PFT법에 의한 수직적 3 ZONE 분할 조건에서의 환기량 측정

김훈(Hoon Kim) 대한설비공학회 2013 설비공학 논문집 Vol.25 No.9

The PFT (PerFluorocarbon Tracergas Technique) is of advantage to field surveys for evaluating the ventilation condition, due to its simplicity and convenience. On the other hand, it requires researchers to make some additional considerations that include uncertainties, such as the substance concentration distribution in indoor air, representativeness of a sampler, deviation of emission sources, and analysis error. In this study, the PFT and CO₂ tracer gas methods were applied simultaneously, to evaluate the accuracy of PFT on six ventilation conditions in the three-storied detached house. The air exchange and the outdoor air introduction a between and into zones were measured. As the results, deviations of PFT concentration distributions were observed at a sufficiently low level for an accurate determination for a house where the interior height was large, and there were relatively many partition walls. However, when a uniform airflow appeared in the indoor air, it was also validated that the indoor air would be exhausted without sufficient mixing, and consequently the measurement error of the PFT would be large.

Development and Validation of a Perfect KASP Marker for Fusarium Head Blight Resistance Gene Fhb1 in Wheat

Singh, Lovepreet,Anderson, James A,Chen, Jianli,Gill, Bikram S,Tiwari, Vijay K,Rawat, Nidhi The Korean Society of Plant Pathology 2019 Plant Pathology Journal Vol.35 No.3

Fusarium head blight (FHB) is a devastating wheat disease with a significant economic impact. Fhb1 is the most important large effect and stable QTL for FHB resistance. A pore-forming toxin-like (PFT) gene was recently identified as an underlying gene for Fhb1 resistance. In this study, we developed and validated a PFT-based Kompetitive allele specific PCR (KASP) marker for Fhb1. The KASP marker, PFT_KASP, was used to screen 298 diverse wheat breeding lines and cultivars. The KASP clustering results were compared with gelbased gene specific markers and the widely used linked STS marker, UMN10. Eight disagreements were found between PFT_KASP and UMN10 assays among the tested lines. Based on the genotyping and sequencing of genes in the Fhb1 region, these genotypes were found to be common with a previously characterized susceptible haplotype. Therefore, our results indicate that PFT_KASP is a perfect diagnostic marker for Fhb1 and would be a valuable tool for introgression and pyramiding of FHB resistance in wheat cultivars.

Development and Validation of a Perfect KASP Marker for Fusarium Head Blight Resistance Gene Fhb1 in Wheat

Lovepreet Singh,James A Anderson,Jianli Chen,Bikram S Gill,Vijay K Tiwari,Nidhi Rawat 한국식물병리학회 2019 Plant Pathology Journal Vol.35 No.3

Fusarium head blight (FHB) is a devastating wheat disease with a significant economic impact. Fhb1 is the most important large effect and stable QTL for FHB resistance. A pore-forming toxin-like (PFT) gene was recently identified as an underlying gene for Fhb1 resistance. In this study, we developed and validated a PFTbased Kompetitive allele specific PCR (KASP) marker for Fhb1. The KASP marker, PFT_KASP, was used to screen 298 diverse wheat breeding lines and cultivars. The KASP clustering results were compared with gelbased gene specific markers and the widely used linked STS marker, UMN10. Eight disagreements were found between PFT_KASP and UMN10 assays among the tested lines. Based on the genotyping and sequencing of genes in the Fhb1 region, these genotypes were found to be common with a previously characterized susceptible haplotype. Therefore, our results indicate that PFT_ KASP is a perfect diagnostic marker for Fhb1 and would be a valuable tool for introgression and pyramiding of FHB resistance in wheat cultivars.

COPD와 양도락의 진단적 관련성에 대한 연구

장석현,김상진,정희재,정승기,이범준,Jang, Seok-Hyun,Kim, Sang-Jin,Jung, Hee-Jae,Jung, Sung-Ki,Lee, Beom-Joon 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4

Objectives: Ryodoraku is a physiological function test using electric current. Since it can evaluate the patient's overall condition as well as a function of individual organs, Ryodoraku can be assumed as an effective way to diagnose chronic obstructive pulmonary disease (COPD). Therefore, this study aimed to investigate the values of Ryodoraku for diagnosing COPD. Methods: We designated a COPD group, who were over 40 and satisfying COPD criteria, $FEV_1$/FVC<0.7. The Control group also consisted of members over 40 years old but without COPD and any other lung disease. We conducted a comparative study by checking the Ryodoraku score (RS), the average of Rt.&Lt. H1 (mean H1), the mean difference value between both H1s (${\mid}H1^R-H1^L{\mid}$) and the ratio of patients whose RS was under 40. Then we investigated the correlation between the mean H1 and the results of pulmonary function test (PFT). Results & Conclusions: In the COPD group, RS, mean H1 and ${\mid}H1^R-H1^L{\mid}$ were significantly lower and the ratio of 'RS<40' patients was meaningfully higher than in the Control group. On the other hand, PFT seems not to be replaced by Ryodoraku since there was no correlation between mean H1 and the results of PFT. Though more experiments and researches are needed to be further confirmed, Ryodoraku is expected to be an adequate way for prediagnosing and following up the COPD patients.

현장 실측을 통한 패시브 PFT법과 SF₆ 및 CO₂ 트레이서 가스 환기량 측정법의 비교

김훈(Kim, Hoon),타나베 신이치(Tanabe, Shin-ichi) 대한건축학회 2012 대한건축학회 학술발표대회 논문집 Vol.32 No.2

Technegas를 이용한 폐환기 검사와 폐기능 검사의 상관관계에 관한 고찰

김상규,김진구,백송이,강천구,김재삼,Kim, Sang-Gyu,Kim, Jin-Gu,Baek, Song-EE,Kang, Chun-Koo,Kim, Jae-Sam 대한핵의학기술학회 2019 핵의학 기술 Vol.23 No.1

폐 환기 검사는 직접 방사성 기체를 흡입한 후 이를 영상화 한다. 그러나 실제 폐 환기 검사 시 활용할 수 있는 흡입과 관련한 지표는 널리 알려진 바가 없다. 따라서 본 연구를 통해 흡입과 관련한 객관적인 지표로써 폐 환기 검사 계수율과 폐 기능검사 결과 값의 상관관계를 확인하고 그 유용성을 알아보고자 한다. 2010년 10월부터 2018년 9월까지 본원에서 폐 환기 검사와 폐 기능 검사를 모두 시행한 만성폐쇄성 폐질환 환자 36명을 대상으로 중증도(Mild, Moderate, Severe)별로 분류하였다. 폐 환기 검사는 Technegas Generator (Vita Medical Ltd, Australia)로 Technegas를 생성하여, 환자에게 흡입하게 하였다. 영상은 Forte (Philips Medical Systems, Netherlands) 장비를 사용하였으며, 폐 기능 검사는 Vmax Encore 22 (Carefusion Corporation, USA)를 사용하였다. 폐 환기 검사에서는 양측 폐에 관심 영역을 설정하여 계수율을 측정하였고, 이와 함께 폐 기능 검사의 결과 값 중 노력 폐활량(FVC), 1초 노력 호기량($FEV_1$), 일초율($FEV_1/FVC$) 사이의 상관관계를 비교 분석하였다. 만성폐쇄성폐질환 환자의 폐 환기 검사 계수율과 폐 기능 검사 결과 값의 상관관계를 분석한 결과, 중증도별 $FEV_1/FVC$와 계수율 사이의 상관계수는 Severe에서 -0.773, Moderate에서 -0.750, Mild에서 -0.437이였다. Severe, Moderate 결과 값은 통계적으로 유의하였으며(P<0.05), Mild는 유의하지 않았다(P=0.155). 반면에 FVC와 계수율 사이의 상관계수는 Mild에서만 0.882로 통계적으로 유의한 것을 확인하였다(P<0.05). 만성폐쇄성폐질환 환자를 대상으로 시행한 폐 환기 검사 시 계수율과 폐 기능 검사 결과 값의 상관관계를 확인할 수 있었다. 이를 통해 폐 환기 검사 시 호흡력에 대한 지표로써 폐 기능 검사 결과 값을 활용할 수 있을 것으로 생각된다. Purpose Lung Ventilation Scan(LVS) images directly inhaled radiation gas to evaluate lung ventilation ability. Therefore, it is influenced by various factors related to inhalation, including number of breaths, respiratory duration, respiration rate, and breathing method. In actual LVS examinations, it is difficult for objectify the patient's ability to inhale, and there is currently no known index related to inhalation. Therefore, this study confirms the correlation between counts per second(cps) in LVS and the results of pulmonary function test(PFT) and evaluate its usefulness as an objective indicator of inhalation. Materials and Methods From October 2010 to September 2018, 36 Chronic Obstructive Pulmonary Disease(COPD) patients who had both LVS and PFT were classified by severity(Mild, Moderate, Severe). LVS was performed by creating Technegas with Vita Medical's Technegas Generator and inhaling it to the patient. LVS images were acquired with Philips's Forte equipment., and PFT used Carefusion's Vmax Encore 22. The correlation between the cps measured by setting the region of interest(ROI) of both lungs on the LVS and the forced vital capacity(FVC), forced expiratory volume in one second($FEV_1$), $FEV_1/FVC$ of the results of PFT was compared and analyzed. Results We analyzed the correlation between cps of LVS using Technegas and the results of PFT by classifying COPD patients according to severity. Correlation coefficient between $FEV_1/FVC$ and cps was Severe -0.773, Moderate -0.750, and Mild -0.437. The Severe and Modulate result values were statistically significant(P<0.05) and Mild was not significant(P=0.155). On the other hand, the correlation coefficient between FVC and cps was statistically significant only in Mild and it was 0.882(P<0.05). Conclusion According to the study, we were able to analyze correlation between cps of LVS using Technegas and the results of PFT in COPD Patients. Using this result, when performing a LVS, the results of PFT can be used as an index of inhaling capacity. In addition, it is thought that it will be more effective for the operation of the exam rooms.

Construction of an PFT database with various clinical information using optical character recognition and regular expression technique

Park, Man Young,Park, Rae Woong Korean Society for Internet Information 2017 인터넷정보학회논문지 Vol.18 No.5

The pulmonary function test (PFT) is an essential data source for evaluating the effect of drugs on the lungs or the status of lung function. However, the numeric values of PFT cannot be easily used for clinical studies without labor-intensive manual efforts, because PFTs are usually recorded as image files. This study was aimed at constructing a de-identified, open-access PFT database with various clinical information. For constructing the PFT database, optical character recognition (OCR), regular expression, and the parsing technique were used to extract alphanumeric data from the PFT images in a Korean tertiary teaching hospital. This longitudinal observational database contains 413,000 measurements of PFT from 183,000 patients.

방사선 폐렴의 임상적 특징

이재호(Jae Ho Lee),현인규(In Gyu Hyun),최동철(Dong Chul Choi),유철규(Chul Gyu Yu),송재훈(Jae Hoon Song),정기석(Ki Suck Jung),김영환(Young Whan Kim),한성구(Sung Ku Han),심영수(Young Soo Shim),김건열(Keun Yeol Kim),한용철(Yong Chul Han 대한내과학회 1991 대한내과학회지 Vol.40 No.3

N/A Radiation pneumonitis is one of the most important early complication of radiation therapy. In order to examine whether or not the increasing in patients suffering from concurrent COPD and Lung Ca, and to study clinical features of radiation pneumonitis, the writers conducted a retrospective study on 60 patients with proven lung cancer who underwent radiation therapy during the period from 1985 to 1988 and had their PFT performed before the radiation and obtained the following results; 1) Non productive cough was the most frequent clinical symptom of radiation pneumonitis and dyspnea, whitish sputum, chest tightness, mild fever was also present. The clinical symptom was not related to radiation dose, initial time of pneumonitis, PFT, age but was more serious in the patients with FEV1/FVC more than 70%. 2) Radiation pneumonitis occurred most frequently between the period of 4 weeks and 12 weeks and onset time of radiation pneumonitis was not related to the radiation dose, PFT, age, 3) Chest X-ray showed alveolar, alveolar-interstitial mixed, interstitial pattern, fibrosis confined to radiation field and changed with time. 4) There was no significant difference between FEV1, FVC, FEV1/FVC and incidence of radiation pneumonitis but in patents with FEV1/FVC more then 70%, there was significantly higher incidence of radiation pneumonitis. 5) The incidence of radiation pneumonitis was increased as radiation dose was increased.

The value of FEF25-75% can be an early predictor for development of chronic obstructive pulmonary disease

( Do Sun Kwon ),( Yong Jun Choi ),( Tae Hee Kim ),( Min Kwang Byun ),( Hyung Jung Kim ),( Hye Jung Park ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Backgrounds: The value of forced mid-expiratory flow (FEF)_25-75% is the most effort-independent and sensitive marker to reflect obstructive peripheral airflow. However, the role of FEF_25-75% to detect early chronic obstructive pulmonary disease (COPD) is still controversial. Methods: From 1st July 2008 to 31th June 2009, we recruited 3,624 subjects from Gangnam Severance Hospital and checked the results of the subject’s PFT records. We retrospectively reviewed electronic medical records of selected 167 subjects (≥ 40yrs and without COPD at baseline) who presents normal forced expiratory volume in one second (FEV₁)/forced vital capacity (FVC), FVC, and FEV₁ value and who have followed PFT records after at least 1 year. The value of FEF_25-75% less than 80% is considered to be low. We defined development of COPD when FEV₁/FVC is less than 0.7 until 31th July 2019. Results: Among 167 subjects, 84 (50.3%) subjects presented low FEF_25-75%. Subjects who presented low FEF_25-75% have diabetes more predominantly, and show lower FEV₁ and FEV₁/FVC than subjects who presented normal FEF_25-75%. Cox regression analysis showed that low FEF_25-75%, depression, low FEV₁, and low FVC are significant predictors for development of COPD. After adjustments, cox regression analysis showed that low FEF_25-75% is the only predictive factor for development of COPD (HR, 4.66; 95% CI, 1.63-12.27; P-value= 0.004). In sub-group analysis, the COPD development risk went up further according to the severity of FEF_25-75% impairment. Conclusion: The value of FEF_25-75% can be useful to predict development of COPD. We should carefully monitor subjects who present low FEF_25-75%, although they show normal lung function.

연구논문 : 여수 공단지역 거주자들의 폐기능과 영향 요인

홍은주,안기섭,정은경,손부순,( Xinbiao Guo ) 한국환경과학회 2011 한국환경과학회지 Vol.20 No.7

Objectives: This study is aimed at identifying the influential factors on the pulmonary function of ordinary residents in the surrounding areas of Yeosu Industrial Complex. Methods: The PFT (Pulmonary Function Test) was conducted on the target residents numbering 989 people (male 361, female 628). The exposed group (813 people) resided within the radius of 5km from Yeosu Industrial Complex and the control group (176 people) resided in the radius of more than 15 km from May 2007 to November 2007. The survey also took into account other factors including personal characteristics, life habits, respiratory diseases and allergic symptoms, medical histories, and the living environments of the residents in order to further identify influential factors on pulmonary function. Result: When comparing the PFT values of the exposure groups to the control group of the same city, values of the exposure groups were meaningfully lower with an %FEV1 of 107.05% and %FVC of 100.28%. Conversely, the control group reported an %FEV1 and %FVC of 107.26% and 102.85% respectively, indicating that ambient air pollutants reduce lung function. The odds ratio of asthma diagnosis history increased when a subjects residence was close to a heavily trafficked road, traffic amount was huge, a bed was used, and the family had less than four members. However the results were not statistically meaningful. The odds ratios of abnormal pulmonary function were statistically higher among those with asthma(OR=4.29, CI=1.75-10.56), wheezing (OR=2.59, CI=1.24-5.41), and nasal congestion (OR=2.87, CI=1.36-6.08) (p<0.01). The factors affecting FEV1 were symptoms including asthma, passive smoking and allergic eye disease (R2=0.049, p<0.001). For the FVC symptoms including asthma (R2=0.014, p<0.001) were measured. The analysis showed that FVC decreased with increases in O3 and CO(p<0.01). Furthermore, FEV1 decreased with increases in O3(p<0.01). Conclusions: These results will provide preliminary data for establishing responsive measures to protect the health of residents in industrial complexes from air pollution, and to develop lasting environmental health policies.