간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

Method for Protection of Single‑Line‑Ground Fault of Distribution System with DG Using Distance Relay and Directional Relay

Jung‑Hun Lee,Min‑Su Park,Hong‑Seon Ahn,Kyung‑Won Park,Jun‑Seok Oh,Seung‑Gyu Jeon,Dong‑Kyu Kim,Jae‑Eon Kim 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.4

When large scales DG are connected to the distribution system of unidirectional power currents, bi-directional power currents are formed, making it impossible to use conventional overcurrent protection methods alone to detect and isolate fault sections for ground and short-circuit faults. To solve these problems, this study proposed the method of protection against single-line-ground fault of common neutral line multi-contact local power distribution system using distance relay and directional relay. The proposed protection method was applied to the common neutral multi-ground distribution system to validate the protection against single-line-ground fault through the PSCAD/EMTDC software package and efectively detect and isolate only the zone of single-line-ground fault without malfunctions.

발열이 있는 호중구 감소증 환자에서의 위험도 예측인자

정중식,권운용,김규석,임용수,이중의,서길준,윤여규 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: Most febrile neutropenic patients are treated in an aggressive manner. However, identification of low-risk patients may enable clinicians to administer risk-based treatment. The object of this study is to certify the factors associated with increased risk at the time of visiting the emergency department. Methods: This is a retrospective study. We reviewed the medical records of 101 febrile neutropenic patients who had visited the emergency department of Seoul National University Hospital from January 1998 to August 1999. We assumed 22 risk prediction factors that could be assessed at admission to the emergency department and 5 factors that could be assessed during treatment course. To find independent risk-prediction factors, we analyzed these factors respectively by using multiple regression analysis. Results: Tachycardia(aOR=136.5), altered mentality(aOR=28.8), decreased renal function(aOR=20.1), and significant comorbidity(aOR=17,2) are the independent factors associated with higher mortality. Altered mentality(aOR=31.6) and decreased renal function(CCr < 75㎖/min, aOR=5.4) are those associated with a higher incidence of septic shock. Independent factors associated with persistent(more than 3 days) fever are the early(within 10 days) onset of fever after last chemotherapy(aOR=8.8) and the existence of new pulmonary infiltrates on a simple chest X-ray(aOR=4.3). Conclusion: The stability of vital signs, the change of mentality, the renal function, the existence of significant comorbidity, the existence of new pulmonary infiltrates, and the rate of neutropenia are clinically useful risk-prediction factors in febrile neutropenia at the time of visiting the emergency department.

異功散의 免疫增强效果에 관한 實驗的 硏究

안규석,이경태,장성구,정지창,노영수 世明대학교 한의학연구소 1999 韓醫學硏究所 論文集 Vol.2 No.-

This experimental study was carried out to evaluate the immunomodulatory effects of Ekong-san. To evaluate the immunomodulatory effects of Ekong-san, delayed type hypersensitivity, hemagglutinin and hemolysin titers for hymoral immune response, rosette forming cells for cell-mediated immune response, natural killer cell activity, proliferation of lymphocyte, productivity of Interleukin-2, and carbon clearance were measured with methotrexate treated mice. The results were summarized as follows; 1.The influence of the treatment on hemagglutinin and hemolysin titers, rosette forming cells, the proliferation of lymphocyte, and productivity of Interleukin-2 was dose-dependent and the results showed a significant difference when compared to control group. This implies that the humoral immune response was activated. 2.The natural killer cell activity was significantly increased in both sample groups as compared to the control group when the effector cell:target cell ratios were 100:1 and 0:1. However when the ratio was 10:1, there was no significant difference with the control group. 3.Carbon clearance, the proliferration effect of phagocytes was significantly increased sample group as compared to the control group. According to the results, Ekong-san has the immuno-activity. We could suggest that Ekong-san is able to be applied to the anti-cancer treatment and prevention.

결핵균 α-항원의 정제와 면역화학적 분석에 관한 연구

김석권,백태현,김화중,박정규,최대경 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

α-antigen from the culture filtrate of Mycobacterium tuberculosis H37Rv was purified by improved purification procedures and immunoaffinity chromatography using rabbit anti-α serum. Improved purification procedures were involved 50% ammonium sulfate precipitation, hydroxylapatite chromatography, Sephadex G-75 chromatography and preparative natural polyacrylamide gel electrophoresis(PAGE). We also produced seven monoclonal antibodies against α-antigen by hybridoma technique and analyzed immunochemical characterization of α-antigen by SDS-PAGE, ELISA and Western bolt using monoclonal antibodies. The results were summarized as follows; 1. The purification of α-antigen from the unheated culture filtrate by 50% ammonium sulfate precipitation, hydroxylapatite chromatography and Sephadex G-75 chromatography resulted in recovery of 16% of α-antigen and 28.5-fold purification. α-antigen purified further by preparative natural-PAGE showed a single distinctive band of 30 KDa molecule on SDS-PAGE. 2. The molecular weight of α-antigen was 30,000 as determined by SDS-PAGE and Sephadex G-75 chromatography. 3. α-antigen was purified by immunoaffinity chromatography as single step. The affinity purified α-antigen showed a band of 30 KDa molecule and showed another contaminated band of 32 KDa molecule on SDS-PAGE. 4. By Western blot analysis, seven monoclonal antibodies against α-antigen showed a distinct band of 30 KDa molecule and multiple different bands between 25 KDa and 65 KDa molecules. 5. All monoclonal antibodies produced were revealed strong cross reactivities with the sonicate antigens of slow growing and rapid growing mycobacteria by ELISA. These results suggest that α-antigen, 30 KDa of molecular weight, could be purified well by the im-proved above purification procedures and contains many cross-reactive antigenic determinants on the molecule.

정형외과영역의 호기성 그람 음성균 감염증에 대한 Aztreonam(Azactam^(�))의 임상적 효과

이준규,안상로,조성일,김석범 中央醫學社 1989 中央醫學 Vol.54 No.1

유리섬유보강 폴리머 복합패널의 피로특성 : Fatigue Properties of Glass Fiber Reinforced Polymer Composite Panel

연규석,정중호,권택정,김성기 강원대학교 부설 석재복합신소재 제품연구센터 2004 석재연 논문집 Vol.9 No.-

본 연구는 압축강도 1,020 kgf/㎠를 갖는 폴리머 모르타르를 중심부로 하고 내·외표면은 고인장의 GF RP로 보강된 샌드위치 패널의 피로 특성에 관한 연구이다. 이를 위해 중심부 폴리머 모르타르와 압축 및 인장측 GERP보강층 두께를 달리하는 샌드위치 형식의 패널 시험체를 제작하고 이에 대한 휨 피로 시험을 수행함으로써 폴리머 모르타르 두께와 GFRP보강층 두께가 패널의 휨피로거동에 미치는 영향 즉 피로하중수준-피로수명과의 상관관계를 구명하였다. 실험결과 하중수준이 증가함에 폴리머 모르타르 및 GFRP 보강두께에 관계없이 샌드위치 패널의 피로수명은 감소하는 경향을 나타냈고, 동일 하중수준에서는 폴리머 모르타르 두께가 증가함에 따라 피로수명은 감소하는 경향을 나타냈으며, GFRP 보강층 두께가 증가함에 따라 피로수명이 증가하는 경향을 나타냈다. 한편 이러한 폴리머 모르타르 및 GFRP 보강층 두께에 따른 피로응력수준-피로수명 상관관계는 수정된 Miner의 법칙과 부합됨을 확인 할 수 있었다. Is this study, the fatigue properties of the sandwich panel of which core was made of the polymer mortar and inner and outer facings were reinforced by a high-tensile GFRP were surveyed. Sandwich-panel specimens consisted of polymer mortar core and GFRP compressive and tensile sides with various thickness were produced for the experimental study. Flexural fatigue tests were conducted to figure out the correlation between fatigue load and fatigue life for various thickness of core and facings, and its results are presented. The correlation obtained in this study between fatigue load and fatigue life for various thickness are in good agreement with the modified Miner's law.

폐결핵 환자 혈청에서 수용성 Interleukin 2 수용체 및 Adenosine Deaminase 활성도에 관한 연구

고정희,박성규,백상현,박찬권,박병수,안진영,최우석,박정규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Interleukin-2 (IL-2) induces T cell proliferation in an autocrine manner and provides a means by which antigen triggered T cells can be clonally expanded in vitro. During the following activation, the activity of IL-2 is mediated by specific high affinity IL-2 binding membrane receptors which are expressed shortly after activation. In this process, a 42 KD-fragment (soluble IL-2R) is continuously cleaved off and circulates as a soluble marker of T lymphocyte activation. Elevated level of soluble IL-2R has been identified in the serum of patients with malignant autoimmune and allergic disorders, systemic parasitic infection, undergoing graft versus host disease, acute or chronic lymphocytic leukemia and HIV-infection. ADA (adenosine deaminase) completes the process of differentiation of T cell and is essential for progression of T cell maturation. Therefore level of ADA is to correlated with magnitude of T cell immune response. The fact that expression of sIL-2R and ADA activity increases in peripheral blood T-lymphocytes of patients with active pulmonary tuberculosis suggests that T cell activation might have a major role in the pathogenesis of pulmonary tuberculosis. In order to evaluate the T cell immune response in pulmonary tuberculosis, we measured the serum concentration of sIL-2R and ADA activity in 17 patients with current pulmonary tuberculosis, 10 chronic inactive pulmonary tuberculosis, 10 as normal controls. (1) Current pulmonary tuberculosis had significantly higher levels of sIL-2R (237.24±95.47)when compared with those of inactive tuberculosis (78.6±11.06). and the control (68.17±15.4) group. (2) ADA activity in current pulmonary tuberculosis was significantly increased (34.41±20.63) when compared with those of inactive tuberculosis (24.7±14.36) and control (17.65± 5.94) group. (3) There was good correlation between sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group. (4) sIL-2R concentration and ADA activity was decreased significantly 6 months after anti-tuberculosis drug medication. In conclusion, sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group was increased when compared with those of inactive pulmonary tuberculosis and the control group. By the way, T cell mediated immune response was enhanced in current pulmonary tuberculosis, but in inactive chronic pulmonary tuberculosis who had treated by antituberculosis drug medication, the concentration of sIL-2R and ADA activity was nearly normal.

태종대 등대 주변의 식생현황 및 식생복원 방안

남정칠,이기철,김석규 東亞大學校 建設技術硏究所 2006 硏究論文集 Vol.29 No.2

This study is to survey and analyze the vegetation status around a Lighthouse area in Taejongdae for suggesting a revegetation method. 8 field surveys were conducted from Sept. to Oct., 2005, then representative sites were classified for further analysis. The results of the study are as follows. 1. Total of 100 plant species consisting 43 woody plants and 57 herbaceous plants were identified from the field survey. 2. 4 woody plants and 17 herbaceous plants were found in site A. Dominant woody plant were Pinus thunbergii & Eurya japonica. Trachelospermum asiaticum, Hedera rhombea, Oplismenus undulatifolius were mainly covered as the ground cover plants. 3. 4 woody plants were found in B-1 site and dominant species were Boehmeria pannosa, Pittosporum tobira, Elaeagnus macrophylla, etc. 4. 14 herbaceous plants were found in B-2 site and dominant species were Lysimachia mauritiana, Crepidiastrum lanceolatum, Setaria viridis, etc. 5. B-3 site is concrete wall. Thus it's concluded that such herbaceous plants as Parthenocissus tricuspidata, Hedera rhombea are suggested for rapid revegetation. 6. B-3 site is a flower bed area covered by Rhododendron indicum, Liriope platyphylla. Thus, it's recommended that such native plants as Aster spathulifolius, Farfugium japonicum etc. need to be placed. 7. 5 woody plants and 22 herbaceous plants were found in 8-5 site and dominant species were Pinus thunbergii, Boehmeria pannosa, etc. 8. Seed-spray and SF, CODRA, PEC landscape engineering techniques are suitable for revegetation in 8-2 and 8-5 sites. 9. It's also concluded that native plants and their seed were most suitable for the recovery of the original vegetation of 8-2 and 8-5 sites were when considering the factors of natural succession, landscape ecology and surrounding landscape.

거푸집 개발용 GFRP보강 폴리머 복합패널의 휨 특성

연규석,권택정,정중호,김성기 강원대학교 부설 석재복합신소재 제품연구센터 2004 석재연 논문집 Vol.9 No.-

본 연구는 반영구수명의 교량상판용 영구거푸집을 개발할 목적으로 리브를 갖는 GFRP보강 폴리머 콘크리트 복합패널을 제작하고 이에 대한 휨특성을 고찰한 것이다. 연구에서 리브높이와 인장측 GFRP보강층 두께를 달리하는 12종류의 GFRP보강 폴리머 콘크리트 복합패널 시험체를 제작하고 이에 대한 휨시험을 수행함으로써 리브 높이와 GFRP보강층 두께가 복합패널의 휨특성에 미치는 영향을 실험적으로 구명하였다. 시험결과 GFRP보강 폴리머 콘크리트 복합패널의 극한 모멘트는 GFRP 보강두께가 증가 1.0에서 4.0 mm로 증가 할때, 리브 높이에 관계없이 약 93~101%의 거의 일정한 중가폭을 보였고, 리브 높이가 1.0에서 3.0cm로 증가할 때, GFRP 보강층 두께에 관계없이 약 35~41%의 거의 일정한 증가폭을 보였다. 또한 강도설계법에 기초한 극한모멘트 예측식은 실험결과와 잘 부합되어 리브를 갖는 GFRP 보강 폴리머 콘크리트 복합패널을 영구거푸집에 적용할 시 지간에 따른 상용 단면설계에 매우 유용하게 적용될 것이다. In this study, twelve different GFRP-reinforced polymer concrete composite panel specimens with various rib heights and tensile side and reinforced side thickness were produced. flexural tests were conducted to figure out the effect of the height and thickness influencing on the flexural properties of composite panel. Test results of the study are presented. Especially, a prediction equation of the ultimate moment based on the strength design method agrees well with the test results, and it is thought to be useful for the corresponding design of cross-section according to various spans as the GFRP-reinforced polymer concrete composite panel is applied for a permanent form.