Indoor Physical Activity Reduces All-Cause and Cardiovascular Disease Mortality Among Elderly Women

박소영,이중엽,강동윤,이철우,박병주 대한예방의학회 2012 Journal of Preventive Medicine and Public Health Vol.45 No.1

Objectives: The aim of this study was to investigate whether a medium to high degree of total physical activity and indoor physical activity were associated with reduced all-cause and cardiovascular mortality among elderly Korean women. Methods: A prospective cohort study was done to evaluate the association between physical activity and mortality. The cohort was made up of elderly (≥65 years of age) subjects. Baseline information was collected with a self-administered questionnaire and linked to death certificates retrieved from a database. Cox proportional hazard models were used to estimate the hazard ratios (HRs) with 95% confidence interval (CI) levels. Results: Women who did not suffer from stroke, cancer, or ischemic heart disease were followed for a median of 8 years (n=5079). A total of 1798 all-cause deaths were recorded, of which 607 (33.8%) were due to cardiovascular disease. The group with the highest level of total physical activity and indoor physical activity was significantly associated to a reduced all-cause mortality (HR, 0.60; 95% CI, 0.51 to 0.71 and HR, 0.58; 95% CI, 0.50 to 0.67, respectively) compared to the group with the lowest level of total physical activity and indoor physical activity. Additionally, the group with the highest level of total physical activity and indoor physical activity was significantly associated to a lower cardiovascular disease mortality (HR, 0.53; 95% CI, 0.40 to 0.71 and HR, 0.51; 95% CI, 0.39 to 0.67, respectively) compared to the group with the lowest level of total physical activity and indoor physical activity. Conclusions: Our study showed that regular indoor physical activity among elderly Korean women has healthy benefits.

Indoor Physical Activity Reduces All-Cause and Cardiovascular Disease Mortality Among Elderly Women

Park, So-Young,Lee, Joong-Yub,Kang, Dong-Yoon,Rhee, Chul-Woo,Park, Byung-Joo The Korean Society for Preventive Medicine 2012 Journal of Preventive Medicine and Public Health Vol.45 No.1

Objectives: The aim of this study was to investigate whether a medium to high degree of total physical activity and indoor physical activity were associated with reduced all-cause and cardiovascular mortality among elderly Korean women. Methods: A prospective cohort study was done to evaluate the association between physical activity and mortality. The cohort was made up of elderly (${\geq}65$ years of age) subjects. Baseline information was collected with a self-administered questionnaire and linked to death certificates retrieved from a database. Cox proportional hazard models were used to estimate the hazard ratios (HRs) with 95% confidence interval (CI) levels. Results: Women who did not suffer from stroke, cancer, or ischemic heart disease were followed for a median of 8 years (n=5079). A total of 1798 all-cause deaths were recorded, of which 607 (33.8%) were due to cardiovascular disease. The group with the highest level of total physical activity and indoor physical activity was significantly associated to a reduced all-cause mortality (HR, 0.60; 95% CI, 0.51 to 0.71 and HR, 0.58; 95% CI, 0.50 to 0.67, respectively) compared to the group with the lowest level of total physical activity and indoor physical activity. Additionally, the group with the highest level of total physical activity and indoor physical activity was significantly associated to a lower cardiovascular disease mortality (HR, 0.53; 95% CI, 0.40 to 0.71 and HR, 0.51; 95% CI, 0.39 to 0.67, respectively) compared to the group with the lowest level of total physical activity and indoor physical activity. Conclusions: Our study showed that regular indoor physical activity among elderly Korean women has healthy benefits.

40세 이상 중·노년의 질병 유무에 따른 신체활동과 우울증의 관계

김정운 ( Jung-woon Kim ) , 김준식 ( Joon-sik Kim ) , 임정준 ( Jung-jun Lim ) , 김연수 ( Yeon-soo Kim ) , 이온 ( On Lee ) , 최보율 ( Bo-youl Choi ) , 김미경 ( Mi-kyung Kim ) 한국스포츠정책과학원(구 한국스포츠개발원) 2020 체육과학연구 Vol.31 No.1

[목적] 본 연구의 목적은 질병 유무에 따른 신체활동과 우울증의 관계를 알아보는데 있다. [방법] 농촌기반 코호트 사업에 참여한 40세 이상 남녀 2,754명(남자 1,025명, 여자 1,729명)을 대상으로 설문조사와 기초평가를 실시하였다. 설문조사는 신체활동 설문과 우울증 척도 검사(K-CESD), 질병유무 설문을 실시하였으며, 기초평가는 신장, 체중, 체지방률 등을 측정하였다. 데이터는 로지스틱 회귀분석을 통해 신체활동과 우울증 유병률의 관계를 분석하였다. [결과] 첫째, 일반사람과 질병을 가진 환자에서 신체활동은 우울증 유병률을 각각 33%, 51% 감소시켰다. 둘째, 주 1회~2회의 신체활동은 질병을 가진 환자의 우울증 유병률을 51% 감소시키며, 3회 이상은 일반사람 37%, 질병을 가진 환자 33%의 우울증 유병률을 감소시켰다. 셋째, 주150분 미만의 신체활동은 질병을 가진 환자의 우울증 유병률을 43% 감소시켰으며, 주 150분 이상 300분미만의 신체활동은 일반사람 43%, 질병을 가진 환자 52%의 유병률을 감소시켰다. 주 300분 이상의 신체활동은 일반사람에서 38%의 우울증 유병률 감소 효과가 있었다. [결론] 결론적으로, 우울증 유병률을 최대로 감소시키기 위해서는 ACSM 가이드라인에서 제시하고 있는 신체활동 수준이 적합하다. 또한, 질병을 가진 환자는 일반사람보다 적은 빈도와 양의 신체활동만으로도 효과를 볼 수 있음을 알 수 있었다. [Purpose] The purpose of this study was to investigate the relationship between physical activity and depression according to the presence of disease. [Methods] A survey and basic assessment were conducted for 2,754 (Male=1,025 and Female=1,729) aged 40 and over who participated in the rural-based cohort study. The survey included physical activity, depression scale and disease preservation. The basic assessment measured height, weight, and body fat percentage. The measured data were analyzed by using logistic regression to examine the relationship between physical activity and depression prevalence. [Results] First, physical activity reduced the prevalence of depression by 33% and 51%, respectively, in the general population and in patients with the disease. Second, physical activity once or twice per week reduced the prevalence of depression in patients with disease by 51%, and at least three physical activities reduced the prevalence of depression by 37% in the general population and 33% of patients with disease. Third, physical activity less than 150 minutes per week reduced the prevalence of depression in patients with disease by 43%, and physical activity of more than 150 minutes and less than 300 minutes per week reduced the prevalence of 43% of the general population and 52% of patients with disease. Physical activity over 300 minutes per week had a 38% reduction in the prevalence of depression in the general population. [Conclusion] This study suggests that the level of physical activity suggested by the ACSM guidelines is appropriate to reduce the prevalence of depression. In addition, the patients with the disease was found to be effective with less frequency and amount of physical activity than the general person.

류마티스 관절염 환자에서 Phospholipase A2 활성도

오동호 ( Dong Ho Oh ),최정윤 ( Jung Yoon Choe ),송용호 ( Yong Ho Song ),손호상 ( Ho Sang Shon ),장성국 ( Sung Guk Chang ),김상경 ( Sang Gyung Kim ),이종명 ( Jong Myung Lee ),김능수 ( Nung Soo Kim ),장현욱 ( Hyeun Wook Chang ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.2

Objectives: A limited retrospective study of patients with rheumatoid arthritis(RA) found that serum phospholipase A2(PLA2) activity correlates with disease activity. To assess the strength of this relationship we investigated prospectively 25 patients with RA using a double blind approach. Methods: Twenty five patients who fulfilled the 1987 American College of Rheumatology criteria for RA had clinical and laboratory assessments. PLA2 activity was measured before and after treatment of 3 months in patients with RA. Fourteen healthy individuals were also enrolled as controls. PLA2 activity was assayed using E. coli membrane phospholipid substrate labelled with [14C]-oleic acid. Results: 1) Serum PLA2 activity was significantly higher in patients with RA than that of normal healthy controls(p<0.001). 2) In patients with RA, synovial fluid PLA2 activity was higher than serum PLA2 activity, and a positive correlation between PLA2 in synovial fluids and matched sera was found in these patients(p<0.05). 3) After treatment, PLA2 activity was significantly decreased with improvement of clinical(morning stiffness and Ritchie index) and laboratory(ESR, CRP and rheumatoid factor) assessments(p<0.001). 4) Among the clinical and laboratory markers of disease activity, ESR showed the best correlation with serum PLA2 activity(r=0.493, p<0.05). 5) In the patients who did not respond clinically to treatment (n=5), there was no significant decrease in PLA2 activity. Conclusion: PLA2 activity significantly correlates with RA activity and may serve as an index of disease activity in RA.

신체활동 특성이 노인 만성질환자의 정신건강에 미치는 영향

박재우 ( Jae Woo Park ),황병덕 ( Byung Deog Hwang ) 대한보건협회 2015 대한보건연구 Vol.41 No.1

연구목적 : 본 연구는 노인 만성질환자를 대상으로 신체활동 특성을 파악하여 정신건강과의 관계를 분석함으로써 노인 만성질환자의 정신건강상태 향상을 위한 기초자료를 제공하기 위한 상관관계 분석연구이다. 연구방법 : 본 연구 자료는 한국보건사회연구원과 국민건강보험공단이 실시한 "한국의료패널(2011)"의 원시자료를 사용하였으며, 연구대상자는 의사진단을 받은 55세 이상의 만성질환자로 총 4,118명 이였다. 본 연구 자료의 통계분석을 위해 SPSS 21.0 프로그램을 이용하였다. 분석대상자의 인구사회학적 특성, 신체활동 특성, 정신건강 특성을 파악하기 위해 빈도분석을 실시하였으며, 분석대상자의 신체활동 특성에 따른 각 변수들 간의 차이를 파악하기 위해 교차분석을 실시하였다. 정신건강에 영향을 미치는 요인은 로지스틱 회귀분석을 하여 그 교차비를 보았다. 연구결과 : 본 연구의 결과는 다음과 같다. 첫째, 신체활동 특성에 따른 정신건강 요인의 변이는 스트레스정도, 우울감 경험, 자살충동 경험에서 통계적으로 유의한 차이가 있었다. 신체활동 특성이 양호할수록 정신건강 요인에 긍정적인 영향을 미쳤다. 둘째, 정신건강에 영향을 미치는 주요 요인의 결과는 주관적 건강상태, 건강신체활동 도달 여부 두 변수와 인구사회학적 요인의 성별, 경제활동 유무가 통계적으로 유의한 영향을 주는 것으로 분석되었다. 결론 : 본 연구 결과, 노인 만성질환자의 신체활동 특성이 양호할수록 정신건강 상태가 좋아지는 것을 알 수 있었다. 노인만성질환자의 정신건강 향상을 위해 규칙적인 신체활동과 일상생활 상태 개선으로 신체적 기능을 높여 노년기 삶의 질에 긍정적인 영향을 주는 것이 효과적인 방법이라 사료된다. Objective: This study is a correlation analysis study to identify characteristics of physical activities of the aged with chronic diseases, analyze the relationship with mental health and to provide basic data to improve mental health of the aged with chronic diseases. Methods: Data used in this study include "Korea Health Panel(2011)" conducted by the Korea Institute for Health and Social Affairs and the National Health Insurance Service and study subjects were total of 4,118 people over the age of 55 who were diagnosed with chronic diseases. SPSS 21.0 program was used for statistical analysis of the data. Frequency analysis was conducted to identify the characteristics of sociology of population, physical activity and mental health of the subjects; and cross-tabulation analysis was conducted to identify differences among the variables depending on characteristics of physical activity. Logistic regression analysis was conducted to draw odds ratio of factors that affect mental health. Results: The results of the study are as follows. First, modification of mental health factors according to physical activity characteristics showed significant difference in stress level, history of depression and history of suicidal impulse. And good physical activity characteristics have more positive effect on mental health factors. Second, major factors that affect mental health showed statistical significance in two variables-subjective health conditions, capability of healthy physical activity-and factors of sociology of population such as gender and economic activity. Conclusion: The results indicate that better physical activity characteristics of the aged with chronic diseases affect improvement of mental health. It will be effective to make positive effect on quality of life in senescence for better mental health of the aged with chronic diseases by physical activity on a regular basis and improvement of daily activities and physical activities.

농촌 만성질환 노인의 신체활동관련 요인

백현희,김정자,Peak, Hyun-Hee,Kim, Jeong-Ja 한국임상보건과학회 2014 한국임상보건과학회지 Vol.2 No.4

Purpose. This study is based on physical and mental health and physical activity differences in Practice rate each physical activity according to the body to target the 319 people who live in rural areas of 65 and older who have chronic diseases Practice rate activities, general characteristics of chronic diseases, elderly differences in physical activity and investigate the factors that influence. Methods. Physical activity Practice rate was used for descriptive statistics. Each physical activity Practice rate in accordance with the general characteristics of the rural elderly chronic disease were independent T test and One-way ANOVA test. To evaluate the factors influencing the physical activity was the multiple logistic regression analysis. Results. Results of physical activity practice was the most flexibility exercise was walking then, Practice rate each physical activity in accordance with the general characteristics of the elderly are tangible and physical activity radish age, housing type, education level, health insurance part statistically significant were different. Physical health status according to the presence or absence of physical activity showed a significant difference in daily life activities and limited mental health differences were not significant. Factors affecting the physical activity of the elderly with chronic diseases appeared to limit the presence and activities of daily living. Conclusions. As well there is no activity restrictions can be more physically active everyday life well. It is suggested that it is important to approach everyday life, I can help eliminate the factors that independently giving limits on the activities of the elderly with chronic diseases.

Serum leucine-rich α2-glycoprotein is elevated in patients with systemic lupus erythematosus and correlates with disease activity

Ahn, Sung Soo,Park, Younhee,Jung, Seung Min,Song, Jason Jungsik,Park, Yong-Beom,Lee, Sang-Won Elsevier 2018 Clinica chimica acta Vol.486 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>We evaluated whether serum leucine-rich α2-glycoprotein (LRG) is associated with disease activity in patients with systemic lupus erythematosus (SLE).</P> <P><B>Methods</B></P> <P>We measured serum LRG in 194 SLE patients. SLE disease activity index-2000 (SLEDAI-2 K) was used to assess SLE activity, and patients with SLEDAI-2 K ≥5 were defined as having active SLE. Correlation between serum LRG, SLEDAI-2 K, and laboratory variables was estimated by Pearson's correlation analysis. The optimal serum LRG cut-off value for predicting active SLE was calculated using receiver operator characteristic (ROC) curve, and multivariable logistic regression was used to determine the odds ratio (OR) of laboratory variables.</P> <P><B>Results</B></P> <P>In total, 74 (38.1%) and 120 (61.9%) patients were classified as active and inactive SLE, respectively. Serum LRG was higher in patients with active SLE than in inactive SLE and healthy controls (26.6 vs. 14.4 vs. 1.2 ng/ml, <I>p</I> < .001). Serum LRG significantly correlated with SLEDAI-2 K (<I>r</I> = 0.340, <I>p</I> < .001) and laboratory variables. ROC analysis revealed that optimal serum LRG cut-off value for active SLE was >45.7 ng/ml. In multivariable logistic regression analysis, serum LRG >45.7 ng/ml (OR 4.089, 95% confidence interval 1.351, 12.376, <I>p</I> = .013) was an independent predictor of active SLE.</P> <P><B>Conclusions</B></P> <P>Serum LRG might be a biomarker for estimating SLE disease activity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Serum leucine-rich α2-glycoprotein (LRG) is elevated in patients with SLE and correlates with disease activity. </LI> <LI> Serum LRG was capable of predicting active SLE independently of laboratory variables used to assess SLE disease activity. </LI> <LI> Serum LRG might be a potential biomarker for estimating SLE disease activity. </LI> </UL> </P>

A Study on the Biological Activity of Commonly Consumed Spring Herbs in Korea

Hee-Jae Chung,Ae-Jung Kim 한국피부과학연구원 2021 아시안뷰티화장품학술지 Vol.19 No.4

목적: 본 연구에서는 국내에서 다소비 되고 있는 봄나물류 8종을 선정하고 생리활성(항산화 및 효소활성)을 평가하여 우리나라 봄 나물의 우수성을 재조명하고자 하였다. 방법: 8종의 봄나물을 열수 추출하여 항산화 활성(total polyphenol 함량, total flavonoid 함 량, DPPH radical 소거능, ABTS radical 소거능) 및 효소 활성(α-glucosidase 저해 활성, ACE 저해 활성)을 측정하였다. 결과: 8종 의 다소비 봄나물 중 total polyphenol 함량은 냉이, 원추리, 곰취가 1-3위를 차지하였으며, total flavonoid 함량으로 유채, 냉이, 쑥 이 1-3위를 차지하였으며, DPPH radical 소거능은 냉이, 원추리, 유채가 1-3위를 차지하였으며, ABTS radical 소거능은 냉이, 쑥, 유채가 1-3위를 차지하였다. α-Glucosidase 저해 활성은 쑥, 곰취, 달래가 1-3위를 차지했고, ACE 저해 활성은 두릅, 유채, 달래 가 1-3위를 차지하였다. 결론: 8종의 봄나물 중 항산화 활성에서는 냉이와 유채, 항당뇨 활성은 쑥, 항고혈압 활성은 두릅에서 각 각의 우수한 효능이 나타나 차후 봄나물류의 현대인의 생활습관병 개선 식품 개발의 기초자료로 활용되기를 기대된다 Purpose: This study was conducted to study the superiority of Korean spring herbs by selecting eight spring herbs that are commonly consumed in Korea and evaluating their biological activity. Methods: Antioxidant (total polyphenol content, total flavonoid content, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and 2,2'-azino-bis-3-ethylbenzothiazoline–6-sulfonic acid (ABTS) radical scavenging activity) and enzyme activities (α-glucosidase inhibitory activity and angiotensin converting enzyme (ACE) inhibitory activity) were measured using the hot-water extract of the selected spring herbs. Results: In case of total polyphenol content, the shepherd’s purse, daylily, and gomchwi took first, second, and third place. In case of total flavonoid content, rape, shepherd’s purse and mugwort took first, second, and third place, and in case of DPPH radical scavenging activity, shepherd’s purse, daylily, and rape took first, second, and third place. In case of ABTS radical scavenging activity, the shepherd’s purse, mugwort and rape took first, second, and third place. In case of α-glucosidase inhibitory activity, mugwort, gomchwi, and wild garlic were classified in the first, second, and third place. Lastly, Korean angelica tree, rape, and wild garlic were classified in the first, second, and third, in case of ACE inhibitory activity. Conclusion: From these results, among the selected spring herbs, the shepherd’s purse and rape showed exceptional effects in antioxidant activity, mugwort in antidiabetic activity, and Korean angelica tree sprout in antihypertensive activity, respectively. Therefore, the present study is expected to provide basic data for future development of foods using spring herbs to remedy lifestyle-related diseases.

Correlation between Physical Activity and Lung Function in Dusty Areas: Results from the Chronic Obstructive Pulmonary Disease in Dusty Areas (CODA) Cohort

( Yuri Han ),( Yeonjeong Heo ),( Yoonki Hong ),( Sung Ok Kwon ),( Woo Jin Kim ) 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.4

Background: Although physical activity is known to be beneficial to lung function, few studies have been conducted to investigate the correlation between physical activity and lung function in dusty areas. Therefore, the purpose of this study is to investigate the correlation between physical activity and lung function in a Korean cohort including normal and COPD-diagnosed participants. Methods: Data obtained from the COPD in dusty areas (CODA) cohort was analyzed for the following factors: lung function, symptoms, and information about physical activity. Information on physical activity was valuated using questionnaires, and participants were categorized into two groups: active and inactive. The evaluation of the mean lung function, modified Medical Research Council dyspnea grade scores, and COPD assessment test scores was done based on the participant physical activity using a general linear model after adjusting for age, sex, smoking status, pack-years, height, and weight. In addition, a stratification analysis was performed based on the smoking status and COPD. Results: Physical activity had a correlation with high forced expiratory volume in 1 second (FEV₁) among CODA cohort (p=0.03). While the active group exhibited significantly higher FEV₁ compared to one exhibited by the inactive group among past smokers (p=0.02), no such correlation existed among current smokers. There was no significant difference observed in lung function after it was stratified by COPD. Conclusion: This study established a positive correlation between regular physical activity in dusty areas and lung function in participants.

Correlation between Physical Activity and Lung Function in Dusty Areas: Results from the Chronic Obstructive Pulmonary Disease in Dusty Areas (CODA) Cohort

한유리,허연정,홍윤기,권성옥,김우진 대한결핵및호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.4

Background: Although physical activity is known to be beneficial to lung function, few studies have been conducted to investigate the correlation between physical activity and lung function in dusty areas. Therefore, the purpose of this study is to investigate the correlation between physical activity and lung function in a Korean cohort including normal and COPD-diagnosed participants. Methods: Data obtained from the COPD in dusty areas (CODA) cohort was analyzed for the following factors: lung function, symptoms, and information about physical activity. Information on physical activity was valuated using questionnaires, and participants were categorized into two groups: active and inactive. The evaluation of the mean lung function, modified Medical Research Council dyspnea grade scores, and COPD assessment test scores was done based on the participant physical activity using a general linear model after adjusting for age, sex, smoking status, pack-years, height, and weight. In addition, a stratification analysis was performed based on the smoking status and COPD. Results: Physical activity had a correlation with high forced expiratory volume in 1 second (FEV1) among CODA cohort (p=0.03). While the active group exhibited significantly higher FEV1 compared to one exhibited by the inactive group among past smokers (p=0.02), no such correlation existed among current smokers. There was no significant difference observed in lung function after it was stratified by COPD. Conclusion: This study established a positive correlation between regular physical activity in dusty areas and lung function in participants.