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Factors Associated with Adherence to Allergen Specific Subcutaneous Immunotherapy
이지호,이소희,반가영,예영민,남동호,박해심,신유섭 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.6
Purpose: Allergen-specific immunotherapy (AIT) is known to be the only therapeutic modality to alter the natural course of allergicdiseases. However, at least 3 years of treatment is recommended for achieving long-term disease modifying effect. This studyaimed to investigate factors associated with immunotherapy non-adherence in real practice. Materials and Methods: We retrospectively reviewed medical records of patients who were diagnosed with allergic rhinitis, asthma,or atopic dermatitis, and received AIT to common allergens such as house dust mite and/or pollens from January 2007 toAugust 2014. In this study, non-adherence was defined as not completing 3 years of AIT. Results: Among 1162 patients enrolled, 228 (19.6%) failed to complete 3 years of AIT. In multivariate analysis, age less than 20years [odds ratio (OR) 3.11, 95% confidence interval (CI) 1.70–5.69] and 20 to 40 years (OR 2.01, 95% CI 1.17–3.43), cluster buildup(OR 1.78, 95% CI 1.05–3.02) and ultra-rush build-up schedules (OR 5.46, 95% CI 2.40–12.43), and absence of visit to other departmentsin the same hospital (OR 1.87, 95% CI 1.05–3.32) were independently associated with immunotherapy non-adherence. Disease duration of 5–10 years was negatively associated with non-adherence compared to shorter disease duration of less than 5years (OR 0.61, 95% CI 0.40–0.94). Although male sex and commercial product of AIT, Tyrosine S®, compared to Novo-Helisen®were non-adherent factors in univariate analysis, no statistical significances were identified in multivariate analysis. Conclusion: Various factors are associated with immunotherapy adherence affecting the utility of immunotherapy. Cliniciansshould be aware of factors associated with adherence to maximize the utility of allergen-specific subcutaneous immunotherapy.
에너지 효율 극대화를 위한 진공농축장치 및 Ejector 성능 검증 연구
이지호,하진욱 순천향대학교 부설 산업기술연구소 2016 순천향 산업기술연구소논문집 Vol.22 No.2
In this paper, we conducted a study of the performance validation of Thermal Vapor Recompression type concentrator on qualification for the proceedings to reduce energy usage and efficiency of enrichment technology, widely used in industrial fields. We evaluated the performance of vaccum concentrator with the results of basic experiment and field application. IC analysis was used as evaluation method. We designed a vacuum concentrator which can concentrate of waste solutions from 27% to 50%. And the steam consumption of vacuum concentrator can be reduced more than 60% with ejector.