Dietary Intake Assessment and Biochemical Characteristics of Blood and Urine in Patients with Chronic Gastritis

( Mi-kyeong Choi ),( Myung-hwa Kang ),( Mi-hyun Kim ) 한국임상영양학회 2015 Clinical Nutrition Research Vol.4 No.2

Chronic gastritis is a prevalent gastroentestinal disease in Korea. The purpose of this study was to investigate status of foods and nutrients intake and health related biochemical indicators in the patients with chronic gastritis. Daily food and nutrient intake, blood lipids, and antioxidant indicators in the urine, were compared between a group of 19 patients diagnosed with chronic gastritis and a control group of 27 subjects having normal gastroscopy. No significant differences were found in age, height, weight, body mass index, and blood pressure between the two groups. Daily energy intakes were 1900.6 kcal for the chronic gastritis patient group, and 1931.8 kcal for the normal control group without significant difference. No significant difference was found between the two groups in all nutrient intakes except for cholesterol. The chronic gastritis patients consumed lower amount of sugars and sweeteners but greater amount of starchy food groups such as potatoes and legumes than subjects of control group consumed. Also the chronic gastritis patients showed higher serum triglyceride concentration than the normal subjects. These results indicate that the dietary pattern of chronic gastritis patients may have relation to a change in the serum lipid level; however, more systematic research with a larger samples size is required.

한국인 만성위염의 특성과 위암발생의 상관관계에 대한 조직구축학적 연구 - 1. 조기위암에 수반된 만성위염의 조직구축학적 분포 -

김용일,김우호,김태진,최규완 ( Yong Il Kim,Woo Ho Kim,Tae Jin Kim,Kyoo Wan Choi ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.2

A total of 51 cases of surgically resected stomachs with early gastric carcinoma (EGC) were processed for histotopographic analysis of chronic gasitritis and their anatomic-topographic distribution patterns were correlated with pathologic features of EGCs. All the resected stomachs were fixed in 10% formalin and submitted for histotopographic procedures. Chronic gastritis was classified into chronic atrophic gastritis and metaplastic gastritis and their distribution patterns were subdivided into antral, intermediate, diffuse, and localized types by topography. Metaplastic gastritis was associated in 90.2% of EGCs, of which 58.8% showed a distribution pattern of either transitional or diffuse gastritis. The extent and severity of metaplastic change was well correlated with gross (elevated type) and histologic types (differentiated type) of EGCs over age of 50. The majority of transitional gastritis was chronic atrophic gastritis occurring more likely in stomachs associated with poorly differentiated adenocarcinoma of the depressed type, especially in woman, Of the localized form, metaplastic gastritis prevailed. Two cases of microadenocarcinoma (< 5 mm) showed an incipient tumor growth from the surrounding metaplastic mucosa, leading to a suggestion of its direct transformation into adenocarcinoma. We conclude that metaplastic gastritis is an important and probably the most possible preceding background mucosal lesion at least in gastric cancinogenesis among Koreans.

만성위염 환자의 유문부 Gastrin 세포의 분포 및 Gastrin 농도

김부성(Boo Sung Kim),최상욱(Sang Wook Choi),정진우(Jin Wu Jeong),박두호(Doo Ho Park),신여림(Yeo Rim Sim),김명석(Myung Suk Kim),박인선(In Sun Park),정진웅(Jin Woong Chung) 대한내과학회 1989 대한내과학회지 Vol.36 No.1

N/A This study was conducted to investigate the influence of chronic gastritis on the distribution of gastrin (G)-cells and gastrin levels in antral mucosa and blood in Korean patients. Fifty-one subjects were divided into three groups according to histological findings of biopsied specimens by endoscopy: normal subjects, patients with chronic superficial gastritis and patients with chronic atrophic gastritis. The G-cells in the antral mucosa were stained by the immunohistochemical method with gastrin antiserum and the number of G-cell per unit area (1 mm breadth of a 5 ㎛-thick sectioned mucosa) was counted. Gastrin levels in the antral mucosal tissue and plasma were measured by means of radioimmunoassay. The results were as follows: 1) The number of G-cells and the antral tissue gastrin level in normal subjects were 106±36.6 and 10.6±6.2㎍/g, respectively. Plasma gastrin concentrations of the normal subjects in fasting and postprandial states, 20 min and 40 min after ingestion of a meat meal, were 63.1±24.5, 141.8±73.8 and 126.0±62.5 pg/ml, respectively. 2) In patients with chronic superficial gastritis, fasting and postprandial plasma gastrin concentrations increased significantly compared with those of the normal subjects, while the number of the G-cells and antral tissue gastrin were not significantly different from the normal values. 3) In patients with chronic atrophic gastritis, the number of G-cells and antral tissue gastrin levels tended to decrease, but fasting and postprandial plasma gastrin concentrations tended to increase compared with the normal values. 4) No G-cells were observed in the region with intestinal metaplasia. The above results indicate that patients with chronic gastritis showed a marked increase in plasma gastrin concentration while the number of antral G-cells and antral tissue gastrin level decreased.

위화(胃火) 1호(號)로 호전(好轉)된 만성위염(慢性胃炎) 환자(患者) 치험(治驗) 2례(例)

이경민,이세연,임성철,서정철,한상원,Lee, Kyung-min,Lee, Se-yun,Im, Sung-chul,Seo, Jung-chul,Han, Sang-won 대한침구의학회 2003 대한침구의학회지 Vol.20 No.6

Objective: This study was designed to investigate the effect of Wihwa herbal-acupuncture on chronic gastritis. Methods: Wihwa herbal-acupuncture was administered two times a week. The following points were selected: CV12(中脘), CV13(上脘), S36(足三里), Liv3(太衝). We checked pain rating score(P.R.S.), visual analogue scale (V.A.S.) and Gastroscopy. Results: After 6 weeks of treatment, the patient showed that clinical symtoms was disappeared, Lee's P.R.S. changed from 77 to 8 and Park's P.R.S. from 55 to 0 and gastric erosion disappeared on gastroscopy. Conclusions: These results suggest that and Wihwa herbal-acupuncture has good effect on chronic gastritis. But further studies are required to concretely prove the effectiveness of Wihwa herbal-acupuncture for treating chronic gastritis.

위염 분류의 역사적 배경

임성균,서승영 대한상부위장관ㆍ헬리코박터학회 2023 Korean Journal of Helicobacter Upper Gastrointesti Vol.23 No.2

Gastritis is common worldwide. The combination of Helicobacter pylori (H. pylori) infection with background gastritis, including atrophic gastritis or intestinal metaplasia is implicated as an important etiopathogenetic contributor to gastric cancer. Since the gastritis classification proposed by Schindler, research has focused on classification of gastritis for accurate diagnosis and prediction of prognosis. Advances in endoscopic technology have enabled more accurate visualization of the gastric mucosa and ‘targeted’ biopsies with the emergence of newer classifications based on visual findings (Kimura-Takemoto classification) and more specific histopathological findings using targeted biopsies (Whitehead classification). Following the discovery of H. pylori, it is mandatory to consider its role as an important contributor to gastritis. Therefore, it was necessary to redefine the classification of gastritis and arrive at a consensus, which led to the establishment of an international consensus classification, referred to as the Sydney system. However, the Sydney system alone cannot predict the gastric cancer risk, and scoring systems such as the Operative Link for Gastritis Assessment and the Operative Link on Gastritis Assessment based on Intestinal Metaplasia were proposed. These systems are based on histopathological findings observed in endoscopic biopsy specimens. However, availability of high-definition images following technological advances has facilitated the emergence of a visual classification, the Kyoto classification. In contrast to the Sydney system, the Kyoto classification is based exclusively on interpretation of visual findings and focuses on detection of H. pylori infection and gastric cancer prediction. In this review, we summarize the history and background of the various classifications of gastritis.

Helicobacter pylori에 감염된 십이지장궤양과 만성 위염에서 장형화생 빈도와 혈중 Pepsinogen치의 비교

김상우(Sang Woo Kim),정인식(In Sik Chung),이강문(Kang Moon Lee),이동수(Dong Soo Lee),윤종구(Jong Goo Yoon),김성수(Sung Soo Kim),양영상(Young Sang Yang),최명규(Myung Gyu Choi),한석원(Sok Won Han),최규용(Kyu Yong Choi),박두호(Doo Ho Pa 대한소화기학회 2000 대한소화기학회지 Vol.36 No.2

Background/Aims: The aim of this study was to investigate the differences in the frequency of intestinal metaplasia, its subtypes, and serum pepsinogen levels between Helicobacter pylori (H. pylori)-infected patients with duodenal ulcer and patients with chronic gastritis. Methods: We evaluated the area of atrophic change, frequency of intestinal metaplasia and subtypes, serum pepsinogen (PG) levels, and seropositivity of CagA and VacA in 25 H. pylori-infected patients with duodenal ulcer and 25 patients with chronic gastritis. Results: Eight percent of patients with duodenal ulcer showed open type, whereas 52% of patients with chronic gastritis showed it (p=0.001). The intestinal metaplasia was less frequently observed in patients with duodenal ulcer (36% vs. 68%, p<0.005). However, there was no difference in frequency of intestinal metaplasia subtypes between the two groups. The patients with duodenal ulcer showed significantly high serum PG I/II ratio (3.3±1.1 vs. 2.2±0.8, p<0.001). There was no difference in the seropositivity of CagA and VacA between the two groups. Conclusions: H. pylori-infected patients with duodenal ulcer have the significantly smaller area of atrophic change and lower frequency of intestinal metaplasia than patients with chronic gastritis. Serum PG I/II ratio which is significantly high in patients with duodenal ulcer reflects the degree of the atrophic change of the gastric mucosa, but CagA and VacA do not. (Kor J Gastroenterol 2000;36:155 - 162)

위 전암성 병변에 대한 내시경적 추적 관찰

김규종,박선자,남지현,임현정,김지연,박무인,구자영 고신대학교 의학부 2005 高神大學校 醫學部 論文集 Vol.20 No.1

Background: The aims of this study were to investigate the endoscopic findings of precancerous lesions of stomach and to see whether or not these lesions could progress to the carcinoma. Method: May 2000 to February 2001, consecutive patients diagnosed as having chronic active gastrits (CAG), intestinal metaplasia (IM), dysplasia, adenoma by endoscopic biopsy were enrolled. A total of 359 patients were included in this study and endoscopically followed-up to Autust 2001. Results; Among all 33 patients (26 dysplasia, 7 dysplasia with adenoma) diagnosed as dysplasia by endoscopic biopsy, there were 6 chronic erosive gastritis (CEG), 6 chronic erosion, 17 adenoma, 4 R/O cancer. On follow-up endoscopic biopsy (17 patients), there were 3 IM, 4 dysplasia, 5 adenoma, 5 carcinoma. Among all 107 patients (53 IM, 38 IM with CAG, 14 IM with CEG, 1 IM with adenoma, 1 IM with dysplasia) diagnosed as IM by endoscopic biopsy, there were 52 CEG, 33 chronic erosion, 6 local lesion, 5 adenoma, 5 R/O cancer, 3 gastric polyp, 3 atrophy with IM> On follow-up endoscopic biopsy (25 patients), there were 2 chronic gastritis, 1 CEG, 3 CAG, 14 IM 3 dysplasia, 2 adenoma, 1 carcinoma. Among all 185 patients (147 CAG, 37 CAG with IM, 1 CAG with adenoma) diagnosed as CAG by endoscopic biopsy, there were 86 CEG, 62 chronic erosion, 4 local lesion, 10 adenoma, 16 R/O cancer, 4 gastric polyp, 2 IM, 1 chronic gastritis. On follow-up endoscopic biopsy (35 patients), there were 8 chronic gastritis, 3 CEG, 14 CAG, 5 IM, 2 dysplasia, 1 adenoma, 2 arcinoma. Among All 34 patiets (22 adenoma, 8 adenoma with low grade dysplasia, 2 adenoma with moderate grade dysplasia, 2 adenoma with high grade dysplasia) diagnosed as gastric adenoma by endoscopic biospy, there were 1 local lesion, 24 adenoma, 2 R/O cancer, 7 gastric polyp. On follow-up endoscopic biopsy (17 patients), there were 2 CEG, 2 low grade dysplasia, 1 high grade dysplasia, 4 adenoma 1 adenoma with dysplasia, 4 adenoma with low grade dysplasia, 2 adenoma with high grade dysplasia, I cancerous change. Conclusions: Althought it was short period, there were some of cancerous change in precancerous lesions at follow-up endoscopy. This study suggests that screening for precancerous lesions, is one method of improving the prognosis of gastric carcinoma and when the precancerous lesions are diagnosed on endoscopy, serial endoscopic follow-up should be done to find early gastric cancer.

위 전암성 병변에 대한 내시경적 추적 관찰

김규종,박선자,남지현,임현정,김지연,박무인,구자영 고신대학교(의대) 고신대학교 의과대학 학술지 2005 고신대학교 의과대학 학술지 Vol.20 No.1

Backgrounds : The aims of this study were to investigate the endoscopic findings of precancerous lesions of stomach and to see whether or not these lesions could progress to the carcinoma. Methods : May 2000 to February 2001, consecutive patients diagnosed as having chronic active gastritis (CAG), intestinal metaplasia (IM), dysplasia, adenoma by endoscopic biopsy were enrolled. A total of 359 patients were included in this study and endoscopically followed-up to Augus 2001. Results : Among all 33 patients (26 dysplasia, 7 dysplasia with adenoma) diagnosed as dysplasia by endoscopic biopsy, there were 6 chronic erosive gastritis (CEG), 6 chronic erosion, 17 adenoma, 4 R/O cancer. On follow-up endoscopic biopsy *17 patients), there were 3 IM, 4 dysplasia, 5 adenoma, 5 carcinoma. Among all 107 patients (53 IM, 38 IM with CAG, 14 IM with CEG, 1 IM with adenoma, 1 IM with dysplasia) diagnosed as IM by endoscopic biopsy, there were 52 CEG, 33 chronic erosion, 6 local lesion, 5 adenoma, 5 R/O cancer, 3 gastric polyp, 3 atrophy with IM. On follow-up endoscopic biopsy (25 patients), there were 2 chronic gastritis, 1 CEG, 2 CAG, 14 IM, 3 displasia, 2 adenoma, 1 carcinoma. Among all 185 patients (147 CAG, 37 CAG with IM, 1 CAG with adenoma) diagnosed as CAG by endoscopic biopsy, there were 86 CEG, 62 chronic erosion, 4 local lesion, 10 adenoma, 16 R/O cancer, 4 gastric polyp, 2 IM, 1 chronic gastritis. On follow-up endoscopic biopsy (35 patients), there were 8 chronic gastritis, 3 CEG, 14 CAG, 5 IM, 2 dysplasia, 1 adenoma, 2 carcinoma. Among all 34 patients (22 adenoma, 8 adenoma with low grade dysplasia, 2 adenoma with moderate grade dysplasia, 2 adenoma with high grade dysplasia) diagnosed follow-up endoscopic biopsy (17 patients), there were 2 CEG, 2 low grade dysplasia, 1 high grade dysplasia, 4 adenoma, 1 adenoma with dysplasia, 4 adenoma with low grade dysplasia, 2 adenoma with high grade dysplasia, 4 adenoma, 1 adenoma with dysplasia, 4 adenoma with low grade dysplasia, 2 adenoma with high grade dysplasia, 1 cancerous change. Conclusions : Although it was short period, there were some of cancerous change in precancerous lesions at follow-up endoscopy. This study suggests that screening for precancerous lesions, is one method of improving the prognosis of gastric carcinoma and when the precancerous lesions are diagnosed on endoscopy, serial endoscopic follow-up should be done to find early gastric cancer.

맥파의 특징점 추출 방법에 따른 만성위염 판별 모형

최상호(Sang-Ho Choi),신기영(Ki-Young Shin),김재욱(Jeauk Kim),진승오(Seung-Oh Jin),이태범(Tea-Bum Lee) 대한전자공학회 2014 전자공학회논문지 Vol.51 No.1

한방병원에 입원한 요추관협착증을 동반한 만성 위염 환자에 대한 한방 치료 1례

김소원,박진훈,왕연민,김상윤,백길근,윤상훈,이형철,강만호,박성환,이지영 대한한방내과학회 2022 대한한방내과학회지 Vol.43 No.5

Objectives: The purpose of this study is to report the efficacy of applying Korean medical treatment to chronic gastritis. Methods: We treated a chronic gastritis patient with Korean medical treatments (herbal medicines, acupuncture, and herbal acupuncture therapy). To evaluate the results of this treatment, we took measurements using the Gastrointestinal Symptom Rating Scale and Visual Analogue Scale for abdominal pain, heartburn, nausea, and abdominal distension. The patient’s generic health status was evaluated using the European Quality of Life 5 Dimensions Scale. Results: Improvements in gastrointestinal symptom ratings and the European Quality of Life 5 Dimensions Scale were observed after the treatments. Relief of symptoms was observed in abdominal pain, heartburn, nausea, vomiting, and abdominal distension using the Visual Analogue Scale. Conclusions: This study suggests that Korean medicine may be effective in the treatment of chronic gastritis.