정신분열병 환자에서 가족력, 산과적 합병증 및 신체미세기형의 관련성에 관한 연구

안용민,김용식,정희연,신지용,윤세창,배안,이중서,주은정,이창인 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 저자들은 태생기 동안에 받는 유전외적 요인, 즉 환경적 요인이 산발성 정신분열병 환자들의 발병에 크게 관여할 것이라고 가정하였다. 이를 검증하기 위하여 형제 중 1인 이상이 발병하여 가족력을 분명히 알 수 있는 정신분열병 환자군(이하 형제 환자군)과 가족력이 없는 산발성 정신분열병 환자군(이하 산발성 환자군) 및 정상대조군을 대상으로 산과적 합병증, 신체미세기형 및 정신분열병의 임상 양상을 비교하였다. 방 법 : 연구 대상은 형제 환자군 43명(남 22명, 여 21명), 산발성 환자군 43명(남 23명, 여 20명), 정상대조군 43명(남 20명, 여 23명)이었다. 산과적 합병증은 Lewis 척도를 이용하여 평가하였고 신체미세기형은 Waldrop 척도를 이용하여 측정하였다. 임상 양상으로서 발병 연령, 병전 기능 수준, 정신병리, 약물에 대한 반응, 회복시의 전반적 기능 수준, 지연성 운동장애의 유무를 평가하였다. 결 과 : 정상대조군과 정신분열병 환자군 전체를 비교하였을 때 산과적 합병증과 신체미세기형의 총점과 각 소항목의 점수에 차이가 없었다. 산발성 환자군과 형제 환자군을 비교하였을 때 산과적 합병증의 전체 점수에서는 유의한 차이가 없었으나, 출생 당시에 태아가 받은 스트레스 항목의 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형에서는 전체 점수 및 입의 미세기형 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형의 전체 점수가 4점 이상인 환자수도 산발성 환자군에서 높은 경향성을 보였다. 산과적 합병증과 신체미세기형 사이의 상호 연관성은 찾을 수 없었다. 정신분열병의 임상 양상 중에서는 Krawiecka 척도의 총점 및 양성 증상 점수와 회복시의 전반적 기능 수준만이 형제 환자군에 비해 산발성 환자군에서 유의하게 높았다. 성별에 따라서는 형제 환자군에서 남자 환자의 산과적 합병증이 유의하게 높았다. 결 론 : 본 연구를 통해 산과적 합병증 및 신체미세기형 연구가 정신분열병의 원인을 규명하기 위한 유용한 방법임이 시사되었지만, 가족력, 산과적 합병증 및 신체미세기형의 관련성에 대해서는 분명한 결론을 내리지 못하였다. The authors hypothesized that sporadic schizophrenic patients had more chances of receiving environmental insults during the fetal neural development compared with familial schizophrenics. We tested our hypothesis by comparing obstetric complications(OCs), minor physical anomalies(MPAs) and other clinical features, and examining the correlation between OCs and MPAs in schizophrenic patients who had one or more sibling with schizophrenia(sibling group) and sporadic schizophrenics(sporadic group) and normal controls. OCs were evaluated by the scale of Lewis, and MPAs were measured by the Waldrop scale. There were no significant difference in OCs and MPAs between schizophrenic and control groups. Sporadic group had significantly higher fetal distress, total Waldrop score and Waldrop score for mouth than sibling group. And there was a tendency that the number of subjects having the Waldrop score over 4 points was greater in the sporadic group. No significant correlation was observed between CCs and MPAs. The scores of initial psychopathology and post-treatment functioning were much higher in the sporadic group, but the other clinical feature showed no difference. Although male patients had more OCs than female patients in sibling group, no sex difference were observed as a whole. Our results suggest that, if the methodological weakness were complemented, OCs and MPAs would be useful tools in the search for the cause of schizophrenia.

지난 4년간 학회지 "신경정신의학" 심사 평가보고

오병훈,권준수,남궁기,김승현,지익성,김창윤,하규섭,박원명,김성곤,오강섭,김정범,이수정,정한용,이창욱,박용천,이영문,김세주,이병욱 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5

Four Years Reports of "Journal of Korean Neuropsychiatric Association" during 2001 to 2005 were evaluated by 18 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation Processes, "Journal of Korean Neuropsychiatric Association" will develop a good journal.

콩 단백질/펙틴/몬모릴로나이트 나노복합 필름의 특성 및 산소 투과도 연구

정세환,김성철,조규순,신용섭,장상희,홍기헌,이태진,신부영 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.2

In this study, Mechanical property, thermal property, watervapor, and oxygen permeability of biodegradable Soy protein/Pectin-montmorillonite nanocomposite, prepared with Na^(+)-MMT, have been studied. X-ray diffraction and TEM experiments an polymer/silicate composite samples demonstrated that the intercalation of polymer chains leads to increase in the spacing between silicate layers. In addition, it were found that the intercalated Soy protein/Pectin/montmorillonite nanocomposite were prepared. It was found that the addition of only a small of clay was enough to improve the thermal stability and mechanical property of Soy protein/Pectin/montmorillonite nanocomposite. watervapor of Soy protein/Pectin/montmorillonite nanocomposite was generally lower than that of Soy protein/Pectin. oxygen permeability of Soy protein/Pectin/montmorillonite nanocomposite was generally lower than that of Soy protein/Pectin.

부비동 환기의 연구를 위한 인체 비부비동 모형

정용수,김상렬,김동환,정동근,최순섭,정인호,서세훈 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.9

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

수직적 안모형태와 치아성숙도의 상관관계에 대한 연구

구용한,현홍근,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

본 연구는 수직적 안모형태와 치아성숙도의 관계를 평가하고 이러한 연관성에 대한 사춘기 성장의 영향을 평가하기 위한 것이다. 이번 연구를 위해 7세에서 9세, 13세에서 15세 환자 1306명을 Ricketts의 VERT index를 이용하여 수직적 안모 형태를 분류하였고 환자들의 치령을 Demirjian법으로 평가하여 다음과 같은 결과를 얻었다. 1. 모든 군에서 치령이 역령과 비교 시 통계적으로 유의한 수준에서 크게 측정되었다. 2. 사춘기 연령군에서 brachyfacial type의 경우가 dolichofacial type 보다 치아성숙도가 크게 나타나는 경향을 보였다. 여성의 경우는 통계적으로 유의성있게 차이가 나타났으며, 남성의 경우는 통계적 유의성은 보이지 않았다. 3. Brachyfacial type의 경우 사춘기전 군들과 비교 시 사춘기 군들에서 치아성숙도가 유의성있게 높게 나타났으며, dolichofacial type의 경우는 연령층간 치아성숙도의 차이를 보이지 않았다. The purpose of this investigation was to study the relationship between vertical facial pattern and dental maturation in children in pubertal and pre-pubertal periods. The material consisted of lateral head films and panoramic radiographs of 1306 patients. The subjects were selected according to Ricketts's VERT index and other including criteria. These subjects were divided by VERT index to brachyfacial group and dolichofacial group. In each selected subject, dental age was determined according to Demirjian's dental maturity score. All subjects were distributed according to age, vertical facial type and sex, mean and standard deviation of chronological age, dental age and age difference were determined in each group. And the data were analysed to find the difference of tooth maturation by facial pattern. Findings of this study include: 1. In all groups, dental age was determined higher than chronological age in statistically significant level. 2. Compared by vertical facial pattern, in pubertal age groups, it seems that subjects with brachyfacial type presented the tendency to have an advanced dental maturation, only in female group. 3. Compared by pubertal period, brachyfacial groups presented more advanced dental maturation in pubertal groups than pre-pubertal groups.

최근 10년간 마취에 관한 임상적 고찰

신용섭,임정혁,최세진 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

To evaluate the specificity and the historical trends of the anesthetic agents and anesthetic methods used in Chungnam National University Hospital, anesthetic experiences of 21, 595 in total performed at Chungnam National University Hospital from January 1977 to December 1986 were analyzed stastically and clinically according to age, sex, surgical department, physical status, elective and emergency surgery, premedicants, induction agents, anesthetic methods, main anesthetic agent, anesthetic technique and muscle relaxants. The results were as follows: 1. The number of cases has been steadily increased. Considerable increase in the cases has been noted since 1985, when Chungnam National University Hospital was enlarged. 2. The distribution of the number of patients according to the age were 15, 332 cases (70. 9%) in the group of 16-60 years. 3. There were 12, 109 male (56. 1%) and 9,486 female (43.9/'0) cases. 4. 6, 128 cases (28.4%) were in general surgery, 4, 276 cases (19. 8%) in orthopedic surgery, 3, 138 cases (14.5%) in OB-GY and 1, 888 cases (8.7%) in ENT in order of numbers. 5. According to the ASA classification of physical status, most of the cases were belonged to the class 1 (33. 9%) class 2 (26.6%), class 1E (14.2%) and class 2E (12.5%). Almost cases were relatively in good physical status. 6. The rate of elective to emergency was 66. 5% (14, 370 cases) to 33. 5% (7, 225 cases). 7. As premedicants, a group of atropine, diazepam and hydroxyzine (33.4%) was given most frequently. Recently, glycopyrrolate has been used increasingly. 8. Thiopental sodium has been mainly used for intravenous induction agent. 9. General anesthesia has been used as the main method of anesthesia. 10. Halothane was the most commonly used anesthetic agent. Since 1979, the use of enflurane has been increased yearly. 11. The semiclosed circle breathing system was mainly employed. 12. Succinylcholine was given to most cases. Pancuronium was the most commonly used nondepolarizing muscle relaxant. Vecuronium has been used since 1986.

성남시 어린이집 원아 어머니의 구강보건의식과 행태에 관한 조사연구

안용순,김은숙,임도선,정세환,이홍재 한국구강건강증진학회 2000 한국구강건강증진학회지 Vol.1 No.1

The purpose of this study was to evaluate behaviour about oral health of child's mothers in Songnam city, to obtain the data on oral health programs for young child of child care institutions. A self-developed questionnaire with 10 items was delivered to 713 mothers. Mothers were selected by a cluster sampling method. The 662 collected data was analyzed by profession state. The obtained results were as follows : 1. The house wives without job didn't appear the better behaviors about child's oral health than those with job except child's tooth brushing number per day. 2. There were needed to develop mothers' education program, caries prevention program, periodic oral exam program, refer system program after oral exam and tooth brushing program. 3. The 10 subjects were enumerated by contents of mothers' education program.

후방 도달 척추 절제술을 이용한 강직성 요천추 변형의 치료

석세일,정의룡,이정희,김진혁,김성수,이지호,최원기,박용원 대한척추외과학회 2004 대한척추외과학회지 Vol.11 No.2