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Yun Ho Jo,Hwan Lee,Myeong Hwan Oh,Gyeong Hee Lee,You Jin Lee,Ji Sun Lee,Min Jung Kim,Won Yong Kim,Jin Seong Kim,Dae Seok Yoo,Sang Won Cho,Seon Woo Cha,Mi Kyung Pyo 한국영양학회 2020 Nutrition Research and Practice Vol.14 No.4
BACKGROUND/OBJECTIVES: This study was designed to investigate the improvement effect of white ginseng extract (GS-KG9) on D-galactosamine (Ga1N)-induced oxidative stress and liver injury. SUBJECTS/METHODS: Sixty Sprague-Dawley rats were divided into 6 groups. Rats were orally administrated with GS-KG9 (300, 500, or 700 mg/kg) or silymarin (25 mg/kg) for 2 weeks. The rats of the GS-KG9- and silymarin-treated groups and a control group were then intraperitoneally injected Ga1N at a concentration of 650 mg/kg for 4 days. To investigate the protective effect of GS-KG9 against GalN-induced liver injury, blood liver function indicators, anti-oxidative stress indicators, and histopathological features were analyzed. RESULTS: Serum biochemical analysis indicated that GS-KG9 ameliorated the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in GalN-treated rats. The hepatoprotective effects of GS-KG9 involved enhancing components of the hepatic antioxidant defense system, including glutathione, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT). In addition, GS-KG9 treatment inhibited reactive oxygen species (ROS) production induced by GalN treatment in hepatocytes and significantly increased the expression levels of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) proteins, which are antioxidant proteins. In particular, by histological analyses bases on hematoxylin and eosin, Masson"s trichrome, α-smooth muscle actin, and transforming growth factor-β1 staining, we determined that the administration of 500 mg/kg GS-KG9 inhibited hepatic inflammation and fibrosis due to the excessive accumulation of collagen. CONCLUSIONS: These findings demonstrate that GS-KG9 improves GalN-induced liver inflammation, necrosis, and fibrosis by attenuating oxidative stress. Therefore, GS-KG9 may be considered a useful candidate in the development of a natural preventive agent against liver injury.
Phosphodiesterase inhibitor improves renal tubulointerstitial Hypoxia of the Diabetic rat Kidney
( Hui Kyoung Sun ),( Yun Mi Lee ),( Kum Hyun Han ),( Han Seong Kim ),( Seon Ho Ahn ),( Sang Youb Han ) 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.2
Background/Aims: Renal hypoxia is involved in the pathogenesis of diabetic nephropathy. Pentoxifyllin (PTX), a nonselective phosphodiesterase inhibitor, is used to attenuate peripheral vascular diseases. To determine whether PTX can improve renal hypoxia, we investigated its effect in the streptozocin (STZ)-induced diabetic kidney. Methods: PTX (40 mg/kg, PO) was administered to STZ-induced diabetic rats for 8 weeks. To determine tissue hypoxia, we examined hypoxic inducible factor-1α (HIF-1α), heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and glucose transporter-1 (GLUT-1) levels. We also tested the effect of PTX on HIF-1α in renal tubule cells. Results: PTX reduced the increased protein creatinine ratio in diabetic rats at 8 weeks. HIF-1α, VEGF, and GLUT-1 mRNA expression increased significantly, and the expression of HO-1 also tended to increase in diabetic rats. PTX significantly decreased mRNA expression of HIF-1α and VEGF at 4 and 8 weeks, and decreased HO-1 and GLUT-1 at 4 weeks. The expression of HIF-1α protein was significantly increased at 4 and 8 weeks in tubules in the diabetic rat kidney. PTX tended to decrease HIF-1α protein expression at 8 weeks. To examine whether PTX had a direct effect on renal tubules, normal rat kidney cells were stimulated with CoCl2 (100 μM), which enhanced HIF-1α mRNA and protein levels under low glucose conditions (5.5 mM). Their expressions were similar even after high glucose (30 mM) treatment. PTX had no effect on HIF-1α expression. Conclusions: PTX attenuates tubular hypoxia in the diabetic kidney.
일부 운수사업장 근로자의 건강진단 유소견자의 사후관리 실행과 관련요인
윤혜은,박종,이영선,강성득,김철호 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Objective : The purpose of this study was to find the relationship between the follow-up management status for medical problem to be treated and various characteristics of some workers at transportation business. Methods : A questionnaire survey was made toward 183 workers with medical problem(C and D2) among 945 examine in 1997. Results: Sixty four point five percent of surveyee received the examination result report and 40.5% were explained about the result 80.3% of surveyee answered that they knew the result of health examination. Most workers felt the necessity of the health examination, but 54.1% were dissatisfied with present health examination system and 66.7% pointed it out as nominal The rate of follow-up management for the medical problem was 62.8% By the multiple logistic regression the follow-up management rate for those who knew the health examination result were 2.98 times higher than those who didn't know the result (OR=2.98, 95% CI 1.41~6.29) The rate for those who perceived the medical problem already were 2.64 times higher than those who perceived the problem for the first time (OR=2.64, 95% CI 1.13~6.15). The rate for those who had subjective symptoms were 2.83 times higher than those who didn't have subjective symptoms. Conclusion : sixty two point eight percent of workers with medical problem performed the follow-up management and perception of health examination result, perception of the problem in the past and experience of subjective symptoms were related with the follow-up management.
벼(Oryza sativa L.) 統一型品種의 溫度에 따른 營養 生長期 主稈 出葉速度와 栽培時期 移動에 의한 主稈總葉數의 變化
尹成浩 건국대학교 1986 論文集 Vol.22 No.1
The response of leaf developing of rice plant to temperature and total number of leaves on mother stem under field condition are important to understand the characteristics of growth duration among the rice varieties. To investigate number of days required to develop a leaf at vegetative stage, 6.1-leaf age, nine indica/japonica Korean rices (Oryza saitva L.) were subjected to four levels of air temperature, at 13, 18, 23, and 28℃ of glass rooms in a phytotron for 168 hours. Also to examine variations of lifelong leaf number on the mother stem of the rices, a field experiment was conducted with transplanted five times from 11 May to 10 July at the 15-day intervals at Suweon, Korea in 1977. Significant varietal differences were observed in number of days required to develop a leaf. The differences were increased by decreased the temperature levels. The number of days required to develop a leaf, overall varietal means at 13, 18, 23, and 28℃ were 15.9, 6.7, 4.5, and 4.2 days respectively. A low temperature, at 13℃, an early maturing rice, Milyang 21 was required 6.8 more days than that in a late maturing rice, Geumgangbyeo. A relationship between daily mean air temperatures (X) and the number of days required to develop a unit leaf (Y) could be fitted significantly as a hyperholic equation: Y=X/aX-b. A base temperature, the threshold temperature for stoppage of leaf developing was estimated 12℃ by the equation. A minimum degree-days required to develop a leaf was 104℃ at 23℃ of mean air temperature in the rices. Total number of leaves on mother stem of overall rices and the transplanting dates in the field condition were ranged 13∼20 leaves of which the late maturing rices had more the loaves than those in early maturing rices, and in the same variety, early season transplanted rices also had more leaves than those in the late season transplanted rices. A negative correlation showed between the total number of loaves on mother stem of overall rices at transplanted in 26 May in the field and number of days required to develop a leaf at 13℃ only under the phytotron condition.
퇴행성 슬관절염 환자 평가 설문도구의 내적 신뢰도, 상관성에 관한 연구
류성룡,안경애,서병관,강중원,이상훈,이재동,최도영,김건식,이두익,이윤호 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-
Objective : The aim of this study is to evaluate internal reliability and correlation among assessment instruments of knee OA. Methods : Data were obtained from 85 patients with knee OA. They were asked to answer VAS pain scale, two disease-specific questionnaires (WOMAC and LFI) and one instrument about health-related quality(KHAQ). Reliability was assessed using cronbach's alpha. Correlation was assessed by examining the pearson's correlation coefficients. Results : Cronbach's alpha of all Index except WOMAC stiffness subscale(.6679) exceeded the value of 0.70. A good correlation was obtained between WOMAC Subscale (especially Pain Subscale) and LFI (.726<cronbach's alpha<.791). Also, Correlation between KHAQ and two disease-specific questionnaires (WOMAC and LFI) was good(.612<cronbach's alpha<.662). Conclusions : All used instruments have good internal reliability. also, There are good correlation among them. The treatment of knee OA must be focused on health related quality. For this, we should use proper assessment instruments.
김성권,김동호,윤병성,이봉학 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A
It is the purpose of this study to identify comprehensive fatigue characteristics of pavement concretes considering coarse aggregate types. The types of coarse aggregates considered are limestone, sandstone and granite, which are the most representative stones in Korea. The static strength tests were carried out to check the compressive strength, flexural strength at 7 and 28 days, and split tension strength at 56 day in order to minimize the various effect of strength during the test. The results are follows. The comprehensive fatigue models of pavement concretes were developed considering coarse aggregate types. The developed model showed a good relationship between aggregate types. The fatigue models with coarse aggregate types were shown, respectively. The combined fatigue models was also shown.
김성주,김윤희,이상호 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1
As the result of comparison and investigation on architectural urban planning code and its applications in individual residential district of 5 new towns in metropolitan area, we found some problems in the codes and its regulation. Though these codes are set for new town, there is lack of consideration on each new town's unique identity and absence of specific design guide lines. We suggest that specific limitations and its maintenance are needed in 1) the land use for each lot, 2) limit of household number for the managing density as planned, 3) usage on the frontal space of each lot. On the other hand, we suggest some supplementary measures such as incentives for the individuals' frontal space contributions, design guide lines on the buildings physical form and materials, and guiding out more open streetscape.