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Is focused parathyroidectomy appropriate for patients with primary hyperparathyroidism?
Won Woong Kim,Yumie Rhee,Eun Jeong Ban,Cho Rok Lee,Sang-Wook Kang,Jong Ju Jeong,Kee-Hyun Nam,Woong Youn Chung,Cheong Soo Park 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.91 No.3
Purpose: The aim of this study was to determine whether focused or complete parathyroidectomy was more appropriate and to compare follow-up data in primary hyperparathyroidism (PHPT). Methods: We retrospectively analyzed 225 operations for PHPT at Yonsei University Health System between 2000 and 2012. After excluding 93 patients, the remaining 132 were divided into 2 groups: those who underwent focused parathyroidectomy (FP) and those who underwent conventional parathyroidectomy (CP). We compared clinicopathological features; preoperative calcium, parathyroid hormone (PTH), phosphorus, vitamin D, 24-hour urine calcium, and alkaline phosphatase levels; postoperative calcium and PTH levels; pathologic diagnosis; multiplicity; and results of a localization study between the 2 groups. Results: There was no significant difference in the rates of development of postoperative persistent hyperparathyroidism (1/122 FP patients and 1/10 CP patients) between the 2 groups due to a technical reason (FP 0.8% vs. CP 10.0%, P = 0.146). Multiglandular disease (MGD) was uncommon in all cases (6 of 132, 4.5%). All MGD cases were diagnosed using a preoperative localization study. Sestamibi scan and ultrasonography sensitivity were 94.2% and 90.2%, respectively. Conclusion: We suggest that FP is appropriate in PHPT, except in cases of MGD if detected before the operation using preoperative imaging. Knowledge of hereditary PHPT and improved preoperative localization studies, such as high-resolution ultrasonography, contributed to the decision to perform FP rather than CP in all cases of unilateral results of the localizing study.
( Yumi Park ),( Jae-gook Shin ),( Sun-young Lee ),( Jeong Seong Yang ),( Jake Whang ),( Eun-soon Son ),( Tae Won Jang ),( Je Hun Kim ),( Jee Youn Oh ),( Jusang Kim ),( Hyungwoo Kim ),( Yong-soon Cho ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background Minimum inhibitory concentration (MIC) of antibiotics has been widely conducted for drug susceptibility test (DST) of most bacterial infectious diseases, except tuberculosis (TB). Current phenotypic DST for TB uses one or two critical concentrations to determine the resistance of anti-TB drugs. The MIC test would be necessary not only for therapeutic drug monitoring-based precision medicine but also for detecting borderline resistance of anti-TB drugs. Here, we present the distribution of MIC of anti-TB drugs in cPMTb cohort Mycobacterium tuberculosis (Mtb) isolates. Methods From 2019-2020, 205 Mtb strains were collected in the cPMTb cohort. Broth microdilution method in 96 well plates were used for the MIC test of anti-TB drugs, except for pyrazinamide (PZA). MGIT960 system was used for PZA MIC determination. Results The proportions of drug-resistant (DR) and drug-susceptible (DS) strains were 13.1% and 86.9%, respectively. Most of the DS MIC were distributed below the critical concentration of the drug. Six discordances between phenotypic or genotypic DST and MIC were found in this study. Two cases of disputed mutation L511P on rpoB were included in the discordance cases. Their MIC of rifampicin was 0.5 ug/ml. It is lower than critical concentration but higher than epidemiological cut-off value. Conclusion MIC of cPMTb cohort 205 strains were distributed mostly below the critical concentration of all drugs. There are 6 cases of discordance between MIC and DST (phenotypic or genotypic). The MIC test could be utilized to overcome the limitation of phenotypic DST using critical concentration and fill the gap between genotypic and phenotypic DST.
( Yumi Park ),( Sun-young Lee ),( Eun-soon Son ),( Jeong Seong Yang ),( Jake Whang ),( Tae Won Jang ),( Je Hun Kim ),( Jee Youn Oh ),( Hyn Kuk Kim ),( Hyo-jung Kim ),( Yong-soon Cho ),( Jae-gook Shin 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Minimum inhibitory concentration (MIC) of antibiotics has been widely conducted for drug susceptibility tests (DST) of most bacterial infectious diseases, except tuberculosis (TB). Current phenotypic DST for TB uses one or two critical concentrations to determine the resistance of anti-TB drugs. The MIC test would be necessary not only for therapeutic drug monitoring-based precision medicine but also for detecting borderline resistance of anti-TB drugs. Here, we present the distribution of MIC of 4 first-line drugs and levofloxacin in cPMTb cohort Mycobacterium tuberculosis (Mtb) isolates. Methods From 2019-2020, 108 Mtb strains were collected in the cPMTb cohort. Broth microdilution Method in 96 well plates was used for the MIC test of anti-TB drugs, except for pyrazinamide (PZA). MGIT960 system was used for PZA MIC determination. Results The proportions of drug-resistant (DR) and drug-susceptible (DS) strains were 15.7% and 84.3%, respectively. Most of the DS MIC were distributed below the critical concentration of the drug. Three discordances between phenotypic DST and MIC were found in isoniazid, which is 2.8% in total. We observed 2 cases (1.9%) of low-level resistance (MIC 0.5 ug/ml), determined as DS for rifampicin in phenotypic DST but DR in genotypic DST. Conclusion MIC of cPMTb cohort 108 strains were distributed mostly below the critical concentration of all drugs. There are 6 cases of discordance between MIC and DST (phenotypic or genotypic). The MIC test could be utilized to overcome the limitation of phenotypic DST using critical concentration and fill the gap between genotypic and phenotypic DST.
( Yumi Park ),( Sung Young Lee ),( Young-kyung Choi ),( Yong-soon Cho ),( Tae Won Jang ),( Je Hun Kim ),( Jee Youn Oh ),( Jaehee Lee ),( Hyewon Seo ),( Jae-gook Shin ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Discordancy across phenotypic (pDST) and genotypic drug susceptibility test (gDST) Results of isoniazid (INH) and rifampicin (RIF) has been reported between 5%-15%, depending on the compared Methods. The strain has been considered as resistant to test drugs, either one is shown as resistant. However, the strain would be considered as drug-susceptible (DS) if it was the false-negative in both pgDST. Here we report five discrepancy cases and one case of false-negative INH resistant strain screened by the MIC test. Method Results of pDST, gDST, and minimum inhibitory concentration (MIC) of 108 cPMTb clinical Mycobacterium tuberculosis (Mtb) isolates were compared. DNA sequences of resistant genes were analyzed by Sanger sequencing for discrepant cases. Anti-tuberculosis (TB) drug concentrations and N-acetyltransferase-2 (NAT2) genotypes of patients were analyzed to estimate the effectiveness of anti-TB drugs based on the pharmacokinetic model. Result Six cases (5.6%) of discrepancy were found among 108 cPMTb MIC tested Mtb isolates. Four of gRpS strains were confirmed as rifampicin or isoniazid low-level resistance. The other two (gS)pS strains were confirmed as low-level resistance of ethambutol or isoniazid. The INH gSpS strain was redefined as an INH-resistance via MIC and DNA sequencing. It harbored a rare mutation Q439R in katG. Despite the INH resistance, the patient was exposed to sufficient INH concentration according to our pharmacokinetic simulation. Conclusion The MIC tests screened one-third of discrepancy cases in this study. Currently, the MIC test is not conducted regularly for first-line anti-TB drugs. The discrepancy rate would be increased if the MIC test and DNA sequencing are widely undertaken.
Bi-dimensional Image Analysis for the Phenotypic Evaluation of Russet in Asian Pear (Pyrus spp.)
Yumi Kim,Sewon Oh,Keumsun Kim,Hae Won Jeong,Daeil Kim 한국원예학회 2022 원예과학기술지 Vol.40 No.2
Russet, one of the fruit skin colors of Asian pears, affects the fruit’s commercial value. A precise phenotyping method is required because fruit skin colors occur irregularly in various pear cultivars. Here, we propose a bi-dimensional image analysis to evaluate the russet of pear skin accurately and effectively by comparing the results of image analysis with the Hunter a value. The fruits of ‘Whangkeumbae’ (non-russet), ‘Minibae’ (russet), and their F1 individuals were used for russet evaluation. The Hunter a value was measured using a color-difference meter. The russet coverage (%) was calculated using Photoshop software. In F1 individuals derived from ‘Whangkeumbae’ × ‘Minibae’, the Hunter a value represented normal distribution, and the russet coverage distributed variously. The positive correlation coefficients between the Hunter a value and russet coverage was confirmed (r > 0.7). Although several F1 individuals showed abundant russet formation, they showed a negative Hunter a value. Therefore, the bi-dimensional image analysis more accurately evaluated russet in pear fruit skin than did the Hunter a value. The bi-dimensional image analysis could be used for high-throughput phenotyping in pears.