Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

머리염색이 인체에 미치는 영향

윤형식,황성호,이현륭,김수호,박연석,권낙현,정호진,김동훈,노현주,홍성호,박병찬,이관,정해관 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

일상생활에서 모발염색은 흔히 접할 수 있는 미용의 한 종류로 특히 젊은층을 중심으로 폭발적으로 유행하고 있다. 염색을 위항 사용하는 약제는 표백제와 발색제 등 각종 화학약품이 사용되고 있으나 이로 인한 건강장해에 대한 연구는 그리 많지 않다. 저자들은 염색이 인체의 모발건강에 미치는 영향을 파악하기 위하여 염색과 관련된 주관적 증상과 모발의 변화에 대한 실험적 연구를 시행하였다. 동국대학교 경주 캠퍼스 재학생 80명을 대상으로 설문조사를 시행하여 염색 유 ·무 및 염색 후에 경험한 증상에 대해 설문 조사하였고, 의과대학 재학생 46명을 대상으로 피부 반응 테스트를 실시하였다. 또한 염색 전후의 모발 탄성도를 측정하였고 모발의 상태를 파악하기 위해 전자 현미경검사를 실시하였다. 설문조사 결과 염색 전에 비하여 염색 후 안구혼탁, 안구건조, 시력저하, 발진 및 접촉성 피부염, 모발손상, 모근손상 등의 증상을 더 많이 경험한다고 호소하였다(p<0.05). 모발손상과 모근손상은 헤어드라이어 사용 빈도에 따라 증가하는 것으로 조사되었다(p<0.05). 피부반응검사에서 가려움증이 가장 많은 증상이었으며 이는 여성보다는 남성에서 높은 것으로 조사되었다. 염색 전후의 모발장력은 염색 전 134.5±10.37g, 염색 128.0±30.69g, 염색 이틀 후 112.5±19.69g으로 나타났다. 염색 전후의 모발의 전자현미경 케라틴 층이 현저히 감소하고 모발이 가늘어지는 차이를 보였다. 염색은 모발손상, 모발 케라틴 손상 및 모근 손상, 발진 및 접촉성 피부반응, 안구혼탁, 안구건조, 시력 저하를 유발한다. 따라서 염색약으로 인한 손상에 대한 주의와 예방이 필요하다고 생각한다. 예방대책으로 염색 전 피부테스트를 통한 적합성 여부를 판단하는 것이 필요하며 가급적 염색을 피하는 것이 좋을 것이다. 염색약에 발암물질이 포함되어있다는 보고도 있어 염색 제조사의 철저한 실험과 염색 물질의 선별이 염색으로 인한 부작용을 최소화하는데 중요한 역할을 할 것이다. Hair coloring has became one of the most popular cosmetic activities to younger generations during last decade. However, there are few studies on the health effect of widespread use of chemical dyes. This study was conducted to study the effects of hair coloring dye on hair and other systems. We conducted a questionnaire survey of 80 persons in Kyongju campus, Dongguk University. We have done open patch skin test on 46 medical students. We also conducted scanning electron microscopy to examine the hair strength and structure before and after hair coloring process. Injury of hair and hair bulb, contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity were the main symptoms complained after hair coloring (p<0.05). Injury of hair and hair bulb were increased by frequency of hair-dryer use(p<0.05). In open patch test, pruritus was complanined by more than half of the subjects. Mean strength of hairs before and after hair coloring was as follows; 134.5 (SD 10.37)g before hair coloring, 128.0 (SD 30.69)g immediately after hair coloring, and 112.5 (SD 19.69)g after two days. The scanning electron microscopic findings of hair surface before and after hair coloring showed decreased keratin layer and thinning of the hair. Hair coloring induces injury to hair, its keratin layer, and hair bulb as well as contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity. Therefore, we think that precaution is needed in use of hair coloring dye. To prevent complications induced by hair coloring dye, it is necessary, especially to those with allergy or skin disorders, to perform skin test before action and avoid hair coloring whenever possible. Longterm health effects of hairdye should be studied and manufacturing companies should try to minimize complications induced by hair coloring dye.

실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교

황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.

스포츠와 정치에 관한 이론적 고찰

성영호,이석영,노덕선,권지윤 龍仁大學校 體育科學硏究所 1997 體育科學硏究論叢 Vol.7 No.1

An attempt of indicating al perspective for the systematic arrangement of studies on sports and politics was made examining the contents and method of preceding studies conies concerned. Main results are as follow; 1. The concrete domains of the study on sports and politics are classified into such five categories as sports policy sports and political ideology, political functions of sports, sports and social regime, and sports international relations. After indicating the problems to be solved in terms of the systematic arrangement of the studies in each category, they are mutually related and a guideline for the systematization of studies on sports and politics is presented. 2. Politics can basically be understood as policy which has a certain logical relation with public interests and power, for the analysis of mutual relation between sports and politics standing on the basic of policy it is inevitable to clarify the meaning of in fluence relation and function Especially logical improvement of the method of functional analysis is indispensable.

고속 주행 모드에서 자동차 디퓨저의 스트레이크 개수와 배치에 따른 공기저항 유동해석

이진호,박성하,최동석,한영진,곽나영,이상욱 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

This study proposes an optimized diffuser strake design that can improve driving performance for cars in high-speed driving mode. The speed of the vehicle is set to 160km/h, and the number of strake is set to 4, 6 and 8, and the angle of the diffuser is set to 4, 5 and 6 degrees. The arrangement of the strake is centered, edged and equally arranged. The optimized diffuser design induced with the Ansys Fluent analysis shows a drag coefficient of 16% less than the basic diffuser-free model at a diffuser angle of 6 degree, 8 strakes, and equal arrangement.

후방 도달 척추 절제술을 이용한 강직성 요천추 변형의 치료

석세일,정의룡,이정희,김진혁,김성수,이지호,최원기,박용원 대한척추외과학회 2004 대한척추외과학회지 Vol.11 No.2

흉요추부 골절의 수술적 치료

김명호,유문집,이성철,박진영,유석주,박희곤 단국대학교 1996 論文集 Vol.30 No.-

The purpose of operative treatment in thoracolumbar spine fractures is anatomical reduction and stabilization of the fractures and thus promote neurological recovery and early rehabilitation. To achieve these goals, complete preoperative assessment and recognition of the fracture pattern is necessary in addition to good surgical technique. The authors analyzed 27 cases of thoracolumbar spine fractures operated from Jun. 1994 to Dec.1995 at the Department of orthopaedic surgery, Dan-kook University Hospital. All cases were analysed according to McAfee classification. In deciding the appropriate surgical approach, fracture pat-tern, stability and neurologic status were considered. The result were as follows; 1. Unstable burst fracture, 11 cases, was the most frequent type. 2. 1st lumbar fracture was the most common level in this series. 3. Fall down, 15 cases out of 27, was the most common cause on thoracolumbar spine fracture. 4. Anterior approach was performed in 8 cases and posterior approach was performed in 19cases. 5. Good results were obtained through firm fixation and early rehabilitabion.

주요 우울증을 동반한 신경성 식욕과항진증 1례

신석호,권용실,김보연,이정태,이성필 한국의학사 1992 診斷과治療 Vol.12 No.7

전슬관절 동통환자의 등속성 근력 평가에 관한 연구

柳碩柱,李聖喆,朴泰永,柳文集,金明昊,鄭宣根 단국대학교 1995 論文集 Vol.29 No.-

We studied 25 cases of patients with anterior knee joint pain without any other knee problems with a isokinetic evaluation technique using Cybex. The results are 1. The peak torques for the knee extensor muscles were decreased statistically 2. The peak torques for the knee flexor muscles were decreased relatively also but not statistically 3. TAE(Torque Acceleration Energy) values for knee extensor & flexors were all decreased from disuse atrophy 4. The torque curve for extensors showed decreased power around 30 degrees of knee flexion

닭의 능력검정정보 통계분석시스템 개발

최연호,서강석,조상문 한국농업정보과학회 2000 농업정보과학 Vol.1 No.2

This study was carried out to develop RSTASystem (Random Sample Test Analyses System) and internet homepage for providing chick random sample test infermation to rhick breeders and farmers. RSTA-System is the applied statistical package sofhvare which can be used to analyse the random sample test data collected since 1985 by the chick random sample test station in Ansung. Microsoft Visual Basic(V6.0) was used for developing RSTASystem, and the system was composed of 4 main menus and 10 sub-menus. Random sam-ple test information acquisited by RSTASystem could be provided through the internet homepage (agis.nlri.go,kr/www.poultry.or.kr). Major contents are as fnllows : introduction and schedule of random sample tesL summary reports from 1910 to 1999 for tapers and broilers, full reports from 1990 to 1999 for layers and broilers, down-load of RSTASystem fnes and database file. Users could acquire random sample test data and relevant information easily and quitkly through this system, and the information would be applied for selecting chick strains and producing of making more profits.