제2형 당뇨병 환자의 치료에서 복약순응도가 혈당 조절에 미치는 영향

김경선,김민정,박소현,박영주,허정순,이은경,김선영,이수형,김상수,강양호,손석만,김인주,김용기 한국병원약사회 2009 병원약사회지 Vol.26 No.2

Abstract: As known in clinical trial like DCCT, UKPDS, tight glycemic control is essential to prevent complications from diabetes mellitus(DM). In type 2 diabetes taking multiple medication, nonadherence to medications is common problem. The aim of our study is to investigate adher-ence rate of patients with type 2 DM and to evaluate association between many factors including adherence rate and HbA_(1C). 441 patients with type 2 DM who visited Busan National University Hospital endocrine internal department from Aug 13 to Sep 2, 2008(3weeks) were enrolled. We conducted a man-to-man questionnaire survey about general knowledge about diabetes mellitus, medicine and adherence, and measured HbA_(1C). Among them, 305 patients taking oral hypo-glycemic agent(OHA) were analyzed to investigate correlation between adherence rate and glycemic control. We studied 305 patients(male 126, female 179, average age 61.2±9.8 years, DM duration 8.6±6.4 years, average adherence 88.8±16.2%, average HbA_(1C) 7.03± 1.18%). HbA_(1C) showed significant relation with DM duration(r=0.137, p=0.017), number of aHA in regimen (r=0.135, p=0.018), dosage frequency(r=0.132, p=0.026), Medication Refill Adherence(MRA)(r=-0.124, p=0.030) and adherence(r=-0.168, p=0.003). Adherence had significant relation with MRA(r=0.148, p=0.010) but didn't have statical corelationship with DM duration, number of aHA and dosage frequency. Patients that their adherence rate exceed 90% took fewer OHA(p=0.011) and went on a better dietary treatment(p=0.007). In patients controlling diabetes mellitus with aHA, when adherence rate and MRA was higher, HbA_(1C) was lower. As a result, to improve adher-ence rate, it is necessary to enhance patient education, do careful consideration about prescrip-tion medicine number and dosage frequency

한국인에게서 그레이브스병 약물치료의 적정기간

이형숙,이동훈,정희선,이종우,김정은,신승수,정윤석,이관우,김현만 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.1

연구배경: 그레이브스병의 치료에는 항갑상선제, 수술 및 방사성 요오드법이 선택되어 사용되고 있다. 이중 항갑상선제는 가장 많이 선호되고 있으나 낮은 관해율과 높은 재발율로 장기간 치료기간이 요구된다. 저자들은 그레이브스병 환자에게서, 선택되는 치료법의 선호도와 각 치료법의 관해율을 조사하고자 본 연구를 시행하였다. 또한 본 연구에서는 항갑선제 치료의 적정기간을 평가하고자 하였다. 방법: 아주대학교병원에 내원한 환자 중 1년 이상 추적관찰이 가능한 205명의 그레이브스병 환자를 대상으로 조사하였다. 항갑상제군, 수술군 및 방사성 요오드군은 각각 170명, 29명 그리고 6명이었다. ROC curve를 이용하여 약물치료의 예후예측인자를 분석하였다. 결과: 1) 그레이브스병 환자의 치료 방법의 선택은 항갑상선제군, 수술군 및 방사성 요오드군 각각 170명(83.0%), 29명(14.1%) 그리고 6명(2.9%)으로 항갑상선제 치료가 가장 선호되었다. 2) 그레이브스병의 관해율은 항갑상선제군, 수술군 및 방사성 요오드군에서 각각 60.0%(102/170명), 96.5%(28/29명) 그리고 83.0%(5/6명)으로 수술군이 가장 높았다. 3) ROC curve의 AUC는 치료기간과 진단시 TBII가 각각 0.709 및 0.648이었고 적절한 약물투여 추적 관찰기간은 26개월이었다. 결론: 그레이브스병의 일차 치료법으로는 항갑상선제가 선호되고 있으나 수술 및 방사성 요오드 치료군에 비해 상대적으로 낮은 관해율을 보였다. 따라서 항갑상선제 치료로 26개월 이상 관해가 되지 않을 경우에는 치료 방법의 변경을 고려하는 것이 관해율을 높이는데 도움이 될 것으로 생각된다. Background: Graves' disease in an organ specific autoimmune disease. Three kinds of therapeutic modalities (antithyroid drugs, ablation with radioactive iodine and subtotal thyroidectomy) are frequently performed for the management of this disease. The most popular therapeutic policy for the disease in Korea is antithyroid treatment. We analysed and compared the remission rates of all three modalities for Graves' disease, and evaluated the antithyroid modality to determine the correct duration of treatment. Subjects & Methods : The medical records of 205 patients with Graves' disease were reviewed. For the evaluation of the antithyroid modality medical treatment, antithyroid drugs were administered for more than 1 year. The prognostic factors associated with remission were analysed by means of an ROC curve. Results: 1) Of the 205 patients, proportions that received medical therapy, subtotal thyroidectomy and radioiodine therapy were 83.0, 14.1 and 2.9%, respectively. 2) The remission rates of the medical therapy, surgery and radioiodine therapy were 60.0, 96.5 and 83.0%, respectively. 3) The remission rate of the medical therapy was associated with the duration of medication and TBII activity. The determined proper duration for the antithyroid treatment was 26 months from the ROC curve analysis. Conclusion: The above results suggest that the proper duration of antithyroid treatment for Graves' disease is 26 months, after which time the subtotal thyroidectomy or radioiodine therapy should be considered if the disease has not remitted (J Kor Soc Endocrinol 18:24∼31, 2003).

Self-Leveling재의 최적 결합재비 산정을 위한 기초적 연구

김진만,조성현,조헌영,한기석,서정목 공주대학교 방재연구센터 1998 공주대학교 방재연구센터 논문집 Vol.2 No.-

Self-leveling material is the floor finishing material that is able to make surface level by itself, it can go on a next construction in a short time. Self-leveling materials are composed of various binders and chemical additions, and it is difficult to catch suitable mixing proportion of composion materials. This study is to investigate and analyze consistency and strength properties of according to component ratio of main materials and we endeavor to get suitable mixing propertion of binders by experimental design and statistical analysis. The results of this study are showed that suitable mixing proportions of binders are OPC(Ordinary Portland Cement) 70~80%, AC(Alumina Cement) 5~10%, AG)Anhydrous Gypsum) 5~20%.

PM_(10) 개인노출과 공중이용시설내 농도에 관한 연구

김만구,정영림,임양석 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-

PM_(10) concentrations were measured measured in underfround stores located in 4 major cities, Chuchon, Wonju, Donghae and Sockcho, in Kangwon-Do using scattering light integrated type digital dust indicator. Personal exposure to PM_(10) for two women(housekeeper and granduate stuent) and a man(undergraduate student were measured also. The dimensional conversion factors for mass concentrations(K) showed some difference among underground stores which were 2.0,2.7,3.4,2.6㎍/㎥·CPM in chunchon, Wonju, Donghae and Sockcho, respectively. Average PM(10) concentrations at underground stores were 178㎍/㎥ in Chunchon, 141㎍/㎥ in Wonju, 125㎍/㎥ in Donghe and 59㎍/㎥ in Sockcho. The portion of PM_(10) in total suspended particles was about 50~60 % as weight. The exposure of graduate student, housekeeer and undergraduate to PM_(10) during 12 hours were 1004.3(㎍/㎥)·hr, 907.0(㎍/㎥)·hr and 691.2(㎍/㎥)·hr, respectively. Personal exposure to PM_(10) showed very different according to their activity parttern and they had more than 90% of their PM_(10) exposure at indoor envirnment.

직접전단시험에 의한 송이의 강도특성

남정만,이병걸,황한석 제주대학교 해양연구소 1997 해양자원연구소연구보고 Vol.21 No.-

Cheju island formed by volcanic activity which results many distribution of cindercone all over the island. Cindercone is composed of mainly scoria which is called "song-I" in Cheju dialect. The engineering properties of this scoria is completely different from granitic residual soils or sandy soils. Cheju island is being composed of mainly volcanic basalt. because of lack of quartzous sandy materials. Scoria is widely used as road foundation. aggregate for concrete and filler for retaining walls. Therefore scoria is studied on the behaviors of crushability strength. compactability and shearing strength. From this study, the variation of grain size, water content and the influence of shearing strengh due to compaction is observed and correlation of mechanical properties of decomposed granitic soil and scoria is made. The results of compacion test and direct shearing test are as follows (1) Scoria is vesicular perform high permeability accordingly and shows microcrytalline texture with fewer clay minerals while granitic weathered soil has granular texture of which feldspar produce abundant clay minerals by kaolitxation (2) The decompose granitic soils behave increment of density and decrement of optimum moisture content by increasing compaction energy. scoria shows increment of density but no variation in optimum moisture content is observed during the application of compaction energy. This indicates the higher ratio of micro vesicular in scoria. The void ratio after compaction is higher in scoria than decomposed granitic soils. (3) The crushing index is the highest in grain size of 0.1 - 0.5mm in decomposed granitic soil and constant increment of ratio is obseved in scoria. (4) At O.M.C state. the angle of internal fricion is increasing and cohesive index is decreasing due to increment of compaction energy while both angle of internal friction and cohesive index is decreasing due to the increasing simultaneously in scoria. The increment range of shear strength is higher in scoria than decomposed granitic soils. (5) In stress-strain curve this increment range of shearing strength of scoria is larger than granitic soil but the horizontal strain up to failure point is smaller.

발의 위치가 편마비 환자의 의자에서 일어서기에 미치는 영향

김종만,노정석 한국전문물리치료학회 1997 한국전문물리치료학회지 Vol.4 No.1

한국산 배의 Polyphenol 화합물군이 쥐의 면역기능에 미치는 영향

최희진,한호석,박정혜,배종호,우희섭,안봉전,배만종,김현구,최청 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.4

This study was conducted to investigate immunofunctional activity of the polyphenol fractions isolated from Korean pear. In the experimental of Rosette forming cell, the results showed that all the polyphenol fractions enhance the cell count compared with the control group. Especially polyphenol fraction II and III showed highly significant effect on Rosette forming cell, and allergy inhibition. After antigen challenge, histamine content of blood of the polyphenol groups was lowered to near the normal group.

전류 비유 모델에 의한 초등학생의 전류 개념 변화 분석

유병길,강인석,김병철,남만희,박선희,소하연,윤희정,이영아,이하룡,전병문,정승호 부산교육대학교 과학교육연구소 2000 科學敎育硏究 Vol.25 No.-

There exists a major impediment to learning electricity which may illuminate why direct presentation of scientists' ideas is too aggressive a strategy. This impediment lies in thinking that electricity is used up and in envisaging the light bulb as a consumer. This view is based on a powerful idea which summarises much of our experience; it declares that 'things get used up', 'you cannot get something for nothing', and 'intuitive thinking'. To replace this view with scientific view, we made the analogy model. It is suggested that the analogy model is more effective in teaching electricity circuits than conventional teaching method.

남자 고등학교 세팍타크로 경기의 공격기술에 관한 분석 연구

김영호,고문석,제임스전,이영익,차정훈,현종건,김범수,임종만,이석인 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

This research aims at analysis of attack technique in sepaktakraw games. For this purpose, 3 high school coaches observed and recorded each game Five times in videos of high school male players' thirty games in 2003. The conclusion from the analysis of the recorded data are as follows. 1. Scissors spike was the most popular (favorite) attack technique. Rolling spike, tapping spike and heading spike was popular in order. 2. Heading spike showed the highest success rate (73.5%) in attack technique. And tapping spike (69.5%), scissors spike (57.8%) and rolling spike (67.11) showed a lower success rate in order. In failure rate, heading spike (5.5%), tapping spike (36.5%), scissors spike (32.2%) and rolling spike (32.9%) had a higher percentage in order. 3. When receive was stable, the success rate in attach technique was 47.1%, the failure rate was 20.1%. On the other hand, when receive was unstable, the success rate in attach technique was 16.5%, the failure rate was 14.3%.

Alkali 감령처리된 Polyethylene Terepthalate Filament 직물에 나타난 흰얼룩의 원인분석

曺煥,李石榮,許萬宇,鄭元圭 嶺南大學校 工業技術硏究所 1983 연구보고 Vol.11 No.1

A study has been undertaken to know the reason why the white specks appear in the polyethylene terephthalate (PET) filament fabrics which were made alkali weight loss treatment in the dyeing and finishing factories of Taegu area. The results are as follows 1. Main component of the white spects in PET filament fabrics is CaCo₃. 2. The CaCO₃was extracted from the washing water and adhered to the PET filament fabrics during the dyeing and finishing process. 3. When PET filament fabrics were treated with hard water, the warp sizing agent did not dissolve to make specks on dyed fabrics. Then the insoluble sizing agent can not be got rid of by alkali treatment. 4. On account of using Na₂CO₃ in washing PET filament fabrics, white spects also can be appeared.