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Hisae Oku,Fumika Kitagawa,Yoshihisa Kato,Tomoya Miyashita,Masaomi Hara,Toshitaka Minetoki,Shizuo Yamada 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.5
We evaluated the effects of unripe mandarin orange (Citrus unshiu) extract powder (unripe mandarin extract powder [UMEP]) treated with subcritical water on allergic diseases by using animal models. High performance liquid chromatography (HPLC) analysis revealed that subcritical water is a more effective solvent than alcohol and hot water, as it quickly extracted approximately 90% of the functional compounds narirutin (1) and hesperidin (2) from whole fruits. Repeated oral administration of UMEP significantly reversed the peripheral blood flow decline observed during the promotion of allergies after sensitization with the antigen, hen egg-white lysozyme (HEL). UMEP also significantly inhibited compound 48/80-induced scratching behavior in HEL-sensitized mice, which are more sensitive to itching stimuli than are normal mice, without suppressing locomotor activity. In addition, repeated oral administration of UMEP in ovalbumin-challenged guinea pigs significantly suppressed the late phase of nasal airway resistance. This study provides evidence that the subcritical water extract powder of unripe C. unshiu fruit is an effective anti-allergic functional food.
Ductile cracking simulation procedure for welded joints under monotonic tension
Liang-Jiu Jia,Toyoki Ikai,Lan Kang,Hanbin Ge,Tomoya Kato 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.60 No.1
A large number of welded steel moment-resisting framed (SMRF) structures failed due to brittle fracture induced by ductile fracture at beam-to-column connections during 1994 Northridge earthquake and 1995 Kobe (Hyogoken-Nanbu) earthquake. Extensive research efforts have been devoted to clarifying the mechanism of the observed failures and corresponding countermeasures to ensure more ductile design of welded SMRF structures, while limited research on the failure analysis of the ductile cracking was conducted due to lack of computational capacity and proper theoretical models. As the first step to solve this complicated problem, this paper aims to establish a straightforward procedure to simulate ductile cracking of welded joints under monotonic tension. There are two difficulties in achieving the aim of this study, including measurement of true stress-true strain data and ductile fracture parameters of different subzones in a welded joint, such as weld deposit, heat affected zone and the boundary between the two. Butt joints are employed in this study for their simple configuration. Both experimental and numerical studies on two types of butt joints are conducted. The validity of the proposed procedure is proved by comparison between the experimental and numerical results.
Tamaki Tanaka,Kazuhiro Takehara,Natsumi Yamashita,Mika Okazawa-Sakai,Kazuya Kuraoka,Norihiro Teramoto,Kenichi Taguchi,Katsushige Yamashiro,Hidenori Kato,Tomoya Mizunoe,Rie Suzuki,Dan Yamamoto,Arisa Ue 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.5
Objective: To clarify the frequency of deficient mismatch repair (dMMR) in Japanese ovarian cancer patients, we examined microsatellite instability (MSI) status and immunohistochemistry (IHC) subtypes, including endometrioid carcinoma (EMC), clear cell carcinoma (CCC), or a mixture of both (Mix). Methods: We registered 390 patients who were diagnosed with EMC/CCC/Mix between 2006 and 2015 and treated at seven participating facilities. For 339 patients confirmed eligible by the Central Pathological Review Board, MSI, IHC, and MutL homolog 1 methylation analyses were conducted. The tissues of patients with Lynch syndrome (LS)-related cancer histories, such as colorectal and endometrial cancer, were also investigated. Results: MSI-high (MSI-H) status was observed in 2/217 CCC (0.9%), 10/115 EMC (8.7%), and 1/4 Mix (25%). Additionally, loss of MMR protein expression (LoE-MMR) was observed in 5/219 (2.3%), 16/115 (14.0%), and 1/4 (25%) patients with CCC, EMC, and Mix, respectively. Both MSI-H and LoE-MMR were found significantly more often in EMC (p<0.001). The median (range) ages of patients with MMR expression and LoE-MMR were 54 (30–90) and 46 (22–76) (p=0.002), respectively. In the multivariate analysis, advanced stage and histological type were identified as prognostic factors. Conclusion: The dMMR rate for EMC/CCC was similar to that reported in Western countries. In Japan, it is assumed that the dMMR frequency is higher because of the increased proportion of CCC.