Dietary Effect of Green Tea Extract on Epidermal Levels of Hydration, Filaggrin, Free Amino Acids and Peptidylarginine Deiminase-3 Protein Expression in UV-irradiated Hairless Mice

Sumin Choi,Kyungrhim Lee,Jae Sung Hwang,Yunhi Cho 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

Identification of signature gene set as highly accurate determination of metabolic dysfunction-associated steatotic liver disease progression

Sumin Oh,Yang-Hyun Baek,Sungju Jung,Sumin Yoon,Byeonggeun Kang,Su-hyang Han,Gaeul Park,Je Yeong Ko,Sang-Young Han,Jin-Sook Jeong,Jin-Han Cho,Young-Hoon Roh,Sung-Wook Lee,Gi-Bok Choi,Yong Sun Lee,Won K 대한간학회 2024 Clinical and Molecular Hepatology(대한간학회지) Vol.30 No.2

Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by fat accumulation in the liver. MASLD encompasses both steatosis and MASH. Since MASH can lead to cirrhosis and liver cancer, steatosis and MASH must be distinguished during patient treatment. Here, we investigate the genomes, epigenomes, and transcriptomes of MASLD patients to identify signature gene set for more accurate tracking of MASLD progression. Methods: Biopsy-tissue and blood samples from patients with 134 MASLD, comprising 60 steatosis and 74 MASH patients were performed omics analysis. SVM learning algorithm were used to calculate most predictive features. Linear regression was applied to find signature gene set that distinguish the stage of MASLD and to validate their application into independent cohort of MASLD. Results: After performing WGS, WES, WGBS, and total RNA-seq on 134 biopsy samples from confirmed MASLD patients, we provided 1,955 MASLD-associated features, out of 3,176 somatic variant callings, 58 DMRs, and 1,393 DEGs that track MASLD progression. Then, we used a SVM learning algorithm to analyze the data and select the most predictive features. Using linear regression, we identified a signature gene set capable of differentiating the various stages of MASLD and verified it in different independent cohorts of MASLD and a liver cancer cohort. Conclusions: We identified a signature gene set (i.e., CAPG, HYAL3, WIPI1, TREM2, SPP1, and RNASE6) with strong potential as a panel of diagnostic genes of MASLD-associated disease.

Prevalence Risk of Metabolic Syndrome Associated with Alcohol Use Behavior in Korean Women

SuMin Kwak,MiRan Choi,SolHee Bang,InYoung Choi,MiJung Rho,Hyun Jo,DaiJin Kim 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.2

Objective-Considerable research has been conducted on the relationship between alcohol consumption and metabolic syndrome. Although various standards for the amount and frequency of alcohol consumption have been suggested, a tool to measure individual alcohol use behavior against a consistent standard is required. Moreover, the association of alcohol use behavior with health should be examined on the basis of such a standard. In this study, we examined the relationships between alcohol use behavior according to the Alcohol Use Disorders Identification Test (AUDIT) and metabolic syndrome and its components in Korean women. Methods-This study utilized data from the fifth Korean National Health and Nutrition Examination Survey, which was administered from 2010 through 2012. We investigated the relationships between alcohol use behavior and metabolic syndrome and its components in a sample of 2,906 women by using analysis of covariance and logistic regression analysis. Results-After adjusting for confounding variables, alcohol use behavior was significantly associated with metabolic syndrome [odds ratio (OR) 2.877; 95% confidence interval (CI) 1.523–5.435 in the problem use group]. AUDIT score also was significantly related to abdominal obesity (OR 2.263; 95% CI 1.704–4.459 in the problem use group), hypertension (OR 3.377; 95% CI 1.871–6.095 in the problem use group), hypertriglyceridemia (OR 3.204; 95% CI 1.800–5.702 in the problem use group), and impaired fasting glucose (OR 3.034; 95% CI 1.721–5.348 in the problem use group). Conclusion-In this study, positive associations were observed between AUDIT score and risk of metabolic syndrome and its components.

An Efficient Crosstalk-Included Eye-Diagram Estimation Method for High-Speed Interposer Channel on 2.5-D and 3-D IC

Choi, Sumin,Kim, Heegon,Jung, Daniel H.,Kim, Jonghoon Jay,Lim, Jaemin,Kim, Joungho [Institute of Electrical and Electronics Engineers 2017 IEEE transactions on electromagnetic compatibility Vol.59 No.3

<P>In this paper, we first propose an efficient crosstalk-included eye-diagram estimation method for high-speed interposer channel on 2.5-D and three-dimensional (3-D) IC. The proposed method includes crosstalk effects from adjacent channels, which can considerably degrade the transmitted signal on a victim channel. This method enables to estimate worst and statistical eye-diagrams in a short time with high accuracy. While 3-D EM simulation has been widely used for accurate estimation of the channel performance, it requires substantial amount of computational time and resources. Therefore, in order to reduce the eye-diagram estimation time, the coupled microstrip channels are modeled using resistance, inductance, conductance, and capacitance components, whose values are derived from the physical dimensions. The equivalent circuit model can also enhance physical insight of the coupled channels. The proposed method is verified by time-domain simulations and measurements at data rates of up to 4 Gb/s. According to the estimated crosstalk-included eye-diagrams, the proposed method reduces simulation time over 99% and shows a high accuracy of approximately 93%. The proposed method is applied to the high-bandwidth memory channels on silicon, organic, and glass interposer.</P>

Feasible Optimization of Stereotactic Ablative Radiotherapy Dose by Tumor Size for Stage I Non–small-cell Lung Cancer

Lee, Sumin,Song, Si Yeol,Kim, Su Ssan,Choi, Wonsik,Je, Hyoung Uk,Back, Geum Mun,Cho, Byungchul,Jeong, Seong-Yun,Choi, Eun Kyung Elsevier 2018 Clinical lung cancer Vol.19 No.2

<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>The purpose of this study was to assess the effect of dose escalation of stereotactic ablative radiotherapy (SABR) by investigating the long-term clinical outcomes of SABR for stage I non–small-cell lung cancer (NSCLC).</P> <P><B>Methods</B></P> <P>A retrospective analysis was performed on a total of 169 patients with 178 lesions of stage I NSCLC treated with SABR at a single institution from June 2000 to May 2015. The standard dose scheme for SABR was 48 Gy in 4 fractions during the early period of the analysis, but it was escalated to 60 Gy in 4 fractions from June 2009. All failures were recorded over the follow-up period.</P> <P><B>Results</B></P> <P>Median follow-up time was 32 months. The 5-year overall survival rate was 46.7%, and the actuarial local control rate was 79.3%. Tumor size was an independent prognostic factor for survival. No relapse occurred in tumors ≤ 2 cm irrespective of SABR dose. Escalated doses of approximately 60 Gy in 4 fractions (biologically effective dose [BED] = 150 Gy<SUB>10</SUB>) achieved higher local control compared with 48 Gy in 4 fractions (BED = 106 Gy<SUB>10</SUB>) (76.2% vs. 60.6%) at 5-year follow-up (<I>P</I> = .022) in tumors > 2 cm. There were no differences in treatment-related toxicities between the dose groups. Major failures consisted of distant metastasis to another lung parenchyma.</P> <P><B>Conclusion</B></P> <P>SABR provides satisfactory long-term local control and high overall survival in medically inoperable stage I NSCLC. Tumors ≤ 2 cm had no local recurrence regardless of dose; whereas for tumors > 2 cm, an escalated BED of approximately 150 Gy<SUB>10</SUB> provided significantly higher local tumor control.</P>

자외선 조사와 병행된 녹차추출물 식이공급이 무모생쥐의 표피보습 개선 및 유리아미노산 생성 관련 대사에 미치는 영향

최수민(Choi, Sumin),신지혜(Shin, Jihye),이보민(Lee, Bomin),조윤희(Cho, Yunhi) 한국영양학회 2016 Journal of Nutrition and Health Vol.49 No.5

본 연구에서는 자외선 조사를 병행하여 녹차 추출물의 식이공급을 10주간 공급한 무모생쥐 (UV+1%GTE군)의 표피 보습과 filaggrin 의 대사물질 및 관련 효소인 PAD3의 발현 및 함량 변화를 정상대조군 (UV-군) 및 자외선 조사군 (UV+군)과 비교 분석하였으며 결과는 다음과 같다. UV+군의 피부 보습은 UV-군보다 유의적으로 낮은 반면 UV+1%GTE군 의 피부 보습은 UV+군에 비해 유의적으로 높았고, UV-군에는 미치지 못하였다. UV+군의 profilaggrin 함량은 UV-군과 유의적인 차이가 없었으나, filaggrin의 함량은 UV-군에 비해 유의적으로 낮았다. UV+1%GTE군 에서 profilaggrin은 UV- 및 UV+에 비해 현저히 높았고, filaggrin은 UV-군과 유사한 수준으로 높았다. UV+군의 PAD3 효소 발현은 UV-군에 비해 유의적으로 낮았다. UV+1%GTE군은 UV+군에 비해 유의적으로 높았으며, UV-군에 비해 높았다. 자연보습인자의 주요 아미노산인 serine 및 glycine, alanine의 함량은 UV-군과 UV+군간 유사하였으나 UV+1%GTE군에서는 UV- 및 UV+군에 비해 현저히 높았다. UV-군과 비교하여 UV+군의 피부 보습함량이 낮게 측정된 것에 비해 유리아미노산 함량에는 변화가 없어 자외선에 따른 피부 보습에 관여되는 또 다른 메커니즘인 표피 지질함량 분석과 함께 녹차추출물의 효과에 대한 연구가 추후 이루어질 필요성이 있다. 그러나, 결론적으로 자외선 조사와 병행된 녹차 추출물 식이 공급은 (pro)filaggrin의 함량 및 PAD3의 발현이 높게 나타남에 의한 표피 유리아미노산의 함량이 높아 궁극적으로 자외선 조사에 의해 야기된 피부건조를 완화시켰다. Purpose: Ultraviolet (UV) irradiation decreases epidermal hydration, which is maintained by reduction of natural moisturizing factors (NMFs). Among various NMFs, free amino acids (AA) are major constituents generated by filaggrin degradation. This experiment was conducted to determine whether or not dietary supplementation of green tea extract (GTE) in UV-irradiated mice can improve epidermal levels of hydration, filaggrin, free AAs, and peptidylarginine deiminase-3 (PAD3) expression (an enzyme involved in filaggrin degradation). Methods: Hairless mice were fed a diet of 1% GTE for 10 weeks in parallel with UV irradiation (group UV+1%GTE). As controls, hairless mice were fed a control diet in parallel with (group UV+) or without (group UV-) UV irradiation. Results: In group UV+, epidermal levels of hydration and filaggrin were lower than those in group UV-; these levels increased in group UV+1% GTE to levels similar to group UV-. Epidermal levels of PAD3 and major AAs of NMF, alanine, glycine and serine were similar in groups UV- and UV+, whereas these levels highly increased in group UV+1% GTE. Conclusion: Dietary GTE improves epidermal hydration by filaggrin generation and degradation into AAs.

통행량 자료를 이용한 충청권 도시 중심성 변화 분석

최수민 ( Sumin Choi ) 충남연구원 2022 충남연구 Vol.6 No.1

본 연구는 충청권(대전, 세종, 충북, 충남) 36개 시군구 간의 통행량 자료를 활용하여 현재(2019년)의 도시 중심성과 2040년에 예상되는 중심성 변화를 분석하는 것이 목적이다. 분석에 이용한 자료는 한국교통DB(KTDB)에서 수집한 통근·통학 및 쇼핑·여가 통행량 자료이며, 보나시치 위계 중심성 분석방법을 적용하였다. 분석 결과, 현재는 대전이 중심성이 가장 높은 것으로 분석되었으나 2040년에는 세종의 중심성이 큰 폭으로 상승하며 대전과 유사한 위계를 갖게 될 것으로 나타났다. 또한 현재의 중심성이 기존 대전·세종 중심에서 주변지역으로 분산되면서 지역간 격차가 상대적으로 감소하는 경향을 확인하였다. 따라서 충청권의 도시 중심성은 기존 세력의 계속적 유지보다는 다양한 요인에 의한 장기적 변화와 지역 내 균형적 발전이 이루어질 가능성이 예상되었다. 본 연구에서 충청권의 중심성 변화에 대한 구체적인 요인을 분석하지 못하였으나, 다양한 광역 범위의 계획 수립 시 향후의 도시 세력 변화에 대한 예측이 기초자료로 유의미하게 사용될 수 있을 것으로 기대하였다. The purpose of this study is to analyze the current(2019) urban centrality and the expected changes in 2040 using traffic volume data of 36 cities in the Chungcheong region(Daejeon, Sejong, Chungbuk and Chungnam). The traffic volume data used for the analysis are commuting to work/school and shopping/leisure traffic data from the Korea Transport database(KTDB). The Bonacich power centrality analysis method was applied. The result of the analysis reveals that Daejeon currently has the highest centrality in the region, but in 2040, the centrality of Sejong will increase significantly and will have a similar hierarchy to Daejeon. In addition, as the current centrality was dispersed from Daejeon and Sejong to the surrounding cities, it was found that the regional gap decreased. Therefore, in the long term, the urban centrality of Chungcheong region is not maintained continuously, but is expected to be affected by various factors, and there is a possibility of balanced development in the region. Although this study could not analyze the specific factors that caused changes in the centrality of the region, it is expected that the predictors of future urban power change could be used as basic information when establishing various plans for metropolitan areas.

모바일 메신저 기반 인공지능 챗봇의 상품 주문결제 인터페이스 연구

최수민(Sumin Choi),최용순(Yongsoon Choi) 한국HCI학회 2017 한국HCI학회 학술대회 Vol.2017 No.2

최근 새로운 ICT 흐름으로 부상하고 있는 챗봇연구에 사회적 관심이 집중되고 있다. 본 연구에서는 인공지능 챗봇 서비스 중 현재까지 가장 많은 기업들이 공통적으로 제공하고 있으며 향후 특히 높은 수요가 예상되는 주문/결제 서비스에 초점을 맞추어 모바일메신저 플랫폼에 적합한 형태의 챗봇 주문/결제서비스의 효율적인 인터랙션 방식과 주요 인터페이스 요소들을 도출하고자 한다. 이를 위하여 한국, 미국, 중국의 주문 결제 챗봇 서비스를 제공하고 있는 모바일 메신저 플랫폼의 챗봇 인터페이스를 비교 분석하고, 서비스 프로세스에 따라 주요 요소들을 도출한 후 이를 토대로 사용자 조사와 전문가 인터뷰를 병행하였다.

해시 함수를 이용한 CAN 프레임 비트 위변조 방지 및 검증에 관한 연구

최수민(SuMin Choi),신용태(YongTae Shin) 한국정보과학회 2019 한국정보과학회 학술발표논문집 Vol.2019 No.6

Wi-Fi 채널 상태 정보 분산 수집을 통한 보행자 탐지 기법

최영진(Youngjin Choi),주수민(Sumin Joo),최정식(Jeongsik Choi) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.2