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- 저자 : Shim So-Yun (검색결과 88 건)
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Shim, Jin-Hyung,Jeong, Jae-hyang,Won, Joo-Yun,Bae, Ji-Hyeon,Ahn, Geunseon,Jeon, Hojun,Yun, Won-Soo,Bae, Eun-Bin,Choi, Jae-Won,Lee, So-Hyoun,Jeong, Chang-Mo,Chung, Ho Yun,Huh, Jung-Bo Institute of Physics Publishing Ltd 2018 Biomedical Materials Vol.13 No.1
<P>The appropriate porosity and pore size of barrier membranes were associated with the transportation of biomolecules required for new bone formation and angiogenesis. In this study, we fabricated three-dimensional (3D)-printed resorbable polycaprolactone (PCL) membranes with different porosities (30%, 50%, and 70%) to evaluate the effective pore size for guided bone regeneration (GBR) membranes. To analyze mechanical properties and cytocompatibility, PCL membranes prepared using extrusion-based 3D printing technology were compared in dry and wet conditions and tested in vitro. The proliferation rates and pattern of fibroblasts and preosteoblasts on PCL membranes with different porosities were determined using a cell counting kit-8 assay and scanning electron microscopy. PCL membrane porosity did not affect cell proliferation, but osteogenic differentiation and mechanical properties were increased with lower porosity (30%) on day 14 (p < 0.001). Similar results were found in an in vivo calvarial defect model; new bone formation was significantly higher in PCL membranes with lower porosity (p < 0.001). These results indicate that 3D-printed PCL with 30% porosity (130 mu m pore size) is an excellent pore size for GBR membranes.</P>
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Shim So-Yeon,Yun Ji Yun,Cho Su Jin,김민호,Park Eun Ae 대한의학회 2021 Journal of Korean medical science Vol.36 No.11
Background: Despite the advances in neonatology, the incidence of bronchopulmonary dysplasia (BPD) is increasing. It is important to prevent the development of BPD in the first place. The online BPD outcome estimator from National Institute of Children Health and Human Development and Neonatal Research Network is available. However, it is not applicable for Asians. Moreover, limits are set for birth weight and gestational weeks excluding those who may still have BPD. The aim of this study was to develop a prediction model for BPD using first hour perinatal and neonatal factors in Korean very low birth weight infants (VLBWIs). Methods: Data were collected for 8,022 VLBWIs with gestational age (GA) ≥ 22 weeks who were born between January 1, 2013 and December 31, 2016, and admitted to the neonatal intensive care units of the KNN. Multiple logistic regression models reanalyzed by stepwise selection with significant clinical indicators for BPD. PROC package was used to calculate the area under curve (AUC) and corresponding 95% confidence intervals. Moreover, it was used to search the best cut-off value. External validation was performed with the 2017 Korean neonatal network (KNN) data. Results: After all missing data were excluded, 4,600 VLBWIs were included in the training dataset of the prediction model. Predictability of presence of BPD was 90.8% and prediction P value cut off was 0.550. Five-minute Apgar score, birth weight, GA, sex, surfactant use were significant indicators. Predictability of severe BPD was 81.5% and prediction P value cut off was 0.160. Five-minute Apgar score, birth weight, maternal PIH, chronic maternal hypertension, GA, sex, respiratory distress syndrome, need of resuscitation at birth were significant indicators. After external validation, sensitivity and specificity did not change significantly. Conclusion: From this study, high predictability was obtained using clinical parameters obtained within one hour of life. P value for prediction of each grade of BPD and equation for calculation was presented. It can be helpful for the early prediction of BPD in Korean VLBWI. This study will contribute to the prediction of BPD in Asians especially Korean VLBWIs, not currently included in the NICHD BPD online BPD predictor. In addition, the predictive power may be continuously increased with the cumulative data of KNN.
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Ji Yun Yun,Ji Sun Kim,So-Yeon Shim,조수진,박은애,정현주 대한신생아학회 2020 Neonatal medicine Vol.27 No.4
Purpose: The aim of this study was to evaluate the physiological and behavioral effects of auditory stimulation with their own parent’s voice on heart rate and sleep states of very-low-birth-weight infants (VLBWIs) in neonatal intensive care unit. Methods: The data of 28 VLBWIs at the Ewha Womans University Mokdong Hospital between October 2016 and May 2017 was analyzed. They were exposed to sounds similar to those of mothers’ heartbeat they had heard in the uterus and their own parent’s voice. Heart rate was assessed as the physiological responses and sleep state of infants as behavioral response. The sleep states were categorized into six states. The music intervention program was provided twice a week. Results: Twenty-eight babies with an average gestational age of 28 weeks (average birth weight of 1.09 kg) had undergone the sessions (average of 16 times) average of 16 times. During the initial period, there were no meaningful differences of the heart rates measured by the physiological functions before and after the sessions. However, as we move to the adaptive phase, the average heart rate was 156.96±12.22, and the pre-discharge was 149.11±12.01, which indicates meaningful differences (P<0.05). Infants’ behavioral function was statistically insignificant. Conclusion: The music intervention techniques in the neonatal intensive care unit environment in Korea have provided positive influence to VLBWIs' physiological reactions. We were not able to come up with the relevant indicators during this phase of the study but we do plan to announce the future study results after indexing the observation results.
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맹꽁이 서식처 복원을 위한 서식처 적합성 지수(HSI) 개발
심윤진 ( Yun Jin Shim ),조동길 ( Dong Gil Cho ),박소현 ( So Hyun Park ),이동진 ( Dong Jin Lee ),서윤희 ( Yun Hee Seo ),김상혁 ( Sang Hyuk Kim ),김덕호 ( Duck Ho Kim ),고상범 ( Sang Beom Ko ),차진열 ( Jin Yeol Cha ),성현찬 ( Hyun C 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2014 한국환경복원기술학회지 Vol.17 No.2
Kaloula borealis is the species of Amphibia which belongs to Kaloula genus and it is the only species inhabiting in Korea. The population size and habitat of Kaloula borealis have been significantly decreased on a national scale due to the diversified developments and the uses of agricultural pesticides. Accordingly, the Ministry of Environment has designated and managed them as the class II of endangered species, in accordance with ?Endangered Species Protection and Management Act?; however, a particular study focused on the ecological restoration of Kaloula borealis is desperately needed to prevent their extinction. This study was conducted to propose the HSI (Habit Suitability Index) of Kaloula borealis based on literature survey on ecology and habitats of Kaloula borealis, as well as their HSI. Factors to be investigated in HSI include: space, feed, cover, water(breeding) and threatening factors and the variables of each factor were also proposed. The distance from wetland, grassland, farm, stream and rice paddy, as well as the altitude of spawning pond were proposed as the variables of space, whereas the bed structure of forest and low-rise grassland were proposed as the variables of feeding. The variables of water (breeding) include the area of permanent and temporary wetlands, coverage of emerged pants (ratio of open water), water depth, water temperature, water quality, pH level, etc., whereas the presence of predator, distance from street and pollutants were proposed as the variables of threatening factor. The sub-standards by HSI factor of Kaloula borealis have been drawn from in-depth consultation with experts and based on this, the final HSI of Kaloula borealis was developed.
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심화정,윤혜은,강수경,이재란,송미라,김기순,류소연 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Background and Objectives : This study was conducted to investigate the actual conditions and the relevant factors of acnes, the most common skin troubles of the adolescent period. Materials and Method : This study was carried out through a survey on 382 female students in a high school from October 24, 2002 to October 31. The survey was formed with questions on the general characteristics of the subject; questions relevant to the actual conditions of acnes; questions of the bio-rhythm; questions on washing and hair shape, the condition of the skin, eating habits; and questions on stress and sicknesses Chi-square test, t-test and multiple logistic regression were used as the method of statistical analysis, to investigate the associated factors with acnes that occur on the face. Results : 1. There were 65.4% of the female students who had acnes, and the most common site were on the forehead and nose, then the cheeks and the whole of the face respectively. On the type of the acnes, 39.1% non-inflammatory acnes, 29.7% were inflammatory and 12.3% were the combination of both 2 As a result of bivariate analysis, there was statistically significant relevance of sleeping time, number of time of washing face, type of cleansing product, type of skin, condition of skin, sensitiveness of skin, preference of meat, menstrual irregularity and stress with acnes 3 Multiple logistic regression analysis showed that the odds ratio(OR) of acnes in case of use of soap instead of cleansing products was 3.00 (95% confidence interval(CI): 1.03 - 8.79), in case of the use of special pimple soap was 27.32 (95% CI 2.68 - 278.51), in case of oily face, 9.40 (95% CI 3.45 - 25.61); in case of combination face was 3.95 (95% CI. 1.64 - 9.50); in case of moist face without shine when compared to seriously lightened skin was 0.22 (95% CI. 0.07 - 0.72); in case of non-preference of meat when compared to preference of meat was 2.00 (95% CI : 1.11 - 3.61) Apart from this, there was no significant relevance with sleeping time, menstrual irregularity and stress Conclusion : It was concluded that there was relevance in the skin condition, skin type and face-wash with the acnes on the face of adolescent female students. There is a necessity of conducting studies about the occurrence of acnes and its relevant factors, in the future.
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( So Yeon Jeon ),( Hyun Jeong Shim ),( Ho Young Yhim ),( Chang Yeol Yim ),( Kyu Taek Lee ),( Hwan Jung Yun ),( Na Ri Lee ),( Sang Byung Bae ),( Ki Hyeong Lee ),( Sam Yong Kim ),( Han Jo Kim ),( Hye Su 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Patients with biliary tract cancer have a poor prognosis and the palliative chemotherapy has shown limited effi cacy. This phase II study aimed to evaluate the effi cacy and safety of a combination of docetaxel and oxaliplatin as fi rst-line therapy in patients with advanced biliary tract cancer. Methods: Patients with biliary tract cancer have a poor prognosis and the palliative chemotherapy has shown limited effi cacy. This phase II study aimed to evaluate the effi cacy and safety of a combination of docetaxel and oxaliplatin as fi rst-line therapy in patients with advanced biliary tract cancer. Results: 20 patients (2 patients had locally advanced disease and 18 had metastatic disease) with median age of 57 years (range 45-74) were enrolled. Response was assessable in 18 patients (early death in two). ORR was 4/18 (22.2%; 95% CI, 4.0-40.4%) and disease control rate (PR + SD) was 12/18 (66.7%; 95% CI, 46.0-87.4%). At a median follow-up time of 23.2 months (range 2.3-37.8), median PFS for all patients was 2.8 months (95% CI, 1.7-3.9 months) and median OS was 10.0 months (95% CI, 2.4-17.7 months). The most common grade 3 or 4 hematologic and nonhematologic toxicities were neutropenia (40.0%) and peripheral neuropathy (10.0%), respectively. Conclusions: Docetaxel and oxaliplatin combination was moderately active and feasible in patients with locally advanced or metastatic biliary tract cancer. This regimen warrants further investigation as a fi rst- or second-line therapy for the treatment of unresectable biliary tract cancer.
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만성 B형 간염 환자에서 Recombinant Alpha Interferon 2b (Intron A^(�))의 효과
심재정,권소영,서동진 대한내과학회 1990 대한내과학회지 Vol.38 No.3
To evaluate the therapeutic efficacy and safety of recombinant alpha interferon 2b (Intron A) in chronic HBV infection in Korea, Intron A was given to 12 patients with biopsy-proven chronic active hepatitis, one biopsy-proven chronic persistent hepatitis, and 3 clinical chronic-hepatitis patients who were HBsAg, HBeAg and HBV DNA positive over 6 months. Three million units of Intron A was given intramuscularly thrice weekly for three months. In all patients, the HBV DNA, HBeAg, Anti-HBe and serum transaminase activities were assessed monthly before, during and after Intron A administration. The average follow-up period was 12.0 months. The results were as follows; 1) After three months' administration of Intron A, serum ALT decreased significantly from 207.5±117.8 IU/L to 60.7±51.5 IU/L(p<0.005) and was normalized transiently in nine cases(60.0%). 2) During administration of Intron A, serum HBV DNA decreased markedly in all cases and became negative in 14 cases(93.3%), but during follow-up periods, serum HBV DNA reappeared and increased in all cases except one(6.7%). 3) Although HBeAg disappeared in four cases(26.7%) after Intron A administration, it became positive again in all cases except one with seroconversion rate of 6.7%. 4) 2 courses of Intron A therapy was tried in 3 cases, but seroconversion rate of HBeAg was not increased. 5) Side effects were noted in 87.5% of cases. Fever and chilling were most common, but tolerable. Intron A was discontinued in one case due to aplastic anemia after 2 months. It is suggested that thrice weekly intramuscular injections of 3 MU of Intron A were effective in the suppression of HBV replication and inflammation only transiently in Korean patients with chronic hepatitis B.
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