 유기티타늄 화합물과 같이 알데히드 화합물에 선택적인 반응성을 나타내는 것을 알 수 있었다. Carbanion chemistry is one of the most important field in organic synthesis, expecially for the formation of C-C bond. Though the classical carbanions, for example alkyllithium or Grignard reagent, show high reactivity for the carbonyl compounds, but they react with low selectivity. On the other hand, it is well known that organotitanium compounds generally expressed as RTiX₃(R=methyl, allyl) have high chemo-and stereoselectivity. In this study trichlorophenyltitanium was prepared in situ from phenyllithium and titaniumtetrachloride and was added to carbonyl compounds in order to investigate its reactivity. As a result this reagent was proved to have the same aldehyde reactivity as the other organotitanium compounds.
2-(N, N- dimethylamino) phenyl triisopropoxy titanium 화합물의 카르보닐 화합물에 대한 첨가 반응 연구
이근설,김희정 상명대학교 기초과학연구소 1992 기초과학연구 Vol.7 No.-
카르보음이온 화학은 탄소-탄소 결합을 형성하는 유기합성분야에서 가장 중요한 부분중의 하나이다. 고전적인 카르보음이온, 예를들어 알킬리튬 또는 Grignard시약은 카르보닐 화합물에 대해 높은 반응성을 나타내는 반면 낮은 선택성을 갖는다. 반면에 RTiX₃(R=methyl, allyl)로 표현되는 유기티타늄 화합물은 카르보닐 화합물에 대해 화학적이고 입체적인 선택성이 높은 것으로 알려졌다. 본 연구에서는 2-(N, N-dimethylamino phenyl) triisopropoxy titanium을 합성하여 이것의 카르보닐 화합물에 대한 반응성을 본 결과 다른 유기티타늄 화합물과 같이 알데히드 화합물에 선택적인 반응성을 나타내는 것을 알수있었다. Carbanion chemistry is one of the most important field in organic synthesis, expecially for the formation of C-C bond. Though the classical carbanions, for example alkyllithium or Grignard reagent, Show high reactivity for the carbonyl compounds, but they react with low selectivity. On the other hand, it is well known that organotitanium compounds generally expressed as RTiX₃(R=methyl, allyl) have high chemo-and stereoselectivity. In this study 2-(N, N-dimethylamino phenyl) triisopropoxy titanium was prepared in situ from 2-(N, N-dimethylamino) phenyllithium and chloridetriisopropoxytitanium and was added to carbonyl compounds in order to investigate its reactivity. As a result this reagent was proved to have the same aldehyde reactivity as the other organotitanium compounds.
한우, 칡소 및 제주 흑우 Calpain-Calpastatin 유전자 다양성
이승환,김승창,조수현,최봉환,Aditi Sharma,임다정,당창권,장선식,김재환,고문석,양보석,강희설 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2
The aim of study was to investigate genetic diversity for the calpain/calpastatin gene in three Hanwoo breeds [(Brown (n=62), Brindle (n=81) and Jeju Black (n=30)]. Random samples from three breeds of Hanwoo were selected and genotyped for the 7 SNPs of calpain/calpastatin using TaqMan method. Allele frequencies were investigated for CAPN1/CAST gene. Allele frequency of CAST2 SNP was 0.75, 0.59 and 0.22 for Brown, Brindle and Jeju black, respectively. The CAST3 revealed allele frequency of 0.59 and 0.57 in Brown and Jeju Black, while it showed very low allele frequency (0.07) in Brindle. In particular, favorable allele (G allele) for the CAPN1-2 SNP which was shown a strong association with tenderness in Taurine and Indicine cattle revealed 16% and 17% higher allele frequency in Brown Hanwoo (0.82) comparing Brindle (0.66) and Jeju Black Hanwoo (0.65). AMOVA demonstrated that among population variance occupied only 10% of total variance and among individual variance was 0%, while within individual variance was 90% of total variance. This result showed that population effect contributed very small portion of genetic to these three Hanwoo breeds, while within individual variance contributed large portion of genetic diversity within these Hanwoo breeds. In conclusion, three Hanwoo breeds (Brown, Brindle and Jeju black) showed a genetically homogeneous based on the 7 SNPs of CAPN1/CAST gene and it came from same ancestor to form modern Hanwoo breed.
Validation of the oxford classification of iga nephropathy: A Single-Center Study in Korean Adults
( Ho Young Lee ),( Sul Hee Yi ),( Mi Seon Seo ),( Jin Nam Hyun ),( Jin Seok Jeon ),( Hyunjin Noh ),( Dong Cheol Han ),( Seung Duk Hwang ),( So Young Jin ),( Soon Hyo Kwon ) 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.3
Background/Aims: The recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new classification system must be validated in a variety of cohorts. We investigated whether these pathological features were applicable to an adult Korean population. Methods: In total, 69 adult Korean patients with IgAN were analyzed using the Oxford classification system at Soonchunhyang University Hospital, Seoul, Korea. All cases were categorized according to Lee`s classification. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for pathological variables. Inclusion criteria were age greater than 18 years and at least 36 months of follow-up. We excluded cases with secondary IgAN, diabetic nephropathy combined other glomerulopathies, less than 36 months of follow-up, and those that progressed rapidly. Results: The median age of the patients was 34 years (range, 27 to 45). Mean arterial blood pressure was 97 ± 10 mmHg at the time of biopsy. The median follow-up period was 85 months (range, 60 to 114). Kaplan-Meier analysis showed significant prognostic predictions for M, E, and T lesions. A Cox proportional hazard regression analysis also revealed prognostic predictions for E and T lesions. Conclusions: Using the Oxford classification in IgAN, E, and T lesions predicted renal outcome in Korean adults after taking clinical variables into account.
Health-related quality of life and mental health status in Korean adults with atopic dermatitis
( Sul Hee Lee ),( Ji Yeoun Shin ),( Kyu Rak Hong ),( Sang Hoon Lee ),( Jong Suk Lee ),( Sung Yul Lee ),( Young Lip Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Atopic dermatitis (AD) is a pruritic eczematous skin disorder. Patients with AD often suffer from a lot of mental distress and poor health-related quality of life (HRQoL). Objectives: The aim of this study was to investigate the association of several mental health statuses and poor HRQoL with AD in an adult population in Korea. Methods: A total of 38,741 adults who participated in the Korean National Health and Nutrition Examination Survey, a nationwide, population-based, cross-sectional health survey between 2008 and 2013 were included. HRQoL was assessed by EuroQoL (EQ) 5-dimension questionnaire and EQ-visual analog scale scores. Multiple logistic regression analysis was performed to identify the association of stress, sleep duration, depressive mood, depression, suicidal ideation, and HRQoL with AD relative to matched controls. Results: After adjusting confounding factors, stress, depressive mood, depression, suicidal ideation and poor HRQoL were significantly associated with AD. Conclusion: Dermatologists should be concerned with improving HRQoL and managing the mental health status of adult AD patients.
( Sul Hee Lee ),( Seung Min Lee ),( Ga Hee Jung ),( Moon Kyun Cho ),( Sung Yul Lee ),( Young Lip Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of MAS are well known, several cases that could not be placed into any of these three categories have recently been reported. To the best of our knowledge, the co-existence of psoriasis, vitiligo, and Crohn`s disease has been reported in only one patient, who had a total of five autoimmune diseases (alopecia areata and oral lichen planus in addition to the three conditions mentioned). We herein describe a rare case of MAS presenting with psoriasis, vitiligo, and Crohn`s disease, and suggest that tumor necrosis factor-α may be associated with the pathogenesis of all three conditions.
이한슬,염상민,이동채,김병훈,이종효,이승현,김대식,김건형,박순희 대한내과학회 2002 대한내과학회지 Vol.62 No.5
Allgrove syndrome, also known as Tripple A syndrome is characterized by ACTH-resistant adrenal insufficiency, achalasia of esophagus and alacrima. Since its first description by Allgrove et al. (1978), more than 60 cases from all over the world have been reported. In Korea, however, there was no report of this Allgrove syndrome. We report studies on a 18-year old male patient with this rare triad. The patient had alacrima from birth; isolated glucocorticoids deficiency had been diagnosed at 6 years of age and achalasia at age 18. We report the case with the review of literature.