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강동윤,이동엽,죄보윤,문승희,최은영 대한약물역학위해관리학회 2024 약물역학위해관리학회지 Vol.16 No.1
: The importance of effective adverse drug reaction (ADR) management in local clinics is increasing. This study investigates the current status of ADR management and reporting system use in local clinics, and opinions on development directions for effective ADR prevention. Methods: From January 11th to January 17th, 2022, an online survey was conducted targeting physicians working at local clinics regarding ADR management, use of reporting systems, and development of ADR prevention systems. Results: The awareness of the ADR reporting system was 54.50%, and 22.07% of respondents actually reported ADR incidents. The primary reasons for not reporting were ‘lack of time and unfamiliarity with the process,’ accounting for the highest percentage at 36.62%. Regarding sharing ADR information with other healthcare institutions, 88.56% responded that it would be helpful, and 66.49% indicated they could trust such information. The most crucial areas for improvement identified from the survey were the sharing of ADR records and national-level management. Conclusion: Creating an environment where local clinics can diligently report ADRs and establishing a system to share verified ADR information with other clinics will be a great help to national drug safety. (PeRM 2024;16:57-64
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강동윤,이상봉,이동엽,김지현,문승희,이귀진,최보윤,김예슬,임재형 대한약물역학위해관리학회 2023 약물역학위해관리학회지 Vol.15 No.2
This study aimed to assess the status and characteristics of adverse events caused by treatments of coronavirus disease 2019 (COVID-19) in hospitalized patients in Korea. Methods: The medical records of patients hospitalized with COVID-19 at 30 medical institutions nationwide from January 1, 2020 to November 30, 2021 were retrospectively reviewed. Data of clinical characteristics; type of COVID-19 treatments; symptoms and severity of adverse events according to CTCAE classification; and prognosis of each patient were analyzed and presented descriptively. Results: Adverse events were observed in 853 of 5,740 (14.9%) hospitalized patients with COVID-19: 732 (85.8%), mild; 106 (12.4%), moderate; and 15 (1.8%), severe. Serious adverse events were observed in 70 (1.2%) patients, with 56 prolonged hospitalizations and four deaths. Adverse events were more frequently found in patients with a lower-than-normal body mass index or many concomitant medications. Moreover, 4,912 patients (85.6%) received multiple medications for treatment of COVID-19, wherein the drugs most mainly administered were steroids (66.4%), antibiotics (59.5%), and remdesivir (52.6%). Adverse events were relatively common in patients administered immunoglobulin, other antiviral drugs, and interleukin-6 inhibitors. Each patient with adverse events had an average of 3.8 symptoms. The most frequent symptoms were increased hyperbilirubinemia (n = 256), nausea (n = 216), and pruritis (n = 188). Conclusion: The incidence of adverse events in hospitalized patients with COVID-19 in Korea was approximately 14.9%. The type of treatment of COVID-19 might affect the incidence and prognosis of specific adverse events. Clinicians should consider the possible adverse effects of each medication before initiating treatment
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