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국내 대형할인점의 효율성 분석에 관한 사례연구 : A Case Study
김태웅,임영록,김영곤 한국경영과학회 1999 經營 科學 Vol.16 No.2
A well-designed location strategy is an integral and important part of corporate strategy for retail firms The last five years witnessed major changes in retailing industry A growing city population, rising income levels, and the emergence of suburb areas presented retailers with new challenges Mass discount merchandisers and supermarkets expanded rapidly, spreading from Seoul into smaller cities The rapid increase of mass discount stores raised new concerns and gave rise to the need from a systematic approach to location analysis in this paper, we present the mathematical background and characteristics of DEA(Data Envelopment Analysis) model, and give a short case study where we apply the DEA model to compute the relative efficiency of 11 Korean mass discount merchandisers interpretation of the result is also provided
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Kim, Se‐,Lim,Lee, Soo Teik,Min, In Suk,Park, Young Ran,Lee, Ju Hyung,Kim, Dae‐,Ghon,Kim, Sang‐,Wook JAPANESE CANCER ASSOCIATION 2017 CANCER SCIENCE Vol.108 No.11
<P>Lipocalin 2 (LCN2), a member of the lipocalin superfamily, plays an important role in oncogenesis and progression in various types of cancer. However, the expression pattern and functional role of LCN2 in colorectal cancer (CRC) is still poorly understood. The purpose of the present study was to investigate whether LCN2 is associated with proliferation and the epithelial–mesenchymal transition (EMT) in CRC and to elucidate the underlying signaling pathways. LCN2 was preferentially expressed in CRC cells compared to normal tissues. However, LCN2 expression was significantly lower in metastatic or advanced‐stage CRC than in non‐metastatic or early stage CRC. Knockdown of LCN2 using small interfering RNA (siRNA) in CRC cells expressing a high level of LCN2 induced cell proliferation and a morphological switch from an epithelial to mesenchymal state. Furthermore, downregulation of LCN2 in CRC cells increased cell migration and invasion involved in the regulation of EMT markers. Knockdown of LCN2 also induced glucose consumption and lactate production, accompanied by an increase in energy metabolism‐related genes. Taken together, our findings indicated that LCN2 negatively modulated proliferation, EMT and energy metabolism in CRC cells. Accordingly, LCN2 may be a candidate metastasis suppressor and potential therapeutic target in CRC.</P>
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Separation of gangliosides using cyclodextrin in capillary zone electrophoresis
Kim, Young Sook,Yoo, Young Sook,Ghon, Gil-Ja,Park, Jongsei 이화여자대학교 생명과학연구소 1993 생명과학연구논문집 Vol.4 No.-
Gangliosides are glycosphingolipids containing sialic acid. These glycolipids have been suggested to play important roles in biological processed such as cell growth, differentiation and malignant transformation. Based on these proposed biological functions, gangliosides can be used as diagnostic tools and therapeutics for various human diseases. In this study, capillary zone electrophoresis (CZE) was used to determine the major gangliosides G_M1, G_D1a, G_D1b and G_T1b in mammalian brains, in addition to G_M3 and Lac. Enhancement of selectivity and efficiency of separation was obtained by using 50 mM borate-phosphate buffer containing 16.5 mM a-cyclodextrin (a-CD). Under this condition, several forms of gangliosides were successfully separated from extracts of deer antler, apricot seed and rat brain. The results demonstrate that the CD-modified CZE is a useful method for detecting glycolipids from various biological matrices.
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( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( In Hee Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Current guidelines recommend tenofovir (TDF) and nucleoside analogues( NAs) combination therapy for chronic hepatitis B (CHB) patients with priorlamivudine (LMV) and adefovir (ADV) resistance. This study was aimed to evaluate the effi cacy of TDF monotherapy and TDF plus NAs combination therapy for CHB patients with prior LMV and ADV resistance. Methods: A total of 30 CHB patients with prior LMV and ADV resistance who received with TDF (300 mg/day) (Group A, n=12) or TDF (300 mg/day) plus NAs (Group B, n=18) for 48 weeks were included retrospectively. 8 patients were treated with TDF plus LMV and 10 patients with TDF plus ETV in group B. Results: There was no signifi cant difference in mean serum HBV reduction between two groups after 48 weeks treatment. [group A vs. group B; -2.7±0.9 vs. -3.0±0.6, p=0.452]. The complete virologic response (HBV DNA =20 IU/mL) also showed no significant difference between the groups. [group A vs. group B; 10/12(83.3%) vs. 16/18(88.9%), p=0.454]. Only 1 patient in group A showed persistent serum HBVDNA =2,000 IU/mL, but the HBV DNA titer was in decrease trend. The rates of serum alanine aminotransferase normalization was similar in two groups. The overall HBeAg loss or seroconversion rate was 10.7%(3/28). [group A vs. group B; 1/10(12.5%) vs 2/18(11.1%) p=1.000]. Virological breakthrough did not occur in both two groups during TDF based rescue therapy. Conclusions: TDF monotherapy has similar effi cacy with TDF plus NAs combination therapy as a rescue therapy in CHB patients with prior LMV and ADV resistance. However, more large, prospective, randomized controlled study is need to clear the effi cacy of TDF monotherapy in CHB patients with prior LMV and ADV resistance.
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( Seung Young Seo ),( In Hee Kim ),( Bum Su Choung ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: This study was aimed to investigate the long-term efficacy of entecavir (ETV) monotherapy and ETV plus adefovir (ADV) combination for ADV refractory chronic hepatitis B (CHB) patients with prior lamivudine (LMV) resistance. Methods: A total of 91 ADV refractory CHB patients with prior LMV resistance who received with ETV (1.0 mg/day) (Group A, n=46) or ETV (1.0 mg/day) plus ADV (10 mg/day) (Group B, n=45) for more than 48 weeks were included. Results: Overall serum HBV DNA negativity by PCR (≤20 IU/mL) were 25/91 (27.5%) at week 48 and 27/67(40.3%) at week 96, respectively. A significantly higher proportion of patients on group B achieved negative serum HBV DNA [group A vs. group B; 11/46 (23.9%) vs. 14/45 (31.1%) at week 48, p=0.002; 10/29 (34.5%) vs. 17/38 (44.7%) at week 96, p= 0.004]. However, the rates of serum alanine aminotransferase normalization and HBeAg loss or seroconversion were similar in two groups. The incidence of virological breakthrough in group B was significantly lower than in the group A [group A vs. group B; 8/46 (17.4%) vs. 0/45 (0.0%) at week 48, p=0.006; 13/29 (44.8%) vs. 1/38 (2.6%) at week 96, p<0.001]. Treatment strategy (group A vs. group B) was independently significant factor associated with viral breakthrough in multivariate analysis (Odd ratio 5.887, 95% CI 1.663-119.364, p=0.015). Conclusions: As a rescue therapy in ADV refractory CHB patients with prior LMV resistance, ETV plus ADV combination therapy was more efficient than ETV monotherpay in reducing of viral breakthrough during treatment.
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김영곤(Kim Young Ghon),성기현(Sung Kee Hyun) 한국부동산학회 2004 不動産學報 Vol.23 No.-
1. CONTENTS (1) RESEARCH OBJECTIVES More systematic and comprehensive research on the land traffic logistics is needed because last decade passengers and goods transportation has been increased by the metropolitan and its outskirts' concentration. So, under the observation, this study will be done on three subjects : ① reviewing on the existing logistic industry and facilities in Kyeonggi Area ; ② proposing some ideal location of logistics by developing the location models for the activation of the local economy; and ③ improving the logistic facilities that are flooded rashly. (2) RESEARCH METHOD Literature study and case approach (3) RESEARCH RESULTS Chapter one, as an introduction, gives the background, aim, methodology, and structure of this study; chapter two, as a theoretical consideration of the logistics, gives new paradigm through the critical points of the existing studies and cases (from the domestic and abroad) on the notions and industry of logistics; chapter three, as the present situation of the logistic facilities, gives the characteristics and problems of the domestic logistic industry, and the present situation of the logistic facilities in the national, metropolitan, Kyeonggi, and Yongin areas by the rapid changes of the logistic environment according to the e-business; chapter four, as selecting the location model of the logistic facilities for activating the positive local economy, examines proper models by inputting data, established in a FUZZY modeling, measuring solution of PC (Product Control) location selection, and MS(Management Science) OR(Operation Research); and chapter five searches for the task and policy of the logistic facilities by using the results of my study, and mentions a further research topics. 2. RESULTS Present study will evaluate the present situation of the logistic industry, the logistic location ofthe companies, and the data of the logistic agencies in Yongin area that are classified by the warehousing. A model for selecting a proper alternative location of logistics will be provided under the pressure of the rise of costs (that is, of the land prices and rental cost, of the transportation and delivery by the delay of the traffics), and the unbalanced development of the logistic facility areas in Kuseong and Kiheung districts in comparison with near residential places. 3. KEY WORDS Logistics Location, Regional Economy, Product Control
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( Seung Young Seo ),( In Hee Kim ),( Bum Su Choung ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: This study was aimed to investigate the long-term efficacy of entecavir (ETV) monotherapy and ETV plus adefovir (ADV) combination for ADV refractory chronic hepatitis B (CHB) patients with prior lamivudine (LMV) resistance. Methods: A total of 91 ADV refractory CHB patients with prior LMV resistance who received with ETV (1.0 mg/day) (Group A, n=46) or ETV (1.0 mg/day) plus ADV (10 mg/day) (Group B, n=45) for more than 48 weeks were included. Results: Overall serum HBV DNA negativity by PCR (≤20 IU/mL) were 25/91 (27.5%) at week 48 and 27/67(40.3%) at week 96, respectively. A significantly higher proportion of patients on group B achieved negative serum HBV DNA [group A vs. group B; 11/46 (23.9%) vs. 14/45 (31.1%) at week 48, p=0.002; 10/29 (34.5%) vs. 17/38 (44.7%) at week 96, p= 0.004]. However, the rates of serum alanine aminotransferase normalization and HBeAg loss or seroconversion were similar in two groups. The incidence of virological breakthrough in group B was significantly lower than in the group A [group A vs. group B; 8/46 (17.4%) vs. 0/45 (0.0%) at week 48, p=0.006; 13/29 (44.8%) vs. 1/38 (2.6%) at week 96, p<0.001]. Treatment strategy (group A vs. group B) was independently significant factor associated with viral breakthrough in multivariate analysis (Odd ratio 5.887, 95% CI 1.663-119.364, p=0.015). Conclusions: As a rescue therapy in ADV refractory CHB patients with prior LMV resistance, ETV plus ADV combination therapy was more efficient than ETV monotherpay in reducing of viral breakthrough during treatment.
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김영곤(Kim, Young Ghon) 한국부동산학회 2012 不動産學報 Vol.49 No.-
1. CONTENTS (1) RESEARCH OBJECTIVES The purpose of this study is to expand permanent rental house market in Korea using real market simulation. (2) RESEARCH METHOD This study was focused on feasibility analysis. The data for this analysis were collect from companies in Korea. Land value is metropolitan area price which can be located a rental apartments. (3) RESEARCH FINDINGS In the results of this analysis, the most problem is the shortage of long term fund for rental house construction and management. 2. RESULTS This study offers two conditions to expand the rental house market for middle class in Korea. 1) It is strongly suggested using private sector fund through RElTs. 2) To expand the permanent rental apartments, It needs one another clasification in land-use.
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영상단지개발을 통한 지역경제 효과 분석 - 포천 영상단지개발계획 사례를 중심으로
김영곤(Kim Young Ghon) 한국부동산학회 2006 不動産學報 Vol.27 No.-
1. CONTENTS<BR> (1) RESEARCH OBJECTIVES<BR> Many regional governments in Korea have tried to develop movie theme park. But, a few park could operate successfully. Some planned parks drop in difficul situations. The study would try to find the real regional economic effect through developing movie theme park and important factors for each project.<BR> (2) RESEARCH METHOD<BR> Literature research, case study, market and policy research<BR> (3) RESEARCH RESULTS<BR> Movie theme park would be helpful business for the regional economy because the park could generate various field, so called windowing industry. To be a healthy business, many factors, like land problem, ideal program, crazing hardware, wonderful software have to be prepared by developers.<BR> 2. RESULTS<BR> The result which analyzes Pochon City case actualy proof the economic effect for the region. It would also generate other industries, for example, tourism, hotel, construction and so on. But, the theme park business is very sensitive and ideal. So, to do a successful business, many parts like verity companies, regional government, educational and research institutes, broadcasting industry, IT industry could be joined for the theme park.
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