복합운동 프로그램이 비만여성의 신체조성과 식욕조절 호르몬에 미치는 영향

김수민,김병완,송영은 대전대학교 기초과학연구소 2016 自然科學 Vol.30 No.-

The purpose of this study is to identify effects of 12 weeks walking-resistance exercise and running-resistance exercise on body composition and appetite regulating hormones. Participants consist of 17 overweight women who are 40's and have higher than 30% of the percentage body fat. They are randomly divided into two groups; Walking and Resistance Group (WRG, n=9) and Running and Resistance Group (RRG, n=8). For the walking group, exercise intensity of walking is gradually increased by 50%-70% every 4 weeks. There are 4 exercise sessions a week. On the other hand, there are 4 exercise sessions provided for the running group. Each session lasts for 30 minutes. The exercise is performed with intensity of 60% HRmax, (from 1st to 4th week), 70% HRmax (from 5th to 8th week) and 75% HRmax (from 9th to 12th week). The common resistance exercises provided to both groups are Bench press, Lat pull-down, Leg extension, Triceps extension, Leg curl, Biceps curl, Calf raises and Sit-up, which are performed with 60-70% of 1RM. First, for the body composition, it is found that weight, BMI and percentage body fat of the WR group and the RR group are significantly decreased during the exercise period. Second, for appetite regulating hormones, leptin in both groups shows statistically significant decrease while ghrelin is significantly increased. According to the results of 12 weeks duration combined exercise for the Walking and Resistance Group and the Running and Resistance Group, it is shown that body composition has been positively changed and appetite regulating hormone are improved. Therefore, this study concludes that the combined exercise is effective to treatment of obesity.

결핵성 경부임파선염의 전산화 단층촬영 소견

송창준,정연수,최창락,윤완규,조준식 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Purpose : To evaluate the computed tomography (CT) findings of the cervical tuberculous lymphadenitis Methods and materials : The CT features in 10 patients of tuberculous lymphadenitis were retrospectively reviewed. We characterized the morphologic appearances of lymphadenopathy on post-contrast CT scan and comparatively evaluated the densities of central necrotic portion and peripheral solid portion of necrotic nodes on pre-contrast CT scan. All examines were performed on a General Electric Hispeed Advantage RP System. Ten millimeter and five millimeter contiguous sections from skull base to thoracic inlet were obtained for the pre-contrast and post-contrast images respectively. Results : Most patients were young adults. A painless neck mass was the most common chief complaint and the duration of the symptoms was about 5 months. The average number of diseased lymph nodes was 3.7. Unilateral involvement was 4 times as common as bilateral location. Central necrotic lymphadenopathy was 78.3% of 37 enlarged lymph nodes and the density of the nerotic portion was isodense to the density of the peripheral wall on pre-contrast images in 71.4% of necrotic lymph nodes. The most common morphologic features of cervical tuberculous lymphadenitis was the type of a multichambered or conglomerated necrotic lymphadenopathy with a peripheral irregular enhancement. Conclusion : The tuberculous cervical lymphadenitis was highly suggestive when the diseased lymph nodes show the central necrosis, the morphologic features of multichambered or conglomerated necrotic lymphadenopathy with a strong peripheral irregular contrast enhancement, and necrotic materails isodense to peripheral solid portion on pre-contrast CT scan in young adult patients who complain of a painless neck mass.

국내 호중구감소성 발열 환자에게 경험적 항진균제로 투여한 Amphotericin B deoxycholate와 Itraconazole 주사제의 비용-확인분석 : 예비보고

이동건,송영구,유진홍,최수미,최정현,박선희,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

목적 : 진균감염이 점차 증가되고 있고 이를 치료하기 위한 비용 역시 증가하고 있지만 국내에서는 비용분석에 대한 연구가 거의 없는 실정이다. 본 연구에서는 호중구감소성 발열 환자에게 경험적 항진균제로 amphotericin B deoxycholate (ABV)혹은 정맥내 itraconazole (ITZA)을 투여할 때의 약물경제학적 측면을 후향적으로 비교해보고자 하였다. 재료 및 방법 : 같은 반응률을 보인다고 가정한 비용-확인분석 모델을 이용하여 가톨릭대학교 조혈모세포이식센터에서 혈액종양으로 항암치료 혹은 조혈모세포이식을 시행한 환자를 대상으로 자료를 수집하였다. 항진균제 투여에 대한 정보는 기존에 출판된 논문 및 학회 심포지움자료를 참고하였고, 논문에서 얻지 못한 정보는 가톨릭대학교 성모병원 의무기록실, 정보지원팀, 진료비관리팀의 협조를 받아 2003년 6월 1일부터 11월 30일까지의 자료를 분석하였다. ITZA에 대한 자료는 2003년 11월 제한적으로 1차 약제로 사용할 수 있게 되었던 때의 자료와 경험을 참조하였다. 결과 : 320명의 환자 중 149명(46.5%)에서 경험적 항진균제를 사용하였고 평균 투여일수는 ABV 17.0일, ITZA 9.8일이었다. 이상반응 발현율은 ABV 54%, ITZA 5%였다. ABV 투여환자 중 11명 (7.4%)에서 혈액투석을 평균 6.5일간 시행하였다. ITZA 투여시 간독성으로 혈장분리반출술, 인공간 등이 필요한 경우는 없었다. 경험적 항진균제를 ABV로 시작한 군(ABV군)은 1인당 1,229,495원, ITZA로 시작한 군(ITZA군)은 1인당 1,434,605원이 소요되어 ITZA군에서 205,110원 (16.7%)이 더 소요되었다. 평균 16일간 항진균제를 사용하여 1일 12,819.4원의 차이가 있었다. 결론 : 비용-확인 분석법에서 ITZA군이 ABV군 비해 하루 12,819.4원의 비용이 더 소요되었다. 비록 ITZA군에서 비용이 더 들었지만 1일 약가차이인 4.7배와 비교하여 많이 감소하여 항진균제의 비용을 1일 약가로 비교하는 것보다는 재원일수, 이상반응 발현율 등을 고려하는 총입원비용으로 약물경제학을 비교하는 것이 더 합당할 것으로 사료된다. 그 외에 환자의 예후, 삶의 질, 사회적 간접비용 등을 고려하는 전체적인 약물경제학을 비교하는 잘 계획된 전향적 연구가 추가로 필요하겠다. Background : The increasing incidence of systemic fungal infections and the rising medical cost have focused the need to determine the economic issues of antifungal agents. Nevertheless there have been only few reports about the cost analysis in Korea. We retrospectively investigated to compare the pharmacoeconomic aspects of amphotericin B deoxycholate (ABV) with those of intravenous itraconazole (ITZA) in the empirical treatment of febrile neutropenic patients. Materials and Methods : Through the cost-identification analysis model, on the presumption that two groups would show identical response, we collected data of patients who received hematopoietic stem cell transplantation (HSCT) or chemotherapy in Catholic HSCT center from Jun 1, 2003 to Nov 30, 2003. The literatures about information on antifungal therapy were extensively reviewed. Other unpublished information was provided by information assistant team, cost management team, and medical record unit in the same hospital. Results : Empirical antifungals were given to 149 out of 320 patients (46.5%). The average duration of administration were 17.0 days for ABV and 9.8 days for ITZA. The rates of adverse events were 54% and 5% for ABV and ITZA, respectively. Eleven (7.4%) patients given ABV received hemodialysis for 6.5 days in average. Among patients given ITZA, none developed hepatotoxicity requiring plasmapheresis or artificial liver. It cost 1,229,495 won/patient for the ABV group (starting ABV as empirical antifungal agent) and 1,434,605 won/patient for the ITZA group (starting ITZA as empirical antifungal agent) which was 16.7% more expensive than ABV group. When we compare the average daily cost for 16 days, the ITZA group spent 12,819.4 won/patient/day more than the ABV group. Conclusion : The cost-identification model in this study revealed that ITZA group cost more than ABV group. However, the difference in expense decreased when 1 day-cost was compared (4.7 times greater than ABV). It would be more reasonable to consider the total cost of anti-fungals during the hospitalization rather than 1 day cost in considering pharmacoeconomics. Well designed prospective study considering prognosis of patients, quality of life, and indirect social cost should be warranted.

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

저독성 난연제를 첨가한 에폭시 수지의 경화 동력학 및 유변학적 특성

박수진,송수완,이재락,민병각,신재섭 한국공업화학회 2004 공업화학 Vol.15 No.1

본 실험에서는 2관능성 에폭시 수지(EP)에 저독성 난연제인 tris (chloroisopropyl) phosphate (TCPP) 를 100:0~100:40 phr의 비율로 첨가한 후 이에 따른 경화 동력학과 유변학적 특성을 고찰하였다. 2EP/TCPP 시스템의 경화 활성화 에너지(E_(a))와 진화량(α)은 동적 DSC를 통하여 알아 보았으며, 유변학적 특성은 레오미터를 이용하여 등온 조건하에서 고찰하였다. 또한, 난연성 test인 UL94를 통하여 TCPP 함량에 따른 난연성의 변화를 살펴보았다. 실험 결과, E_(a)는 에폭시 수지 내에 TCPP의 함량이 증가할수록 증가하는 반면, 전화량(α)과 전환속도(d/dt)는 감소하는 경향을 나타내었다. 가교 활성화 에너지(E_(c)) 값은 구한 E_(a) 값과 유사한 경향을 나타내었으며, 이러한 결과는 TCPP의 증가로 인해 2EP 고유의 interpenetrating polymer network (IPN) 구조형성이 방해받기 때문이라 판단된다. 또한, TCPP의 함량이 30 phr 이상인 경우 난연성이 향상되었는데, 이는 TCPP 내의 난연성을 갖는 인과 염소의 영향으로 판단된다. In this work. the cure kinetics and rheological properties of difunctional epoxy (2EP) resins containing a low toxicity flame-retardant based on tris(chloroisopropyl) phosphate (TCPP) are investigated. The 2EP/TCPP content was varied within 100 : 0 ∼100 : 40 phr. The cure system are studied under the isothermal condition using a rheometer, Also, the flame resistance is determined by UL94 vertical test. From experimental results, the Ea of 2EP/TCPP system is higher than that of pure 2EP. While, the conversion (α1 and conversion rate (d/dt) are decreased with increasing of the TCPP content. The cross-linking activation energy (E_(e)) of the system is similar to (E_(a)). This is probably due to the increase of TCPP content. which obstructs the formation of interpenetrating polymer network (IPN) structure of the 2EP. Also, the improvement of flame resistance is achieved by addition of 30 phr TCPP in the 2EP/TCPP system. which can be attributed to the existence of incombustible phosphorous and chlorines in the TCPP.

농업인 평생학습체계 구축을 위한 농업인교육 발전방안 연구

정철영,송병국,김진모,문택석,허영준,주대진,최수정,한승완 한국농업교육학회 2008 농업교육과 인적자원개발 Vol.40 No.2

이 연구의 목적은 우리나라 농업인의 평생학습체계 구축을 위한 농촌진흥기관의 역할을 정립하고, 한국농업대학의 농업인대학 운영 본부화 방안을 수립하는데 있다. 이를 위해 관련 문헌고찰, 농업인 및 농촌진흥기관의 농업인 교육 담당자들의 인식 및 요구분석, 전문가 자문 및 협의회 등의 방법을 활용하였으며, 이를 토대로 도출된 연구의 결과를 제시하면 다음과 같다. 첫째, 농촌진흥기관의 농업인교육관련 연계를 위해서는 한국농업대학이 농업인평생교육기관으로 평가인정을 받고, 전국의 농업인대학을 총체적으로 지원하는 역할을 수행하는 것이 바람직하다. 이때 지역의 농업기술센터는 한국농업대학과 협력적 관계를 구축하여 학점은행제 운영에 소요되는 교육 및 이력관리를 지원하는 역할을 수행하는 것이 필요하다. 둘째, 한국농업대학의 농업인대학 운영본부화를 위하여 평생학습원의 조직이 추가되는 것이 바람직하다. 이에 따라 평생학습원의 비전, 미션 및 전략이 제시되었으며, 조직의 기능 및 세부과제가 제시되었다. 셋째, 농업인교육의 학점은행제를 도입을 위한 체계를 설정한 후, 농업관련 기존 표준교육과정 분석, 농업인 요구분석, 전국 농업인대학 교육과정 분석, 기존 농업관련 전공 교육과정 분석, 전문가 검토 등의 과정을 거쳐서 '영농 전문학사'와 '농업 경영 학사'의 표준교육과정을 개발하였다. 넷째, 고졸미만 농업인을 위한 사전학습제도화를 위하여 농업인교육의 평가인정을 통한 방안과 One-Stop 평생학습모델을 통한 방안을 제시하였다. The purposes of this research were to assign the role of rural development organizations, and to establish the strategy for the making headquarter of farmer's university. The study was performed as follows: (1) analyzing the related literatures, documents, records review, (2) need analysis of farmers and members ig rural development organizations in terms of farmer's lifelong learning, (3) consulting experts. The following four findings are the results of this study: (1) Korean national agricultural college should be headquarter of farmer's universities and be approve for lifelong learning credit. Also, agricultural technology & extension centers should run educational program for the lifelong learning credit. (2) For the doing role of headquarter of farmer's university, division of lifelong learning should be add to department of technology training in Korea agricultural college. In relation with this, vision, mission and strategy of division of lifelong learning were suggested. (3) Steps for introduction of credit bank system of farmer education were suggested. Also standard curriculums of 'farming associate degree' and 'agricultural management bachelor's degree' were developed through analyzing existing standard curriculum related with agriculture, analyzing need of farmer, analyzing curriculum of farmer's university, analyzing curriculum of agriculture major. (4) For farmer who do not have high school graduate, two solutions were suggested which are approving farmer's education and one-stop lifelong learning model.

호중구감소증 환자에서의 기관-기관지 아스페르길루스증 1예

권재철,송명준,김기조,오유경,김성용,박선희,최수미,이동건,이석,신완식,김춘추 대한감염학회 2004 감염과 화학요법 Vol.36 No.1

저자들은 급성 림프구성 백혈병 환자에서 항암치료 후 호중구감소증이 지속되는 상태에서 침습성 아스페르길루스증의 드문 형태인 치명적인 아스페르길루스 기관기관지염을 경험하고 문헌고찰과 함께 증례를 보고하는 바이다. Tracheobronchial aspergillosis is an uncommon clinical form of invasive aspergillosis, particularly found in patients with AIDS and in lung transplant recipients than in other immunocompromised patients. The rapidity of the disease progression can result in fatal airway obstruction in a short period of time that the patient may need emergency tracheostomy without knowing the cause of the obstruction. We describe a case of fatal tracheobronchial aspergillosis which developed in a 43-year-old female patient with acute lymphoblastic leukemia. Dyspnea and stridor developed on the 20th day after 2nd consolidation chemotherapy, which was during the prolonged neutropenic period. Airway narrowing was observed on the computed tomograph scan of neck and emergency tracheostomy was performed. Infiltration with aspergillus hyphae was found in the tracheal ring and bronchial mucosa. Despite the use of amphotericin B, the patient died of bleeding and airway obstruction.

Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

배출식 CA 저장 중 생대추의 내부 기체농도에 대한 저장조건의 적합성 판단

박천완(Chun Wan Park),이희수(Hee Su Lee),조정화(Jung Hwa Jo),최동수(Dong Soo Choi),이수장(Su Jang Lee),김용훈(Yong Hun Kim),김진세(Jin Se Kim),박종우(Jong Woo Park),최승렬(Seung Ryul Choi),이진수(Jin Su Lee),송주희(Ju Hee Song),박석호(S 한국원예학회 2016 한국원예학회 학술발표요지 Vol.2016 No.5

Screening of Poly-γ-glutamic Acid (γ-PGA) Producing Bacteria from Environmental Soils

( Wan Taek Ju ),( Yong Su Song ),( Young Ju Kim ),( Woo Jin Jung ),( Ro Dong Park ) 한국키틴키토산학회 2013 한국키틴키토산학회지 Vol.18 No.3

Application of γ-PGA is limited due to the high cost associated with its production. Screening bacterial strains in order to find a more efficient producer is one of the platforms towards overcoming its limited usage. Over the 1500 colonies of bacteria were isolated from soil samples. From them, the 6 isolates, MJ80, CS4-29, HB-31, HB-31c, H1-19, and H1-07, were selected as candidates for γ-PGA production. Based on their morphological and biochemical properties and 16s rDNA sequences, MJ80 and CS4-29 were ultimately identified as Bacillus subtilis, H1-07 as B. thuringiensis, HB-31and HB-31c as B. anthracis, and H1-19 as B. sonorensis. The yield of γ-PGA ranged from 3.28 to 4.4%. It turned out that B. subtilis MJ80 and B. subtilis CS4-29 utilized both glutamic acid (GA) and soybean for γ-PGA production. B. thuringiensis H1-07 was identified as GA-dependent, while the other 3 strains were GA-independent. All strains produced high molecular weight γ-PGA over 200 kDa.