Association of XPD Lys751Gln gene polymorphism with susceptibility and clinical outcome of colorectal cancer in Pakistani population: a case–control pharmacogenetic study

Sumera Gul,Abad Khan,Abida Raza,Ismail Khan,Shumaila Ehtisham 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: XPD Lys751Gln polymorphism may modulate inter-individual variation in repair capacity of DNA, which may enhance a person’s susceptibility to develop colorectal cancer (CRC). The analysis of XPD Lys751Gln polymorphism may provide important information for identifying high-risk individuals and for selecting the most appropriate treatment for poor prognostic CRC patients. Objective: The overall objective was to find out the association of XPD Lys751Gln gene polymorphism with the risk of having a colorectal cancer and the ultimate clinical outcomes. In this study a total of 300 subjects (CRC and Controls), were genotyped for XPD Lys751Gln. Methods: Using PCR–RFLP methods, the association of XPD Lys751Gln gene polymorphism with the risk of having a colorectal cancer was studied. In addition to overall risk assessment, genotyping results were also investigated with respect to the lifestyle risk factors, patients treated with oxaliplatin-based chemotherapy and clinicopathological characteristics. Results: The overall correlation between the XPD Lys751Gln genetic variation and the CRC risk was observed to be significant with both the homozygous variant genotype Gln/Gln as well as heterozygous genotype Lys/Gln being associated with the increased risk of CRC. Additional stratified analyses revealed that XPD Lys751Gln variants remarkably increased risk of CRC in males and younger individuals (≤ 50 years), Naswar users (8.09-fold) and high intake of red meat. Conclusions: Our findings suggest that the relationship between the XPD Lys751Gln variants and lifestyle factors modulates the risk for CRC in Pakistani population.

위 유암종의 임상병리학적 특징

정진호 ( Jin Ho Chung ),오승종 ( Seung Jong Oh ),정국현 ( Kuk Hyun Jung ),황윤선 ( Yoon Sun Hwang ),최민규 ( Min Gew Choi ),노재형 ( Jae Hyung Noh ),손태성 ( Tae Sung Sohn ),배재문 ( Jae Moon Bae ),김성 ( Sung Kim ),최성희 ( Seon 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.2

목적: 본원에서 진단된 위 유암종의 임상병리학적 특성과 치료방법 및 예후에 대해 분석하였다. 방법: 1997년 1월 1일부터 2009년 12월 31일 까지 본원에서 병리조직검사 결과 위의 유암종으로 진단 및 치료 받은 52명의 환자를 대상으로 Rindi 분류에 따라 진단, 치료, 및 경과에 대해 후 향적 연구를 통해 분석하였다. 결과: 남자가 29명, 여자가 23명 (1.26:1) 이었고 평균나이는 54.6세이고 평균추적관찰 기간은 36개월이었다. 그 중 1형은 45 예로 40예(88.9%)에서 단일결절이며 만성위축성위염과 동반된 소견을 보였다. 2형은 2예로 복합내분비신생물 1형 증후군과 병발하였다. 3형은 5예로 모두 T2 이상의 병변이었다. 이들 환자중 절제가 가능한 49예중 12예에서 수술이 시행되었으며 37예에서 내시경적 용종절제술 및 점막하 절제술이 시행되었다. 52명중 3명이 사망하였고 1명이 유암종으로 인한 사망이었다. 결론: Rindi 분류를 통한 국내의 위 유암종은 악성빈혈이 동반되지 않았으며 남성이 더 많이 발생하며 단일결절이 많아 외국의 보고와는 다른 특징을 보였다. Purpose: We analyzed the clinicopathologic characteristics of patients with gastric carcinoid tumor, which is a rare gastric tumor Methods: We reviewed 52 carcinoid patients who were treated from 1997 to 2009. Carcinoids were classified as 3 types along the Rindi et al. The clinicopathologic characteristics, the treatment modalities were retrospectively analysed. Results: There were 29 man, and 28 woman patients.(1.26:1) The mean age of onset was 54.6 years. The average follow up period was 36 months. There were 40 of 45 type I patients who had solitary lesion and all of 45 patients combined with chronic atrophic gastritis. There were 2 type II paitents who combined with Multiple Endocrine Neoplasm type-1. There were 5 type III patients who had above T2 lesions. In the 49 patients who can resection, 12 underwent surgery, and 37 underwent endoscopic polypectomy and submucosal dissection. 3 of 52 patients death and only 1 case were death by disease. Conclusion: Higher incidence of gastric carcinoid tumor with man, less multiplicity, and no concurrence of pernicious anemia were identified in our study compared with previous reports.

근치 자궁절제술 및 골반 림프절절제술을 시행한 자궁경부암 환자에서 편평세포암종과 샘암종의 임상병리학적 특징 및 예후인자에 관한 비교

서영진,정대훈,손영실,이은숙,정은정,조유경,김영남,이경복,성문수,김기태 대한부인종양학회 2007 Journal of Gynecologic Oncology Vol.18 No.4

Objective:To compare clinicopathologic characteristics and prognostic factors between squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the uterine cervix. Methods:We reviewed medical records and pathologic reports of 568 patients with SCC and 78 patients with AC who underwent radical hysterectomy and pelvic lymphadenectomy from January 1988 to December 2004. We analyzed clinicopathologic factors and 5-years survival rate (5-YSR), and than compared 5-YSR between SCC and AC according to clinicopathologic factors. Results:At the stage I, the incidence of AC (82.0%) was more than SCC (69.6%) and at the stage II, the incidence of SCC (30.4%) was higher than AC (18.0%). The rate of lymph-vascular space invasion was higher in SCC (28.2%) than AC (15.4%). The 5-YSR was not different between SCC (85.7%) and AC (86.9%). In multivariate analysis, depth of invasion, resection margin, pelvic lymph node metastasis were independent prognostic factors in SCC and FIGO stage, pelvic lymph node metastasis were independent prognostic factors in AC significantly. At the 5-YSR between SCC and AC, the prognosis of AC (50.0%) was poorer than SCC (78.0%) in the case of the one pelvic lymph node metastasis (p=0.0632). Conclusion:The FIGO stage and lymph-vascular space invasion were significant different in clinicopathologic characteristics between SCC and AC. The prognosis of AC was poorer than SCC in the case of the one pelvic lymph node metastasis (p=0.0632). But, the overall 5-YSR was not different between SCC and AC. 목적:자궁경부 편평세포암종과 샘암종의 임상병리학적 특징과 예후인자를 비교 분석하고자 하였다. 연구 방법:1988년 1월부터 2004년 12월까지 자궁경부암으로 근치 자궁절제술 및 골반 림프절절제술을 시행한 편평세포암종 환자 568명과 샘암종 환자 78명의 임상기록지와 병리조직결과지를 분석하여, 두 암종의 임상병리학적 특징과 5년 생존율을 알아보고, 두 암종 간의 임상병리학적 특징에 따른 5년 생존율을 비교하였다. 결과:편평세포암종(30.4%)은 샘암종(18.0%)보다 II기가 많았고, 샘암종(82.0%)은 편평세포암종(69.6%)보다 I기가 많았다. 림프혈관 공간 침범은 편평세포암종(28.2%)이 샘암종(15.4%)보다 많았다. 5년 생존율은 편평세포암종이 85.7%, 샘암종이 86.9%로 차이가 없었다. 다변량 분석에서 편평세포암종의 경우 기질 침범 깊이, 절단면 잔류암, 골반 림프절 전이가 독립적인 예후인자였고, 샘암종의 경우 임상 병기, 골반 림프절 전이가 독립적인 예후인자였다. 골반 림프절 전이가 한 군데 있는 경우에 샘암종(50.0%)의 5년 생존율은 편평세포암종(78.0%)보다 나빴는데, 이는 통계적으로 경계적 유의성을 나타내었다(p=0.0632). 결론:편평세포암종과 샘암종 간의 FIGO 임상 병기, 림프혈관 공간 침범의 빈도는 차이가 있었고, 골반 림프절 전이가 한 군데 있는 경우에 샘암종의 예후가 편평세포암종보다 경계적 유의성을 가지고 나빴으나, 전체적인 5년 생존율은 차이가 없었다.

수술을 시행한 갑상선 우연종의 임상적 고찰

이창호,윤현조,정성후,Chang Ho Lee,Hyun Jo Youn and Sung Hoo Jung 대한갑상선-내분비외과학회 2006 The Koreran journal of Endocrine Surgery Vol.6 No.1

Purpose: An incidentaloma is a tumor that is found incidentally without clinical symptoms. This study was carried out to evaluate the clinicopathologic characteristics and to offer the optimal diagnostic and therapeutic strategies for surgical treated thyroid incidentaloma. Methods: We reviewed the medical records of 139 consecutive patients who were operated on for incidentally detected thyroid nodules from January 2000 to June 2005, and we retrospectively investigated the clinicopathologic characteristics, preoperative diagnostic methods, operative methods and histologic diagnosis of surgical treated thyroid incidentaloma. Results: The male-to-female ratio was 1:9.7 (13:126) and the mean age was 45.8 years. The mean tumor size was 1.27 cm and 122 cases (87.8%) were 1.5 cm or less in diameter. 138 patients underwent ultrasonography and 34 patients (24.6%) were diagnosed with malignant nodules. US-guided fine needle aspiration cytology (FNAC) was performed in 118 patients and 42 patients (35.6%) were diagnosed with papillary carcinoma. According to postoperative histologic diagnosis, 70 cases (50.3%) were adenomatous goiter, 14 cases (10.2%) were follicular adenoma and 54 cases (38.8%) were papillary carcinoma. Among the papillary carcinoma, capsular invasion were presented in 3 cases (5.6%) and lymph node metastasis were presented in 5 cases (9.3%). According to the TNM staging, 33 cases (61.1%) were stage I, 16 cases (29.6%) were stage II, and 5 cases (9.3%) were stage? By the AMES scoring system, 2 cases (3.7%) were in the high risk group.Conclusion: Although most patients with incidental thyroid carcinomas were low stage, their clinicopathologic characteristics were similar to those of general thyroid carcinoma. Therefore, high risk patients with thyroid incidentaloma should have active diagnostic methods performed such as FNAC for confirming the presence of carcinoma. (Korean J Endocrine Surg 2006;6:12-16)

북한 이탈 주민에서 발생한 암의 임상병리적 특징

박재민(Jae Min Park),김은영(Eunyoung Kim),정일용(Il Yong Chung),박세혁(Sei-Hyeog Park),박종민(Jong-Min Park),윤여규(Yeo-Kyu Youn),오흥권(Heung-Kwon Oh),김중석(Joong-Suck Kim),주성홍(Sung-Hong Joo) 대한종양외과학회 2014 Korean Journal of Clinical Oncology Vol.10 No.2

Clinicopathologic Characteristics of Breast Cancer in Jamaica

Chin, Sheray Nicole,Green, Cheryl,Strachan, Georgiana Gordon,Wharfe, Gilian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Breast cancer is the most common cancer in Jamaican women. This study assessed the clinicopathologic features of cases in a hospital-based specialist clinic in Kingston, Jamaica. A retrospective chart review was performed for the 2-year study period and relevant clinical and surgico-pathologic data were recorded and analyzed. Median age of the 121 breast cancer patients was 52 years (range 22-84, IQR 20) and there was 1 case of male breast cancer. Most patients (65%) were referred from the surgical service after definitive breast cancer surgery, 20% were referred for pre-operative systemic therapy, and 15% had a diagnosis of metastatic disease. The surgico-pathologic group comprised 78 women who were referred for adjuvant therapy. The majority had presented with a palpable breast lump (91%), with median tumour size 3.5cm (range 0.4-13, IQR 4). Most tumours were node positive (56%). Approximately one-third of patients had stage III disease (33%). Most women presented with large palpable tumours and had lymph node involvement confirmed on surgicopathological evaluation, indicative of limited early breast cancer detection. A national screening mammography programme is recommended for detection of earlier lesions. Pre-operative systemic therapy should be considered as an option for eligible patients.

갑상선 미세 유두상 암의 임상적 특징

나병곤,배학연,조현진,김권천 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.3

Purpose: Papillary thyroid microcarcinoma (PTMC) is increasing in incidence because of ultrasound-guided fine-needle aspiration cyology (FNA). According to WHO, PTMC is defined as a papillary thyroid cancer of 1 cm or less in diameter. Within the group of patients with PTMC, prognosis is known to be very favorable. This study was carried out to evaluate the clinicohistological characteristics of PTMC and to determine a reasonable extent of surgery for them. Methods: From Mar. 2002 to Dec. 2007, 610 patients with thyroid diseases underwent thyroidectomy at Chosun University hospital. Among these patients, 205 patients (33%) had a thyroid papillary carcinoma less than or equal to 1 cm in great diameter. The clinicopathologic features and treatment outcome of these patients were evaluated retrospectively. Results: In the period 2002-2007, PTMC incidence rate in our institution increased from 10% to 20%. There were 19 men and 186 women with a median age of 46 years (range; 16-74). PTMC diameter ranged from 0.1 to 1 cm. (mean 0.54 cm) 15.7% of patients with PTMC presented with preoperative symptoms (palpable mass, fatigue, pain, hoarseness). Preoperatively 84.3% of these 205 cases were diagnosed by ultrasonography. We performed unilateral lobectomy (41%), near total thyroidectomy (44%), and total thyroidectomy (11%) with or without central compartment neck node dissection. During a mean follow-up of 36 months, 5 patients (2.4%) developed locoregional recurrence with no distant metastasis. There were no significant difference on recurrence rate by size, capsular invasion. But multiplicity of primary tumor has a higher locoregional recurrence rate (p= 0.04). The detection rate of PTMC is increasing due to FNA technique in our hospital. This study shows that PTMC may have capsular invasion, lymph node involvement, multiplicity and locoregional recurrence likely to larger (>1 cm) papillary carcinoma. Conclusion: We suggest that total or near total thyroidectomy with central compartment neck dissection is proper therapeutic operation for PTMC and modified neck dissection shoud be performed if lateral neck lymph node are enlarged or diagnosed as metastatic tumor.

외음부 전정염 증후군 환자 30예의 임상병리적 특성 및 치료에 관한 고찰

정민형 ( Min Hyung Chung ),박정훈 ( Jung Hun Park ),김낙인 ( Nack In Kim ),김봉희 ( Bohng Hee Kim ),이주희 ( Juhie Hee Lee ),허주엽 ( Chu Yeop Huh ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12

Objective : This study was performed to evaluate and introduce the clinicopathologic characteristics and treatment modalities of vulvar vestibulitis, a subset of vulvodynia, may cause physical disabilities, phycological or emotional distress, sexual dysfu

Clinicopathological Characteristics of Iranian Patients with Lung Cancer: a Single Institute Experience

Adnan, Khosravi,Zahra, Esfahani-Monfared,Sharareh, Seifi,Shirin, Karimi,Habib, Emami,Kian, Khodadad Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

Background: Lung cancer has long been a leading cause of cancer related death in both women and men worldwide. The focus of this study was to review clinicopathological features of Iranian patients diagnosed with lung cancer. Materials and Methods: Clinicopathological data of 1353 primary lung cancer patients diagnosed during 17 years (1997-2014) in the "National Institute of Tuberculosis and Lung Disease" (NRITLD), Tehran, Iran, were retrospectively reviewed. Results: The median age of patients was 60 (mean: 58.95 years, range: 16-99) and adenocarcinoma was the most prevalent pathology (45.2%). Male/female ratio was 3.22 and 57.2% of patients were smokers (men 70.3%, women 15%). The majority (85.3%) were referred in advanced stages (stage IIIB and IV). Conclusions: Although some of our findings are in concordance with other studies in lung cancer but there are some discrepancies particularly in terms of smoking status and median age of Iranian patients. Further clinical and epidemiological studies are warranted to elucidate etiologic and factors other than smoking contributing to development of lung cancer such as environmental exposures or genetic predisposition.

자궁내막암 100 례의 임상병리학적 특성 및 예후에 관한 연구

전우진(Woo Jin Jeon),문을주(Eul Ju Moon),유상영(Sang Young Ryu),김종훈(Jong Hoon Kim),김병기(Byoung Gie Kim),박상윤(Sang Yoon Park),이재규(Jae Kyu Lee),이의돈(Eui Don Lee),이종성(Jong Sung Lee),이경희(Kyung Hee Lee) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9

Objective : This study was performed to evaluate the clinicopathologic characteristics and prognosis of uterine endometrial cancer.Methods : From Jan. 1988 to Dec. 1997, medical records including operation record and pathologic reports of 100 patients with histologically proven endometrial cancer at Korea Cancer Center Hospital were reviewed. The survival of patients was determined by description of last follow up date in medical records. If more than 3months passed from last follow up date, we used mail and phone call to identify the status of patients. Results : The mean age of these patients was 52years, the most common presenting symptom was abnormal vaginal bleeding(89%). All except one case of papillary serous adenocarcinoma were endometrioid adenocarcinoma(99%). The grades were classified into G1(38%), G2(39%), G3(7%) and unknown(16%). The FIGO surgical stages were classified as ; stage I(73%), stage II(3%), stage III(18%) and stage IV(1%) and unknown stage(5%). Most of the patients(85%) were treated by surgery only or surgery followed by adjuvant radiotherapy. The overall 5-year disease free survival rate(5YDFSR) was 86.9%: FIGO surgical stage I and II, 90.3%; stage III and IV, 73.6%. A age, parity, grade and preoperative Pap test were not significant prognostic factors. The depth of uterine invasion(p=0.039), FIGO surgical stage(p=0.0249) and lymph node metastasis(p=0.0054) were significant prognostic factors by univariate analysis. Conclusion : Although the number of patients was not enough, the depth of myometrial invasion, FIGO surgical stage and lymph node metastasis seemed to be significant prognostic factors of uterine endometrial cancer.