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이상민 ( Sang-min Lee ),최윤식 ( Yoonsik Choe ) 한국정보처리학회 2004 한국정보처리학회 학술대회논문집 Vol.11 No.2
본 논문은 이동통신을 위한 입력영상을 취득할 때 사용되는 웨이블릿, 소벨 필터 기반의 화질 평가 방식을 다양한 실험을 통해 검증하고 영상과 전처리 기법에 따라 주관적 평가에 근접한 화질 평가방식을 제안한다.
Kyongha Cho,Yoonsik Kim,Sang-Hoon Yoon 한국한의학연구원 2019 Integrative Medicine Research Vol.8 No.2
We are reporting the combined therapeutic effect of miniscalpel acupuncture and splint therapy on osteoarthritis of the hand accompanying severe joint deformity. The patient, female, 55 years of age, was diagnosed with symptomatic osteoarthritis of hand based on radiological examination and the American College of Rheumatology classification criteria. The patient was classified a grade 4 of Kellgren–Lawrence (KL) scale upon initial consultation. Over five months, the patient was treated with miniscalpel acupuncture with splint therapy. The patient's pain, decreased from 6–2 on numeral rating score (NRS) scale. The combined therapeutic effect of miniscalpel acupuncture and splint therapy seems to have positive results on OA of hand accompanying joint deformity, albeit being limited to a single case.
Hurh, Kyungduk,Park, Yoonsik,Kim, Gyu Ri,Jang, Sung-In,Park, Eun-Cheol The Korean Society for Preventive Medicine 2021 Journal of Preventive Medicine and Public Health Vol.54 No.1
Objectives: Recent studies have suggested that assessing handgrip strength (HGS) asymmetry together with HGS may be helpful for evaluating problems in geriatric patients. This study aimed to identify whether HGS asymmetry, weakness, or both were associated with depression in Korean older adults. Methods: This study included 4274 subjects from the sixth and seventh Korea National Health and Nutrition Examination Survey. Depression was measured using the Patient Health Questionnaire-9. The maximum HGS of the dominant hand was used as a representative value. HGS symmetry was categorized by the ratio of the HGS of the dominant hand to that of non-dominant hand. The odds ratio (OR) for depression was calculated according to the HGS and its symmetry. Results: In total, 240 (12.5%) men and 534 (22.7%) women had depression. HGS or HGS asymmetry showed no statistically significant associations with depression in elderly men. Elevated odds of depression were observed in elderly women with low HGS (OR, 1.93; 95% confidence interval [CI], 1.33 to 2.81) or prominent HGS asymmetry (OR, 1.46; 95% CI, 1.02 to 2.08). There was a positive additive interaction between asymmetric HGS and weakness, as women with low and prominently asymmetric HGS showed higher odds of depression (OR, 3.77; 95% CI, 2.16 to 6.59) than women with high and symmetric HGS. Conclusions: Depression in elderly Korean women was associated with both low and asymmetric HGS. Our findings support the potential value of HGS asymmetry as an indicator of HGS.
Lim Sungsu,Shin Seulgi,Sung Yoonsik,Lee Ha Eun,Kim Kyu Hyeon,Song Ji Yeon,Lee Gwan-Ho,Aziz Hira,Lukianenko Nataliia,Kang Dong Min,Boesen Nicolette,Jeong Hyeanjeong,Abdildinova Aizhan,Lee Junghee,Yu By 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Tau oligomers play critical roles in tau pathology and are responsible for neuronal cell death and transmitting the disease in the brain. Accordingly, preventing tau oligomerization has become an important therapeutic strategy to treat tauopathies, including Alzheimer’s disease. However, progress has been slow because detecting tau oligomers in the cellular context is difficult. Working toward tau-targeted drug discovery, our group has developed a tau-BiFC platform to monitor and quantify tau oligomerization. By using the tau-BiFC platform, we screened libraries with FDA-approved and passed phase I drugs and identified levosimendan as a potent anti-tau agent that inhibits tau oligomerization. 14C-isotope labeling of levosimendan revealed that levosimendan covalently bound to tau cysteines, directly inhibiting disulfide-linked tau oligomerization. In addition, levosimendan disassembles tau oligomers into monomers, rescuing neurons from aggregation states. In comparison, the well-known anti-tau agents methylene blue and LMTM failed to protect neurons from tau-mediated toxicity, generating high-molecular-weight tau oligomers. Levosimendan displayed robust potency against tau oligomerization and rescued cognitive declines induced by tauopathy in the TauP301L-BiFC mouse model. Our data present the potential of levosimendan as a disease-modifying drug for tauopathies.