한국인 관상동맥의 변화양상에 대한 형태학적 연구

권태정,이상용,이한영,고영창,권기석,조재홍,김태공,김유훈,조갑래,서중석,이원태 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

전치부 개교합을 가진 골격성 제 Ⅲ급 부정교합 환자에 있어서 하악지 시상분할 골절단술후 술후 안정성에 관한 평가

임재석,권종진,장현석,손형민,남영원,최철민 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

The purpose of this study is to assess the postoperative stability and the tendency of relapse after both sagittal split ramus osteotomy in skeletal class III with anterior open bite. This retrospective study was based on the examination of 15 patients, 6 males and 9 females, with a mean age 23.1 years. The patients were divided into two groups based on the amount of preoperative overbite(group I:<1mm, group II:≥1mm). Serial lateral cephalometric radiographs were taken within 2 weeks preoperatively, within 1 week postoperatively and at a follow up period that ranged from 7 to 24 months postoperatively. All cephalometric radiographs were traced and digitized using the Quick ceph image Pro for analysis. And then, horizontal and vertical changes of reference points(B point, Pogonion, L1) were assessed by the linear measurements in millimeters on both axes. The results were as follows : 1 Mean horizontal relapses were 0.67±0.93mm (11%) at B point (P<.05) and 0.81±1.01mm (13.2 %) at Pogonion (P<.01). 2, Mean vertical relapses were 0.63±1.62mm (33.3%) at B point and 0.53±1.95mm (31.4%) at Pogonion (P>.05) 3. The mean angular change of occlusal plane to SN was 0.24±1.19 (P>.05) and that of mandibular plane to SN was 1.03±1.85 (P<.05). 4. There was correlation between the extent of preoperative overbite and the postsurgical relapse at B point and Pogonion. 5. There was no correlation between the amount of surgically produced horizontal movement and the postoperative horizontal relapse at B point.

심도자법으로 진단한 선천성 심질환

이재호,이양원,권오균,홍혜숙 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

Statistical analysis of the 172 congenital heart disease patients who had diagnosed by cardia catheterization and angiography in the Department of Pediatrics, Chungnam National University College of Medicine from Sept. 1982 to Nov. 1985 was performed. The annual numbers of cardiac catheterization is increased. The overall congenital heart disease is most common in less than 3 year age group (27.3%) and then, 4-6 year age group (22.1%), 7-9 year age group (22.1%), 10-12 year age group (17.4%) and 13-15 year age group (11.1%) in this order. The most, common congenital cardiac anomaly is VSD(40.3%), and the next are PDA(28.8%) ASD(11.0%) and TOF(10.7%). VSD is the most common disease in the below 3 year age group, and above 7 year age group and PDA is in the 4-6 year age group.

지속적 및 간헐적 가압력이 치주인대 배양세포의 Alkaline Phosphatase 활성도에 미치는 영향

성재현,경희문,배성민,권숙이 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.4

지속적 및 간헐적인 가압력이 배양치주인대 세포의 ALP활성도에 미치는 영향을 알아보기 위하여 치주인대세포를 24 well 배양접시에 배양한 후 밀생상태가 되었을 때, 세포배양기 속의 특수제작된 사각상자에 배양접시를 넣은 후 실험기간동안 300g/㎠의 압력을 10분간 가압시킨 후 10분간 가압이 중지되도록 한 간헐적 가압군, 그리고 압력을 가하지 않은 군을 대조군으로 하여 각각 실험 24시간, 72시간 후의 alkaline phosphatase의 활성도를 측정하여 다음과 같은 결과를 얻었다. 1. 가압 24시간 군에서는 간헐적 가압군이 대조군에 비하여 ALP활성도가 낮게 나타났다(p>0.05). 2. 가압 48시간 군에서는 실험군은 대조군에 비하여 ALP활성도에 유의한 차이는 나타나지 않았다. 3. 가압 72시간 군에서는 지속적 가압군이 대조군에 비하여 ALP활성도가 높게 나타났다(p>0.01). The purpose of this study was to evaluate the effect of cellular activity on PDL cells dependent on intermittent and continuous compressive force by determining the alkaline phosphatase activity. An intermittent and continuous compressive force were applied on PDL cells at the confluent stage. The alkaline phosphatase activity was measured on control and experimental groups every 24, 48, 72hours. The experimental group were consist of continuous and intermittent compressive group which were compressed by 300g/㎠ of diaphram pump. The intermittent compressive group was connected by timer which was worked on 10 minutes and off 10minutes. The results were as follows; 1. The alkaline Phosphatase activity of intermittent compressive group was lower than control at 24 hours(p>0.05). 2. The alkaline Phosphatase activity between each groups showed no significant differences at 48hours. 3. The alkaline Phosphatase activity of continuous compressive group was significantly higher than control group at 72 hours(p>0.01).

손상평가도를 이용한 용접구조물의 균열형 결함에 대한 사용적합성 평가

李精錫,朱章福,張宰溢,金禹植,고영대,權東一 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.10

Flaws nucleated during operation of structures such as nuclear power plants, petroleum facilities and gas equipment raise many safety problems, and thus the integrity assessment of crack-like flaws in structures has been very important. Since large-scale structures include weldments with complex micro-structures and inhomogeneous material properties, it is essential to consider both metallurgical and mechanical factors. In this study, a methodology for integrity assessment in welded structures was developed based on API 5L X65 grade natural gas pipeline (an approximately 2400 ㎞ pipeline in Korea). A failure assessment diagram(FAD), which includes all failure modes from linear elastic fracture to plastic collapse, was used for integrity and fitness-for-service(FFS) assessment of the pipeline. Since tensile properties and fracture toughness of base metal, weld metal and heat affected zone(HAZ) are required for the FAD, tensile tests and fracture toughness tests were performed on each region. In particular, the evaluation of representative properties of HAZ make it possible to assess FFS accurately by using the HAZ-based FAD when crack-like flaws exist in HAZ. This HAZ-based FAD is different from current codes, which assess integrity by the material properties of weld metal or base metal even when flaws exist in HAZ.

생물검정법을 이용한 하수슬러지 장기연용 토양의 독성평가

남재작,이승환,권순익,홍석영,임동규,고문환,송범헌 한국환경농학회 2004 한국환경농학회지 Vol.23 No.4

생물검정법에 의한 토양 내 독성평가의 유용성을 확인하기 위해 두 종류의 하수슬러지를 7년간 연용한 토양을 Microtox^(?) 생물검정법과 상추종자 뿌리 신장법을 사용하여 독성을 평가하였다. 이 방법들은 하수오니의 종류나 시용량에 따른 토양의 독성 정도를 잘 평가 할 수 있었다. 상추종자 뿌리 신장법은 특별한 장비나 복잡한 처리 없이도 유의성 있는 결과를 구할 수 있었고 Microtox^(?) 검정법은 전반적으로 재현성과 감도에서 유의성이 있었으며 또한 유기화합물에 대한 종합적인 평가도 가능하였다. 하수오니와 같이 다양한 화합물이 혼재되어 있는 유기성 자원의 토양 시용시 기존의 제한된 화학성분의 토양 분석법만으로는 독성평가에 한계가 있고 또 개별적으로는 별 영향이 없더라도 여러 화합물이 복합적으로 존재할 때 나타나는 독성작용에 대한 평가는 더욱이 어렵다. 그러므로 이러한 영향을 종합적으로 평가할 수 있는 생물검정법이 토양의 독성 평가에서 화학분석법을 보완하는 평가방법으로서의 중요성은 충분하다고 할 수 있다. 그리고 생물독성법의 유용성을 높이기 위해서는 생물검정법의 시료 추출방법 개선과 실험의 재현성을 높이기 위한 노력이 필요하리라 생각된다. 따라서 이런 생물검정법의 많은 제약에도 불구하고 환경의 종합적인 평가에 있어서 생물검정법의 중요성은 대단히 크며 직접적으로 생물을 이용하는 방법뿐만 아니라 유전독성 평가 방법 등 다양한 방법들이 환경독성 평가에 응용될 수 있을 것으로 판단된다. Bioassay was employed to assess toxicity of soil which had been treated with sewage sludges for seven years. The Microtox^(?) and root elongation test of lettuce (Lactuca Saliva) elucidated that the intensity of soil toxicity was closely related with the types and amount of sewage sludges applied. Both bioassay methods proved to be useful in an assessment of soil toxicity and were consistent to some extent with the conventional chemical analysis methods. EC_(50) values resulted from Microtox^(?) were highly correlated with concentration of heavy metals in soils amended with sewage sludges : Cu (r²= 0.86^(**)), Cr (r²= 0.84^(**)), Ni (r²= 0.83^(**)), and Zn (r²= 0.69^(**)). This demonstrated that both bioassay techniques could be employed as tools for soil toxicity assessment when the soil was exposed to solid wastes such as sewage sludge.

마우스의 BCG감염이 R.tsutsugamushi의 증식에 미치는 영향

김인재,전창덕,홍영권,정현택,이복수,장우현,김익상,박석돈 대한감염학회 1993 감염 Vol.25 No.2

It has recently been reported that gamma-inteferon(INF-r) and tumor necrosis factor(TNF) or lipopplysaccharide(LPS) activate macrophages to kill intracellular parasites by means of nitrc oxide (NO). It is now generally accepted that NO is the endothelium-derived relaxing factor, and that it also paticipates in the regulation of the nervous and immune systems. Activated macrophages form NO?? and NO?? from the terminal guanidino nitrogen atoms of L-arginine by the process now known to proceed via the formation of NO. This pathway is inhibited by the L-arginine analog(N?? monomethyl-L-arginine; N??MMA), forms L-citrulline as a co-product and is responsible for the cytotoxic action of macrophages. In this study, the authors found that INF-r and/or LPS induced murine macrophages to kill Rickettsiae tsutsugamushi in vitro and macrophages from BCG-infected mice got the host resistance against R.tsutsugamushi in vitro as well as in vivo. The rickettsicidal effect induced by the combination of INF-r and/or LPS induced mice got the host resistance against R.tsutsugamushi in vitro as well as in vivo. The rickettsicidal effect induced by the combination of INF-r and/or LPS can also be completely inhibited by N??MMA, leading to a dose-dependent inhibition of NO production. These datademonstrate that INF-r and/or LPS as well as BCG-activated macrophages mediate host resistance aganist R.tsutsugamushi infection through NO, which is necessary for the intracellular parasite.

유년기 안구적출술 및 방사선치료로 인하여 발생된 안와 열성장에 대한 재건 치험례

홍관석,김성문,김훈,임재석,최미숙,최성원,권종진 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.1

There are many reports of the surgical management for the craniofacial abnormalities arising from the irradiation of the head and face for treatment of childhood cancers. Since the mordern combined-modality theraphy for childhood cancers began in the late 1960s and the early 1970s, recent reports have described the occular, dental and maxillo-facial abnormalities after irradiation in long-term survivors of cancers of the head and face. The resultant deformities may be known to be difficult to reconstruct with surgical techniques. This paper describes the late reconstructive surgery for the unilateral orbital and malar hypoplasia after eyeball enucleation and irradiation during childhood to correct the facial asymmetry and expand the contracted orbital socket into the functional dimension for the retaining eyeball prosthesis with spherical implant. We reports the satisfactory preliminary results from the midfacial osteotomy through the supero-lateral orbital rim and malar bone and the antero-lateral repositioning with the autogenous bone grafting in 26 year-old female patient who will be planned to make the new eyeball prosthesis by the department of ophthalmology.

뉴턴 운동법칙에 관한 문제에서 갈등상황의 유형이 학생들의 인지적 갈등 유발에 미치는 영향

임이숙,이영직,권재술 한국교원대학교 과학교육연구소 1998 청람과학교육연구논총 Vol.8 No.1

학생들의 개념변화를 위해서는 갈등상황을 제시하여야 한다고 여러 연구자들이 주장하였다. 본 연구에서는 뉴턴 운동법칙에 관한 문제에서 갈등상황을 제시하여 그 유형이 학생들이 인지적 갈등 유발에 미치는 영향을 알아보고자 하였다. 연구 대상은 읍소재지의 남자 고등학교 1학년으로 사전검사를 통하여 연구 목적에 합당한 34명을 선발하였다. 본 연구에서는 여러 가지 갈등상황의 유형 중 시범 기구로 ‘현상’을 직접 보여주거나 논리적인 ‘논증’을 제시하는 두 가지 갈등상황을 이용하였다. 인지적 갈등 정도는 본 연구에서 개발한 준거에 따라 4단계의 Likert 척도로 연구자 외 2인이 면담에 함께 참여하여 판정하였다. 연구 결과는, 정확하고 눈금이나 수치로 나타나는 ‘현상’이 효과적이며 외부변인이 개입된 현상은 학생의 주의를 오도하므로 갈등유발이 어려웠다. ‘논리’를 제시할 때, 오개념을 가진 학생은 과학적 논리에 대면하여 갈등을 회피하며 오히려 다른 오개념의 논리에 의하여 갈등유발이 잘되었다. 과학적 개념을 가지고 있는 학생은 논리제시로써 갈등을 유발하기 어려웠다. ‘현상’을 제시할 때와 ‘논리’를 제시할 때, 유발된 갈등을 비교해 보면 ‘논리’보다는 ‘현상’이 효과적이었다. 따라서 학생들의 개념변화를 위해서는 직접 현상을 보여주는 인지적 갈등 전략이 바람직하며 이 때 제시되는 현상은 정확하고 분명한 것이 효과적이라 하겠다. A learner's cognitive conflict with his/her existing conception is regarded to be one of the most important factors for a conceptual change. In this study, the effects of the conflict situation types on inducing students' cognitive conflicts in Newton's law were examined. The thirty-four students of 10th grade were selected from a rural high school based on the result of pre-test. The two different types of conflict situations among many possible types were used in this study. One type was using logical conflict situation and the other was demonstrating real conflict situation. The levels of cognitive conflict were measured by 4-point Likert scale by three interviewers. As the results, the demonstration method was more effective than the logical argument method. In case of the logical argument method, rather than showing scientific conceptions, suggesting another misconception was more effective to the students who have misconception. However, logical argument method was not effective to those who have scientfic conceptions. To the students who have unscientific conceptions, the demonstration method was very effective for inducing cognitive conflict. From the results of this study, demonstration method of teaching seems to be very effective for inducing students' cognitive conflict and overcoming their misconceptions on scientific concept.

임프란트 식립을 위한 상악동 거상술의 임상적 연구

임재석,권종진,장현석,이성재,이부규 大韓顎顔面成形再建外科學會 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.4

A variety of materials and procedures such as sinus floor elevation, sinus-lift graft, inlay bone graft using Le Fort I osteotomy, and onlay graft have been used to create adequate bone volume in the maxillary sinus for placement of endosseous implants in the posterior atrophic maxilla. Because of the frequent lack of bone in the posterior maxilla, sinus lift procedure has become a commonly practiced treatment modality. The 138 endosseous implants of 36 patients with sinus augmentation procedures performed in Korea University Hospital from January 1991 to December 1998 were summarized and analysed. The result of this study were as follows : 1. Age ranged from 39 to 57, with a mean of 50.7. 2. The mean survival rate for 138 implants with maxillary sinus lift procedure was 80.4%. 3. There was no corelationship between the fixture length, width and the survival rate. 4. The result showed that the healing period for 8-12 months was necessary if the residual alveolar bone height was less than 5mm. 5. Autogenous iliac corticocancellous block graft showed the most favorable survival rate(95%).