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Yu-Jin Jo,In-won Lee,Seong-min Jeong,Jeong-woo Kwon,Nam-Hyung Kim,Suk Namgoong 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2
Zinc (Zn2+) is one of essential factors during mammalian oocyte maturation and fertilization. Previous studies showed that depletion of cellular Zn by metalion chelator impair asymmetric division of oocyte. But the detailed mechanism of these phenomena is unclear. We found that depletions of zinc by cell-permeable heavy metal chelator N,N,N',N'- tetrakis(2-pyridylmethyl)ethane-1,2-diamine (TPEN) caused the decrease of cytoplasmic actin mesh level. Spire2-GFP is co-localized with zinc at the cortex and intracellular vesicle. By the treatment of TPEN, number of Spire2-GFP decorated vesicle is drastically decreased, indicating that Zn2+ is essential for the localization of the spire in mouse oocyte. Two putative zinc-binding regions were located in the C-terminal part of Spire2. Mutations of zinc binding site on spire abolish its localization at the intracellular vesicle. Over expression of C-terminal region containing zinc binding site of spire impair oocyte maturations and decrease cytoplasmic actin mesh. Taken together, these results suggest that intracellular zinc is crucial for the proper localizations of spire in the mouse oocyte, and unraveling the novel regulatory mode of actin nucleator spire by Zn2+.
Very high open-circuit voltage in dual-gate graphene/silicon heterojunction solar cells
Won, Ui Yeon,Ly, Thuc Hue,Kim, Young Rae,Kang, Won Tae,Shin, Yong Seon,Lee, Ki Young,Heo, Jin Seong,Kim, Kun Nyun,Lee, Young Hee,Yu, Woo Jong Elsevier 2018 Nano energy Vol.53 No.-
<P><B>Abstract</B></P> <P>Two dimensional (2D) layered materials and their heterojunctions with other materials are attracted because of their remarkable electrical and optical properties. In particular, graphene/semiconductor Schottky heterojunction is used for high performance solar cells. Here, we demonstrated very high open circuit voltage (<I>V</I> <SUB> <I>oc</I> </SUB> <I>)</I> in graphene/silicon heterojunction solar cell by dual-gate electric field application. The low density of states near Dirac point in graphene allows large modulation of graphene Fermi-level and corresponding Schottky barrier in a graphene/silicon junction. The top and bottom gate electric fields independently adjust the built-in potentials of respective upper and lower silicon energy band to induce higher band bending (1.22 eV) than the bandgap (1.12 eV). As a result, a maximum <I>V</I> <SUB> <I>oc</I> </SUB> of 0.94 V is achieved at the − 8 V of top-gate voltage and 10 V of bottom-gate voltage, exceeding highest known <I>V</I> <SUB>oc</SUB> for previous graphene/silicon solar cell (<I>V</I> <SUB>oc</SUB> = 0.61 V) and the S-Q Limit (0.84 V) of conventional silicon solar cell – a thermodynamic limit for the energy conversion efficiency of solar cells with a single band gap energy. The ratio of output power gain to input gate power (Δ<I>P</I> <SUB>G</SUB>/Δ<I>P</I> <SUB>C</SUB>) is approximately 10<SUP>12</SUP>–10<SUP>14</SUP> with negligible power consumption in the gate (<I>P</I> <SUB>C</SUB> = 1 fW/cm<SUP>2</SUP>–10 pW/cm<SUP>2</SUP>), resulting in the significant advances in the power generation (<I>P</I> <SUB>G</SUB> = 40 mW/cm<SUP>2</SUP>).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Graphene/silicon hetero-junction solar cell was demonstrated by applying dual gate bias in 1-sun condition. </LI> <LI> Highest Open circuit voltage over the S-Q limit was recorded by modulating electrostatic doping. </LI> <LI> The ratio of output power gain to input gate power (Δ<I>P</I> <SUB>G</SUB>/Δ<I>P</I> <SUB>C</SUB>) is approximately 10<SUP>12</SUP>–10<SUP>14</SUP> with negligible power consumption in the gate (<I>P</I> <SUB>C</SUB> = 1 fW/cm<SUP>2</SUP> – 10 pW/cm<SUP>2</SUP>). </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Won, Yu Deok,Kim, Jae-Min,Ryu, Je-Il,Koh, Seong-Ho,Han, Myung-Hoon,Cheong, Jin-Hwan The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.5
Objective : Hemorrhagic transformation (HT) can be occurred after acute cerebral infarction. HT can worse symptoms in severe cases and adversely affect long-term prognosis. As bone and vascular smooth muscle are composed of type 1 collagen, we aimed to identify a potential relationship between bone mineral density (BMD) and HT after acute cardioembolic stroke. Methods : As an indicator of BMD, we used mean frontal skull Hounsfield unit (HU) values on brain computed tomography (CT). Multivariative hazard ratios were calculated using Cox regression analysis to identify whether the osteoporotic condition was an independent predictor of HT after acute cardioembolic stroke. Results : This 11-year analysis enrolled 506 patients who diagnosed as acute cardioembolic infarction. The first tertile of skull HU value was an independent predictor of HT development compared to the third tertile (hazard ratio, 2.12; 95% confidence interval, 1.13-3.98; p=0.020). We observed no interactions between age and skull HU with respect to HT statistically. Conclusion : The results of this study revealed an association between osteoporotic conditions and HT development after acute cardioembolic stroke. A convenient method to measure the cancellous bone HU value of the frontal skull using brain CT images may be useful for predicting HT in patients with acute cerebral infarction.
Device characterization and Fabrication Issues for Ferroelectric Gate Field Effect Transistor Device
Yu, Byoung-Gon,You, In-Kyu,Lee, Won-Jae,Ryu, Sang-Ouk,Kim, Kwi-Dong,Yoon, Sung-Min,Cho, Seong-Mok,Lee, Nam-Yeal,Shin, Woong-Chul The Institute of Electronics and Information Engin 2002 Journal of semiconductor technology and science Vol.2 No.3
Metal-Ferroelectric- Insulator- Silicon (MFIS) structured field effect transistor (FET) device was fabricated and characterized. Important issues to realize ferroelectric gate field effect transistor device were summarized in three sections. The choice of interlayer dielectric was made in the consideration of device functionality and chemical reaction between ferroelectric materials and silicon surface during fabrication process. Also, various ferroelectric thin film materials were taken into account to meet desired memory window and process compatibility. Finally, MFIS structured FET device was fabricated and important characteristics were discussed. For feasible integration of current device as random access memory array cell address schemes were also suggested.
The Beneficial Effects of Dioscorea Batatas Dence Peel Extracts on Skin Health
Yu-Hyeon Kim,Yu-Rim Lee,Tae-Won Kim,Tae-Hwan Lee,Hun-Seong Kim,Dong-Yup Hahn,Nam-Joo Kang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The demands for bioactive compounds from natural sources have increased in the cosmeceutical industry. Dioscorea Batatas Dence Flesh (DBF) with various bioactive substances is widely used in the cosmetic industry, while most of Dioscorea Batatas Dence Peel (DBP) is not utilized and is discarded. However, recent studies have shown that DBP has higher bioactive substances than DBF. In this study, we examined the skin biological activities of DBP extract from different solvents. DBP extracts obtained by 70% ethanol (70% EtOH DBP) and 95% ethanol (95% EtOH DBP) were shown to have skin whitening activity by inhibiting the melanin content of B16F10 cells and tyrosinase activity in 20 μg/mL. Ethyl acetate extract of DBP (EA DBP) also inhibited tyrosinase activity in 5 μg/mL. In HDF cells, treatment of DBP extracts after UVB irradiation (20 mJ/cm²) up-regulated type I pro-collagen (Pro-COL1A1) expression and down-regulated matrix metalloproteinase-1 (MMP-1) level. Additionally, DBP extracts inhibited MMP-1 activity in a dose-dependent manner. The results of this study indicated that DBP extracts can be used as cosmetic ingredients for skin-whitening and anti-photoaging.
Yu, Seong-Bin,Lee, Seung-Ho,Mehran, Muhammad Taqi,Hong, Jong-Eun,Lee, Jong-Won,Lee, Seung-Bok,Park, Seok-Joo,Song, Rak-Hyun,Shim, Joon-Hyung,Shul, Yong-Gun,Lim, Tak-Hyoung Elsevier 2018 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.335 No.-
<P><B>Abstract</B></P> <P>By using electricity from renewable sources, high-temperature solid oxide co-electrolysis cells (SOCs) can perform advantageous conversion of H<SUB>2</SUB>O/CO<SUB>2</SUB> to high-value syngas. In this work, we investigated the performance of tubular solid oxide co-electrolysis cells for the production of syngas by electrochemical conversion of H<SUB>2</SUB>O/CO<SUB>2</SUB>. The tubular solid-oxide electrolysis cells comprise Ni-yttria stabilized zirconia (Ni-YSZ) based fuel-electrode supported cells, a yttria or scandia-stabilized zirconia (YSZ and ScSZ) electrolyte, and a composite air-electrode of (La<SUB>0.85</SUB>Sr<SUB>0.15</SUB>)<SUB>0.9</SUB>MnO<SUB>3</SUB> (LSM) and La<SUB>0.6</SUB>Sr<SUB>0.4</SUB>Co<SUB>0.2</SUB>Fe<SUB>0.8</SUB>O<SUB>3</SUB> (LSCF). The electrochemical performance of the tubular SOCs for various operating conditions was analyzed using I-V curves, EIS analysis, and gas chromatography. From the results, we confirm the correlation between the operating conditions and the electrochemical performance of the co-electrolysis process in the tubular SOCs. Furthermore, we found that the syngas yield of the ScSZ electrolyte-based SOC cell was better than that of the YSZ electrolyte-based SOC. The results show that using a tubular SOC offered highly efficient conversion of H<SUB>2</SUB>O/CO<SUB>2</SUB>, with high yield and good-quality syngas.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effect of temperature, inlet gas composition on syngas yield investigated. </LI> <LI> In coelectrolysis, ScSZ electrolyte based SOC performs better than YSZ based SOC. </LI> <LI> Higher amount of CO<SUB>2</SUB> in the feed gas produces more CO in syngas. </LI> <LI> It is possible to achieve high syngas yield through optimized the conditions. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Yu Jin-Won,Kim Seong-geun,정우영,김양익,최정은,이인원 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1
This paper predicts resistance and propulsion performances in regular and irregular head waves of a 1800 TEU container ship. ‘Calm-water tests’ and ‘resistance test in regular waves’ have been performed. Methods applied are the LVM-W and the revised ITTC-78. Added propeller revolution, thrust, and torque in waves linearly increase as added resistance does. The relative contributions of added propulsion performances in waves have been evaluated using the logarithmic derivative. The spectral method in operating sea states has been applied. The response spectra of added propeller revolution, thrust, and torque show similar characteristics to those of added resistance. The FSEM, LVM-IR, ITTC78-IR, DPM, RTIM, QNM, and TNM are useful to predict added delivered power and propeller revolution in irregular waves when SS < 5. These differences between the DPM/RTIM/QNM/TNM and the Spectral(LVM-W) are dependent on the linearity of fitting line for overload factor. The TNM underpredicts added delivered power due to the lower wake fraction in waves.
Yu, Seong-Hyun,Lee, Youn-Jin,Park, Soo-Jin,Lee, Ye-Won,Cho, Kun,Kim, Young-Hwan,Oh, Han-Bin Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
In the present study, the approach of high accuracy mass measurements for phospholipid identifications was evaluated using a 7 T ESI-FTMS/linear ion trap MS/MS. Experiments were carried out for porcine brain, bovine liver, and soybean total lipid extracts in both positive and negative ion modes. In total, 59, 55, and 18 phospholipid species were characterized in the positive ion mode for porcine brain, bovine liver, and soybean lipid extracts, respectively. Assigned lipid classes were PC, PE, PEt, PS, and SM. In the negative ion mode, PG, PS, PA, PE, and PI classes were observed. In the negative ion mode, for porcine brain, bovine liver, and soybean lipid extracts, 28, 34, and 29 species were characterized, respectively. Comparison of our results with those obtained by other groups using derivatization-LC-APCI MS and nano-RP-LC-MS/MS showed that our approach can characterize PC species as effectively as those methods could. In conclusion, we demonstrated that high accuracy mass measurements of total lipid extracts using a high resolution FTMS, particularly, 7T FTMS, plus ion-trap MS/MS are very useful in profiling lipid compositions in biological samples.