초발 정신분열증의 정신병리와 혈장 Homovanillic acid 및 5-hydroxyindoleacetic acid 와의 관계

구민성 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1

Initial treatment of schizophrenia may not be successful due to the side effects of antipsychotic drugs and absence of insight in the patients. Schizophrenic patients go into the chronic and devastating process due to the characteristics of disease itself and making it necessary to predict therapeutic response in the initial stages of treatment. The changes of plasma metabolites, an objective method which measures therapeutic responses, is sensitive to many factors like age, disease duration, drug exposure period, and schizophrenia is made of not just one symptoms, but several symptoms. To control these confounding factors, it is necessary to study with first-episode drug-naive patients. The purposes of this study were to examine the changes of plasma homovanillic acid(HVA), 5-hydroxyindoleacetic acid(5-HIAA), and HVA/HIAA ratio during an 6-week risperidone trial and to investigate the relationship between the plasma monoamine metabolites and treatment responses. Seventeen first-episode drug naive schizophrenic patients were treated for 6 weeks with risperidone. The psychopathology was assessed at baseline just before SDA trial and then at 2 week and 6 week after SDA treatment. At the same time plasma HVA and 5-HIAA were evaluated by HPLC(high performance liquid chromatography). The results were as follows: 1.Plasma HVA and 5-HIAA levels were significantly decreased during an 6-week risperidone treatment, although plasma HVA/5-HIAA ratio showed no significant change. 2.The changes of plasma HVA levels were in significant correlations with the changes of PANSS positive scores, and the changes of plasma 5-HIAA levels were in significant correlations with the changes of PANSS negaive scores. These results suggest that the antipsychotic effect of risperidone on positive symptoms may be associated with dopaminergic blocking activity, and on negative symptoms may be associated with serotonergic blocking activity. The changes of plasma HVA and 5-HIAA levels may be useful therapeutic predictors in the treatment of risperidone. Key Words : first-episode schizophrenia, changes of psychopathology, plasma HVA, 5-HIAA, serotonin dopamine antagonist

Surface chemical structure and doping characteristics of boron-doped Si nanowires fabricated by plasma doping

Oh, Seung-Hoon,Ma, Jin-Won,Bae, Jung Min,Kang, Yu-seon,Ahn, Jae-Pyung,Kang, Hang-Kyu,Chae, Jimin,Suh, Dongchan,Song, Woobin,Kim, Sunjung,Cho, Mann-Ho Elsevier 2017 APPLIED SURFACE SCIENCE - Vol.419 No.-

<P><B>Abstract</B></P> <P>We investigated the conduction characteristics of plasma-doped Si nanowires (NWs) after various rapid thermal annealing (RTA) times. The plasma doping (PD) process developed a highly-deposited B layer at the NW surface. RTA process controls electrical conductivity by mediating the dopant diffusion from the surface layer. The surface chemical and substitutional states of the B plasma-doped Si NWs were analyzed by x-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. To elucidate the detailed structure of the NWs, we analyzed the change in the optical phonon mode caused by the incorporated B atoms. For this purpose, we examined Fano resonance by the investigation of the asymmetry, line-width, and phonon wavenumber in Raman spectra. The changes in symmetry level of the Raman peak, phonon lifetime, and internal strain were closely related to the number of electrically activated borons, which was drastically increased with RTA time. The change in electrical and optical characterizations related to the doping characteristics of the NWs was investigated using a 4-point probe and terahertz time-domain spectroscopy (THz–TDS). The resistivity of the NWs was 3000 times lower after the annealing process compared to that before the annealing process, which is well consistent with the optical conductivity data. The data provide the potential utility of PD in conformal doping for three-dimensional nanodevices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Dopant activations of plasma-doped (PD-) Si NWs are investigated with RTA time. </LI> <LI> Chemical states and Fano factor of PD-Si NWs are changed with the dopant activation. </LI> <LI> Both electrical and optical conductivity of PD-Si NWs increase greatly and coherently. </LI> <LI> Carrier generation by PD process is more effective at 1D Si NW than 2D Si substrate. </LI> </UL> </P>

Preparation of plasma reduced graphene oxide / organic phase change material composites for latent heat storage application

이경섭,이충현,장정식 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0

Various organic phase change materials (PCMs) - paraffin, polyethylene glycol (PEG) and octanoic acid - were absorbed into the expanded structure of plasma-reduced graphene oxide (PrGO) to fabricate diverse PrGO/PCM composites. Because of large surface area and expanded structure, organic PCMs could be successfully impregnated into the PrGO structure. As-prepared PrGO/PCM composites had highest thermalconductivity value of about 0.75 W/m K which was about 3-fold increase of that of the pristine PCMs. Furthermore, thermal stability was also increased while there was no decrease in heat of fusion because of low fraction of PrGO composition (1 wt%). These simply fabricated PrGO/PCM composites can be applied to thermal energy management and solar energy storage.

개 자가부분 간이식에서 이식간 초기 기능 지표로서 혈청 젖산 및 아미노산의 단계별 대사 변화

김상준(Sang Joon Kim),서경석(Kyung Suk Suh),이건욱(Kuhn Uk Lee),최재운(Jae Won Choi),안세현(Sae Hyun Ahn),정성은(Sung Eun Jung),배수동(Soo Tong Pai),김주섭(Joo Seop Kim),조홍래(Hong Rae Cho),정중기(Jung Kee Chung),이우정(Woo Jung Lee 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5

N/A Living-related segmental liver transplantation is currently accepted as one method of treatments of pediatric endstage liver diseases. Immediate recovery of graft function is prerequisite for patients survival, In case of graft failure, early prediction is necessary for retransplantation to avoid decease. Since amino acids and lactic acid are metabolized in liver, levels of those components lin plasma are frequently used as indicators for hepatic graft function. we have investigated the wequential changes of amino acids and lactic acid following autologous segmental liver transplantation in canine to identify the significance of these indicators. Ten mongrel dogs were prepared by harvesting the left lobe frorn experimental dogs, removing the rest of liver using total vascular exclusion and veno-venous bypass, and implanting the left lobe taken at first stage in the orthotopic position. The plasma amino acids and lactic acid concentrations in arterial blood obtained at preoperative period, anhepatic phase, reperfusion-15 min., 1 hour, 3 hours, 6 hours, were measured on Beckman system 6300 amino acid analyzer and Kodak Ektachem 700 XR, Among ten dogs, five of them died within 20 hours (Group 1), and the rest of them died after 20 hours (Group 2). The results indicate: (1) ln both Group, all plasma amino acid levels were increased in anhepatic phase except Valine, Isoleucine, and Arginine. Most highly increased amino acid was Alanine. (2) In group 1, most amino acids were slightly decreased till reperfusion 1 hour, and then increased to the level of anhepatic phase in reperfusion 6 hours. (3) In group 2, most plasma amino acid levels were decreased to preoperative values within 6 hours following reperfusion. (4) The changing patterns of TFPAA (total free plasma amino acid), BCAA/AAA ratio (Branched chain amino acid/aromatic amino acid ratio), and severaI amino acids (Phenylalanine, alanine Proline, Tyrosine) revealed statistically significant difference between two Groupe. (5) While plasma concentration of lactate continued to rise until 6 hours after reperfusion in Group 1, already increased plasma concentration of lactate in anhepatic phase reached plateau during 6 huurs after reperfusion in Group 2. The above changing pattern of plasma concentration of lactate showed statistically significant difference between both Groups (p<0.05). (6) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were increased equally during operation and reperfusion in two Groups. Therefore, the sequential changes of plasma amino acids and lactic acid are useful indicators for detection of early graft function in canine autologous segmental liver transplantation

운동생리학 : 다양한 운동형태의 일회성 운동이 혈장량과 혈중 지질 및 지단백 콜레스테롤에 미치는 영향

심윤택(SimYunTaeg),김광희(KimGwangHui),박동호(ParkDongHo),김도윤(KimDoYun) 한국체육학회 2003 한국체육학회지 Vol.42 No.5

Acute plasam volume change(PVC) and high-density lipoprotein (HDL), triglyceride(TG), total cholesterol(TC), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) changes were determined in 18 healthy college aged-men completing three-counterbalanced running trials at different exercise intensities: trial 1 at 50%LT, trial 2 at 100%LT intensity and 75%LT intensity. For each trial, blood samples were collected at pre-exercise (baseline), immediately post-exercise (PE), 24 hours(24h) and 48 hours post-exercise. Serum samples were analyzed for HDL, LDL, VLDL, TC, and TG. In addition, capillary blood samples were collected for analysis of blood lactate concentrations during incremental test to determine LT. All samples were corrected for plasma volume changes and compared to pre-exercise (baseline). The result through the statistical analysis of plasma volume change and lipid profiles as follows:1. PVC was not changes among the intensities while the differences of PVC over time were detected at 50%LT (baseline vs immediately post-exercise, p<.05) and 75% LT (immediately post-exercise vs 48h PE, p<.05). 2. No significant difference was determined in changes of HDL, LDL, VLDL, TG, and TC at various intensities over time. However, there was favourable changing tendency of HDL & TG at the 100%LT intensity. Consequently, exercise at LT intensity might favourably alter the lipid profile as demonstrated in increasing tendencies of 24h and 48h HDL concentrations in combination with decreasing tendencies of TG and VLDL at in 24h and 48h. Therefore, the 100%LT intensity might be the favourable threshold intensity of acute aerobic exercise (expending over 400 ㎉ or spending over 38min for exercise duration) necessary to promote a significant increase in HDL.

Physiological Relationship Between Thirst Level and Feed Intake in Goats Fed on Alfalfa Hay Cubes

Prasetiyono, Bambang W.H.E.,Sunagawa, Katsunori,Shinjo, Akihisa,Shiroma, Sadao Asian Australasian Association of Animal Productio 2000 Animal Bioscience Vol.13 No.11

The present study was carried out to measure changes of feed intake and thirst level caused by water deprivation in goats fed on dry feed and to elucidate the relationship between those two parameters. Water deprivation significantly (p<0.01) decreased cumulative feed intake and rate of eating at 30, 60, 90 and 120 min, respectively, after feed presentation. Cumulative feed intake, after completion of 2 h feeding, was reduced by about 20, 21 and 64 % due to water deprivation during feeding for 2 h (WD2), for 22 h (WD22) and for 46 h (WD46), respectively, compared to free access to water (FAW). Compared to the FAW, WD2, WD22 and WD46 increased thirst level by about 5, 5 and 9 times, respectively. Mean thirst level (X, g/30 min) was negatively correlated with cumulative feed intake (Y, g DM) after completion of 2h feeding (Y=1302-0.2 X, $r^2=0.97$, p<0.05). Water deprivation depressed plasma volume and there was a significant positive regression between plasma volume (X, ml) and cumulative feed intake (Y, g DM) after completion of 2h feeding (Y=-1003+0.6 X, $r^2=0.99$, p<0.01). Mean plasma osmolality (X, mOsmol/l) correlated significantly and negatively with cumulative feed intake (Y, g DM) after completion of 2h feeding (Y=27004-84.9 X, $r^2=0.95$, p<0.05). In conclusion, a decrease of feed intake during water deprivation is mainly due to an increase of thirst level quantitatively, and the act of feeding itself induces thirst more than the length of water-deprivation periods in goats fed on dry feeds. The present findings suggest that plasma osmolality and plasma volume which affect thirst level are involved in the decrease of feed intake in water-deprived goats.

울트라 마라톤(100 km)에서 삼투압 농도와 전해질 대사의 생화학적 요인 변화에 대한 안전성 평가

신경아 ( Kyung A Shin ),김영주 ( Young Joo Kim ) 대한임상검사과학회 2016 대한임상검사과학회지(KJCLS) Vol.48 No.2

본 연구는 22명의 남자 아마추어 선수를 대상으로 100 km 울트라 마라톤에서의 전해질 대사 반응의 안전성을 평가하기 위해 실시하였다. 대상자의 평균 연령은 50.91±4.77세, VO2max는 48.19±6.43 mL/kg/min, 그리고 평균 경기 완주시간은 829.64±89.31분이었다. 혈액검사에 포함된 전해질 지표로는 칼슘, 무기인, 마그네슘, 소디움, 포타슘, 염소, 총이산화탄소, 음이온차이, 혈장량 변화와 삼투압 농도를 경기 전, 50 km 지점, 경기 종료 직후 측정하였다. 본 연구결과 소디움 농도는 경기 전보다 50 km 지점에서 감소하였고 50 km 지점보다 100 km 지점에서 감소하였으나, 고나트륨혈증 및 저나트륨혈증은 나타나지 않았다. 100 km 울트라 마라톤 경기에서 다른 모든 전해질 지표들의 거리별 변화는 참고범위 내에서 이루어졌으며, 혈장량 변화는 나타나지 않았다. 결론적으로 아마추어 지구력 선수들의 전해질 대사에 있어서 경기중 통계적인 차이는 있었으나 임상적으로 의미 있는 삼투압 농도와 전해질의 변화는 나타나지 않았으며 안전한 경기로 나타났다. This study was conducted to investigate the electrolyte metabolic responses to a 100 km ultra-marathon in 22 male amateur runners. Their average age was 50.91±4.77 years old and their VO2max value was 48.19±6.43 mL/kg/min. The participants completed the race with a mean finishing time of 205.55±19.61 minute. Electrolyte parameters based on blood tests including calcium, inorganic phosphorus, magnesium, sodium, potassium, chloride, total carbon dioxide, anion gap, plasma volume change and osmolality were measured pre-race, at 50 km, and at 100 km (post-race). Only slight changes in sodium level with no cases of hypernatremia or hyponatremia were observed. Additionally, all the electrolyte parameters changes were within the normal range and plasma volumes were unchanged. Overall, amateur marathon runners are not at risk to develop clinically significant electrolyte or osmolality changes during a 100 km ultra-marathon.

교실의 HCHO와 VOCs 방출특성에 관한 측정 연구

송진용(Song Jin-Yong),황정하(Hwang Jung-Ha) 대한건축학회 2008 대한건축학회논문집 Vol.24 No.1

In this study, we divided schools into several groups based on the year of building completion. We also categorized their classrooms into general classroom [GC] and special classroom [SC], then we compared and analyzed the pollutantdensity distribution of formaldehyde(HCHO) and volatile organic compounds(VOCs) and the emission quantity of pollutants over time through an on-the-spot survey. In addition, we presented the indoor air change rate and the pollution-reducing effect of the plasma operation time as a method to improve indoor air quality. When we compared general classrooms with special classrooms to detect their pollution densities, the density of special classrooms was higher than that of general classrooms, which suggests the fact that the various appliances and surface-finishing materials of special classrooms affected those densities. A method to protect indoor air from pollutants (1) We installed the air-change system [ALT-1] and changed air, which appliedthe air change rate at 1.3 times/h [AH-13] and 2.0 times/h [AH-20]. As a result, the density of HCHO and VOCs decreased over time, which suggests that the ventilator has an effect on the reduction of pollutant density. (2) We also studied the emission density depending on plasma operation time [ALT-2]. It may be safely said that plasma effectively reduced the emission quantity of indoor pollutants in a short time.

Plasma Arc와 35% Carbamaide Peroxide의 미백효과와 법랑질 표면에 미치는 영향

구효진 ( Hyo Jin Gu ),송근배 ( Keun Bae Song ) 한국치위생과학회 2009 치위생과학회지 Vol.9 No.5

Comparison of Intestine Microbiota Between Wild and Farmed Korean Rockfish, Sebastes schlegelii

유지현,강민주,김윤재,박미정,임재규,노충환,강성균,이현숙,이정현,권개경 한국해양과학기술원 2021 Ocean science journal Vol.56 No.3

The Korean rockfish, Sebastes schlegeli, is most commonly farmed in sea cages along the coast of Korea; however, detailed information on intestinal microbiota regarding this fish is not readily available. In this study, comparison of the seasonal changes of microbial communities in the intestine between farmed and wild through the amplicon sequencing approach was conducted. The composition of major species in the intestine of this fish was very simple compared to that of other marine fish species, with members affiliated with the family Vibrionaceae hyper-dominating and comprising on average 97.6% of microbiota. However, the composition at the genus or species level and the pattern of seasonal changes of diversity indices showed significant differences between farmed and wild fish. In the farmed fish, Photobacterium phophoreum was most dominant throughout the year, accounting for 58.8% of the total. Aliivibrio fisherii and/or Aliivibrio finisterrensis also were dominant in the fall to winter but substituted by Photobacterium damselae during spring to summer. In the wild fish, on the other hand, opportunistic pathogens in the genera Aliivibrio or Vibrio were dominant in most of the samples. The analysis of shared species between gut microbiome, feed microbiota, and seawater microbiota indicated that the intestinal microbial diversity of farmed fish was affected more by microbiota of seawater than that of feed in spring and winter seasons. Additionally, the proportion of potential pathogenic Vibrio spp. in the gut showed a negative correlation with plasma glucose levels of the host. This study and following studies will be helpful in understanding the interaction between microbiome hosts and the development of techniques to enhance production of healthy Korean rockfish.