Lithographically-featured photonic microparticles of colloidal assemblies

Lee, Su Yeon,Kim, Shin-Hyun,Heo, Chul-Joon,Hwang, Hyerim,Yang, Seung-Man Royal Society of Chemistry 2010 Physical Chemistry Chemical Physics Vol.12 No.38

<P>We have described a new and promising strategy for the fabrication of composite and porous photonic crystal microparticles that combines the self-assembly of colloidal particles with photolithography techniques. We fabricated silica/SU-8 composite microparticles with photonic bandgaps <I>via</I> four steps: (1) deposition of the silica colloidal crystals on the photoresist, (2) embedding of the colloidal crystals in the photoresist, (3) UV exposure through a photomask and subsequent development, and (4) release of the microparticles from the substrate. Embedding was performed above the glass transition temperature (<I>T</I><SUB>g</SUB>) of uncrosslinked SU-8. At such temperatures, capillary forces on the silica particles facilitate the migration of colloidal crystals in the SU-8 matrix. Particle migration ceased when the top colloidal crystal layer was trapped at the interface between air and SU-8. In addition, we also prepared porous microparticles with an inverse opaline structure by dissolving the embedded silica particles from the composite structures. The porous microparticles showed enhanced reflectivity at the bandgap position due to the large refractive index contrast. The bandgap position of the microparticles was controlled by the size of the silica particles, which determined the lattice constant. Bilayered composite and porous microparticles with two distinct photonic bandgaps were also prepared by sequential deposition of colloidal crystals composed of two differently sized silica particles.</P> <P>Graphic Abstract</P><P>A new and promising fabrication strategy of photonic crystal microparticles was demonstrated by combining colloidal self-assembly with photolithography. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cp00134a'> </P>

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

Gene pyramiding effect of two major bakanae disease resistance gene using qBK1 and qBKWD

Sais-Beul Lee,Tae-Heon Kim,Su-Min Jo,Jun-Hyun Cho,Ji-Yoon Lee,Jong-Hee Lee2,Dongjin Shin,You-Chun Song,Myung-Kyu Oh,Dong-Soo Park 한국작물학회 2017 한국작물학회 학술발표대회 논문집 Vol.2017 No.-

신경세포의 Outgrowth 향상을 위한 마이크로 파이버 지지체와 전단응력의 영향

김인애,박수아,김영직,김수향,신호준,이용재,신지원,신정욱 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

We introduced mechanical stimuli and micro patterned substrate with micro fibers to investigate the effects of those on neurite outgrowth along with nerve growth factor (NGF) in vitro. Micro fiber substrates were fabricated using an electros pinning process. And PC-12 cells cultured on substrates were simulated with newer growth factor and laminar flow shear stress in a fluid flow system. The results suggest that micro fiber substrates and fluid-induced shear stress are promising for simulating neuronal regeneration in a desired direction.

저령차전자탕(猪苓車前子湯)의 기원(基源), 변천과정(變遷過程) 및 구조원리(構成原理)

권오원,김배수,이지원,신승원,이의주,Kwon, Oh-Won,Kim, Bae-Su,Lee, Ji-Won,Shin, Seung-Won,Lee, Eui-Ju 사상체질의학회 2016 사상체질의학회지 Vol.28 No.2

Objectives This paper investigates the origin, the progressive changes and the constructive principles of Jeoryoungchajeonja-tang(猪苓車前子湯).Methods Jeoryoungchajeonja-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including 『Sanghannon(傷寒論)』, 『Keumkuaeyoryak(金匱要略)』, 『Donguibogam(東醫寶鑑)』, 『Donguisusebowon‧Sasangchobongwon(東醫壽世保元‧四象草本卷)』, 『Donguisusebowon‧Gabogubon(東醫壽世保元‧甲午舊本)』, 『Donguisusebowon‧Sinchukbon(東醫壽世保元‧辛丑本)』Results and Conclusions 1) The origin of Jeoryoungchajeonja-tang is discovered in the prescriptions for Lee-su(利水), that is, Jeoryoung-tang(猪苓湯). 2) Ohryoung-san(五苓散) introduced in 『Donguisusebowon‧Sasangchobongwon(東醫壽世保元‧四象草本卷)』progressively transformed into Shihosaryoung-san(柴胡四苓散)(『Donguisusebowon‧Gabogubon(東醫壽世保元 ‧甲午舊本)』) and ultimately into Jeoryoungchajeonja-tang(『Donguisusebowon‧Sinchukbon(東醫壽世保元‧辛丑本)』), a prescription appropriate for usage in the Mangeum symptomatology(亡陰證). 3) The Jeoryoungchajeonja-tang is composed of 10 herbs. Of these, Notopterygium incisum Ting(羌活), Aralia cordata Thunb.(獨活), Schizonepeta tenuifolia Briq.(荊芥), Saposhnikovia divaricata Schischk.(防風) make the Pyoeum(表陰) drop, and Anemarrhena asphodeloides Bge.(知母), Gypsum fibrosum(石膏) scatter the uihwa(胃火), and Poria cocos Wolf.(茯苓), Alisma canaliculatum(澤瀉), Polyporus umbellatus Fr.(猪苓), Plantago asiatica L.(車前子) facilitate urination.

정신과 환자 집단간 추상화 추론(Abstract Reasoning) 능력 비교 : SPM(Standard Progressive Matrices) 중심으로

이지화,신동균,이수정,이민수 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

고위인지기능 중 시자극에 대한 지각적 관계를 파악하고 유추에 의해서 추론하는 능력을 측정한다고 알려진 SPM(Standard Progressive Matrics)검사를 통해, 추론 기능의 취약성이 예측되는 정신과 환자 집단(기질적 뇌손상, 우울증, 정신분열병)과 정상통제집단에, 추론 기능을 중심으로 고위 인지 기능 손상의 특징적 양상을 비교해 보고자 한다. 방법: 정신분열병 환자 29명, 우울증 환자 22명, 뇌손상 환자 32명을 대상으로 SPM을 실시하여, 집단간의 수행 양상의 차이를 비교하되, SPM 총점과 5개의 소검사 점수를, 변량분석 및 사후 검증을 통해 비교하였다. 정상 집단과 뇌손상 집단간 SPM 소검사의 판별분석을 시행하였다. 결과: 정신과 환자 집단의 SPM 수행 결과에 있어 뇌손상환자, 우울증환자, 정신분열병환자 세 집단 모두 정상집단에 비해 유의미하게 낮았으며, 특히 뇌손상환자는 우울증환자, 정신분열병환자보다도 유의미하게 낮은 수행을 나타냈다. B,E 소검사가 뇌손상 집단과 정상 집단을 가장 잘 변별해주는 소검사로 판별되었다. 정신분열병환자와 우울증환자간에 유의미한 차이는 관찰되지 않았으며, 모양의 배열과 조합을 추론해야하는 D 소검사에서는 우울증환자와 뇌손상환자간에 유의미한 차이를 나타냈으나, 정신분열병환자와 뇌손상환자간에 유의미한 차이를 보이지 않았다. 결론: 추상화 추론 기능을 중심으로한 고위인지기능 저하가 예상되는 우울증, 정신분열병, 및 뇌손상환자간에 인지적 손상의 특징적 양상을 SPM 검사가 잘 변별해 줌을 보여주었다. 뇌손상 환자의 인지적 손상은 정신분열병 및 우울증 환자의 인지적 손상과는 질적으로 차이가 있음을 시사하는 것이며, SPM이 지능 검사의 대체 검사뿐만 아니라 신경 심리 검사로서 활용될 수 있음을 확인한 것이다. Objectives: This study was aimed to compare abstract reasoning in patients with mental disorders ; Depression, Schizophrenia, Organic Brain Syndrome(OBS), and normal control group using Standard Progressive Matrices(SPM), known as a test measuring visual pattern matching ability and reasoning ability by analogy. Method: SPM test in Vienna Test System□ was administered to 82 normal adults, 29 schizophrenic patients, 22 depression patients, and 32 OBS patients. SPM total score and 5subtest scores in four groups were compared, using ANOVA and post-hoc comparison. SPM subtest scores in OBS and normal group were compared, using discriminant function analysis. Results: SPM total score and all subtest scores in mental disorders group(schizophrenia,depression, OBS) were lower than in normal control group. SPM total score and all subtest scores in OBS group were lower than in schizophrenia and depression group. No difference between SPM total score in Schizophrenia and depression group was found. Discriminant function of B, E subtest was the hightest. Conclusions: The impairment of higher cognitive function, especially abstract reasoning impairment in OBS, was qualitatively defferent from that of schiophrenia and depression. SPM can differentiate specific pattern of abstract reasoning impairment in mental disorders, so SPM can be used not only as a substitute for intelligence test but also as a neuropsychological test.

코일과 클립을 선택적으로 적용해서 성공적으로 치료했던 다발성뇌동맥류 1례 : A case report

이덕구,김범태,황선철,임수빈,이세영,신원한 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

The author report a case of multiple cerebral aneurysm successfully treated with an appropricate selection of surgical clipping and coil embolization. A 64 years old female patient was admitted with stuporous consciousness. Initial 3D CT angiography showed diffuse subrarachnoid hemorrhage on the basal cisterns, saccular aneurysms on the terminal basilar artery and right middle cerebral artery(MCA). Converntional angiography confirmed the ruptured aneurysm was basilar one. Coil embolization was perfromed on the basilar aneurysm with 6 Guglielmi detachable coils(GDC) on the 3 days after ictus. Sugical clipping was done on the unruptured right MCA aneurysm on 10 days after ictus without any morbidity. Each treatment modalities can be appropriate indicated for the coiling or clipping aneurysms.

8-Azaxanthine과 그 유도체의 합성 및 시험관내 항암 활성

李奉憲,辛貞姬,張太植,朴章洙,姜信源 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-

8-Azaxanthine(1), 3-β-D-ribofuranosyl-8-azaxanthine(2),3-β-D-ribofuranosyl-8-azaxanthine-5'-monophosphate(3), 그리고 3-β-D-ribofuranosyl-8-azaxanthine-5'-(3-pyridinylcarbonyl)monophosphate(4)를 합성한 후 Mouse leukemia P388,Murine mammary carcinoma FM3A, Human histiocytic lymphoma U937암세포들에 대해 시험관내 항암활성을 MTT를 이용한 방법으로 예측하고 IC_50(μmol/mL)으로 나타내었다. 그 결과, 비정상적인 염기의 N-3와 당의 C-1'glycoside결합을 가진 2는 세가지의 암세포에 대해 감수성이 좋아 IC_50이 각각 0.05, 0.06,0.06μmol/mL이었으나 항세균 활성 예측에서는 감수성을 보이지 않았다. Human histiocytic lymphoma U937세포에 대한 IC_50은 1이 0.33,2는 0.06,3은0.25그리고 4는 0.33μmol/mL로 구조 변화에 따라 서로 다른 값을 보였다. 8-Azaxanthine(1), 3-β-D-ribofuranosyl-8-azaxanthine(2),3-β-D-ribofuranosyl-8-azaxanthine-5'-monophosphate(3), 3-β-D-ribofuranosyl-8-azaxanthine-5'-(3-pyridinylcarbonyl)monophosphate(4) were synthesized. The in vitro antitumor activities of the synthesized compounds against P388 mouse leukemia,FM3A mammary carcinoma, and U937 human histiocytic lymphoma cells were determined by MTT assay. 2 with unnatural N-3 and C-1'glycoside bond had activityagnist three tumor cell lines and IC_50s of these compounds were 0.05,0.06μmol/mL against three tumor cell lines, repectively. But these compounds had no antibacterial activity. IC_50s aganist U937 human histiocytic lymphoma cells were verfied with the structural modification:IC_50s of 1,2,3, and 4 were 0.33,0.06,0.25, and 0.33μmol/mL, respectively.

사염화탄소의 간독성에 대한 파두 다당류분획의 예방효과

이은경,길이룡,소동수,창동신,전선덕,정명규,문창규 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.2

In present study, we fractionated polysaccharides from Croton tiglium and investigated their hepatoprotective effects on CCI₄ intoxication. Polysaccharide fraction of which molecular weight is over 300,000(HP) showed the most potent hepatoprotective effects on CC1₄ intoxication. Lipid peroxidation, BAST and sALT were used as parameters to evaluate the liver damage. Glucose, xylose and arabinose were found to be monosaccharides composing sugar moiety of HP.

영지 액체 배양의 Wall Growth에 미치는 Polyacrylic Acid의 첨가 효과

이신영,이학수 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.A

This study was carried out to screen the effective polymeric additives preventing wall growth during mycelial submerged cultivation of Ganoderma. ludicum. Effects of additives on mycelial growth and exo-polysaccharide (EPS) production in flask culture and jar fermenter system under 3 different pH processes were investigated, and changes of mycelial morphology were also examined. From flask culture of G. lucidum wish additives of different concentrations, 0.1%(w/v) polyacrylic acid was effective for EPS production. As the polyacrylic acid of 0.1%(w/v) was added in medium, wall growth of G. lucidum mycelium grown in jar fermenter system could be protected. The addition of 0.1%(w/v) polyacrylic acid to medium was also improved the mycelial growth and EPS production in the later of submerged culture G. lucidum and no changes of mycelial morphology were observed.