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CHIME 연대측정의 간섭 보정 계수 결정과 표준 물질의 준비를 위한 실험실 표준법
조등룡,Takenori Kato,Kazuhiro Suzuki 한국지구과학회 2006 韓國地球科學會誌 Vol.27 No.5
The EPMA analysis for CHIME dating requires standard materials, which include nuclear fuel materials thatare rare and sensitive to handle. Any laboratory that does not meet these standards has had difficulties adopting thewithout use of nuclear fuel materials. Mineral samples, such as small pieces of monazite that are homogeneous in X-rayintensities, are calibrated using well-characterized primary standards in one laboratory. Once this procedure is done, theycan be readily usable as working standards in the other laboratories, only with measurement of X-ray intensities. Thismethod is applicable in preparing standard materials for both chemical compositions and determination of X-rayinterference correction factors, and it is independent from chemical composition of mineral standard.......... working standard, CHIME dating, EPMA, interference correction factor, X-ray spectrometry. . : CHIME ..... .. ...... (EPMA)... ..... . .. .. . ... ... .. CHIME 연대측정을 위한 전자현미분석(EPMA)에서는 통상적으로 핵 연료 물질 등 구하기 어렵고 관리에 민감한 표준 물질을 사용하므로 이를 구하지 못하는 실험실에서는 적용에 어려움이 있다. 이 연구에서는 이러한 표준 물질을 대신할 수 있는 새로운 실험실 표준법을 제시한다. CHIME 연대 측정이 원활하게 이루어지고 일련의 표준 물질이 잘 구비된 실험실에서 X선 세기가 균질함이 확인된 모나자이트와 같은 광물편을 대상으로 보정 상수를 정확히 구하고, Th, U 등의 특성 X선 세기를 측정해두면, 다른 실험실에서는 단지 광물편의 특성 X선 세기를 측정하는 것만으로 바로 사용할 수 있는 표준 물질로 활용할 수 있다. 이 기법은 전자 현미 분석에서 화학성분과 X선 간섭 보정 계수의 결정에 필요한 표준 물질로 모두 활용이 가능하며, 광물 표준 물질의 복잡한 화학 성분에 대해 독립적이다.
Yuko Kato-Mori,Michiko Sato,Kenji Sera,Takenori Orihashi,Yuta Kanai,Katsuro Hagiwara 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6
Lactobacillus gasseri OLL 2716 promotes the elimination of Helicobacter pylori and is utilized in yogurts that are specifically labeled as health foods. On the other hand, milk whey fermented by Propionibacterium freudenreichii ET-3, which increases the numbers of Bifidobacterium, is effective for intestinal disorders. We previously demonstrated that oral administration of L. gasseri and P. freudenreichii fermentation metabolites (LP-FM) improved calf intestinal microflora and reduced the incidence of diarrhea. However, the detailed immunological mechanisms responsible for these effects remain to be fully understood. In this study, we investigated whether LP-FM stimulates the innate immune response and promotes the elimination of Listeria monocytogenes in mice. The C57BL/6 female mice that were treated with LP-FM or L. gasseri fermentation metabolites alone for 4 weeks had more peripheral white blood cells than the untreated control mice. In particular, LP-FM-treated mice had higher CD4- and CD8-positive T-cell counts. The levels of reactive oxygen and nitrogen species produced by peritoneal macrophages were also higher in LP-FM-treated mice. Furthermore, LP-FM-treated mice that were infected with L. monocytogenes exhibited significant enhancement of the elimination of Listeria from the spleen and the liver in comparison with untreated control mice infected with Listeria. The activation of innate immunity by LP-FM was increased by the combination of fermentation metabolites from P. freudenreichii. These results suggest that LP-FM, which contains metabolites from L. gasseri and P. freudenreichii, stimulates the function of the innate immune system, thereby significantly promoting the elimination of L. monocytogenes in mice.
Hirotaka Hasegawa,Masahiro Shin,Jun Kawagishi,Hidefumi Jokura,Toshinori Hasegawa,Takenori Kato,Mariko Kawashima,Yuki Shinya,Hiroyuki Kenai,Takuya Kawabe,Manabu Sato,Toru Serizawa,Osamu Nagano,Kyoko Ao 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.2
Background and Purpose To assess the long-term outcomes of intracranial dural arteriovenous fistula (DAVF) treated with stereotactic radiosurgery (SRS) alone or embolization and SRS (Emb- SRS) and to develop a grading system for predicting DAVF obliteration. Methods This multi-institutional retrospective study included 200 patients with DAVF treated with SRS or Emb-SRS. We investigated the long-term obliteration rate and obliteration-associated factors. We developed a new grading system to estimate the obliteration rate. Additionally, we compared the outcomes of SRS and Emb-SRS by using propensity score matching. Results The 3- and 4-year obliteration rates were 66.3% and 78.8%, respectively. The post-SRS hemorrhage rate was 2%. In the matched cohort, the SRS and Emb-SRS groups did not differ in the rates of obliteration (P=0.54) or post-SRS hemorrhage (P=0.50). In multivariable analysis, DAVF location and cortical venous reflux (CVR) were independently associated with obliteration. The new grading system assigned 2, 1, and 0 points to DAVFs in the anterior skull base or middle fossa, DAVFs with CVR or DAVFs in the superior sagittal sinus or tentorium, and DAVFs without these factors, respectively. Using the total points, patients were stratified into the highest (0 points), intermediate (1 point), or lowest (≥2 points) obliteration rate groups that exhibited 4-year obliteration rates of 94.4%, 71.3%, and 60.4%, respectively (P<0.01). Conclusions SRS-based therapy achieved DAVF obliteration in more than three-quarters of the patients at 4 years of age. Our grading system can stratify the obliteration rate and may guide physicians in treatment selection.