마늘 잼의 저장과정 중 성상변화

박혜민,곽효순,김소희,문미아,오만진 충남대학교 농업과학연구소 2008 농업과학연구 Vol.35 No.2

In order to make a functional jam containing garlic, sugar, acid and pectin were mixed with garlic and concentrated by heating the mixture under atmosphere or vacuum conditions. And changes of some physico-chemical properties of the garlic jam(i.e., color, textural properties, vitamin C) were investigated during storage at 30℃. It was found that lightness(L) was higher in sample of vacuum concentration than that in atmosphere concentration and redness(a) and yellowness(b) were higher in sample of atmosphere concentration. During the storage lightness was found to decrease for all samples with more drastic decrease in sample of atmosphere concentration where browning was more severely observed after 8 weeks of storage. In terms of textural properties, hardness, chewiness and gumminess were higher in sample of atmosphere concentration than that in vacuum concentration. And springiness and cohesiveness were higher in sample of vacuum concentration. Although sensory score for garlic jam found to be lower than that for the existing strawberry jam, the present garlic jam might have high marketability if considering its physiological value. 마늘을 이용한 기능성 잼을 제조하기 위하여 마늘에 당, 산, 펙틴을 첨가하고 평압과 감압에서 농축하여 마늘잼을 제조한 후 색도, 조직특성을 조사하고 30℃에서 저장하면서 색도, 조직의 변화, 비타민 C의 변화를 측정한 결과는 다음과 같다. 원료마늘의 일반성분은 수분 57.2%, 탄수화물 23.6%, 조단백 1.9%, 조지방 0.75%, 회분0.93%이었고 비타민 C는 8.4 mg/l00g이었다. 명도는 진공농축한 것이 평압농축한 것보다 높았고 적색도와 황색도는 평압의 것이 높았다. 저장기간에 따라 명도는 모두 감소하였으나 평압에서 농축한 것이 감압보다 크게 감소하였으며 갈변화가 저장 8주에는 심하게 나타났다. 마늘잼의 조직특성은 hardness, chewiness, gumminess는 평압농축이 감압농축에 비하여 높았고 springiness, cohesiveness는 평압농축이 낮았다. 마늘잼의 기호성은 딸기잼에 비하여 떨어지지만 기능성을 감안할 때 시장성이 매우 높을 것으로 판단한다.

퍼지 추론을 이용한 분류 벡터 양자화기의 성능 개선

황병하,김혜숙,서재성,박민식,곽훈성 全北大學校 1994 論文集 Vol.37 No.-

In Classified Vector Quantization(CVQ) for image coding, the block classification pondering the block characteristics will be the most important procedure if we consider system performance. But it does not take effect because classification of conventional CVQ followed act on a heuristic and statistics method. In order to solve the problem of conventional methods, i.e, for block classification effectively we propose a fuzzy inferencing algorithm to improve its performance. To do this, fuzzy rules must be generated in the first. Our rules are based on energy distribution in transform domain with respect to spatial variation. Ultimately fuzzy inferencing of this paper apply these fuzzy rules for efficient block classification on a input image. As a result of efficient classification, our proposed method shows that blocking effect is decreased and PSNR(peak to peak signal to noise ratio) is increased by about 1 ∼ 2 dB for 0.2 ∼ 0.6 bpp range, when the performance is compared with Aizawa's scheme^[9].

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women

Kwak, Soo Heon,Kim, Sung-Hoon,Cho, Young Min,Go, Min Jin,Cho, Yoon Shin,Choi, Sung Hee,Moon, Min Kyong,Jung, Hye Seung,Shin, Hyoung Doo,Kang, Hyun Min,Cho, Nam H.,Lee, In Kyu,Kim, Seong Yeon,Han, Bok- American Diabetes Association 2012 Diabetes Vol.61 No.2

<P><B/></P><P>Knowledge regarding the genetic risk loci for gestational diabetes mellitus (GDM) is still limited. In this study, we performed a two-stage genome-wide association analysis in Korean women. In the stage 1 genome scan, 468 women with GDM and 1,242 nondiabetic control women were compared using 2.19 million genotyped or imputed markers. We selected 11 loci for further genotyping in stage 2 samples of 931 case and 783 control subjects. The joint effect of stage 1 plus stage 2 studies was analyzed by meta-analysis. We also investigated the effect of known type 2 diabetes variants in GDM. Two loci known to be associated with type 2 diabetes had a genome-wide significant association with GDM in the joint analysis. rs7754840, a variant in <I>CDKAL1</I>, had the strongest association with GDM (odds ratio 1.518; <I>P</I> = 6.65 × 10<SUP>−16</SUP>). A variant near <I>MTNR1B</I>, rs10830962, was also significantly associated with the risk of GDM (1.454; <I>P</I> = 2.49 × 10<SUP>−13</SUP>). We found that there is an excess of association between known type 2 diabetes variants and GDM above what is expected under the null hypothesis. In conclusion, we have confirmed that genetic variants in <I>CDKAL1</I> and near <I>MTNR1B</I> are strongly associated with GDM in Korean women. There seems to be a shared genetic basis between GDM and type 2 diabetes.</P>

β-Secretase (BACE1) Inhibitors from Pomegranate (Punica granatum) Husk

Hye-Min Kwak,So-Young Jeon,Bang-Ho Sohng,Jong-Guk Kim,Jin-Man Lee,이경복,Hyun-Hee Jeong,Jong-Moon Hur,강영화,송경식 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.12

In the course of screening for anti-dementia agents from natural products, two β-secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activityguided purification. They were identified as ellagic acid and punicalagin with IC50 values of 3.9 ×10-6 and 4.1×10-7 M and Ki values of 2.4×10-5 and 5.9×10-7 M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to α-secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1.

[ $\beta$ ]-Secretase (BACE1) Inhibitors from Pomegranate (Punica granatum) Husk

Kwak Hye-Min,Jeon So-Young,Sohng Bang-Ho,Kim Jong-Guk,Lee Jin-Man,Lee Kyung-Bok,Jeong Hyun­Hee,Hur Jong-Moon,Kang Young-Hwa,Song Kyung-Sik The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.12

In the course of screening for anti-dementia agents from natural products, two $\beta$-secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activity-guided purification. They were identified as ellagic acid and punicalagin with $IC_{50}$ values of 3.9 $\times$$10^{-6}$ and 4.1$\times$$10^{-7}$ M and Ki values of 2.4$\times$$10^{-5}$and 5.9$\times$$10^{-7}$ M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to $\alpha$-secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1.

Comparison of conservative therapy and steroid therapy for Bell's palsy in children

Yoo, Hye Won,Yoon, Lira,Kim, Hye Young,Kwak, Min Jung,Park, Kyung Hee,Bae, Mi Hye,Lee, Yunjin,Nam, Sang Ook,Kim, Young Mi The Korean Pediatric Society 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.10

Purpose: Bell's palsy is characterized by sudden onset of unilateral facial weakness. The use of corticosteroids for childhood Bell's palsy is controversial. This study aimed to identify clinical characteristics, etiology, and laboratory findings in childhood Bell's palsy, and to evaluate the efficacy of corticosteroid treatment. Methods: We conducted a retrospective analysis of children under 19 years of age treated for Bell's palsy between January 2009 and June 2017, and followed up for over 1 month. Clinical characteristics, neuroimaging data, laboratory findings, treatments, and outcomes were reviewed. Patients with Bell's palsy were divided into groups with (group 1) and without (group 2) corticosteroid treatment. Differences in onset age, sex, laterality, infection and vaccination history, degree of facial nerve palsy, and prognosis after treatment between the groups were analyzed. Results: One hundred patients were included. Mean age at presentation was $7.4{\pm}5.62years$. A total of 73 patients (73%) received corticosteroids with or without intravenous antiviral agents, and 27 (27%) received only supportive treatment. There was no significant difference in the severity, laboratory findings, or neuroimaging findings between the groups. Significant improvement was observed in 68 (93.2%) and 26 patients (96.3%) in groups 1 and 2, respectively; this rate was not significantly different between the groups (P=0.48). Conclusion: Childhood Bell's palsy showed good prognosis with or without corticosteroid treatment; there was no difference in prognosis between treated and untreated groups. Steroid therapy in childhood Bell's palsy may not significantly improve outcomes.

대체서식지 조성을 위한 모듈화

곽혜민(Hye Min Kwak),이식모(Suk Mo Lee) 한국해양환경·에너지학회 2007 한국해양환경공학회 학술대회논문집 Vol.2007 No.-

공유수면의 매립으로 사라져 가고 있는 연안의 생물의 서식지를 대체하기 위해 본 연구에서는 대체 서식지 조성 시 필요 인자들을 모듈화 하였다. 연안의 대체 서식지 조성의 모듈화를 위하여 연안의 대표생태계를 염습지, 갯벌, 해조장으로 분류하고 염습지는 토양의 염분농도, 해수의 침수정도, 토성에 따라 분류 하였고, 갯벌은 퇴적물의 조성에 따라 모래갯벌과 펄갯벌로 분류하였으며, 해조장은 생육기질에 따라 암초성 조장과 사니질 조장으로 분류하고 각각의 대체서식지에 대한 무생물 환경과 그에 알맞은 식생을 분류, 대표종을 선택하여 대체서식지 조성시의 모듈을 작성하였다. This study have modulized the factors that are necessary to create alternative habitats for the coastal creatures which have been lost their habitats by Tidal land reclamation. To modulize, coastal ecosystem has been separated into salt marshes, tidal flats and seaweed beds, respectively. Salt marshes has been separated again by salinity of soil, flooding frequency and kinds of soil. Tidal flat has been separated into sand tidal flat and mud tidal flat by component of sediment. Seaweed beds has 머so been separated into rocky bed and sandy bed by kinds of substrate. Representitive creatures has been selected for each alternative habitats for Module.

HPLC에 의한 산지별 한국산 석류과피 중 항산화화합물의 함량분석

곽혜민 ( Hye Min Kwak ),정현희 ( Hyun Hee Jeong ),송방호 ( Bang Ho Sohng ),김종국 ( Jong Guk Kim ),이진만 ( Jin Man Lee ),허종문 ( Jong Moon Hur ),송경식 ( Kyung Sik Song ) 한국응용생명화학회 2005 Applied Biological Chemistry (Appl Biol Chem) Vol.48 No.4

Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells

Kim, Min Joo,Choi, Ok Kyong,Chae, Kyung Sil,Kim, Min Kyeong,Kim, Jung Hee,Komatsu, Masaaki,Tanaka, Keiji,Lee, Hakmo,Chung, Sung Soo,Kwak, Soo Heon,Cho, Young Min,Park, Kyong Soo,Jung, Hye Seung Korean Endocrine Society 2015 Endocrinology and metabolism Vol.30 No.1

<P><B>Background</B></P><P>Damaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells. Here, we investigated mitochondrial function and the expression of mitochondrial complexes in autophagy-related 7 (<I>Atg7</I>)-deficient β-cells.</P><P><B>Methods</B></P><P>To evaluate the effect of autophagy deficiency on mitochondrial function in pancreatic β-cells, we isolated islets from <I>Atg7</I><SUP>F/F</SUP>:RIP-<I>Cre</I>+ mice and wild-type littermates. Oxygen consumption rate and intracellular adenosine 5'-triphosphate (ATP) content were measured. The expression of mitochondrial complex genes in <I>Atg7</I>-deficient islets and in β-TC6 cells transfected with si<I>Atg7</I> was measured by quantitative real-time polymerase chain reaction.</P><P><B>Results</B></P><P>Baseline oxygen consumption rate of <I>Atg7</I>-deficient islets was significantly lower than that of control islets (<I>P</I><0.05). Intracellular ATP content of <I>Atg7</I>-deficient islets during glucose stimulation was also significantly lower than that of control islets (<I>P</I><0.05). By Oxygraph-2k analysis, mitochondrial respiration in <I>Atg7</I>-deficient islets was significantly decreased overall, although state 3 respiration and responses to antimycin A were unaffected. The mRNA levels of mitochondrial complexes I, II, III, and V in <I>Atg7</I>-deficient islets were significantly lower than in control islets (<I>P</I><0.05). Down-regulation of <I>Atg7</I> in β-TC6 cells also reduced the expression of complexes I and II, with marginal significance (<I>P</I><0.1).</P><P><B>Conclusion</B></P><P>Impairment of autophagy in pancreatic β-cells suppressed the expression of some mitochondrial respiratory complexes, and may contribute to mitochondrial dysfunction. Among the complexes, I and II seem to be most vulnerable to autophagy deficiency.</P>