EMLA Cream 도포와 1% Lidocaine 침윤 후 요골동맥천자시 진통정도의 비교

윤석화,황원재,최세진 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

In a double blind study, the efficacy of topical 5% EMLA cream was compared with that of 1% lidocaine infiltration in the pain-relief and incidence of complication after radial arterial cannulation. Forty three premedicated adults were allocated randomly to two groups to receive EMLA cream and 1% lidocaine infiltration. Following arterial cannulation, pain was assessed by the patient using visual analogue score (VAS) and by a independent observer using four-caregory verbal rating score (VRS). There no significant differences between the EMLA group and 1% lidocaine infiltration group both patient and observer assessments. Compared with lidocaine infiltration group, significantly lower trial numbers of puncture in those recieving EMLA cream group, but no difference of discomfortness of puncture were observed in EMLA cream group.

수술중 기계적 환기시 HME (Heat and Moisture Exchanger)가 기도저항에 미치는 영향

윤석화,김일문,이상묵,유재현 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

To compare the airway resistance effects of two heat and moisture exchangers(HME) during short-term intraoperative volume controlled mechanical ventilation. Following a randomized order, the patients were ventilated during 3hrs with two HMEs(Pall conserve and Humi-vent filter). In each patient and for each 5 min, lhr, 2hrs and 3 hrs period, body temperature and airway resistance were measured. The hydrophobic HME (Pall conserve) had a good theraml conservation capacity, but increase airway resistance(11.7±2.9cm H_2O/1/s to 15 4±3.4 after lhr, to 17.3±2.5 after 2hrs, to 17.5±3.3cm H_2O/l/s after 3hrs). The hygroscopic filter(Humi-vent filter) had a good thermal conservation capacity, and less increase airway restance than Pall conserve(13.0±2.3 to 15. 4±3.4. after 1hr, 15.9±2.5 after 2hrs, 15.0±3.3 cmH2O/I/s after 3hrs). The hygroscopic HME had a thermal and humidification capacity and less increase the airway resistance.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

Bacillus lentimorbus WJ5의 감마선유도 돌연변이체들에서 공통으로 발현되는 방사선 관련 유전자의 microarray 분석

이영근,장화형,장유신,허재호,형석원,정혜영 한국환경생물학회 2004 환경생물 : 환경생물학회지 Vol.22 No.3

본 연구에서는 감마선으로 유도된 돌연변이체들에서 공통으로 발현되는 방사선 관련 유전자들의 발현을 연구하기 위하여, B. lentimorbus WJ5의 방사선 유도 돌연변이체에서 발현되는 유전자를 DNA microarray로 동시에 탐색하였다. DNA microarray는 B. lentimorbus WJ5 genome을 무작위로 절단하여 2,000단편으로 구성하였으며, 감마선 (^(60)Co)으로 유도된 7돌연변이체의 발현을 정량적으로 관찰하였다. 클러스터 분석결과 발현된 408 유전자 중 27개가 감마선 유도 돌연변이체 모두에서 유의하게 발현이 증가되었다. 특히, 복구(mutL, mutM)에너지 대사 (acsA, sdhB, p하, yhjB, citB), protease(npr), 산화자극에 대한 환원 (HMM)관련 유전자들이 동시에 증가되었다. 이는 감마선 유도 돌연변이체들에서 자발적인 직/간접 복구 관련 유전자의 발현 증가는 방사선 노출 직후 보이는 stress response와는 다른 현상임을 나타내는 것으로 생각된다. To study the radiation related gene expression in mutants of Bacillus lentimorbus WJ5 induced by gamm radiation, the simultaneous gene expression was analyzed by DNA microarray. We constructed DNA chips including two thousand randomly digested genome spots of B. lentimorbus WJ5 and compared its quantitative aspect with seven mutants induced by gamma radiation (^(60)Co). From the cluster analysis of gene expression pattern, totally 408 genes were expressed and 27 genes were significantly upregulated by the gamma radiation in all mutants. Especially, genes involved in repair (mutL, mutM), energy metabolism (acsA, sdhB, pgk, yhjB, citB), protease (npr), and reduction response to oxidative stress (HMM) were simultaneously upregulated. It seems that the induction of the direct and/or indirect repair related genes in mutants induced by gamma radiation could be remarkably different from the adaptive responses against acute exposure to radiation.

부착형 고분자 압전센서를 이용한 탄성파 검출 연구

김기복,윤동진,권재화,이영섭,이승석 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

스마트 구조물에 적합한 탄성과 검출 센서로서 고분자 압전 필름을 이용한 부착형 센서에 대한 연구를 수행하였다. PVDF와 copolymer에 대하여 센서로서의 특성을 평가하였으며 상용화된 PZT 센서와 비교하였다. 탄성과 속도와 음향임피던스가 서로 여러 가지 재료에 고분자 압전필름 센서를 부착하여 연필심 파괴 시 발생하는 탄성파를 검출하여 분석하였다. 센서의 직경이 증가함에 따라 검출 신호의 피크 전압은 증가하였으나 센서의 dynamic range는 감소하는 것으로 나타났다. 시편의 음향임피던스가 감소할수록 검출신호 파형의 피크 값은 증가하였으며 주로 저주파수의 주파수 성분의 신호에 민감한 것으로 분석되었다. Copolymer 센서가 PVDF 센서보다 감도 면에서 다소 양호한 것으로 나타났다.

CHANNEL ALLOCATION SCHEME FOR VoD SYSTEM

Jae Wook Yoo,Hyeon Seok Ahn,Jun Hwa Lee,Seok Jin Chung,Tae Guen Park,Jae Hyun Park,Doug N. Kim 한국통신학회 1997 한국통신학회 워크샵 Vol.- No.-

DEVELOPING A BUILDING INFORMATION MODELING (BIM) DESIGN PROCUREMENT GUIDE

Seok, Jae-Hwa(석재화),Ock, Jong-Ho(옥종호) 대한건축학회 2019 대한건축학회 학술발표대회 논문집 Vol.39 No.1

Adult Bronchiolitis in South Korea: Prevalence and Comorbidities

( Jae Seok Jeong ),( Yong Chul Lee ),( So Ri Kim ),( Jong Seung Kim ),( Hae Jin Park ),( Kyeong Hwa Park ),( Ki Jae Sung ),( Yeong Hun Choe ),( Seung Yong Park ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Bronchiolitis refers to a condition that is associated with nonspecific inflammatory injury to the small airway, often sparing a considerable portion of the interstitium. Until now, the prevalence, mortality, comorbidities, and medical expenditure for bronchiolitis have not been elucidated. We used sample data of KNHIS-NSC (Korea National Health Insurance Service-National Sample Cohort), which is a stratified random sample of 50 million Koreans considering age, sex, residence area, income, etc. Inclusion criteria were: 1) patients with ICD-10 Code J448 or J684, 2) patients confirmed by CT scan, 3) patients over 20 years old, and 4) patients who visited clinic or hospital in South Korea from 2002 to 2013. We excluded patients diagnosed with acute bronchiolitis (ICD-10 Code J21) or cystic fibrosis (ICD-10 Code E84). The overall prevalence of bronchiolitis was 688 cases per 1,000,000 population. In terms of comorbidities, rhinitis (52.3%) was the most common, followed by asthma (52.2%) HTN (43.7%), GERD (30.6%), chronic rhinosinusitis (28.7%), DM (22.8%) and osteoporosis (17.9%) (Graph 1). Other comorbidities were cerebrovascular disease (16.9%), angina (14.4%) and peripheral vascular disease (13.4%). Healthcare spending on bronchiolitis averaged about 465,000 won (350 euros) per person per year. The mortality rate was the highest due to malignancy (512 cases, 6.2%), followed by bronchiolitis (270 cases, 3.3%), cerebrovascular disease (90 cases, 1.1%), and pneumonia (68 cases, 0.8%). Among the malignant diseases, lung or bronchi cancers (229 cases, 2.8%) accounted for about half of all cases. In Conclusion, bronchiolitis is an underestimated, burdensome disorder with various medical comorbidities, and further study should be carried out for the advancement of its concept.

Case Reports : Delftia acidovorans Isolated from the Drainage in an Immunocompetent Patient with Empyema

Jae Young Chun,Jae Chun Lee,Jae Seok Bae,Mi Yeon Kim,Jae Geun Lee,Sang Yop Shin,Young Ree Kim,Keun Hwa Lee 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.3

Delftia acidovorans is a gram-negative motile rod found ubiquitously in soil and in water. Confirmed isolation from clinical infections is rare, and has been documented mostly in immunocompromised patients or those with indwelling catheters. A 53-year-old man was referred for the evaluation of a huge mass-like lesion found incidentally by chest X-ray. The lesion occupied more than half of the right lung and was diagnosed as a large loculated pleural effusion by CT scan. Bloody pus was drained through a percutaneous catheter, and D. acidovorans, identified by the Vitek GN card and confirmed by amplification of 16S ribosomal RNA and sequencing analysis, was isolated repeatedly from the drained pus. The patient was treated with imipenem/cilastatin to which the organism was sensitive. This is a rare report of chronic empyema associated with D. acidovorans in the respiratory system of an immunocompetent patient.

Poster Session : PS 1424 ; Hemato-Oncology(Oncology) : Successful Treatment of Intracranial Germ Cell Tumor: Report of Unusual Two Cases with Literature Review

( Jae Seok Lee ),( Yun Hwa Jung ),( In Sook Woo ),( Young Yun Cho ),( Yun Duk Jung ),( Deok Jae Han ),( Chi Wha Han ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Primary intracranial germ cell tumor (GCT) is a rare subset of intracranial tumor. They are known to occur primarily in 2nd and 3rd decades of life and arise from midline structure especially pineal gland or suprasellar region due to aberrant migration during embryogenesis. Although intracranial GCT is sensitive to treatment, high recurrence rate, treatment related long term complications, unusual cases including bifocal germinoma or nongerminomaous germ cell tumor (NGGCT) make treatment complicated. Moreover, because of locational feature, hydrocephalus and visual field defect, functional disturbance of pituitary gland can occur and require attention. Treatment primarily relys on chemotherapy and radiation therapy but there is difference between germinoma and NGGCT. Here, we present two cases of intracranial GCT which are relatively uncommon. One case was bifocal intracranial germinoma and the other was intracranial choriocarcinoma. Both cases were treated with neoadjuvant chemotherapy (4 cycles of ifosfamide, carboplatin and etoposide combination chemotherapy) followed by reduced field radiation therapy without significant treatment related complication. Further, we performed a PUBMED search to investigate appropriate treatment strategy of unusual subtype of intracranial germ cell tumor.