Hepatocellular Carcinoma in the Elderly: Clinical Characteristics, Outcomes and Treatment Efficacy, Safety in Older than 75 Years

( Ji Ho Seo ),( Sunmin Kim ),( Eunae Cho ),( Chung Hwan Jun ),( Sun Young Park ),( Sung Bum Cho ),( Chang Hwan Park ),( Hyun Soo Kim ),( Sung Kyu Choi ),( Jong Sun Rew ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) has been increasing because the increase in the longevity of the general population. But there is no proper management based on age stratification in elderly patients. We compared clinical characteristics, outcomes and treatment efficacy, safety between oldest-old (aged more than 85 years), middle-old (aged between 80 and 85 years) and young-old (aged between 75 and 80 years) patients with HCC. Methods: We conducted a retrospective cohort study, from January 2010 to December 2016, at Chonnam National University Hospital. A total of 550 elderly patients whose data included demographics, co-morbidity, etiology of liver disease, presence of cirrhosis, staging of HCC, treatment modality and treatment related adverse event were evaluated retrospectively. Also overall survival was assessed in enrolled patient. Results: Fifty one patients (oldest-old; median 87 years old), 153 patients (middle-old; median 82 years old) and 346 patients (young-old; median 77 years old) were diagnosed with HCC. Both oldest- and middle-old patients, compared to young-old patients had significantly lower rate of alcohol-related disease (13.7% vs 20.9% vs 34.1%, P = 0.001). There were no significant difference in underlying sex, body mass index, presence of co-morbidity, hepatitis C-related disease and stage of HCC. The Child-Pugh class (CPT class A 88.9% vs 84.1% vs 83.6%, CPT class B 11.1% vs 15.9% vs 15.0% and CPT class C 0.0% vs 0.0% vs 1.3%, respectively, P = 0.912) and Model for End Stage Liver Disease score (mean MELD score 7.22±3.34 vs 5.88±3.01 vs 5.77±3.14, P = 0.166) were no significant difference between the patients with active treatment. The modified UICC staging (stage I 5.6% vs 17.1% vs 18.6%, stage II 55.6% vs 46.3% vs 47.3%, Stage III 22.2% vs 24.4% vs 24.8%, Stage IV-A 11.1% vs 6.1% vs 4.9% and Stage IV-B 5.6% vs 6.1% vs 4.4%, respectively, P = 0.826) and Barcelona Clinic Liver Cancer staging (stage 0 5.6% vs 9.8% vs 9.3%, stage A 16.7% vs 17.1% vs 22.1%, stage B 27.8% vs 29.3% vs 24.8%, stage C 50.0% vs 43.9% vs 41.2% and stage D 0.0% vs 0.0% vs 2.7%, respectively, P = 0.878) were no significant difference between the patients with active treatment. Furthermore, there were no difference between the age groups in treatment modality (Surgical resection 0.0% vs 3.3% vs 5.2%, P = 0.166; Radiofrequency ablation 2.0% vs 8.5% vs 11.0%, P=0.113; Transcatheter arterial chemoembolization 21.6% vs 34.6% vs 41.6%, P=0.014; Best supportive care 62.7% vs 40.5% vs 29.2%, P < 0.001), adverse event related treatment (P = 0.731) and disease-free survival days (329 .3±309.1 days vs 271.7 ± 414.2 days vs 357.2 ± 511.6 days, P = 0.336). Multivariate analysis showed that age, performance status, CTP class, MELD score, modified UICC staging, presence of portal vein thrombosis and ruptured HCC are risk factors for mortality. Conclusions: Clinician should make an active treatment in elderly patients with HCC not a age but performance status, liver function and disease status of cancer.

당(唐) 태종대(太宗代) 반위(反胃) 치료법의 개발과 백제(百濟) 의자왕(義慈王)의 질병

박준형 ( Park Jun-hyoung ),서영교 ( Seo Young-kyo ) 대구사학회 2021 대구사학 Vol.142 No.-

Tang China(618-907), which inherited the medical system of the preceding Sui China(589-618), attempted to reorganize it by absorbing various medical traditions which were then monopolized by hereditary medical families. The hereditary remedies and knowledge of medical specialists who were employed as government physicians were integrated into the state medical system, and the newly developed remedies were open to public. The development of Banwi (反胃, gastric disorder) remedy using donkey urine was one of the cases demonstrating the success of the early Tang medical system. The remedy, developed through a joint research by the physicians from three prestigious medical families in early Tang, was soon to be known to Baekje. King Uija (r. 641-660) of Bakje, who had been suffered from Banwi, dispatched envoys to Tang to ask to send Jiang Yuan-chang to Baekje in 644. The Baekje court seems to have regarded Jiang, a physician who participated in the development of new Banwi remedy, as the most qualified person to cure King Uija. Tang government, however, could not dispatch Jiang to Baekje as he was then working near Sichuan province, hundreds miles from Chang'an, the capital of Tang. As a result, King Uija missed a chance of being treated with the new remedy. Then Baekje, which had once promised not to attack Shilla by sending a prince to Tang, resumed invasion of Shilla in 645, spoiling Emperor Taizong's (r. 626-649) plan to mobilize Baekje's army in his campaign against Goguryeo. As the aftermath of this incident, the relation between Baekje and Tang was irreversibly deteriorated, while Shilla succeeded to consolidate the Shilla-Tang alliance which led to the fall of Baekje in 660. From the perspective of medical diplomacy between Baekje and Tang during the mid 7th centuries, Tang’s failure to meet Baekje’s request for the medical support might have had a grave effect on the Baekje’s decision to move against the Tang’s interests. Park, Jun-hyoung (Naval Academy / shimani5075@hanmail.net) Seo, Young-kyo (Jungwon University / syk367@naver.com)

무청시래기를 첨가한 추어 떡갈비의 개발 및 품질특성

유지영 ( Ji Young You ),진금용 ( Jinlong Chen ),임종준 ( Jong Jun Lim ),박지인 ( Ji In Park ),백서준 ( Seo Jun Baek ),최준호 ( Joon Ho Choi ) 한국산업식품공학회 2021 산업 식품공학 Vol.25 No.4

This study was performed to develop tteokgalbi suitable for young-aged individuals by using mudfish and radish greens, major ingredients of Chueo-tang. Mudfish-tteokgalbi (control), in which 15% of the meat and tallow was replaced with mudfish paste, was used while substituting 25 to 100% of the green onions with radish greens. The pHs and sugar contents of the tteokgalbi developed in this study were 6.07-6.28 and 9.94-10.9, respectively, and it was suitable for tteokgalbi sold in the market. Replacing green onions with radish greens while manufacturing tteokgalbi significantly reduced the color (a and b values) and weight loss during cooking compared to the control. Replacing green onions with increasing quantities of radish greens also significantly reduced the adhesiveness of the samples in the texture profile analysis. Although the overall acceptability of the control was the best, the ideal quantity of radish greens as a substitution for green onions appears to be 25-50%. The unique flavor of the supplemented radish greens was indistinguishable in the sensory evaluation and the principal component analysis with an electronic nose. Finally, radish greens were confirmed as a good ingredient for manufacturing tteokgalbi together with mudfish paste.

고령자 급성 췌장염의 임상적 고찰

백용한,서정훈,송건훈,이진헌,송시영,정재복,강진경,박인서,이수진 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

Biomass 유래 퓨란계 단량체를 이용한 폴리에스터의 중합 및 특성 연구

정용석(Yong Seong Chung),이영철(Young Chul Lee),서강진(Kang Jin Seo),김명준(Myeong Jun Kim),정지혜(Ji Hea Jeong),노시태(Si Tae Noh) 한국고분자학회 2011 폴리머 Vol.35 No.6

바이오매스에서 유래된 2,5-dihydroxymethylfuran(DHMF)을 KMnO4 산화반응으로 furan-2,5- dicarboxylic acid(FDCA)를 합성하였다. 합성한 FDCA와 다이올류를 에스테르화 반응과 축중합 반응을 진행시 켜 폴리에스터를 중합하였다. 폴리에스터는 NMR을 통해 조성을 분석하였고 DSC와 TGA를 통해 열적특성을 분 석하였다. 합성된 폴리에스터의 고유점도는 0.78∼1.2 dL/g으로 상용화된 poly(ethylene terephthalate)(PET) 와 비슷하였다. 다이올의 길이가 증가할수록 Young`s modulus와 strength는 낮아지고 elongation-to-break는 높아지는 경향을 확인하였다. 합성한 poly(ethylene furandicarboxylate)(PEF)의 Young`s modulus는 3551 MPa, strength는 103 MPa로 상용화된 PET와 비슷하였다. Furan-2,5-dicarboxylic acid (FDCA) was synthesized by KMnO4 oxidation of 2,5-dihydroxymethylfuran( DHMF) derived from biomass. Polyesters were synthesized by esterification and polycondensation of FDCA with various diols(ethane-1,2-diol, propane-1,3-diol, butane-1,4-diol, hexane- 1,6-diol, decane-1,10-diol). The composition of polyesters was characterized by using 1H NMR. Thermal properties of the polyesters were characterized by DSC and TGA. Intrinsic viscosities(IV) of the polyesters were measured to be 0.78∼1.2 dL/g comparable with IV of commercial poly(ethylene terephthalate)(PET). As the chain lengths of diols increased, Young`s modulus and strength decreased and elongation-to-break generally increased. Young`s modulus and strength of the polyesters were measured to be 3551 MPa and 103 MPa, respectively, comparable with commercial PET.

매개변수 불확실성이 존재하는 비선형 계통의 견실한 적응 제어

서삼준,김영렬,김성원 안양대학교 자연과학연구소 1997 自然科學硏究 Vol.4 No.-

본 논문에서 구조적 정합조건이 만족되지 않는 매개변수 불확실성이 존해하는 비서형 계통의 견실한 적응 안정화 기법을 제안하였다. 제안한 기법은 개념적으로 단순한 Liapunov 안정도 해석법을 기반으로하였고 미지의 플래트 매개변수가 선형적으로 나타날 때 매개변수 불확실성을 보상하도록 적응칙을 제안하였다. 빠른 수렴특성과 견실성을 동시에 향상시키기 위해 미지의 매개변수의 추정치를 포함하는 새로운 비선형 좌표 변환과 궤환 제어를 도입하였다. 제안한 제어기의 우수성을 입증하기 위하여 컴퓨터 모의실험을 수행하였다. In this paper, we examine the robust adaptive stabilization of a class of uncertain nonlinear systems for which the parametric uncertainties are not necessarily required to satisfy the so-called structure matching conditions. The proposed design methodology is based on a conceptually simple Liapunov's stability analysis. The adaptive update law is proposed to counteract parametric uncertainties in the case when unknown plant parameters appear linearly. In order to obtain fast convergence and improve robustness simultaneously, we introduce the new nonlinear coordinate transformations and feedback controls which contain the estimated values of unknown parameters. Numerical examples are discussed as illustrations.

1992학년도 신입생 실태조사 결과분석

전광희,편서영 충남대학교 1993 學生生活硏究 Vol.20 No.-

1993년 신입생 실태조사 결과분석

전광희,편서영 충남대학교 1994 學生生活硏究 Vol.21 No.-

알루미나 연마제가 혼합된 희석된 실리카 슬러리의 CMP 특성

서용진,박창준 대불대학교 2002 論文集 Vol.8 No.1

In this paper, we have studied the CMP(chemical mechanical polishing) characteristics of diluted slurry by adding of raw alumina abrasive and annealed alumina abrasive. As a experimental results, we obtained the comparable slurry characteristics compared with original silica slurry in the view point of high removal rate and low non-uniformity. Therefore, we can reduce the cost of consumables(COC) of CMP process for ULSI applications.

개에서 발생한 자궁축농증 1례

서수원,손정민,윤기영,최호정,박성준,이영원,정성목,신상태,조종기 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2006 動物醫科學硏究誌 Vol.14 No.-

A 12-year-old, female miniature pinscher dog with history of fever and vaginal discharge 3 days ago was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. A diagnosis of pyometra was made by survey of abdominal radiographs and ultrasonography. The uterus appeared as convoluted and tubular appearance filled with anechoic to hypoechoic fluid. Ovariohysterectomy was the choice of cervical patency. Medical therapy for pyometra may be appropriate in bitches that were of breeding age and that were not systemically ill. The surgery was fine. After 1 week, the dog was getting better.