악성 흉막삼출액에서 Bleomycin을 이용한 흉막유착설의 시술효과

박정현,김학렬,양세훈,정은택 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.1

목적: 악성 흉막삼출액이 반복적이고 지속적으로 발생하는 경우, 호흡곤란, 흉통등의 증상을 유발시키므로 흉막경화제에 의한 흉막유착술을 시행할 수 있다. 흔히 사용되던 talc의 심각한 부작용이 보고되고 있고, doxycycline 주사제도 국내에서 발매되지 않고 있다. 이에 연자들은 항암제로 소개된 bleomycin을 이용한 흉막유착술의 단기와 중기효과, 부작용 및 생존율 등을 전향적으로 확인하였다. 방법: 2000년 1월부터 2001년 12열까지 원광대학교 부속병원에 내원하여 반복적이고 지속적인 악성 흉막삼출액으로 흉막유착술이 필요한 26명의 환자를 대상으로 특별한 전 처치 없이 bleomycin 60 unit를 식염수와 함께 흉강 내 주입 후, 1일 후의 흉관에 의한 배액량을 확인하고 부작용을 관찰하였으며, 1개월 후에 흉부 방사선상으로 재 저류 유무를 확인하였다. 또한 시술 반응군과 비반응군으로 나누어 중앙생존기간을 비교분석 하였다. 결과: 시술 1일 후 26예중 10예(38%)에서 배액이 없었고, 8예(31%)에서 배액량이 100ml이하였으며, 8예(31%)는 100ml이상이었으나 시술 전보다 감소하였으며 증가된 경우는 없었다. 유의할만한 부작용은 4예(고열 3예, 흉통 1예)에서 발생하였으나, 대증요업으로 조절되었다. 시술 1개월 후 흉부 방사선과 26예중 9예(35%)는 재 저류액이 없었고, 10예(38%)는 저류액이 있으나 시술 전보다 감소하였으며, 1예(4%)는 이전과 변화가 없었고, 6예(23%)는 시술 전보다 저류액이 증가하였다. 시술 후 단기 및 중기효과를 반응군과 비반응군으로 나누어 중앙생존기간으로 양군간을 비교하였을 때, 반응군에서 연장이 되었으나 통계적으로 유의한 차이는 없었다. 결론: 이상의 결과로서 bleomycin에 의한 흉막유착술은 다른 경화제보다 특별한 전 처치가 필요 없는 간편하고, 비교적 부작용이 적은 안전한 방법이며, 효과적인 치료성적을 보이는 시술로 사료된다. Background : Malignant pleural effusions are common and significant problems in patients with advanced malignancy. Repeated thoracentesis provides temporary symptomatic improvement, but most patients progressively cause dyspnea or pleuritic pain. So pleurodesis with sclerosing agent is effective as a palliative treatment. There are many drugs used as pleural sclerosing agents. But doxycycline hasn't been used in Korea since 1999. And recently talc has been reported serious side effects. In this study, pleurodesis with bleomycin was prospectively investigated for its short term and middle period effects and its side effects. Methods : Twenty-six patients with malignant pleural effusion were prospectively analyzed to estimate the effects of bleomycin pleurodesis. Without special management before the procedure, 60 units of bleomycin in 50-100ml of normal saline were instilled into the pleural space via a small bore catheter(8-10 F). Andthen repeated positional changes and rotations were done for 2 hours. We measured the drainage amount and evaluated the side effects after 24 hours and checked the existence of the effusion by chest radiography after 1 month. Results : After 24 hours, the drainage amount showed that the responder group(none or ≤ 100ml) was 69%, and that the nonresponder group(> 100ml) was 31%. Side effects (high fever in 3 cases and severe pleuritic pain in 1 case) were 15%(4/26), but patients recovered easily by symptomatic management. After 1 month, chest radiography showed that the response rate(complete or partial response) was 73%. Differences of survival times between responder and nonresponder group was not statistically significant. Conclusions : We are suggest that bleomycin as a pleural sclerosing agent is a relatively simple, safe and effective agent. But a prospective study with a larger number of patients must be warranted.

흡연에 의한 급성 호산구성 폐렴 2예

박종빈,김학렬,주현준,유태양,신성남,신정현,송정섭,황기은,김소영,양세훈,정은택 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

최근 흡연을 시작한 젊은 성언에서 급성 호산구성 폐렴의 발생에 대한 증례가 보고되고 있다. 급성 호산구성 폐렴은 대개 발열을 동반하기 때문에 초기에는 감염성 폐렴으로 잘못 진단, 치료되는 경우가 많다. 아직 정확한 병태 생리 및 조직학적 소견은 밝혀져 있지 않지만 병력 청취 및 임상 양상, 방사선 소견의 관찰을 통해 급성 호산구성 폐렴을 의심하고, 진단을 위해 기관지 폐포 세척액 검사를 시행한다면 좀 더 쉽게 진단 내릴 수 있을 것이다. 본 저자들은 최근 처음 시작한 흡연에 의해 발생한 급성 호산구성 폐렴을 진단하고, 스테로이드를 투여하여 성공적으로 치료한 환자 2예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Acute eosinophilic pneumonia(AEP) is characterized by acute febrile respiratory illness associated with diffuse pulmonary infiltration and pulmonary eosinophilia. The specific etiology for acute eosinophilic pneumonia is elusive. By some investigators, cigarette smoking is suggested as a causative substance which can cause AEP. In recent, the authors experienced two cases of AEP following cigarette smoking. Both cases had characteristic features including age around 20 years, new onset smoking before occurance of AEP, diffuse infiltration on chest radiography, pulmonary eosinophilia based on bronchoalveolar lavage and acute improvement after steroid therapy. These clinical features are resemble with previous smoking induced AEP case reports. Base on these clinical features, cigarette smoking associated AEP could be diagnosed more easily.

내시경적 역행성 췌담관조영술중 췌선방 조영 후 발생한 중증 췌장염 1예

장세중,기승석,김훈일,신혜영,박장원,송은훈,태재웅 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

내시경적 역행성 담췌관조영술 후 발생한 급성췌장염의 발생인자로 여러 가지 인자들이 관여하지만 특히 담췌관조영술 시행 후 과도한 췌선방 조영화에 의한 중증의 췌장염 증례를 경험하였기에 보고하는 바이다 Endoscopic retrograde cholangiopancreatography (ERCP) has been considered as a valuable tool for the diagnosis and management of disease of the pancreas and biliary tree. Post-ERCP pancreatitis is the most frequent and clinically significant complication following ERCP. But a few complication associated with this procedure are unforeseeable. Specially, acinarization as a result of a careless cooperation between operator and assistant may be influenced in complications of ERCP. Severe post-ERCP pancreatitis is rare complication, and its prognosis will be poor. Therefore, careful process and good relationship between operator and assistant in ERCP may be prevented this complication, but is not clear. Neglect of acinarization may be resulted in more aggravation of pancreatitis. We have cared for one patient with severe post-ERCP pancreatitis with pseudocyst after water-soluble contrast media spreading into the acini (acinarization) via ERCP in resolving phase idiopathic pancreatitis.

작물 수량과 쏘스-씽크 관계

성락춘,최규훈,박세준 高麗大學校 自然資源科學硏究所 1996 自然資源科學硏究 Vol.4 No.-

Mutations of the LKB1/STK11 Gene in Non-Small Cell Lung Cancer with Loss of Heterozygosity

( Sei Hoon Yang ),( Leah E Mechanic ),( Rajbir Gill ),( Tatiana Dracheva ),( Seong Hoon Park ),( Jung Hyun Park ),( Hwi Jung Kim ),( Hak Ryul Kim ),( Eun Taik Jeong ),( Curtis C. Harris ),( Jin Jen ) 대한결핵 및 호흡기학회 2006 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.103 No.-

만성 폐쇄성 폐질환의 조기 진단과 관리

이세원 ( Sei Won Lee ),유지홍 ( Jee-Hong Yoo ),박명재 ( Myung Jae Park ),김은경 ( Eun Kyung Kim ),윤호일 ( Ho Il Yoon ),김덕겸 ( Deog Kyeom Kim ),이창훈 ( Chang Hoon Lee ),박용범 ( Yong Bum Park ),박주헌 ( Joo Hun Park ),황용일 ( 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.4

Chronic obstructive pulmonary disease (COPD) is a substantially under-diagnosed disorder, and the diagnosis is usually delayed until the disease is advanced. However, the benefit of early diagnosis is not yet clear, and there are no guidelines in Korea for doing early diagnosis. This review highlights several issues regarding early diagnosis of COPD. On the basis of several lines of evidence, early diagnosis seems quite necessary and beneficial to patients. Early diagnosis can be approached by several methods, but it should be confirmed by quality-controlled spirometry. Compared with its potential benefit, the adverse effects of spirometry or pharmacotherapy appear relatively small. Although it is difficult to evaluate the benefit of early diagnosis by well-designed trials, several lines of evidence suggest that we should try to diagnose and manage patients with COPD at early stages of the disease.

SPMSM을 이용한 침상침하용 재봉틀 구동시스템 개발

박내춘(Park Nae Chun),김상훈(Kim Sang Hoon),박세훈(Park Sei Hun),박경두(Park Kyung Doo) 전력전자학회 2010 전력전자학술대회 논문집 Vol.2010 No.7

본 논문에서는 PMSM(Permanent Magnet Synchronous Motor)을 이용한 재봉틀 구동시스템을 개발하였다. 전차원 관측기를 이용하여 속도를 추정하고, 벨트(Belt)에 의한 외란 토크를 추정하여 보상하였다. 개발된 재봉틀 구동시스템을 실제 재봉틀에 장착하여 그 효용성을 검증하였다.

An Integrated Growth Model of Software Reliability Based on the Non-Homogeneous Poisson Process

박세권 ( Sei Kwon Park ),박상옥 ( Sang Wook Park ),웬쾅에이 ( Kuang Wei Wen ),양경훈 ( Kyung Hoon Yang ),류승완 ( Seung Wan Ryu ) 한국경영공학회 2011 한국경영공학회지 Vol.16 No.3

In this paper, we propose an integrated growth model of software reliability based on the non-homogeneous Poisson process. The model shows the relationship between several distinctively developed models. It also demonstrates not only each of the major attributes of the previous models but also the combined hidden attributes of those models. In addition, we derived estimates of the parameters of the integrated growth model and subsequently, tested the model with real world data. We found that our growth model is better than previous models in its flexibility to explain the reliability of software attributes and ability to apply to various situations in the real world.

F-37 : Free Paper Presentation ; Prediction of Drug Resistant Pathogens with Current Criteria of Healthcare-associated Pneumonia

( Jin Kyeong Park ),( Hyun Jung Kim ),( Sei Won Lee ),( Eun Kyung Kim ),( Yee Hyung Kim ),( Ji Yong Moon ),( Kyung Hoon Min ),( Sung Soo Park ),( So Young Park ),( Yong Bum Park ),( Yun Su Sim ),( Kwa 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

Healthcare-associated pneumonia includes a heterogeneous group of patients in frequent contact with health care systems. However, current criteria of HCAP poorly predict the potentially drug-resistant pathogens (PDR). The objective of this review is to assess the accuracy of prediction of PDR pathogens using HCAP criteria. Medline, EMBASE and Cochrane Central Register of Controlled Trials were searched. We examined the titles and abstracts of 6383 articles and the full-text versions of 1598 articles. We included 21 studies in our review and calculated pooled sensitivities and specificities with 95% confidence intervals (CI).Twenty one articles included 12597 patients (7658 community acquired pneumonia and 4939 HCAP patients) from 8 different countries. Pooled sensitivity was 0.65 (95% CI 0.63-0.66) and specificity was 0.70 (95% CI 0.69-0.71). With 10 studies provided all PDR pathogens, sensitivity was 0.66 (95% CI 0.63-0.69) and specificity was 0.69 (95% CI 0.65-0.68). With only Asian population, sensitivity was 0.68 (95% CI 0.65-0.70) and specificity was 0.60 (95% CI 0.58-0.62) while non-Asian population showed sensitivity of 0.63 (95% CI 0.61-0.65) and specificity of 0.74 (95% CI 0.73-0.75). Six prospective studies showed sensitivity of 0.65 (95% CI 0.59-0.70) and specificity of 0.73 (95% CI 0.71-0.74) while 15 retrospective studies showed sensitivity of 0.65 (95% CI 0.63-0.66) and specificity of 0.68 (95% CI 0.67-0.69).Current HCAP criteria comprise a heterogenous group of pneumonia patients and its predictive strength for specific PDR pathogens remains insufficient.Healthcare-associated pneumonia includes a heterogeneous group of patients in frequent contact with health care systems. However, current criteria of HCAP poorly predict the potentially drug-resistant pathogens (PDR). The objective of this review is to assess the accuracy of prediction of PDR pathogens using HCAP criteria. Medline, EMBASE and Cochrane Central Register of Controlled Trials were searched. We examined the titles and abstracts of 6383 articles and the full-text versions of 1598 articles. We included 21 studies in our review and calculated pooled sensitivities and specificities with 95% confidence intervals (CI).Twenty one articles included 12597 patients (7658 community acquired pneumonia and 4939 HCAP patients) from 8 different countries. Pooled sensitivity was 0.65 (95% CI 0.63-0.66) and specificity was 0.70 (95% CI 0.69-0.71). With 10 studies provided all PDR pathogens, sensitivity was 0.66 (95% CI 0.63-0.69) and specificity was 0.69 (95% CI 0.65-0.68). With only Asian population, sensitivity was 0.68 (95% CI 0.65-0.70) and specificity was 0.60 (95% CI 0.58-0.62) while non-Asian population showed sensitivity of 0.63 (95% CI 0.61-0.65) and specificity of 0.74 (95% CI 0.73-0.75). Six prospective studies showed sensitivity of 0.65 (95% CI 0.59-0.70) and specificity of 0.73 (95% CI 0.71-0.74) while 15 retrospective studies showed sensitivity of 0.65 (95% CI 0.63-0.66) and specificity of 0.68 (95% CI 0.67-0.69).Current HCAP criteria comprise a heterogenous group of pneumonia patients and its predictive strength for specific PDR pathogens remains insufficient.

Safety and efficacy of single‐agent docetaxel ( T axotere) administered weekly in non‐small cell lung carcinoma patients in K orea: An observational study

Lim, Sun Min,Park, Byeong Bae,Park, Keun‐,Chil,Kim, Hoon‐,Kyo,Lee, Jong Seok,Bae, Sung Hwa,Lee, Seung‐,Sei,Kang, Jin‐,Hyoung,Park, Se‐,Hoon,Lee, Gyeong‐,Won,Lee, Hy John Wiley and Sons Inc. 2016 Thoracic cancer Vol.7 No.2

<P><B>Abstract</B></P><P><B>Background</B></P><P>To investigate the efficacy, safety, and tolerability of weekly docetaxel treatment in advanced non‐small cell lung cancer (NSCLC) patients in Korea.</P><P><B>Methods</B></P><P>This prospective observational study included Korean advanced NSCLC patients with Eastern Cooperative Oncology Group performance status <2 who received weekly monotherapy of docetaxel at a dose determined by the physician. Efficacy measurements included tumor response rate, overall survival (OS), progression‐free survival, and one‐year survival rate. Safety was analyzed through recorded incidences of adverse events (AEs), serious adverse events (SAEs), deaths, and other related safety parameters, along with their toxicity grades.</P><P><B>Results: </B></P><P>Of 274 patients analyzed, one patient achieved a complete response and 42 partial responses; thus, the overall response rate was 15.7%. The OS rate at baseline and at one‐year follow‐up was 38.3% and 33.8%, respectively. AEs were reported in 229 (83.6%) patients. The most frequently reported hematologic AE of grade ≥3 was a decrease in neutrophils, with 6.6% of the patients developing neutropenia. In non‐hematologic AEs of grade ≥3, the most common were infection with unknown absolute neutrophil count and death not associated with Common Terminology Criteria for Adverse Events (CTCAE) (4.7% each). The most common SAE reported was death, not associated with CTCAE (7.3%).</P><P><B>Conclusions</B></P><P>In Korean patients, the weekly regimen of docetaxel monotherapy was safe and efficacious against advanced NSCLC.</P>