서울 집중호우와 수해

Zheng,Hai-yan,Jin Ri,Kim Dong-joon,Oh,Sung-nam,Lee,Kyoo-seock 한국기상학회 2011 한국기상학회 학술대회 논문집 Vol.2011 No.10-1

의사 역행렬을 이용한 애니메이션의 초개인적 갈등(SPC) 강도 관련 다학제적 연구

김재호(Jae Ho Kim),장정양(Zheng Yang Zhang),왕위차오(Yu Chao Wang),장소은(So Eun Jang),이태린(Tae Rin Lee) 한국전시산업융합연구원 2017 한국과학예술융합학회 Vol.30 No.-

본 연구는 애니메이션 갈등의 VST 특징을 조사하고 강도를 측정한 이태린의 연구 결과에 대한 심화연구로 초개인적 갈등영상과 초개인적 갈등 값을 기반으로 시작되었다. 본 연구의 목적은 초개인적 갈등 강도 값(ESSPC)을 자동 계산하는 모델을 찾아내는 것이다. 따라서 본 논문에서 SPC 영상을 분석하였으며, ESSPC 값을 자동 계산하는 모델을 찾아내기 위해 의사 역행렬(Pseudo Inverse matrix)을 사용하였다. 연구결과 및 내용은 다음과 같다. 이들을 활용하여, 1)SPC를 분석하기 위한 20 개의 영상 Feature값을 제안하였다. 그리고 2)의사 역행렬(Pseudo Inverse matrix)을 사용하여 ESSPC 값을 자동 계산하는 선형모델을 찾아냈다. 그 결과로 3)제안된 시스템은 9.25%의 평균 자승오차의 제곱근 보이며, 그 효율성이 증명되었다. 이러한 연구결과를 바탕으로 이를 계속 발전시켜 성공적 애니메이션의 제작을 위한 자동 검증시스템을 개발하고자 한다. This study is an intensive study on Tae Rin Lee’s research results. A linear system for Estimating the Strength of Super Personal Conflict (ESSPC) in animations is proposed. Tae Rin Lee has extracted the Super Personal Conflict (SPC) shots of animations, and obtained the strength through the experts’ psychological test experiment. The purpose of this study is to find a model that automatically computes the superpersonal conflict intensity value (ESSPC). By utilizing these results, 1) 20 image feature vectors are suggested for analyzing the SPC, and 2) a linear system is found for auto-calculating ESSPC by using the pseudo inverse matrix. The proposed system shows 9.25% root mean square error and the effectiveness is proven.

알록산 투여로 유발된 실험적 당뇨병에 대한 사인추출물의 치료 효과

노혜원,이지나,구본선,조정임,박진우,김형로 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2

연구배경:사인추출물이 알록산에 의한 당뇨 유발을 억제하는 효과가 있음을 이미 확인하였던 바 사인 추출물이 췌장 베타세포가 손상되어 유발된 당뇨병의 치료에 사용할 수 있는지의 가능성을 알아보았다. 방법:실험적 당뇨는 알록산(60㎎/㎏)을 생쥐 꼬리 정맥을 통해 주사하여 유발시켰다. 당뇨에 미치는 사인추출물의 영향을 관찰하기 위하여 사인추출물의 영향을 관찰하기 위하여 사인추출물(2.5㎎/생쥐)을 하루에 두 번 생쥐 복강 내로 투여하였다. 당뇨에 미치는 사인추출물의 영향을 관찰하기 위하여 생쥐에 사인추출물을 처리한 다음 혈당 및 혈청 인슐린 농도 변화 및 조직학적인 소견으로 확인하였다. 결과:생쥐에 알록산을 투여하면 췌장 베타세포가 파괴되어 고혈당 및 hypoinsulinemia가 유발되었다. 사인추출물을 알록산 투여 전 2일 동안 전처리하면 알록산에 의한 고혈당이 완전히 억제되었다. 뿐만 아니라 알록산에 의해 유발된 췌장 베타세포의 손상은 사인추출물의 투여로 현저히 개선되어 혈당 및 혈청 인슐린 농도가 거의 정상 수준으로 회복되었다. 알록산을 투여한 생쥐의 췌장 소도는 정상군에 비해 수가 현저히 감소되었을 뿐 아니라 남아있는 소도의 크기도 현저히 줄어들어 있었으나, 사인추출물을 처리하면 모두 회복되어 정상군과 유사한 양상을 보였다. 결론:사인추출물은 알록산에 의해 유발되는 당뇨병을 억제하는 방어 작용 뿐만 아니라, 알록산 투여로 이미 손상된 췌장 베타세포를 개선시킬 수 있는 치료 효과작용도 가지고 있음을 확인하였다. 이를 토대로 사인의 당뇨 개선 기전을 규명하면 당뇨병 치료제로서 이용할 수 있으리라 사료된다. Background : During the screening of natural products for potential antidiabetogenic components, a strong protective effect of Amomum xanthoides extract on alloxan-induced β-cell damage and in a mice diabetic model. In this study, the therapeutic effect of Amomum xanthoides extract was investigated after induction of diabetes by alloxan. Methods : Experimental diabetes was induced by the injection of alloxan(60mg/kg) to the mouse via the tail vein. To examine the effect the of Amomum xanthoides extract on diabetes, Amomum xanthoides extract (2.5mg/mouse) was admini-strated intraperitoneally. The effect of the Amomum xanthoides extract on alloxan-induced diabetes was observed by measuring the blood glucose and serum insulin level, and a histological examination. Results : Alloxan caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic β-cell. Pretreating the with an Amoumum xanthoides extract completely protected them from the hyperglycemia induced by alloxan. In addition, the Amomum xanthoides extract administe 3 days after the of alloxan injection significantly abolished the hyperglycemia and hypoinsulinemia induced by alloxan. The alloxan-treated mice showed a marked change of in the pancreatic islets: the number of islets was reduced and the size of the remaining islets also decreased. However these effects of alloxan were significantly recovered by a later administration of the Amomum xanthoides extract. Conclusion : The amomum xanthoides extract contains potentially effective components, which both protect and treat alloxan-induced diabetes. The identification and action mechanism of the effective components of the Amomum xanthoides extract requires further investigation and it is suggested that the Amomum xanthoides extract be used as a therapeutic drug for diabetes(J Kor Diabetes 26:126~133, 2002).

배추 시스테인 단백질 분해 효소 억제 유전자 BCPI-1의 발현과 종자 발아 및 유묘 생장과의 연관성

홍준기,이은영,김정률,양경애,최영주,정우식,김호일,윤대진,이상열,조무제,임체오 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Phytocystatins are protein inhibitors of cysteine proteinases of the papain family that have been identified in both monocot and dicot plants. A cDNA encoding a phytocystatin, BCPI-1 (Brassica Cysteine Proteinase Inhibitor-1) has been isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) flower buds. Here, we tested whether BCPI-1 transcription is regulated by hormones, and could be involved in regulating cysteine proteinases during and after germination. BCPI-1 was sensitive to exogenous GA_(3) and ABA, which are important factors controlling seed germination, suggesting that the expression of BCPI-1 is hormonally regulated. We introduced a recombinant plasmid containing the full-length BCPI-1 cDNA under the control of cauliflower mosaic virus 35S promoter into rice embryogenic calli using the particle delivery method, and regenerated a number of transgenic rice plants. Constitutively over-expressed BCPI-1 caused changes in overall plant growth and development, including reduced germination and seedling growth. These data support the role of the BCPI-1 in the regulation of endogenous proteinases during both seed germination and subsequent seedling development. Phylocystatins은 papain계열의 cysteine 단백질 분해 효소 활성을 특이적으로 억제하는 억제자로 다양한 식물 종으로부터 분리되었다. 본고에서는, 배추 화아 cDNA library로부터 분리된 phytocystatin인 BCPI-1(Brassica Cysteine Proteinase Inhibitor-1)의 생체 내 기능에 대해 연구하였다. 먼저, BCPI-1 전사체는 발아 조절에 중요한 영향을 미치는 GA₃와 ABA에 의해 예민하게 증가, 혹은 감소되는 반응을 보임으로써, BCPI-1이 식물 호르몬의 영향을 받으며, 특히 발아나 유묘의 생장 조절에 관련이 있음을 알 수 있었다. Particle bombardment 방법을 통하여 BCPI-1을 벼의 배 형성 세포 내에 도입, 재분화 시켜 형질 전환 벼를 생성하였다. CaMV 35S promoter의 조절에 의해 지속적인 BCPI-1 발현을 보이는 형질 전환 벼의 경우, 발아와 유묘 생장이 현저히 지연되었다. 위의 결과들을 바탕으로, BCPI-1이 식물체 내에서 생성되는 cysteine 계열의 단밸질 분해 효소 활성을 조절하여 종자의 발아와 유묘의 생장에 영향을 미치는 것으로 추측한다.

시멘트 제조사 및 W/C 변화에 따른 콘크리트의 초기 강도발현 특성

金光華,裵正烈,김규도,이승훈,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

This study is to investigate the influence of cement manufacturing company and W/C on the properties of fresh concrete, strength of hardened concrete and rebound value of P type Schmidt hammer. According to the result, setting time of concrete is shortened with and increase of W/C, and when cement made in A and B corporation is used in concrete, the final setting time is measured at about 10 hours and 13 hours. Compressive strength increases with elapse of time and decrease of W/C, and concrete using cement made in A corporation shows higher compressive strength and rebound value until 24 hours, but from 3rd day, the contrary tendency is shown. As for the properties of early strength, the strength develop fast with decrease of W/C, and the time when compressive strength of 5MPa is gained and the form can be removed, is about 15, 18, 21 hours and 20, 22, 27 hours at the W/C 40, 45, 50% in concrete using cement made in A and B Co. respectively. The correlativity between compressive strength and the rebound value, which a coefficient of correlation is over 0.97, is very favorable. Therefore this method is effective to estimate the strength of removing the form.

Inhibitory Action of Exogenous Serotonin on the Pancreatic Exocrine Secretion in Rats

Zheng er Jiang,Hyo Jin Koh,Kyoung Hee Lee,Hyun Joo Lee,Min-Jae Lee,Moo-Ho Won,Yun Lyul Lee 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4

Serotonin (5-HT) is synthesized and released from enterochomaffin cells in the gastrointestinal mucosa and platelets. Most of these serotonins are existed in the gastro-intestine, and only few amounts are existed in the central nervous system. Although most of serotonins are existed in the gastrointestinal tract, a role of serotonin in the gut is still unclear.We previously reported that electrical field stimulation (EFS)-evoked pancreatic volume flow and amylase output further elevated by spiperone hydrochloride, serotonin (5-hydroxytryptamine, 5-HT) antagonist, in the isolated rat pancreas. This study was aimed to investigate roles and the action mechanisms of exogenous serotonin and serotonergic nerves on pancreatic exocrine secretion using the two experimental models (in vivo and exo vivo model). Results of exo vivo experiment: CCK elevated pancreatic volume flow and amylase output in rats. Endogenous insulin released by glucose potentiated the action of CCK. CCK-stimulated pancreatic volume flow and amylase output were not change by exogenous serotonin under hypoglycemic condition. However, exogenous serotonin significantly inhibited CCK-stimulated pancreatic volume flow and amylase. Results of in vivo experiment: CCK elevated pancreatic volume flow and amylase output in the isolated perfused rat pancreas. Endogenous insulin released by 18mM glucose potentiated the action of CCK. CCKstimulated pancreatic volume flow and amylase output were not change by exogenous serotonin under 5.6 mM glucose backgroud. However, exogenous serotonin significantly inhibited potentiated the action of CCK by insulin. These observations are good agreement with our previous in vitro results and strongly indicate that serotonin play a inhibitory role in pancreatic exocrine secretion and insulin may be involved the inhibitory actions.

5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1.

Lee, Jung-Min,Park, Hyojung,Noh, A Long Sae Mi,Kang, Ju-Hee,Chen, Ling,Zheng, Ting,Lee, Juhyun,Ji, Sun-Young,Jang, Chang-Young,Shin, Chan Soo,Ha, Hyunil,Lee, Zang Hee,Park, Hea-Young,Lee, Dong-Seok,Yi American Association of Immunologists 2012 Journal of Immunology Vol. No.

<P>5-Lipoxygenase (5-LO) catalyzes the formation of two major groups of leukotrienes, leukotriene B4 and cysteinyl leukotrienes (CysLTs), and it has been implicated as a promising drug target to treat various inflammatory diseases. However, its role in osteoclastogenesis has not been investigated. In this study, we used mouse bone marrow-derived macrophages (BMMs) to show that 5-LO inhibitor suppresses RANKL-induced osteoclast formation. Inhibition of 5-LO was associated with impaired activation of multiple signaling events downstream of RANK, including ERK and p38 phosphorylation, and IκB degradation, followed by a decrease in NFATc1 expression. Ectopic overexpression of a constitutively active form of NFATc1 partly rescued the antiosteoclastogenic effect of 5-LO inhibitor. The knockdown of 5-LO in BMMs also resulted in a significant reduction in RANKL-induced osteoclast formation, accompanied by decreased expression of NFATc1. Similar effects were shown with CysLT receptor (CysLTR)1/2 antagonist and small RNA for CysLTR1 in BMMs, indicating the involvement of CysLT and CysLTR1 in 5-LO-mediated osteoclastogenesis. Finally, 5-LO inhibitor suppressed LPS-induced osteoclast formation and bone loss in the in vivo mouse experiments, suggesting a potential therapeutic strategy for treating diseases involving bone destruction. Taken together, the results of this study demonstrate that 5-LO is a key mediator of RANKL-induced osteoclast formation and possibly a novel therapeutic target for bone-resorption diseases.</P>

Fabrication of an rhBMP-2 loaded porous β-TCP microsphere-hyaluronic acid-based powder gel composite and evaluation of implant osseointegration

Lee, Jae Hyup,Kim, Jungju,Baek, Hae-Ri,Lee, Kyung Mee,Seo, Jun-Hyuk,Lee, Hyun-Kyung,Lee, A-Young,Zheng, Guang Bin,Chang, Bong-Soon,Lee, Choon-Ki Springer US 2014 Journal of materials science, Materials in medicin Vol.25 No.9

<P>Methods to improve osseointegration that include implantation of rhBMP-2 with various kinds of carriers are currently of considerable interest. The present study was conducted to evaluate if the rhBMP-2 loaded β-TCP microsphere-hyaluronic acid-based powder-like hydrogel composite (powder gel) can act as an effective rhBMP-2 carrier for implantation in host bone with a bone defect or poor bone quality. The release pattern for rhBMP-2 was then evaluated against an rhBMP-2-loaded collagen sponge as a control group. Dental implants were also inserted into the tibias of three groups of rabbits: an rhBMP-2 (200 µg) loaded powder gel composite implanted group, an implant only group, and a powder gel implanted group. Micro-CT and histology of the implanted areas were carried out four weeks later. The rhBMP-2 powder gel released less rhBMP-2 than the collagen sponge, but it continued a slow release for more than 7 days. The rhBMP-2 powder gel composite improved osseointegration of the dental implant by increasing the amount of new bone formation in the implant pitch and it improved the bone quality and bone quantity of new bone. The histology results indicated that the rhBMP-2 powder gel composite improved the osseointegration in the cortical bone as well as the marrow space along the fixture. The bone-to-implant contact ratio of the rhBMP-2 (200 µg) loaded powder gel composite implanted group was significantly higher than those of the implant only group and the powder gel implanted group. The powder gel appeared to be a good carrier and could release rhBMP-2 slowly to promote the formation of new bone following implantation in a bone defect, thereby improving implant osseointegration.</P>

FOA (first-order-analysis) model of an expandable lattice structure for vehicle crash energy absorption of an inflatable morphing body

Lee, Dong-Wook,Ma, Zheng-Dong,Kikuchi, Noboru Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.37 No.6

A concept of crash energy absorbing (CEA) lattice structure for an inflatable morphing vehicle body (Lee et al. 2008) has been investigated as a method of providing rigidity and energy absorption capability during a vehicular collision (Lee et al. 2007). A modified analytical model for the CEA lattice structure design is described in this paper. The modification of the analytic model was made with a stiffness approach for the elastic region and updated plastic limit analysis with a pure plastic bending deformation concept and amended elongation factors for the plastic region. The proposed CEA structure is composed of a morphing lattice structure with movable thin-walled members for morphing purposes, members that will be locked in designated positions either before or during the crash. What will be described here is how to model the CEA structure analytically based on the energy absorbed by the CEA structure.

Evaluation of the Oral Acute Toxicity of Black Ginseng in Rats

Lee, Mi-Ra,Oh, Chang-Jin,Li, Zheng,Li, Jing-Jie,Wang, Chun-Yan,Wang, Zhen,Gu, Li-Juan,Lee, Sang-Hwa,Lee, Jae-Il,Lim, Beong-Ou,Sung, Chang-Keun The Korean Society of Ginseng 2011 Journal of Ginseng Research Vol.35 No.1

We studied the acute oral toxicity of black ginseng (BG) produced by heat process in rats. Single acute BG extract doses of 0, 5, 10, and 15 g/kg dissolved in saline were administered by oral gavage and the animals were kept under observation for 14 days. The single administration of BG extract up to 15 g/kg did not produce mortality, behavioral change or abnormal clinical signs in the rats. These results indicated that the oral $LD_{50}$ of the BG extract in the rats is higher than 15 g/kg. Compared to the control group, no treatment-related biologically significant effects of BG extract were noted in the measurements of the body weight or food intake. At the end of the period, the biochemical parameters and hematological parameters were analyzed in the plasma and blood. A histopathological examination of the liver and kidney was also conducted. Only the blood nitrogen urea and potassium levels in the biochemical indices showed significant differences at 10 and 15 g/kg doses of BG extract compared to the control group. These changes were not considered to be due to the toxicity. None of the other clinical chemistry parameters were affected. Therefore, these results indicate that the BG by heat processing is virtually nontoxic.