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노령 흰쥐의 뇌허혈 손상시 뇌대사활성의 변화 및 량격산화탕의 영향에 대한 [$^{14}C$2-Deoxyglucose Autoradiography 연구
손철훈,신정원,손영주,정혁상,원란,손낙원,Sohn, Cheol-Hoon,Shin, Jung-Won,Sohn, Young-Joo,Jung, Hyuk-Sang,Won, Ran,Sohn, Nak-Won 대한한의학회 2003 대한한의학회지 Vol.24 No.3
Objective : This study investigated the alteration of neural activity and effect of Yanggyuksanhwa-tang (Lianggesanhuo-tang) on cerebral ischemia of rats. Methods : Considering age-related impact on cerebral ischemia, aged rats (18 months old) were used for this study. Ischemic damage was induced by the transient occlusion of bilateral common carotid arteries (BCAO) with hypotension. Yanggyuksanhwa-tang (Lianggesanhuo-tang) was administered twice a day orally. Then alterations of neural activities in the brain of aged BCAO rats were measured by the [$^{14}C$]2-deoxyglucose autoradiography method. Results : The BCAO in aged rats led to significant decrease of neural activity in the whole brain. Treatment with Yanggyuksanhwa-tang (Lianggesanhuo-tang) significantly attenuated the decrease of neural activity in the whole brain following BCAO ischemia. Treatment significantly attenuated the decrease of neural activity in the CA1, CA2, CA3, dentate gyrus of the hippocampus, activated barrel, barrel cortex, somatosensory cortex, cingulate cortex, caudate putamen, and medial septal nucleus following BCAO in aged rats. Treatment with Yanggyuksanhwa-tang (Lianggesanhuo-tang) also significantly attenuated the decrease of neural activity in the anteroventral thalamic nucleus, ventral anterior thalamic nucleus, arcuate nucleus, posterior hypothalamic area, medial mammillary nucleus, lateral periaqueductal gray, dorsal raphe nucleus, interpeduncular nucleus, median raphe nucleus, and medial pontine nucleus. Conclusion : It can be suggested that Yanggyuksanhwa-tang (Lianggesanhuo-tang) has a neuroprotecuve effect on cerebral ischemia through the control of glucose metabolic rate and cerebral blood flow.
양격산화탕(凉膈散火湯)이 뇌해마 조직배양의 허혈손상에 따른 신경세포손상에 미치는 영향
이환성,박성준,정광식,손영주,정혁상,박동일,손낙원,Lee, Hwan-Sung,Park, Sung-Joon,Jung, Kwang-Sik,Sohn, Young-Joo,Jung, Hyuk-Sang,Park, Dong-Il,Sohn, Nak-Won 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1
Objectives : We can find out the experimental reports of Yanggyuksanhwa-tang, which has the function of regulating blood pressure related with cerebral disease, and increasing local cerebral blood stream volume, also has the recoveries for the damage of vessel endothelium, and endothelium hypertrophy caused by angiospasm after subarachnoid hemorrhage, and reduces the contraction of smooth muscle, so simultaneously improves necrosis. The aim of this study is to investigate effect of Yanggyuksanhwa-tang protecting neuronal cells from being damaged by brain ischemia through using organotypic hippocampal slice cultures. Methods : We caused ischemic damage to organotypic hippocampal slice cultures by oxygen and glucose deprivation, and Yanggyuksanhwa-tang extract was added to cultures. Thereafter we measured area percentage of propidium iodide (PI)-stained neuronal cell, lactate dehydrogenase (LDH) levels in culture media and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive cells. Results : Area percentage of PI-stained neuronal cells and count of TUNEL-positive cells in CA1 and DG area of organotypic hippocampal slice culture were significantly decreased in pertinent density level of Yanggyuksanhwa-tang extract. LDH levels in culture media of organotypic hippocampal slice culture were significantly decreased in pertinent density level of Yanggyuksanhwa-tang extract. Conclusions : Within pertinent density level, Yanggyuksanhwa-tang has cell protection effect that prevents brain ischemia damaging neuronal cells and apoptosis increasing.
노령 흰쥐의 뇌허혈 손상시 凉膈散火湯이 뇌해마의 신경세포 및 HSP72 발현에 미치는 영향
박은경,신정원,손영주,정혁상,원란,손낙원 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3
This study investigated the effect of Yanggyuksanhwa-tang on cerebral ischemia of the rats. Considering age-related impact on cerebral ischemia, aged rats (18 months old) were used for this study. Ischemic damage was induced by the transient occlusion of bilateral common carotid arteries (BCAO) under the hypotension. Yanggyuksanhwa-tang was administered twice orally. Then changes of pyramidal neurons and heat shock protein 72 (HSP72) expressions in ischemic damaged hippocampus were of observed. The BCAO in aged rats led significant decrease of pyramidal neurons in CA1 hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the reduction of pyramidal neurons in CA1 hippocampus following BCAO ischemia. The BCAO in aged rats led significant increase of HSP72 expression in CA1 and mild in CA3 hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of HSP72 expression in CA1 hippocampus following BCAO ischemia. The extent of HSP72 expression in CA2 and DG of hippocampus was not different between the sham operated group, the BCAO ischemia control group, and the group of Yanggyuksanhwa-tang administration after BCAO ischemia. The treatment of Yanggyuksanhwa-tang significantly attenuated the increase of normalized optical density depending on HSP72 expression in CA1 hippocampus following BCAO ischemia.
노령 흰쥐의 뇌허혈 손상시 양격산화탕(凉膈散火湯)이 뇌해마의 c-Fos 및 c-Jun 발현에 미치는 영향
김성준,신정원,손영주,정혁상,원란,손낙원,Kim Seung-Jun,Shin Jung-Won,Sohn Young-Joo,Jung Hyuk-Sang,Won Ran,Sohn Nak-Won 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2
This study investigated the effect of Yanggyuksanhwa-tang on cerebral ischemia of the rats. Considering age-related impact on cerebral ischemia, aged rats (18 months old) were used for this study. Ischemic damage was induced by the transient occlusion of bilateral common carotid arteries(BCAO) under the hypotension. Yanggyuksanhwa-tang was administered twice orally. Then changes of immunohistochemical expression of c-fos and c-jun in ischemic damaged hippocampus were observed. The BCAO in aged rats led significant increase of c-fos expression in CA1 and DG of hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of c-fos expression in CA1 hippocampus following BCAO ischemia. Depending on changes of the normalized optical density(NOD) of immunohistochemical c-fos expression, the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of NOD in CA1 and DG of hippocampus. And there was not changes in CA2 and CA3 hippocampus with respect to the control BCAO group. The BCAO in aged rats led significant increase of c-jun expression in CA1 hippocampus. While the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of c-jun expression in CA1 hippocampus following BCAO ischemia. Depending on changes of the NOD of immunohistochemical c-jun expression, the treatment of Yanggyuksanhwa-tang significantly attenuated the increase of NOD in CA1 hippocampus. And there was not changes in CA2, CA3 and DG of hippocampus with respect to the control BCAO group.
정다영,하혜경,이호영,이진아,이남헌,이준경,황대선,신현규,Jung, Da-Young,Ha, Hye-Kyung,Lee, Ho-Young,Lee, Jin-Ah,Lee, Nam-Hun,Lee, Jun-Kyoung,Huang, Dae-Sun,Shin, Hyeun-Kyoo 사상체질의학회 2010 사상체질의학회지 Vol.22 No.4
1. Objectives Yanggyuksanhwa-tang for Soyangin was applied to investigate the immunological activities on antigen (Ag)-specific or Ag-non-specific immune responses on murine macrophage cell line (RAW 264.7) and ovalbumin/aluminium (OVA/Alum)-immunized mice. 2. Methods This study were carried out in nitric oxide (NO) synthesis on RAW 264.7 cells and cellular proliferation on mouse splenocytes. C57BL/6 mice were immunized intraperitonially with OVA/Alum (100 ${\mu}g$/200 ${\mu}g$) on day 1, 8, and 15. Yanggyuksanhwa-tang was administrated to mice orally for 3 weeks from day 1. On day 22, OVA-, lipopolysaccharide (LPS)-, and concanavalin A (Con A)-stimulated splenocyte proliferation and antibodies (OVA-specific antibodies of the IgG, IgG1, and total IgM classes) in plasma were measured. 3. Results Yanggyuksanhwa-tang significantly enhanced cellular proliferation by LPS and Con A on splenocytes from OVA/Alum-immunized mice (p<.001). Yanggyuksanhwa-tang also significantly enhanced plasma OVA-specific IgG (p<.001), IgG1 (p<.001), and total IgM (p<.01) levels compared with the OVA/Alum group. 4. Conclusions These results suggested that Yanggyuksanhwa-tang for Soyangin could be used as immunopotent.
소양인(少陽人) 상소증(上消證)으로 진단한 배뇨장애를 호소하는 신경인성 방광 남환 1례
오지원,강민수,양성필,이의주,Oh, Ji-Won,Kang, Min-Su,Yang, Sung-Pil,Lee, Eui-Ju 사상체질의학회 2018 사상체질의학회지 Vol.30 No.3
Objective The purpose of this study is to investigate the effect of Yanggyuksanhwa-tang on Neurogenic bladder by Frontotemporal dementia in a 65-year-old male patient. Method Patient was treated with Yanggyuksanhwa-tang. Patient's symptom was assessed Total Frequency of urination, Frequency of nocturia, single voided volume. The treatment was executed three times everyday from March, 21th to March 29th of 2018. Patient was observed from March, 20th to March, 30th. Results During 8 days of Yanggyuksanhwa-tang, patient's symptoms were evaluated by Total Frequency of urination, Frequency of nocturia, single voided volume. After the treatment, Total Frequency of urination, Frequency of nocturia decreased. Single voided volume increased. Conclusion The results suggest that Yanggyuksanhwa-tang can be a valuable option in treating Neurogenic bladder by Frontotemporal dementia.
흰쥐의 중대뇌동맥 결찰로 유발된 뇌허혈에서 양격산화탕(凉膈散火湯)이 신경세포에 미치는 효과
신길조,오경환,정승현,이원철,Shin, Gil-cho,Oh, Kyung-hwan,Jeong, Sung-hyun,Lee, Won-chul 대한중풍순환신경학회 2006 대한중풍.순환신경학회지 Vol.7 No.1
Objectives : Yanggyuksanhwa-tang is a prescription used for cerebral infarction clinically. Methods : According to previous research data, the effect of Yanggyuksanhwa-tang on cerebral infarction, we induced cerebral infarction by middle cerebral artery occlusion(MCAO) in rats, and the rats were administered Yanggyuksanhwa-tang. Results: Infarct area, infarct volume were measured, and the level of elements such as c-Fos, Bax and caspase-3 in penumbra of infarct were expressed by immunohistochemical staining. Conclusion : Yanggyuksanhwa-tang showed neuroprotective effect through preventing neuronal cell apoptosis.
양격산화탕(凉膈散火湯)이 고지혈증 흰쥐의 중대뇌동맥 폐쇄에 의한 뇌경색에 미치는 영향
오경환,이원철,Oh, Kyung-Hwan,Lee, Won-Chul 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4
Objectives : Yanggyuksanhwa-tang is a prescription used for cerebral infarction clinically it is known that this formula reduces body fat, serum cholesterol and triglyceride in hyperglycemia and obesity patients. According to previous research data, controlling these types of lipid is considered to decrease the risk of cerebral infarction. Based on this fact, we investigated the relationship between hyperlipidemia and cerebral infarction, and the effect of Yanggyuksanhwa-tang on hyperlipidemic cerebral infarction. Methods : We induced cerebral infarction by middle cerebral artery occlusion (MCAO) in high-fat diet rats, and the rats were administered Yanggyuksanhwa-tang. Results : Infarct area and serum lipid were measured, and the level of elements such as c-Fos, Bax and caspase-3 in penumbra of infarct were expressed by immunohistochemical staining. Conclusions : Yanggyuksanhwa-tang showed neuroprotective effect through preventing neuronal cell apoptosis as well as reducing serum lipid level in hyperlipidemic condition.
양격산화탕(凉膈散火湯) 치험례를 바탕으로 한 소양인 다한증(多汗症)환자에 대한 소고(小考)
이재훈,신미란,Lee, Jae-Hun,Shin, Mi-Ran 사상체질의학회 2011 사상체질의학회지 Vol.23 No.4
1. Objectives This study was designed to investigate the effect of Yanggyuksanhwa-tang(凉膈散火湯) to twelve hyperhidrosis patients. 2. Methods From May, 2008 to August, 2010, we treated hyperhidrosis patients with Yanggyuksanhwa-tang(凉膈散火湯). We survey demographic characters, symptoms of patients and efficacy of Yanggyuksanhwa-tang(凉膈散火湯). 3. Results 1) Twenties, thirties and males were more suffer from hyperhidrosis. 2) The patients who had dysuria got treatment efficacy negatively. 3) Treatment efficacy was affected by number of herbal medicine positively. 4. Conclusions This study shows that Yanggyuksanhwa-tang(凉膈散火湯) has effect to hyperhidrosis in Soeyangin. Treatment efficacy was affected by number of herbal medicine significantly.
금나래,박세원,이용재,김호준,박성식,배효상,Keum, Na-rae,Park, Se-Won,Lee, Yong-Jae,Kim, Ho-Jun,Park, Seong-Sik,Bae, Hyo-Sang 사상체질의학회 2017 사상체질의학회지 Vol.29 No.2
Objectives The purpose of this study was to survey changes in symptoms caused by Sasang medicines. Methods We recruited 45 subjects who were classified 15 typical Soeumin, Soyangin, Taeumin and did a survey about symptoms. We split Soeumin into 3 groups and prescribed medicines Palmulgunja-tang, Yanggyuksanhwa-tang, Taeumjowi-tang. We did same process in Soyangin and Taeumin. After taking medicines for 4 weeks, we did a survey about physical changes. Results There was no consistent changes in symptoms. But medicines which were not suitable to their Sasang constitution induced known reactions. And medicines which were suitable to their Sasang constitution induced reactions. Conclusions Changes in symptoms appeared after taking medicine, but they can be induced by medicine.