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Determining Light Conditions for Improved Carrot Growth in a Closed-type Plant Factory
Sung Bohyun,곽나영,조영열 한국원예학회 2024 원예과학기술지 Vol.42 No.2
A plant factory refers to a cultivation method in which plants are grown in a completely controlled environment that is unaffected by external climate changes to establish and maintain optimal environmental conditions for crop growth, resulting in maximum productivity and quality. This study aimed to determine the optimal lighting conditions for cultivating carrots (Daucus carota L.) in plant factories. Carrots were grown using a system known as the NFT system for 33 d after transplantation, and the growth parameters investigated included the leaf area, shoot and root fresh weight, and dry weight. A carrot-specific nutrient solution was used, which was developed based on the appropriate content of macro elements in the plant (NO3-N:15.0, NH4-N:1.0, P:1.0, K:11.0, Ca:2.0, Mg:1.0, SO4-S:1.0 mM·L-1). The pH of the nutrient solution was maintained between 5.5 and 6.0, and the electrical conductivity was set to 1.0 dS·m-1 during the seedling stage and 1.5 dS·m-1 after transplanting. The lighting conditions were established by adjusting the ratios of red (R), green (G), and blue (B) light based on photosynthetic photon flux density. Four treatment groups were tested with R:G:B ratios of 4:0:6, 7:0:3, 6:0:4, and 6:1:3. The lighting cycle consisted of 12 h of light and 12 h of darkness, and the light intensity was maintained at a fixed value of 200 µmol·m-2·s-1. Leaf number and plant height values were significantly higher in the 6:0:4 and 6:1:3 treatments; however, there were no significant differences between them. Shoot and root fresh weights were significantly higher in the 6:0:4 and 6:1:3 treatments, whereas the shoot dry weight was highest in the 6:1:3 treatment. However, the root dry weight was highest in the 4:0:6 treatment. The total fresh weight was highest in the 6:0:4 and 6:1:3 treatments, whereas the total dry weight was highest in the 4:0:6 treatment. Overall, there were no statistically significant differences in the number of leaves, plant height, shoot and root fresh and dry weights, or total fresh and dry weights between the 6:0:4 and 6:1:3 treatment groups. Overall, these findings suggest that light ratios of 6:0:4 and 6:1:3 provide suitable lighting conditions for promoting optimal carrot growth in a controlled plant factory environment.
Computational Flow Dynamics Study in Severe Carotid Bulb Stenosis with Ulceration
Oh, Tack Sun,Ko, Young Bae,Park, Sung-Tae,Yoon, Kyunghwan,Lee, Sang-Wook,Park, Jee Won,Kim, Jong Lim,Kim, Bohyun,Park, Sang-Ok,Kim, Jong Sung,Suh, Dae Chul Korean Society of Interventional Neuroradiology 2010 Neurointervention Vol.5 No.2
Bohyun Yang,Jae-Sang Ryu,Chan Rim,Jung U. Shin,Min-Soo Kwon 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.1
Atopic dermatitis (AD) and mood disordercomorbidities are typical, but the exact mechanism underlyingtheir interplay has not been clarifi ed. In this study,we aimed to identify the possible mechanisms of anxiety/depressive-like behaviors observed in AD, focusing onmicroglia. AD was induced by Dermatophagoides farinaebody extract (Dfb) in NC/Nga mice and anxiety/depressivelikebehaviors were analyzed by behavioral assessmentssuch as open fi eld test (OFT), tail suspension test (TST),sucrose preference test (SPT), and social interaction. Asclinical symptoms of AD induced, anxiety/depressive-likebehaviors were increased in the OFT and TST and serumglucocorticoid was elevated. AD mice showed an increasedmRNA expression of interleukin-4 (IL-4) in lymph nodesbut decreased arginase 1 (Arg1) mRNA expression withouta change of IL-4 in the hippocampus. In addition, AD miceshowed microglia with a shortened branch of de-ramified form and astrocytes with longer processes and decreasedbranching in the hippocampus, especially in the dentategyrus (DG). The immunofluorescence study of the DGconfi rmed that Arg1 reduction was associated with microglia,but not astrocytes. Furthermore, glucocorticoid receptorreduction, increased 5-HT 1A R, reduced phosphorylatedcAMP response element-binding protein (pCREB),and brain-derived neurotrophic factor (BDNF) expressionwere identifi ed in the hippocampus of AD mice. Notably,an immunofl uorescence study confi rmed that pCREB wasdecreased in the DG of AD mice. Collectively, our data suggestthat the reduced Arg1 positive microglia might contributeto anxiety/depressive-like behaviors via pCREB/BDNFreduction in AD.
Sung Hee Lee,Hye Ah Lee,Eun Ae Park,Su Jin Cho,Se Young Oh,Bohyun Park,Hyesook Park 한국영양학회 2020 Nutrition Research and Practice Vol.14 No.4
BACKGROUND/OBJECTIVES: To assess the longitudinal associations of the antioxidant capacity of zinc and body mass index (BMI) with serum uric acid (SUA) in South Korean children. SUBJECTS/METHODS: Using follow-up data from the Ewha Birth and Growth Cohort, we included subjects who were seen at 3 and 7 years of age (n = 183; 90 boys, 93 girls). Daily zinc intake and BMI were assessed at 3 and 7 years of age. SUA measured at 7 years was used as the outcome variable. Using a general linear model, the effects of dietary zinc intake and BMI on SUA were assessed. We also assessed the combined effect of early dietary zinc intake and BMI on SUA in children. RESULTS: The dietary zinc intake at 3 years of age was negatively correlated (ρ = −0.18, P = 0.04), whereas the BMI at 7 years of age was positively correlated (r = 0.18, P = 0.01), with the SUA level at 7 years of age. The dietary zinc intake level at 3 years of age and the BMI level at 7 years of age were, together, significantly related to SUA in children at 7 years of age. SUA was lower in group 1 (normal-weight, high-zinc group) than in the other two groups (group 2: normalweight, low-zinc and overweight, high-zinc group; and group 3: overweight, low-zinc group). Our results demonstrate the combined effect of zinc intake and BMI on SUA. The combined association remained significant in both the crude and adjusted models (P < 0.01). CONCLUSIONS: SUA was related to combined BMI and dietary zinc intake, and increased zinc intake and normal body weight had a beneficial effect on reducing SUA in children.
( Bohyun Kim ),( Soon Sun Kim ),( Sung Won Cho ),( Jae Youn Cheong ),( Jimi Huh ),( Jai Keun Kim ),( Jei Hee Lee ),( Hye Ri Ahn ),( Hyo Jung Cho ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Liver stiffness (LS) is an emerging imaging-based prognostic biomarker for patients with chronic liver disease. We investigated whether LS quantified using magnetic resonance elastography (MRE) could predict the prognosis of advanced hepatocellular carcinoma (HCC) patients treated with sorafenib. Methods: We selected 50 sorafenib-treated advanced HCC patients who underwent MRE within 3 months before drug administration from a prospectively maintained cohort of chronic liver disease patients, according to the inclusion and exclusion criteria. Univariate and multivariate analyses were performed to evaluate the prognostic role of laboratory data, tumor characteristics, and MRE-assessed LS for overall survival (OS), progression-free survival (PFS), and significant liver injury (≥grade 3) after sorafenib administration. Results: High MRE-assessed LS was significantly associated with poor OS (kPa; hazard ratio [HR], 1.54; 95% confidence interval [CI], 1.23-1.92; P<0.001) as well as higher serum alpha-fetoprotein (AFP, ≥400 ng/mL) and advanced tumor stage (modified Union for International Cancer Control [mUICC] IVb). Higher MRE-assessed LS was also significantly associated with the development of significant liver injury after sorafenib administration (kPa; HR, 1.62; 95% CI, 1.21-2.17; P=0.001). PFS analysis identified higher serum AFP (≥400 ng/mL) and advanced tumor stage (modified UICC IVb) as significant risk factors for early disease progression, whereas LS was not associated with PFS. Conclusions: Higher MRE-assessed LS is a potential biomarker for predicting poor OS and significant liver injury in advanced HCC patients treated with sorafenib.
Bohyun Shin,Hyung-seung Kim,Sang Beom Han 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11
A simple, rapid, and novel method based on high-performance liquid chromatography (HPLC) was developed for the determination of pralidoxime chloride in an antidote autoinjector using chaotropic salt as mobile phase additives. Since pralidoxime chloride is a highly polar compound, the RP-HPLC method without ion-pairing reagent does not retain praridoxime chloride and elutes in the column void time (t0), making quantitative analysis difficult. In this study, the retention time of pralidoxime was increased by using a chaotropic salt in the mobile phase, and satisfactory quantitative results were obtained. The capacity factors were compared when using chaotropic salts and room temperature ionic liquids (RTIL), and concentration of additives was optimized to provide adequate retention times. As a result, RP-HPLC analysis was established using NaPF6, which has the best retention effect among chaotropic salts, as an additive in the mobile phase. The chromatographic separation was achieved by C18 column (150 mm × 4.6 mm, 5 μm) and UV detection at 270 nm. Analytical method validation was performed to assess linearity, accuracy, precision, recovery and repeatability according to Ministry of Food and Drug Safety (MFDS) guideline. Compared to the current official US Pharmacopoeia (USP) and Korean Pharmacopoeia (KP) methods, the retention time of pralidoxime is increased without the use of ion-pairing reagents in a simple way. In addition, it is an economical and eco-friendly method because the analysis time is short.
Liver Imaging : Portal flow steal after liver transplantation
( Bohyun Kim ),( Kyoung Won Kim ),( Gi-won Song ),( Sung-gyu Lee ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.3
Portal flow steal occasionally persists even after the liver transplantation, which may reduce the portal flow and thus threaten the patients’ outcome. Therefore, pre- and peri-operative detection of portal steal phenomenon requiring radiological or surgical interruption is essential for the liver transplantation candidates as well as for the recipients. (Clin Mol Hepatol 2015;21:314-317)
Clostridium difficile-associated Intestinal Disease and Probiotics
Yun, Bohyun,Lee, Sang Dae,Oh, Sejong Korean Society of Milk Science and Biotechnology 2013 Journal of Dairy Science and Biotechnology (JMSB) Vol.31 No.1
Probiotics are traditionally defined as viable microorganisms that have a beneficial effect in the prevention and treatment of pathologic conditions when they are ingested. Although there is a relatively large volume of literature that supports the use of probiotics to prevent or treat intestinal disorders, the scientific basis behind probiotic use has only recently been established, and clinical studies on this topic are just beginning to get published. Currently, the best studied probiotics are lactic acid bacteria, particularly Lactobacillus and Bifidobacterium species. Other organisms used as probiotics in humans include Escherichia coli, Streptococcus sp., Enterococcus sp., Bacteroides sp., Bacillus sp., Propionibacterium sp., and various fungi, and some probiotic preparations contain more than one bacterial strain. Probiotic use for the prevention and treatment of antibiotic-associated diarrhea caused by Clostridium difficile induced intestinal disease as well as for other gastrointestinal disorders has been discussed in this review.