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Radiofrequency Ablation and Excision of Multiple Cutaneous Lesions in Neurofibromatosis Type 1
Kim, Seong-Hun,Roh, Si-Gyun,Lee, Nae-Ho,Yang, Kyung-Moo Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.1
Background Von Recklinghausen disease or neurofibromatosis type 1 is an autosomal dominant genetic disorder of chromosome 17q11.2. The most common characteristic findings of NF 1 include multiple and recurrent cutaneous neurofibromas associated with psychosocial distress. Methods Sixteen patients (9 female, 7 male; average age, 31 years; range, 16 to 67 years) with multiple cutaneous neurofibromas between March 2010 and February 2012 were included in the study. All patients were treated with radiosurgical ablation and excision under general anesthesia. Results All 16 patients were satisfied with the results, when questioned directly during the outpatient department follow-up. The only complaint from a few patients was minimal scarring, but acceptable results were obtained in the end. Conclusions The radiofrequency procedure is almost bloodless and quick, creating a smaller necrotizing zone. Therefore, instead of employing the time consuming traditional surgery, such as laser therapy and electrosurgical excision, that produces uncertain results and can affect normal adjacent tissue, treatment of neurofibromas with radiofrequency ablation and excision can be an alternative choice of treatment for patients with a large number of neurofibromas.
융기성 피부섬유육종의 치료를 위한 광범위절제술과 모즈 미세도식 수술의 비교 연구: 단일 기관의 경험
송기훈 ( Ki Hun Song ),박진 ( Jin Park ),윤석권 ( Seok Kweon Yun ),김한욱 ( Han Uk Kim ),노시균 ( Si Gyun Roh ),이내호 ( Nae Ho Lee ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.1
Background: Dermatofibrosarcoma protuberans is a mesenchymal tumor of the skin of intermediate-grade which is a rare condition. The slow growing and aggressive invasion on local tissues are characteristic features of dermatofibrosarcoma protuberans. The treatment for dermatofibrosarcoma protuberans is mainly a surgical excision such as a wide excision and Mohs micrographic surgery. Objective: The aim of this study was to compare the result of wide excision and Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans at a single institution in Korea. Methods: A retrospective review was done for 24 patients diagnosed with dermatofibrosarcoma protuberans and treated surgically from 1999 to 2010 at Chonbuk National University Hospital. Patient demographics, tumor features, surgical features, and recurrence during the follow-up period were evaluated. Results: 13 patients were treated with wide excision, and 11 with Mohs micrographic surgery. There was no metastasis for all the cases. Mean operation time for the wide excision group was 83 minutes whereas 182 minutes for the Mohs micrographic surgery group, and it was a statistically significant difference. However, no significant difference was observed in post-operative defect size, advanced surgical repair and local recurrence in our study. Conclusion: We suggest that wide excision and Mohs micrographic surgery are both successful modalities for the surgical treatment of dermatofibrosarcoma protuberans. Hence, individualized patient and tumor characteristics should be concerned when determining the surgical options for dermatofibrosarcoma protuberans. (Korean J Dermatol 2013;51(1):13∼20)
LEE, Seo Young,KIM, Geun Tae,ROH, Si Hun,SONG, Jin-Su,KIM, Hie-Joon,HONG, Soon-Sun,KWON, Sung Won,PARK, Jeong Hill Japan Society for Bioscience, Biotechnology, and A 2009 Bioscience, Biotechnology, and Biochemistry Vol.73 No.4
<P>Ginseng is a well known herbal medicine in Asia, and ginsenoside Rg<SUB>3</SUB> has anti-cancer and various pharmacological effects. In particular, 20<I>S</I>-ginsenoside Rg<SUB>3</SUB> may increase the anti-proliferative effects of chemotherapy. The authors investigated the mechanism of the anti-proliferative effect of 20<I>S</I>-Rg<SUB>3</SUB> at the protein level in HT29 colon cancer cells. MTT, caspase-3 assays, and flow cytometry analysis were performed to determine cytotoxicity and apoptosis, and proteomic analysis was performed by two-dimensional gel electrophoresis and MALDI-TOF/TOF MS, and a database was used to identify protein changes in 20<I>S</I>-Rg<SUB>3</SUB> treated HT29 cells. The proteins identified included down-regulated Rho GDP dissociation inhibitor, up-regulated tropomyosin1, and annexin5 and glutathione s-transferase p1, which are apoptosis associated proteins. The anti-proliferative mechanism of 20<I>S</I>-Rg<SUB>3</SUB> was found to be involved in mitotic inhibition, DNA replication, and repair and growth factor signaling. The findings of this study suggest that the cytotoxicity of 20<I>S</I>-Rg<SUB>3</SUB> in colon cancer is dependent on several mechanisms, including apoptosis.</P>
Park, So-ra,Lee, Jin Gyun,Roh, Si Hun,Kim, Gyudong,Kwon, Chan Hyeok,Park, Hee Ra,Kwon, Ki Sung,Kim, Deukjoon,Kwon, Sung Won Informa UK (TaylorFrancis) 2012 Food additives & contaminants. Part B, Surveillanc Vol.5 No.1
<P>There have been a number of reports of dietary supplements contaminated with illegal adulterants that threaten consumers' health because of their adverse pharmacological effects. In the present study, a convenient and economic method was developed to detect illegal pharmaceutics, such as PDE-5 inhibitor and appetite suppressants, using liquid chromatography (LC)/photodiode array (PDA) for screening and LC/mass spectrometry (MS) for successive confirmation. Target peaks were identified by comparison of their chromatographic retention times and PDA spectra with those of synthetic standards and finally confirmed by LC/MS. As a result, tadalafil, a PDE-5 inhibitor, and N-desmethylsibutramine, a derivative of sibutramine, were detected in various dietary supplements at concentrations of 13.5-21.9 mg and 3.0 mg per single dose, respectively. The present study will contribute to the development of an analytical method enabling rapid screening of a variety of health foods, and the result suggests that consumers should be aware of serious health risks related to these illegal compounds.</P>
Management of Defects on Lower Extremities with the Use of Matriderm and Skin Graft
Choi, Jun-Young,Kim, Seong-Hun,Oh, Gwang-Jin,Roh, Si-Gyun,Lee, Nae-Ho,Yang, Kyung-Moo Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.4
Background The reconstruction of large skin and soft tissue defects on the lower extremities is challenging. The skin graft is a simple and frequently used method for covering a skin defect. However, poor skin quality and architecture are well-known problems that lead to scar contracture. The collagen-elastin matrix, Matriderm, has been used to improve the quality of skin grafts; however, no statistical and objective review of the results has been reported. Methods Thirty-four patients (23 male and 11 female) who previously received a skin graft and simultaneous application of Matriderm between January 2010 and June 2012 were included in this study. The quality of the skin graft was evaluated using Cutometer, occasionally accompanied by pathologic findings. Results All 34 patients showed good skin quality compared to a traditional skin graft and were satisfied with their results. The statistical data for the measurement of the mechanical properties of the skin were similar to those for normal skin. In addition, there was no change in the engraftment rate. Conclusions The biggest problem of a traditional skin graft is scar contracture. However, the dermal matrix presents an improvement in skin quality with elastin and collagen. Therefore, a skin graft along with a simultaneous application of Matriderm is safe and effective and leads to a significantly better outcome from the perspective of skin elasticity.
Lee, Seo Young,Kim, Geun Tae,Roh, Si Hun,Song, Jin-Su,Kim, Hie-Joon,Hong, Soon-Sun,Kwon, Sung Won,Park, Jeong Hill Govi-Verlag Pharmazeutischer Verlag [etc.] ; Verla 2009 PHARMAZIE Vol.64 No.4
<P>Ginseng is a representative herbal medicine in Asia and various pharmacological activities of ginsenoside Rd isolated from ginseng have been reported. However, anti-cancer activity and mechanism of ginsenoside Rd in HT29 colon cancer cell lines were not studied yet. We performed proteomic analysis through two-dimensional gel electrophoresis, MALDI-TOF/TOF-MS and database to identify altered protein induced by ginsenoside Rd treatment in HT29. We can identify fourteen proteins contributed to cell growth inhibition induced by Rd. Proteins involved in the inhibition of mitosis (Stathmin1, Microtubule-associated protein RP/EB family and Stratifin) were significantly up- and down-regulated. And proteins associated with apoptosis (Rho GDP dissociation inhibitor, Tropomyosin1 and Annexin5) were significantly changed. Furthermore, ginsenoside Rd in HT29 was involved in cytoprotection, DNA replication and repair, protein synthesis and degradation, metastasis and mutagenesis. It was supposed that ginsenoside Rd contributed to induce anti-cancer activity by complementary functions of these proteins in colon cancer cells.</P>
조용선 ( Yong Sun Cho ),황수란 ( Su Ran Hwang ),송기훈 ( Ki Hun Song ),남경화 ( Kyung Hwa Nam ),박진 ( Jin Park ),윤석권 ( Seok Kweon Yun ),김한욱 ( Han Uk Kim ),노시균 ( Si Gyun Roh ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.9
Nicolau syndrome is a rare adverse reaction and characterized by the acute onset of necrosis of the skin and soft tissue following intramuscular drug injection. Conservative treatments with dressings, debridement, and pain control are the mainstay of therapy. Surgical intervention such as skin graft is rarely required. We report a case of 21-year-old man with this syndrome on the right buttock after an intramuscular injection of diclofenac in which skin graft was necessary. The lesion eventually required debridements and split-thickness skin graft for reconstruction because it was very extensive and not successfully treated by the conservative method for four months. (Korean J Dermatol 2011;49(9):843~846)