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김태형,정원지,엄태진,홍대선 國立 昌原大學校 産業技術硏究所 2000 産技硏論文集 Vol.14 No.-
As personal computers are being developed, most softwares are based on window-based operating systems recently. The programmable logic controllers (PLC's) which are usually operated based on the DOS system should be adapted to the window-based environment in order to have the multi-tasking and flexibility of PLC programs. In this paper, the PLC driving programs which are based on the window-based operating systems are developed for the hardwares in which only DOS-based driving programs are being used currently.
구재경,엄태선,박명균,박세만 명지대학교 산업기술연구소 2007 産業技術硏究所論文集 Vol.26 No.-
An experimental method involving electrical resistant strain gages and the computational method of the Finite Element Technique are employed to determine the location of the stress concentrations for the cellular phone. The results show that this area is highly susceptible to the hinge and it vicinity between folder and the body is found to be the most stress this area is highly susceptible to the Possible initiation of the crack leading to the complete failure and malfunction failure of the phone. Three different materials are considered to be possible candidates to replace the current materials. The higher the young's modules the lower the stress concentrations at the hinge area.
( Sun Young Yim ),( Tae Hyung Kim ),( Suh Sang Jun ),( Eun Sun Kim ),( Bora Keum ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Yoon Tae Jeen ),( Hoon Jai Chun ),( Hong Sik Lee ),( Soon Ho Um ),( Chang Duck 대한간학회 2017 Gut and Liver Vol.11 No.3
Background/Aims: We aimed to clarify the association of hepatitis B surface antigen (HBsAg)/hepatitis B core antigen (HBcAg) with the disease status and treatment response in patients with chronic hepatitis B (CHB). Methods: We investigated 171 biopsy-proven entecavir-treated CHB patients (109 hepatitis B e antigen [HBeAg]-positive, 62 HBeAg-negative). HBcAg expression was positive when ≥10% of hepatocytes stained, and classified into nuclear, mixed, and cytoplasmic patterns. HBsAg expressions were intracytoplasmic (diffuse, globular, and submembranous) and membranous. The histologic activity index (HAI) and fibrosis stage followed Ishak system. Results: In HBeAg-positive patients, older age, increased HAI score, advanced fibrosis, and reduced viral load were observed when HBcAg expression shifted from nucleus to cytoplasm in HBcAg-positive patients, and HBsAg expression from non-submembranous to submembranous in HBcAg-negative patients (all, p<0.05). In HBeAg-negative patients, only intracytoplasmic HBsAg expression patterns had clinical relevance with decreased ALT levels and viremia. In HBeAg-positive patients without favorable predictors of virologic response, negative HBcAg and membranous HBsAg expression predicted greater virologic response (both, p<0.05). The probability of HBeAg seroclearance was higher in patients with increased HAI or lacking HBcAg expression (both, p<0.05). Higher serum HBsAg levels and hepatocyte HBcAg positivity were associated with reduced serum HBsAg during first and post-first year treatment, respectively (both, p<0.05). Conclusions: Hepatocyte HBcAg/HBsAg expression is a good marker for disease status and predicting treatment response. (Gut Liver 2017;11:417-425)
( Sun Young Yim ),( Yoo Ra Lee ),( Han Ah Lee ),( Tae Hyung Kim ),( Hyung Joon Yim ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Soon Ho Um ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Sorafenib is the only standard treatment for advanced hepatocellular carcinoma with (HCC). However, its efficacy is not satisfactory and other treatment options are required. This study investigated the efficacy of chemoembolization and hepatic arterial infusion chemotherapy (HAIC) with or without radiotherapy versus sorafenib alone in patients with portal vein thrombosis (PVT). Methods: This single-center retrospective study involved 105 patients of advanced HCC with portal vein tumor thrombosis (PVT). Enrolled patients had either child-pugh (CP) class A or B liver cirrhosis whom were classified into 3 groups: 1) Sorafenib alone, n=20; 2) Chemoembolization and HAIC, n=26; 3) Chemoembolization and HAIC with radiotherapy, n=59. Sorafenib was initiated with 400mg twice daily and HAIC was based on cisplatin and 5-fluorouracil regimen, performed every 4 weeks. Response of PVT was determined 3 months after completion of treatment and was regarded as responsive when there is at least partial response. Overall survival (OS) was analyzed among the treatment groups and factors associated with mortality were evaluated using multivariate analysis. Results: The median radiation dose, sorafenib treatment duration and chemoembolization sessions were 50 Gy, 40 days, and 4 sessions, respectively. Proportion of patients according to the degree of PVT (main/both vs. first order vs. segmental PV) and bilobar tumor mass involvement did not differ among the three groups of treatment. However, PVT response rate was significantly higher in group 3 (13.5% vs. 6.7% vs. 55%, P=0.014) with lower incidence of solid organ metastasis (60% vs. 23.1% vs. 18.6%, P=0.001) and child pugh class B (70%, 50%, 25.4%%, P=0.001) compared to other groups. In univariate cox analysis, treatment modalities, presence of either lymph node or other organ metastasis, CP class B, decrease in AFP levels were associated with survival. However, multivariate analysis revealed that treatment modalities (group 1 vs. 2, HR, 0.244; 95% CI, 0.06-0.999, P=0.05, group 1 vs. 3, HR, 0.121; 95% CI 0.028-0.51, P=0.004 and group 2 vs. 3, HR 0.495; 95% CI, 0.25-0.98, P=0.044) and decrease in serum AFP level within 2 months of treatment (HR, 1.813; 95% CI, 1.204-2.72; P=0.004) were the only independent factors associated with survival. Median OS was significantly higher in patient treated with radiotherapy (group3, 11.1 months) than group 2 (3.6 months, log rank P<0.001) and group 1 (2 months, P<0.001). Furthermore, median OS survival was still significantly greater in group 2 than group 1, P=0.008. Conclusions: Radiotherapy with chemoembolization and HAIC can be alternative treatment option to sorafenib in patients with advanced HCC and PVT.
Significant Genomic Variants Associated with Hepatitis B Surface Antigen Seroclearance in Korea
( Tae Hyung Kim ),( Soon Ho Um ),( Yeon Seok Seo ),( Sun Young Yim ),( Seung Woon Park ),( Han Ah Lee ),( Sang Jung Park ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Hepatitis B surface antigen (HBsAg) seroclearance is one of the most important goal in treatment of chronic hepatitis B (CHB). Many CHB patients were treated with diverse medication, but only a few were achieved HBsAg seroclearance. There are some studies about factors related to HBsAg seroclearance for prediction, but few studies explored in genomic level. This study aimed to reveal unique genomic variants associated with HBsAg seroclearance. Methods: Total 200 patients were enrolled and composed of 100 patients with HBsAg seroclearance and 100 patients with high expression level of HBsAg. We collected blood samples from them, and genotyped using the Illumina HumanOmni2.5-8 BeadChip. We performed statistical analysis through chi-square test, Fisher’s exact test, and logistic regression model. Results: There were revealed available 2,344,229 single nucleotide polymorphisms (SNPs) after excluding 25,669 by missingness test and 23,027 by HWE test. The Significant 18 SNPs (P-value < 1 x 10-5) were identified: rs4915485, rs12463513, rs1558599, rs1823746, rs171941, rs9692552, rs2153442, rs4748035, rs1809862, rs7945342, rs7944135, rs12593003, rs4377248, rs7230406, rs7056538, rs34110460, rs35988962, rs3992852. Among them, 1 SNP is located on exon and 6 SNPs are located on intron. Conclusions: We identified the most relevant SNPs in HBsAg seroclearance. Further studies are needed to validate and elicit function of SNPs. And that will open up horizons for personalized treatment in chronic hepatitis B.