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난용성 항진균제 이트라코나졸의 액상제제화에 의한 생체이용율 개선
황우신,권광일,방규호,Hwang, Woo-Sin,Kwon, Kwang-Il,Bang, Kyu-Ho 대한약학회 2000 약학회지 Vol.44 No.6
This study was to develop an effective itraconazole liquid preparation which exhibits an enhanced bioavailability. The solubility of itraconazole was increased (72-fold) in itraconazole liquid preparation as compared with itraconazole powder. The dissolution rate of itraconazole was higher for itraconazole liquid preparation filled into a hard gelatin capsule with 90% release within 20 min as compared to 55% for $Sporanox^{\circledR}$capsules. The oral absorption of itraconazole liquid preparation and $Sporanox^{\circledR}$tablets were studied in the rat. The area under the concentration-time curve $(AUC_{0-24hr})$ of itraconazole liquid preparation ($90.25\;{\pm}\;8.36\;{\mu}g{\cdot}hr/ml$) increased by 6.2 times compared to that of Sporanox tablets ($14.58\;{\pm}\;1.26\;{\mu}g{\cdot}hr/ml$) after oral administration of itraconazole 15 mg/rat each. $C_{max}$ also increased to $6.87\;{\pm}\;1.15\;{\mu}g/ml$ after administration of liquid preparation $1.58\;{\pm}\;0.16\;{\mu}g/ml$ of $Sporanox^{\circledR}$tablets. These results indicate that in vivo bioavailability of itraconazole liquid preparation was significantly enhanced as compared with $Sporanox^{\circledR}$tablets.
방향족 아미노산에 의한 대장균 serC-aroA Operon의 발현 억제
황우길,사재훈,김경훈,임창진,Hwang, Woo-Gil,Sa, Jae-Hoon,Kim, Kyung-Hoon,Lim, Chang-Jin 한국미생물학회 1994 미생물학회지 Vol.32 No.2
대장균에서 두 가지 다른 아미노산의 생합성에 관여하는 serC 유전자와 araA유전자는 혼합 operon을 이루고 있다. SerC-aroA 혼합 operon의 발현 조절 현상을 serC-aroA-lacZ fusion plasmid pWH2를 이용하여 측정하였다. serC-aroA 혼합 operon의 발현은 L-tyrosine, L=phenulalanine 및 L-tryptophan 등 방향족 아미노산들에 의하여 억제되었다. 방향족 아미노산에 의한 억제 효과는 $tyrR^-$ 균주 혹은 $trpT^-$ 균주에서는 감소하였다. 또한, 방향족 아미노산은 cyclic AMP에 의한 이 operon의 발현 상승 효과를 감소시키기도 하였다. 이들 결과로부터 대장균 serC-aroA 혼합 operon의 발현은 방향종 아미노산들에 의해 억제된다고 추정하였다. The Escherichia coli aroA and serC genes constitute a mixed-function operon which involves in two different amino acid biosynthetic pathways. The regulation of expression of serC-aroA operon was evaluated through the use of a serC-araA-lacZ fusion plasmid pWH2. The expression of the serC-aroA operon was decreased by aromatic amino acids such as tyrosine, tryptophan, and phenylalanine. The repressible effects were diminished in E. coli tyrR of trpR strain, indicating the involvemnt of TyrR of TrpR protein in the repression. Tyrosine was competitie with cAMP in the influence on the expression of the serC-AroA operon. From these data, it was suggested that the serC-aroA operon is controlled by aromatic amino acids in a negative manner.
황우(Woo Hwang),김성옥(Sung-Ok Kim) 한국정보과학회 1996 한국정보과학회 학술발표논문집 Vol.23 No.2A
퍼지시스템에서의 퍼지숫자와 퍼지변수의 연산에 있어서 모든 변수나 숫자를 임의적으로 퍼지숫자로 만들어서 사용한다는 것은 실세계 시스템을 표현하는데에 문제가 있다. 따라서 기존의 경험적인 통계자료나, 여러 가지 확률변수들을 이용함으로써 퍼지이론의 부정확성이나 수학적 근거의 취약점을 보완할 수 있는 시스템을 만들 수 있다. 따라서 본 논문에서는 기존의 확률변수들을 퍼지화하여 퍼지숫자로 변형하였고 이때 발생할 수 있는 문제점을 제기 하였다. 따라서 이 연구를 통해 확률이론과 퍼지이론의 접목가능성과 문제점 등을 소개한다.
6시그마 방법론을 이용한 웹사이트 응용프로그램의 보안 수준 평가 및 개선
황우 ( Woo Hwang ),이희조 ( Hee Jo Lee ) 한국정보처리학회 2007 한국정보처리학회 학술대회논문집 Vol.14 No.2
보안수준 평가 및 개선에 있어서 온라인 웹사이트 응용프로그램의 경우 측정 기준 설정과 보안 수준 표시에 많은 어려운 점이 있다. 이에 모토롤라부터 도입한 경영혁신 도구로서의 6 시그마 수준 표현 및 개선 기법을 웹사이트 보안수준 평가에 적용할 수 있도록, WASC(Web Application Security Consortium)에서 제공하고 있는 웹 애플리케이션 보안 평가 체크리스트를 사용하여 Bottom-Up 방식으로 웹 사이트에 대한 실제 침해 시도의 결과를 측정, 이를 보안수준 측정 및 개선에 활용할 수 있는 방안을 제시한다.
황우신,황성주,박정숙,조정원 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-
Nanotechnology affects on various aspects including medicine and pharmaceutics. This nanocrystal technology which transforms to nano-sized material is able to develop the innovational formulation strategy for poorly water-soluble drugs due to the change of physicochemical properties of drug. Scale-up methods using pearl milling or high pressure homogenizer was described and commercialized products based on nanotechnology were introduced in this manuscript.
바이오 디젤유 생산을 위한 대두유 에스테르화 반응의 속도론적 연구
황우람,신용섭 慶星大學校 環境問題硏究所 2002 環境硏報 Vol.12 No.1
The esterification of vegetable oil with methanol is one of the best ways to improve it's combustion characteristics. Therefore, in this study, the process which produce the bio-diesel oil from vegetable oil by the esterification reaction was investigated. Especially, the kinetic study on the esterification reaction of soybean oil was performed. Catalysts used in this study were sodium hydroxide as a homogeneous catalyst and calcium hydroxide as a heterogeneous catalyst. Because sodium hydroxide reacted with free fatty acid in the soybean oil and 0.5wt% of the sodium hydroxide was greater than the free fatty acid content in the soybean oil, it is very important for the completion of esterification reaction that the free fatty acid in the soybean oil should be removed before the esterification reaction. Compared with reaction rate constant of the esterification reaction rate constant of saponification had constant value in case of using sodium hydroxide catalyst. Interestingly, rate constant of the esterification reaction was decresed with increase of sodium hydroxide dosage. Compared with reaction rate constant of the esterification reaction, reaction rate constant of saponification had constant value in case of using sodium hydroxide catalyst. Interestingly, rate constant of the esterification reaction was decresed with increase of sodium hydroxide dosage. Using calcium hydroxide catalyste, reaction rate constants in FAMEs production step were Measured from 0.9141 min-1 to 1.0377 min-1, and reaction rate constants in monoglyceride and diglyceride production steps were measured from 0.0093 min-1 to 0.0386 min-1 according to the calcium hydroxide dosage. So, monoglyceride and diglyceride production steps rate controlling steps in overall esterification reaction.