한국·미국·스페인 청소년의 태권도 수련이 인성교육에 미치는 영향

유창재,양정옥,이중숙,이상돈,김영수,조만태 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

The purpose of this study was to analyzed what effect Taekwondo training has upon Juvenile trainees in Korea, America, and Spain. to see if there is a significant difference in their Human nature Education. The subject of this study was set up as 547 Juvenile trainees who are including 183 Koreans, 185 Americans and 179 Spanish people belonging to gymnasia in their own countries, and sampling by purpose sampling. The means in this study is used to amend and complemented after confirming suitability of the contents in the questionnaire that is made on the basis of questionnaire Lee Chul Ho(1996). it is used as study means after modified, whether the substance of question is right in fitness and applicability or not, Reliability of the question, the range of Cronbach's a is showed from .7924 to .8450. The method of statistically analysis adapted one-way ANOVA, two-way ANOVA by using SPSS WIN 10.0 Program. The result of this study are as followed : First, it can be seen that American Juvenile and Spanish Juvenile show more significant change than Korean Juvenile in their Human nature Education by the Taekwondo training according to their nationality. Second, it can be seen that Juvenile who have had the Taekwondo training for more than from three to five year show more significant change in their emotion, sociability and attitude towards life than those who have had the same training for more than other period in their Human nature Education according to their Taekwondo training period. Third, as a result of analytic investigation of what effect the same training has upon the change factors in their Human nature Education in accordance with their training period and nationality, it can be seen that the training itself and nationality has the greater influence on them than the training period. Therefore, judging from the above findings, it can be proved that the Taekwondo training has much more significant and positive effect on Juvenile in their change of emotion, sociability and attitude towards life.

흰쥐 시상하부에서 NMDA에 의한 c-fos의 발현

이영기,최기열,이원돈,유영복,이왕재,황덕호,조사선,장가용 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.3

지역 사회 감염성 폐렴에서 Cefodizime의 효능 및 안전성을 Ceftriaxone과 비교한 연구

심영수,오명돈,한성구,최강원,정희순,김영환,유철규,최형석 대한감염학회 1994 감염 Vol.26 No.3

목적: Cefodizime은 새로운 주사용 제 3세대 항생제이다. 저자들은 감염성 폐렴 환자들에서 이 약물을 하루 1번 정맥주사하였을 때 관찰되는 임상적및 세균학적 효과와 안전성을 ceftriazone과 비교하기 위하여 본 연구를 시행하였다. 방법: 1992년 6월부터 1993년 11월까지 서울대학교 병원에 지역사회 감염성 폐렴으로 입원하였던 환자 32명을 무작위로 3군으로 나누고 제 1군 : Cefodizime 1g(n=11), 제2군 : Cefodizime 2g(n=10), 제3군 : Ceftrizxone 1g(n=11)을 각각 하루 1회 정맥주사로 투여하여 그 치료율및 안전성을 비교하였다. 결과: 1)Cefodizime은 제1군 100%, 제2군 80.0%의 임상적 반응율을 보였다. Ceftriaxone을 투여하였던 제 3군에서는 81.8%의 임상적 반응율을 보였다. 이러한 임상적 반응율의 결과는 세 군간에 통계적으로 유의한 차이를 보이지 않았다(p>0.05). 2)세균학적 반응율도 세 군간에 유의한 차이를 보이지 않았다. 3)Cefodizime의 안전성의 평가에서 제1군 및 제2군에서 구토 및 오심이 2예(9.5%)에서 관찰되었고 일시적인 간효소치의 상승이 1예(4.8%)에서 관찰되었다. 경미한 공복시 위통이 1예(4.8%)에서 관찰되었다. Ceftriaxone으로 치료한 군에서는 특별한 부작용은 관찰되지 않았다. 결론: 이상의 결과로 지역사회 감염성 폐렴의 치료에 있어서 cefodizime 1내지 2g을 정맥 주사로 하루 1회 치료할 경우 적어도 ceftriaxone과 유사하게 효과적이며 안전한 것으로 사료된다. Background:Cefodizime(Modivid) is a new parenteral form of cephalosporin showing the antibacterial specturm of the third generation. The clinical efficacy and safety of cefodizime have been well proven by some previous clinical studies performed in European countries and Japan. The objective of this study was to evaluate the clinical, radiological and antimicrobial efficacy of this drug in patients with community-acquired pneumonia compared to that of ceftriaxone. Methods: We performed an open, controlled, randomized study in 32 patients with community-acquired pneumonia at Seoul national University hospital from June 1992 to November 1993. In the first group(n=11) 1g of cefodizime, and in the second group(n=10) 2g of cefodizime were respectively administered intravenously once a day. and in the third group(n=11), 1g of ceftriaxone was administered intravenously. Results: The results were as follows. 1) Cefodizime showed the clinical response rate of 100% in group I, and 80.0% in group Ⅱ. The clinical response rate of ceftriaxone in group Ⅲ was 81.8%. There was no significant statistical difference(p>0.05). 2) The rates of bacteriological efficacy wee not statistically different among three groups. 3) In the cefodizime treatment group(group Ⅰ, group Ⅱ) nausea and vomiting were observed in 2 cases(9.5%) and transient elevations of hepatic transaminases in 1 case(4.8%). Mild abdominal pain occurred in 1 case(4.8%). No significant adverse reactions were observed in the ceftriaxone treatment group. Conclusion: We could conclude that once a day intravenous cefodizime therapy was as effective and well tolerated as ceftriaxone in the treatment of community-acquired pneumonia.

Agrobacterium을 이용한 고추의 형질전환체계개발

최근원,박영두,박승국,전영주,유일웅,김인태,백운돈 경희대학교 생명자원과학연구원 1997 硏究論文集 Vol.18 No.-

본 실험은 고추의 형질전환체 선발을 위한 최소의 항생제농도를 결정하고 그 결과를 이용하여 형질전환체를 유기하고 효율을 최대화하기 위하여 수행한 바 그 결과는 다음과 같다. 1. 항생제 감응성 검정결과 kanamycin 40㎎/ℓ와 hygromycin 20 ㎎/ℓ에서 신초형성이 완전히 억제되었다. 2. Agrobacterium 제거에 사용되는 carbenicillin과 cefotaxime 처리시 재분화에 아무런 영향을 미치지 않았으며 cefotaxime 200㎎/ℓ 처리에서는 무처리구보다 신초형성이 더 활발하였다. 3. 회복친인 135Q와 276F에서는 형질 전환시 높은 재분화율을 보였으나 형질전환율은 각각 10%와 11.1%의 낮은 빈도를 보였다. 4. 재분화된 신초들을 대상으로 histochemical GUS assay를 실시한 결과 부분적으로 푸른발색이 확인되었다. 5. GUS활성을 보인 신초들에 대한 NPTⅡprimer를 이용한 PCR검정에서 NPTⅡ 유전자의 존재가 확인되었다. A transformation system using Agrobacterium tumefaciens was developed with different genotypes of hot peppers (Capsicum annuum). Four antibiotics commonly used in Agrobacterium-mediated transformation were tested for their effects on shoot regeneration. Shoot induction was completely inhibited by kanamycin at 40㎎/ℓ and hygromycin at 20㎎/ℓ or higher, but not by carbenicillin and cefotaxime. Cotyledon explants of hot peppers were cocultivated with Agrobacterium turnefaciens LBA4404 which carries a binary. vector pBI121 harboring the neomycin phosphotransferase, type Ⅱ (NPT Ⅱ) gene and β-glucuronidase (GUS) gene. For selection of transformed cells, 40㎎/ℓ kanamycin were used because the sensitivity test showed that 40㎎/ℓ kanamycin completely inhibited shoot induction from nontransformed cells. Histochemical GUS assay showed the presence of the GUS gene and PCR analysis confirmed the NP TⅡ gene was integrated. Transformation frequency was about 10.0% and 11.1% of total regenerants from 135Q and 276F, respectively.

오렌지 껍질로부터 분리된 프라보노이드의 화학요법 감작효과

최철익,변익건,차윤정,김선필,민영돈,유진철,송재경 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : The overexpression of P-glycoprotein (Pgp) or multidrug resistanceassociated protein (MRP) confers multidrug resistance (MDR) to cancer cells. MDR cells could be sensitized to anticancer drugs when treated concomitantly with a chemosensitizer. In this study, orange peel have been screened for the development of chemosensitizers reversing MDR. Materials and methods : Expression of Pgp in AML-2/WT and AML-2/D100 were determined using western blot analysis and RT-PCR. Candidates for chemosensitizers were isolated, purified from orange peel using sephadex LH-20 column chromatography and silica-gel column chromatography, whose structure was determined using ^1H-NMR, ^13C-NMR, ^1H-^1H-COSY, 13C-NMR, EI-Mass, IR. Chemosensitizing effect of NP-28 on AML-2/DX100 over expressing Pgp and MRP was determined by the MTT assay. Membrane toxicity was evaluated by the RBC hemolysis test. Antioxidant effects were examined by using a fluorescence probe (2’-7’-dichlorofluorescein diacetate). Results : A potent candidate, NP-28, has a flavonoid nucleus with some methoxy moiety. NP-28 is believed to have high therapeutic index, being non-transportable inhibitor and possibly, of inhibiting other efflux pumps such as MRP and antioxidant effects. NP-28 is also unlikely to be a substrate of Pgp. NP-28 did not increase Pgp levels. Conclusion : NP-28 has a Chemosensitizing effect to reverse Pgp-mediated MDR by increasing the intracellular accumulation of drugs. Furthermore, they do not increase expression of Pgp, which can allow a long term use without the concern about Pgp activation. NP-28 is anticipated as an ideal second-generation flavonoid chemosensitizer and/or possibly other therapeutic agents by further investigation.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Accelerated Hyperfractionated Radiotherapy for Locally Advanced Uterine Cervix Cancers

Young Seok Seo(서영석),Chul Koo Cho(조철구),Seong Yul Yoo(류성렬),Mi Sook Kim(김미숙),Kang Mo Yang(양광모),Hyung Jun Yoo(유형준),Chul Won Choi(최철원),Kyung Hee Lee(이경희),Eui Don Lee(이의돈),Sang Young Rhu(유상영),Suck Chul Choi 대한방사선종양학회 2008 Radiation Oncology Journal Vol.26 No.1

목 적: 이 연구의 목적은 국소진행된 자궁경부암에서의 가속과분할 방사선치료의 효용성을 평가하기 위함이다. 대상 및 방법: 2000년 5월부터 2002년 9월 사이에 자궁경부암 병기 IIB, IIIB, IVA로 가속과분할 방사선치료를 받은 환 자 45명과 같은 기간 동안 고식적 방사선치료를 받은 병기 IIB, IIIB, IVA 환자 134명이 비교 분석되었다. 가속과분할 방사선치료는 전골반에 대하여 총 30 Gy의 방사선을 1.5 Gy씩 하루 2회, 총 10일에 나누어 조사하였다. 전골반 조사 후 중심 차폐하여 자궁주위 조직에 대하여 총 20 Gy의 방사선을 2 Gy씩 하루 1회, 총 10일에 나누어 조사하였다. 외부방 사선치료가 끝난 후 Cs-137을 이용한 저선량 근접치료를 Point A 기준 55∼60 Gy의 방사선치료를 2회 시행하여, Point A 기준 총 85∼90 Gy의 방사선 선량이 주어지도록 치료하였다. 고식적 방사선치료 또한 Point A 기준 총 85~90 Gy의 방사선 선량이 주어지도록 치료하였다. 총 치료기간은 가속과분할 치료군의 경우 중앙값이 37일이었으며, 고식적 치료 군은 중앙값 66일이었다. 통계적 분석은 Kaplan-Meyer 법, log-rank test, 그리고 Chi-square test를 통해 이루어졌다. 결 과: 항암치료를 시행했던 환자군에서, 5년 국소제어율은 각각 100.0%와 79.2%로 가속과분할 치료군이 고식적 치 료군에 비해 통계적으로 유의하게 우수한 성적을 보였고(p=0.028), 5년 생존율은 병기 IIB의 큰 종양군에서 가속과분할 치료군이 82.6%으로 고식적 치료군의 62.1%에 비해 통계적으로 유의하게 우수한 성적을 보였다(p=0.074). 두 군간에 있어서 방사선치료로 인한 후기 합병증의 차이는 없었다(p=0.561). 결 론: 항암치료와 동반된 가속과분할 방사선치료는 국소진행된 자궁경부암에서 생존율 및 국소제어율을 높이는데 효과가 있을 것으로 판단된다. Purpose: To assess the efficacy of the use of accelerated hyperfractionated radiotherapy (AHRT) for locally advanced uterine cervix cancers. Materials and Methods: Between May 2000 and September 2002, 179 patients were identified with FIGO stage IIB, IIIB, and IVA cancers. Of the 179 patients, 45 patients were treated with AHRT (AHRT group) and 134 patients were treated with conventional radiotherapy (CRT group), respectively. Patients undergoing the AHRT regimen received a dose of 30 Gy in 20 fractions (1.5 Gy×2 fractions/day) to the whole pelvis. Subsequently, with a midline block, we administered a parametrial boost with a dose of 20 Gy using 2 Gy fractions. Patients also received two courses of low-dose-rate brachytherapy, up to a total dose of 85∼90 Gy to point A. In the CRT group of patients, the total dose to point A was 85∼90 Gy. The overall treatment duration was a median of 37 and 66 days for patients that received AHRT and CRT, respectively. Statistical analysis was calculated by use of the Kaplan-Meier method, the log-rank test, and Chi-squared test. Results: For patients that received cisplatin-based concurrent chemotherapy and radiotherapy, the local control rate at 5 years was 100% and 79.2% for the AHRT and CRT group of patients, respectively (p=0.028). The 5-year survival rate for patients with a stage IIB bulky tumor was 82.6% and 62.1% for the AHRT group and CRT group, spectively (p=0.040). There was no statistically significant difference for severe late toxicity between the two groups (p=0.561). Conclusion: In this study, we observed that treatment with AHRT with concurrent chemotherapy allows a significant advantage of local control and survival for locally advanced uterine cervix cancers.

Synthesis of dimethyl ether from syngas obtained by coal gas

Young Don Yoo,Seung Jong Lee,Yongseung Yun 한국화학공학회 2007 Korean Journal of Chemical Engineering Vol.24 No.2

characteristics of a tubular fixed-bed reactor for the direct synthesis of dimethyl ether (DME) fromsyngas obtained by coal gasification have been developed. DME synthesis test was conducted with a hybrid DME syn-thesis catalyst (CuO/ZnO/Al2O3 for methanol forming, γ-alumina for methanol dehydration) to understand the per-formance under the conditions of 6.0 MPa, 260oC and GHSV=3,000l/kg-cat·h. The H2 conversion and CO conversionwere 85-92% , 37-45% , respectively. About 68-80% of DME selectivity was observed. DME synthesis reactor also op-erated at the productivity of 4.6-4.9 mol/kg-cat·h, which is slightly higher than that in the Peng’s prediction results incase of H2 : CO=0.5.

Virologic Response at 12 Months of Treatment Predicts Sustained Antiviral Efficacy in Patients with Adefovir-Treated Lamivudine-Resistant Chronic Hepatitis B

( Young Kul Jung ),( Jong Eun Yeon ),( Woo Sik Han ),( Ji Hoon Kim ),( Jeong Han Kim ),( Jong Jae Park ),( Jae Seon Kim ),( Young Tae Bak ),( Wang Don Yoo ),( Sun Pyo Hong ),( Soo Ok Kim ),( So Young 대한소화기기능성질환·운동학회 2010 Gut and Liver Vol.4 No.2

Background/Aims: The aim of our study was to define the potential role of virologic response at 12 months of treatment (VR12) in predicting subsequent virologic and clinical outcomes in adefovir (ADV)-treated lamivudine-resistant chronic hepatitis B. Methods: Two hundred and four patients with lamivudine-resistant chronic hepatitis B virus (HBV) treated with ADV monotherapy were included. Serum HBV DNA was quantified by real-time polymerase chain reactions. VR12 was defined as a HBV DNA level of less than 4 log10 copies/mL after 12 months of ADV treatment. Results: VR12 was observed in 110 of the 204 patients (54%). The mean HBV DNA reductions from baseline after 12 months of ADV treatment were 3.8 and 1.9 log10 copies/mL in patients with and without VR12, respectively (p<0.001). The hepatitis B e antigen (HBeAg) seroconversion rates in patients with and without VR12 were 32% and 14% at 12 months treatment, respectively (p=0.018), and 40% and 27% at 24 months of treatment (p=0.032). The genotypic mutation rates to ADV in patients with and without VR12 were 0% and 6% at 12 months of treatment, respectively (p=0.033), and 21% and 42% at 24 months (p=0.012). The rates of viral breakthrough in patients with and without VR12 were 0% and 7% at 12 months of treatment, respectively (p=0.072), and 9% and 25% at 24 months (p=0.006). Conclusions: Patients without VR12 may need to switch to or add on other potent antiviral drugs in their medical regimens. (Gut Liver 2010;4:212-218)

석탄 가스화를 통한 전력 생산과 DME 병산 공정에 대한 기초 경제성 분석

유영돈 ( Young Don Yoo ),김수현 ( Su Hyun Kim ),조원준 ( Won Jun Cho ),모용기 ( Yong Gi Mo ),송용택 ( Tae Kyong Song ) 한국화학공학회 2014 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.52 No.6

The key for the commercial deployment of IGCC power plants or chemical (methanol, dimethyl ether, etc.) production plants based on coal gasification is their economic advantage over plants producing electricity or chemicals from crude oil or natural gas. The better economy of coal gasification based plants can be obtained by co-production of electricity and chemicals. In this study, we carried out the economic feasibility analysis on the process of co-producing electricity and DME (dimethyl ether) using coal gasification. The plant’s capacity was 250 MW electric and DME production of 300,000 ton per year. Assuming that the sales price of DME is 500,000 won/ton, the production cost of electricity is in the range of 33~58% of 150.69 won/kwh which is the average of SMP (system marginal price) in 2013, Korea. At present, the sales price of DME in China is approximately 900,000 won/ton. Therefore, there are more potential for lowering the price of co-produced electricity when comparing that from IGCC only. Since the co-production system can not only use the coal gasifier and the gas purification process as a common facility but also can control production rates of electricity and DME depending on the market demand, the production cost of electricity and DME can be significantly reduced compared to the process of producing electricity or DME separately.