In vivo screening platform for Shiga Toxin-Producing Escherichia coli (STEC) using Caenorhabditis elegans Model

Subin Hwang,Jung-Gu Choi,Shuai Wei,Ramachandran Chelliah,Byung-Jae Park,Deog-Hwan Oh 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

Renal artery stenosis presenting with nephrotic-range proteinuria: a case report

( Subin Hwang ),( Jun Soo Ham ),( Keum Bit Hwang ),( Suk Hyeon Jeong ),( Sung Hae Ha ),( Eun Hee Koo ),( Ghee Young Kwon ),( Young Soo Do ),( Hye Ryoun Jang ) 대한신장학회 2016 Kidney Research and Clinical Practice Vol.35 No.2

Renal artery stenosis (RAS) is commonly presented with hypertension and chronic kidney disease. We report a rare case of RAS occurring in a 78-year-old man who presented with nephrotic-range proteinuria. Renal biopsy on the left side was performed, and results showed mesangiopathic glomerulonephritis, which was not compatible with the cause of nephrotic-range proteinuria. Proteinuria was decreased by angiotensin receptor blocker, but azotemia was aggravated. Therefore, angiotensin receptor blocker was discontinued inevitably and thorough evaluation for the possibility of RAS was performed. Computed tomography angiography revealed significant RAS on the left side and a renal artery stent was inserted. After stenting, aortic dissection developed and progressed despite tight control of blood pressure. After inserting another stent graft through the true lumen of the left renal artery, the patient``s renal function and proteinuria improved markedly.

Impact of the Early COVID-19 Pandemic on Suicide Attempts and Suicide Deaths in South Korea, 2016–2020: An Interrupted Time Series Analysis

Subin Kim,Min Ho An,Dong Yun Lee,Min-Gyu Kim,Gyubeom Hwang,Yunjung Heo,Seng Chan You 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.9

Objective This study aimed to investigate the impact of coronavirus disease-2019 (COVID-19) on suicide attempts and suicide deaths in South Korea, focusing on age and sex differences. Methods We analyzed the monthly number of suicide attempts and suicide deaths during pre-pandemic (January 2016–February 2020) and pandemic (March–December 2020) periods using nationally representative databases. We conducted an interrupted time series analysis and calculated the relative risk (RR) with a 95% confidence interval (CI), categorizing subjects into adolescents (<18), young adults (18–29), middle-aged (30–59), and older adults (≥60). Results During the pandemic, the number of suicide attempts abruptly declined in adolescents (RR [95% CI] level change: 0.58 [0.45–0.75]) and older adults (RR [95% CI] level change: 0.74 [0.66–0.84]). In older males, there was a significant rebound in the suicide attempt trend (RR [95% CI] slope change: 1.03 [1.01–1.05]). The number of suicide deaths did not change among age/sex strata significantly except for older males. There was a brief decline in suicide deaths in older males, while the trend showed a following increase with marginal significance (RR [95% CI] level change: 0.76 [0.66–0.88], slope change: 1.02 [1.00–1.04]). Conclusion This study suggests the heterogeneous impact of the COVID-19 pandemic on suicide attempts and suicide deaths across age and sex strata in South Korea. These findings highlight the need for more targeted mental health interventions, given the observed trends in suicide attempts and suicide deaths during the pandemic. Psychiatry Investig 2024;21(9):1007-1015

Role of Graphene in Reducing Fatigue Damage in Cu/Gr Nanolayered Composite

Hwang, Byungil,Kim, Wonsik,Kim, Jaemin,Lee, Subin,Lim, Seoyoen,Kim, Sangmin,Oh, Sang Ho,Ryu, Seunghwa,Han, Seung Min American Chemical Society 2017 NANO LETTERS Vol.17 No.8

<P>Nanoscale metal/graphene nanolayered composite is known to have ultrahigh strength as the graphene effectively blocks dislocations from penetrating through the metal/graphene interface. The same graphene interface, which has a strong sp2 bonding, can simultaneously serve as an effective interface for deflecting the fatigue cracks that are generated under cyclic bendings. In this study, Cu/Gr composite with repeat layer spacing of 100 nm was tested for bending fatigue at 1.6% and 3.1% strain up to 1,000,000 cycles that showed for the first time a 5-6 times enhancement in fatigue resistance compared to the conventional Cu thin film. Fatigue cracks that are generated within the Cu layer were stopped by the graphene interface, which are evidenced by cross-sectional scanning electron microscopy and transmission electron microscopy images. Molecular dynamics simulations for uniaxial tension of Cu/Gr showed limited accumulation of dislocations at the film/substrate interface, which makes the fatigue crack formation and propagation through thickness of the film difficult in this materials system.</P>

Effect of surface energy on size-dependent deformation twinning of defect-free Au nanowires

Hwang, Byungil,Kang, Mijeong,Lee, Subin,Weinberger, Christopher R.,Loya, Phillip,Lou, Jun,Oh, Sang Ho,Kim, Bongsoo,Han, Seung Min The Royal Society of Chemistry 2015 Nanoscale Vol.7 No.38

<P>In this study, we report the size-dependent transition of deformation twinning studied using<I>in situ</I>SEM/TEM tensile testing of defect-free [110] Au nanowires/ribbons with controlled geometry. The critical dimension below which the ordinary plasticity transits to deformation twinning is experimentally determined to be ∼170 nm for Au nanowires with equilateral cross-sections. Nanoribbons with a fixed thickness but increased width-to-thickness ratios (9 : 1) were also studied to show that an increase in the surface energy due to the crystal re-orientation suppresses the deformation twinning. Molecular dynamics simulations confirmed that the transition from partial dislocation mediated plasticity to perfect dislocation plasticity with increase in the width-to-thickness ratio is due to the effect of the surface energy.</P>

Alleviation Effect of Salvia plebeia R. Br. Water Extract on Non-Alcoholic Fatty Liver Disease

Subin Bae,Shintae Kim,Suhyun Hwang,Jeongjin Park,Yongjae Kim,Yoo-Hyun Lee,Woojin Jun 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Non-alcoholic fatty liver disease (NAFLD) is accompanied by an lipid accumulation and increase in oxidative stress caused by increase in reactive oxygen species (ROS). This study was designed to investigate alleviation effect of Salvia plevia R. Br. water extract (SPW) on NAFLD. HepG2 cells were pre-treated with 1 mM free fatty acids mixture (2:1 ratio of oleate : palmitate) for 24 h to induce lipid accumulation. As measured by Oil Red O and AdipoRed reagant, FFA groups increased intracellular lipid accumulation, whereas SPW groups significantly decreased. Also, the mRNA expression level of SREBP-1c was down-regulated in the SPW groups. On the other hand, the mRNA expression level of AMPK, PPARα, CPT-1 were up-regulated in the SPW groups. In addition, oxidative stress were increased by FFA, but treatment with SPW significantly decreased these levels. These results will provide that SPW ameliorate NAFLD by inhibition of lipid accumulation and reduction of oxidative stress.

Phlomis umbrosa Turcz. Water Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cell

Suhyun Hwang,Subin Bae,Shintae Kim,Jeongjin Park,Yoo-Hyun Lee,Woojin Jun 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Non-alcholic fatty liver disease (NAFLD) is a disorder characterized by excessive accumulation of lipids in the liver without alcohol consumption. It is considered to be exacerbated from simple steatosis to fibrosis by many factors including oxidative stress, lipotoxicity, and insulin resistance. Phlomis umbrosa TURCZ. (PU) was proved their biological activities such as antioxidant, anti-inflammatory, anti-viral, and anti-osteoporosis. However, the mechanism and effect on hepatic steatosis has not been elucidated. The aim of this study is that investigated the potential of water extracts of PU (PUW) to modulate lipid accumulation and oxidative stress in NAFLD. The antioxidant activities of the PUW was measured by total phenolic compounds, flavonoid contents, DPPH, and ABTS radical scavenging activities. As a result of examining the degree of lipid accumulation in HepG2 cells induced by free fatty acids through AdipoRed, the PUW treatment group showed a significant decrease. It is thought that PUW may improve NAFLD by increasing antioxidant activity and reducing lipid accumulation.

카카오톡 이모티콘 카테고리 중심의 공감성에 대한 선호도 분석

김수빈 ( Subin Kim ),황중환 ( Joonghwan Hwang ) 사단법인 아시아문화학술원 2020 인문사회 21 Vol.11 No.5

본 논문은 이모티콘이 가진 소통의 장점을 유용하게 하고자, 이모티콘이 가진 공감성에 대한 호응도를 알아보고 이를 분석하는 것에 목적이 있다. 현재 국내에서 이모티콘 시장의 규모가 가장 큰 카카오톡 이모티콘을 중심으로, 이후 이모티콘 개발의 쉬운 접근성을 위해 선호도가 높은 카테고리를 선정하여 분석하였다. 카카오톡 이용자 1,000명을 대상으로 각각의 이모티콘 카테고리에 대한 설문 조사를 진행하였다. 본 연구 결과 카테고리 중 공감성을 끌어내기 유용한 주제는 ‘재미있는’과 ‘귀여운’이 압도적으로 높았다. ‘메시지’와 ‘주제별’은 특색이 없고, 단체에서 사용하는 이모티콘이라는 점에서 선호도가 낮았다. 이는 현대사회의 개성과 개인 대한 공감성의 결과라 보았다. 제한으로는 하나, 연령대별 세부조사가 필요하다. 둘, 성별에 따른 이모티콘의 보편적인 세부조사 역시 필요하다. 이모티콘은 공감과 소통의 요소가 특징적인 콘텐츠이다. 이러한 요소를 다루기 위해 더욱 세부적인 연구를 지속하여야 할 것이다. The purpose of this paper is to find and analyze the relationship between emoticons and empathy in order to make the merits of communication with emoticons useful. Currently, KakaoTalk emoticons, the largest emoticon market in Korea, have been selected and analyzed in a category with high preference so that the development of emoticons can be easily accessed. We surveyed 1,000 KakaoTalk users by emoticon category. As a result of this study, ‘fun’ and ‘cute’ were overwhelmingly high among the useful categories to elicit empathy. ‘Message’ and’By Subject’ had no characteristics, and their preference was low in that they were emoticons used by the group. This has been seen in modern society as a result of personal character and empathy. There is one limitation, but a detailed investigation by age is required. Second, a detailed survey of emoticons by gender is also necessary. Emoticons are content characterized by elements of empathy and communication. Further research needs to be continued to address these factors.

지역정신보건센터의 균형성과관리시스템 구축

박수빈(Subin Park),홍진표(Jin Pyo Hong),용효중(Hyo Joong Yong),정희(Hee Jung),이은정(Eun Jung Lee),황윤정(Yun Jeong Hwang),박연옥(Yeon Ok Park),류진(Jin Ryu),이영(Young Lee) 대한사회정신의학회 2009 사회정신의학 Vol.14 No.1

연구목적: 최근 다양한 관점에서 성과를 설계하고, 조직전체의 성과를 강조하고, 성과에 의한 모니터링과 사후조치를 강화한 전략적 성과관리체계인 균형성과관리제(Balanced Scorecard, BSC)의 공공부문에 도입이 확대되어왔다. 본 연구에서는 지역정신보건센터 중 최초로 BSC를 도입한 강동구 정신보건센터의 BSC구축과정을 소개하고자 한다. 방 법: 강동구 정신보건센터 는 2008년 8월 BSC를 도입하기로 결정한 후, 전문가의 자문을 받으면서 조직구성원 전체가 참여하여 2008년 12월 강동구 정신보건센터 BSC를 구축하였다. 결 과: 강동구 정신보건센터는 '안전하면서도 역동적인 정신건강 네트워크를 통해, 지역주민들의 니즈(욕구)에 맞춤화된 최적의 정신 건강서비스를 제공함으로써, 지역주민들이 정신장애에 대한 편견 없이 함께 어울려 사는 삶' 이라는 비전 아래, 시민, 프로세스, 학습 및 성장 관점에서 전략목표를 수립하고 전략지도를 도출하였으며, 각각의 전략목표에 대한 성과목표 및 성과지표를 개발하 였다. 강동구정신보건센터 BSC의 특징과 의미는 다음과 같이 함축된다. 첫째, 강동구 정신보건센터 BSC 구축은 지역정신보건 사업의 성과를 다양하고 균형적인 관점에서 평가하고 관리하고자 한 최초의 시도이다. 둘째, 강동구 정신보건센터의 BSC 구축은 정신보건센터가 행정기관에 의해 수동적으로 업무평가를 받는 대상으로 머물지 않고, 능동적인 사업의 주체가 되겠다는 의지를 드러낸다. 셋째, 강동구정신보건센터의 BSC는 외부 용역에 의해 구축된 것이 아니라 조직구성원 전체의 참여에 의해 구축되 었다. 넷째, BSC구축 과정 동안 지속적으로 외부전문가의 자문을 받으면서 진행함으로써 내외부 시각의 균형을 담은 BSC체계를 구축할 수 있었다. 결 론: 본 연구는 지역정신보건센터에서 BSC를 도입한 최초의 연구로써, 정신보건센터나 관련시설에서 BSC를 도입하고자 할 때 유용한 정보로 활용될 수 있을 것이다.

GPR(Ground Penetrating Radar)을 활용한 지반 탐사 데이터의 필터링 기법 개발

임수빈(Subin Lim),전희망(Heemang Jun),정회광(Hoekwang Jung),황장원(Jangwon Hwang) 대한지질학회 2018 대한지질학회 학술대회 Vol.2018 No.10