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김경석,나기찬,정은경,문경래,박상기,박영봉 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
The measurements of triceps skinfold thickness, body weight and height were done in children aged 7 to 12 years(3,142 boys and 2588 girls) in Kwangju in 1992. The author also observed degree of obesity, prevalence of obesity and average value of triceps skinfold thickness. The results were summarized as follows: 1) The mean value of triceps skinfold thickness acceding to age in male was 7 years 10.5mm, 8 years 10.5mm, 9 years 10.2mm, 10 years 12.3mm, 11 years 13.8mm, 12 years 12.3mm. In the female it was 7 years 11.9mm, 8 years 11.9mm, 9 years 11.6mm, 10 years 12.6mm, 11 years 14.1mm, 12 years 13.6mm. 2) The mean value of triceps skinfold thickness acceding to age in obese male was 7 years 16.3mm, 8 years 17.3mm, 9 years 16.0mm, 10 years 19.5mm, 11 years 23.7mm, 12 years 20.1mm. In the obese female it was 7 years 17.3mm, 8 years 17.9mm, 9 years 18.4mm, 10 years 19.5mm, 11 years 21.2mm, 12 years 20.3mm.
金善奉,朴榮浩 釜山水産大學校 1985 釜山水産大學 硏究報告 Vol.25 No.2
D-glucose-glycine系로 부터 調製한 非透析性 Melanoidin에 過酸化水素를 使用하여 脫色 및 分解를 행하고 그 分解條件의 檢討와 分解生成物의 同定 및 部分構造를 推定하였다. Glucose oxidase를 使用하여 Melanoidin에 作用시켰을 때 Melanoidin의 脫色率은 65%로 나타났다. 本酵素에 의한 Melanoidin의 脫色은 酵素-基質間의 反應生成物인 過酸化水素등에 의한 것으로 밝혀졌다. 그래서, 中性 및 알칼리性 條件下에서 Melanoidin에 過酸化水素를 加하고 37℃에서 28時間 反應시켰을 때, 中性條件下에서의 脫色率은 64%, 알칼리性條件下에서는 97%이었다. 이 處理에 의하여 平均分子量 5,300의 未處理 Melanoidin이 平均分子量 3,500까지 低分子化하였다. 한편, 非透析性 Melanoidin의 過酸化水素處理에 의하여 얻어진 에테르可溶性劃分中의 主要分解生成物은 2-methyl-2, 4-pentanediol, N, N-dimethylacetamide, acetic acid, oxalic acid, Methylpropanedioic acid, propanedioic acid, Butanedioic acid, 2-furancarboxylic acid, 2-hydroxypropanoic acid, 2, 5-furandicarboxylic acid, 5-(hydroxymethyl)-2-furancarboxylic acid 등이었다. 水溶性劃分中의 低分子分解生成物은 glycine이 대부분이었고, 量的으로는 Melanoidin當 1.73%이었다. 이들 Melanoidin의 低分子化 및 分解生成物은 Melanoidin의 糖側鎖-C-CO-結合의 解裂 및 NH-CO結合의 切斷에 의한 것으로 推察된다. Nondialyzable melanoidins prepared from glucose-glycine system were incubated with glucose oxidase under optimal conditions and then the melanoidins were decolorized at a degree of 65%. The decolorization of melanoidin by glucose oxidase mainly caused by hydrogen peroxide produced from enzyme-substrate reaction. Therefore, the oxidative decomposition and decolorization of melanoidins were tried by using hydrogen peroxide. Melanoidins were treated with hydrogen peroxide (final conc. 6.72%) under neutral (pH 7.0) and alkaline (pH 10.0) conditions at 37℃ for 28 hr. Melanoidins were decolorized to 64% and 97% under above optimum conditions, respectively. The mean molecular weight of melanoidins decreased from 5,300 to 3,500 before and after hydrogen peroxide treatment. The major components in ether-soluble fraction obtained from melanoidins by oxidative degradation of alkaline hydrogen peroxide were identified as 2-methy1-2, 4-pentanediol, N, N-dimethylacetamide, phenol, acetic acid, oxalic acid, methylpropanedioic acid, propanedioic acid, 2-furancarboxylic acid, butanedioic acid, 2-hydroxypropanoic acid, 2, 5-furandicarboxylic acid and 5-(hydroxymethyl)-2-furancarboxylic acid. On the other hand, the major degradation product in aqueous fraction was identified as glycine, and 1.73% glycine was produced per melanoidins.
백일해 백신이 Streptozotocin 유발성 당뇨백서의 당대사에 미치는 영향
박상기,문경래,박춘호,김갑승,박영봉,이병래,양남웅 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1
Streptozotocin(STZ) may produce a permanent form of insulin-dependent diabetes (IDD) in experimental animals. This STZ-induced diabetes has become an useful model to study the pathogenesis of IDD in man primarily because it approximate clinical findings and also because it lends itself easily to controlled manipulation. The diabetogenic activity of STZ, however, is known to be modified by several agents such as nicotinamide, diazoxide, adrenergic blockers and pertussis vaccine (PV). The present study was undertaken to observe the protective effect of PV or boiled pertussis vaccine(bPV; incubating the PV at 80℃ for 30 minutes) against the development of IDD induced by STZ in young rats, and also the effect of PV on the activities of glycolytic & gluconeogeneic enzymes in both liver and muscle of rat. PV at a dose of 1.2×10^(10) microorganism was administrated intrapntoneally on 3days before & 7days after a single injection of STZ (GO㎎/㎏ body wt). The blood glucose and insulin levels were measured at 1st wk, 2nd wk, 4th wk, 6th wk and 8th wk after STZ injection, and the enzyme activities were exemined at 8th wk. The following results were obtained. 1. No significant difference was noted in blood glucose levels between STZ group and STZ+PV or STZ+bPV groups (P>0.05). 2. Blood insulin levels in STZ group decreased significantly from 2nd wk(P<0.05). Compared with STZ group, blood insulin levels in STZ+PV & STZ+bPV groups were higher, but not a significant value except at 2nd wk in STZ+PV grouP (P<0.05). 3. Compared with STZ group, hepatic glycolytic enzyme activities were significantly increased in STZ+PV or STZ+bPV groups, and muscular glycolytic enzyme activities were significantly increased in STZ+PV or STZ+bPV groups. 4. Compared with STZ group, hepatic gluconeogeneic enzyme activities were significantly increased in STZ+PV or STZ+bPV groups. These results suggest that the PV has somewhat protective effects on blood insulin levels and tissue glycolytic enzyme activities in rats, but it could not reduced blood glucose levels significantly, probably because of excessive increase of hepatic gluconeogeneic enzymes.
Effect of L - Carnosine on the Cell Proliferation on the Site of Wound
Kim, Tae Bong,Han, Mi Young,Kim, Dae Myung,Lee, Su Yeung 생화학분자생물학회 1988 BMB Reports Vol.15 No.4
On relation to our previous reports on the proliferation effect of cultured fibroblast of L-carnosine, it was found that L-carnosine had a significantly increasing effect on the amount of nuclear RNA, DNA and proteins of wound-site tissues.
Kim, Seon-Bong,Kim, In-Soo,Yeum, Dong-Min,Park, Yeung-Ho 國立統營水産專門大學 附設 水産科學硏究所 1993 수산과학연구소보고 Vol.4 No.-
The mutagenicity for Salmonella Typhimurium TA100 without S9 mix of Maillard reaction products (MRP) obtained from equimolar amounts of glucose and amino acids under different pHs was investigated. MRP derived from arginine and lysine exhibited the strongest mutagenicity, and weaker mutagenicity was shown by the mixtures with alanine, serine, threonine and monosodium glutamate. MRP from proline and cysteine had no detectable mutagenicity. Furthermore, glucose-arginine and glucose-lysine reaction mixtures, which presented a marked mutagenicity, showed pH- and browning intensity-dependent expression of their mutagenic activities. The mutagenicity of MRP, especially glucose-argiune and glucose-lysine mixtures, was significantly suppressed by active oxygen scavengers such as cysteine, mannitol, α-tocopherol, catalase and superoxide dismutase (SOD) and reducing agents such as sodium bisulfite and glutathione. Among these desmutagenic factors tested, cysteine, catalase, sodium bisulfite and glutathione had higher desmutagenic activities than the others. Accordingly, it is assumed that the mutagenicity of MRP is due to the direct action of low-molecular-weight compounds such as carbonyls and heterocyclics produced by the Maillard reaction and is enhanced by active oxygens, especially singlet oxygen and hydrogen peroxide derived from their autoxidation.
해조류 중의 Anti - Tumor Initiator 및 Promoter의 해석 - 4 : 발암성 Heterocyclic Amine에 대한 곰피 추출물 중의 돌연변이원성 억제인자
박영범(Yeung-Beom Park),안종관(Jong-Khan Ahn),유승재(Sung-Jae Yoo),박덕천(Douck-Choun Park),김인수(In-Soo Kim),박영호(Yeung-Ho Park),김선봉(Seon-Bong Kim) 한국식품영양과학회 1998 한국식품영양과학회지 Vol.27 No.3
해조류 중의 돌연변이원성 억제인자를 해석하기 위하여 돌연변이원성 억제작용이 강한 곰피를 시료로 하여 식품의 가열조리시에 생성되는 발암성 heterocyclic amine인 PhIP 및 MeIQx에 대한 돌연변이원성 억제효과와 억제 인자를 살펴 보았다. 실험의 결과, 곰피로부터 추출한 알긴산의 돌연변이원성 억제효과는 미미하였으며, 그 가수분해물은 10㎎/plate의 농도에서 PhIP에 대하여는 41.0~51.6%, MeIQx에 대하여는 24.3~30.5%의 억제효과를 나타내었고, 가수분해시간에 따른 돌연변이원성 억제작용의 영향은 적었다. 곰피의 phenol추출물과 bromophenol은 0.5㎎/plate에서 PhIP 및 MeIQx에 대하여 90% 정도의 돌연변이원성 억제효과를 나타내었다. 그리고, 곰피 색소 중의 chlorophyll 및 그 유도체 중에서는 chlorophyllin이 억제작용이 높게 나타나 PhIP 및 MeIQx에 대하여 각각 90% 및 80% 이상의 억제효과를 나타내었다. 곰피의 carotenoid 성분중에서는 lutein 및 α-cryptoxanthin이 PhIP 및 MeIQx에 대해 약 90%/㎎의 억제효과를 나타내었다. The present study was performed to elucidate desmutagenic principles from Ecklonia stolonifera extracts against 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline{MeIQx) with Salmonella/mammalian-microsome mutagenicity test. Alginate, phenols, chlorophyll and carotenoids from Ecklonia stolonifera were extracted and their desmutagenicities were assayed. Alginate hydrolysates showed desmutagenic activities against PhIP and MeIQx at high level dose. Phenol fractions and bromophenol showed desmutagenic activity of about 90% per 0.5㎎ against PhIP and MeIQx. Chlorophyllin among chlorophyll derivatives exhibited remarkable desmutagenic activities of 92.9% and 82.7% at 20μM against PhIP and MeIQx, respectively. Carotenoids, such as lutein and α-cryptoxanthin isolated from Ecklonia stolonifera exerted also high desmutagenic activity. Major desmutagenic substances from Ecklonia stolonifera are considered to be chlorophyllin, phenols, lutein, α-cryptoxanthin and low molecular alginates.