신연 신생골형성술을 이용한 하악골의 연장 : 실험적 연구 AN EXPERIMENTAL STUDY

백세민,박재현,오재욱 大韓成形外科學會 1995 Archives of Plastic Surgery Vol.22 No.5

Various techniques such as bone graft, vascularized bone and implantation of synthetic material have been used to reconstruct the mandible but these techniques have their own limitations, that is, bony resorption, infection, donor site morbidity and exposure of implant. These limitations could be, however, overcome when the technique of bone lengthening by distraction osteogenesis, the process of generating new bone by gradual distraction. Bone lengthening by distraction osteogenesis has been performed to reconstruct the deficiency of long bones such as tibia since early twentieth century, and is now widely performed in the field of orthopedic surgery. But applying distraction osteogenesis in reconstructing the mandible has a short history. There are few reports describing the optimal rate of mandibular distraction and it remains also controversial whether the nerve injury occurs during distraction. The purpose of this study is to evaluate the process of new bone formation in the mandible and to exzamine the integrity of inferior alveolar nerve histologically when the distraction rate is 1.6mm per day. Six healthy 15 to 20Kg mongrel dogs served as the experimental animals. Left side periosteal preserving reversed L-shape corticotomy was performed from the antegonial notch, and an external lengthening device (Bonefix 200) was fixed parallel to the inferior border of the mandible. After 5 days of latent period, the mandible was lengthened 1.6mm per day(0.8mm in every 12 hrs) for 20 days and held in external fixation for 6 weeks after which all dogs were sacrificed. The specimens were evaluated anthropometrically, radiologically and histologically. Then the results were as follows; 1) The gain in length ranged from 18mm to 25mm(average 23mm). 2) The newly formed bone showed intramembranous ossification. 2 cases contained island of cartilage. 3) Most of nerve fibers in the elongated inferior alveolar nerve showed myelination and normal structure of axon. New bone formation at the distraction rate over 1 mm per day was favorable and most of the new bone was formed by intramembranous ossification, and also inferior alveolar nerve nearly maintained its integrity after distraction. However more detailed study is necessary to determine the ideal distraction rate and exacts ossification mechanism of the mandible.

비만과 정상체중 여고생의 영양섭취 비교 연구

조현숙,김세종,최승욱,백영호 釜山大學校 附設 體育科學硏究所 2005 體育科學硏究所 論文集 Vol.21 No.2

The purpose of this study was to compare the obese and the normal weight girls in high school on the level of the recommended dietary allowances for the Koreans based on total energy intake, the ratio of 3nutrients intake, micro-nutrients intake, daily dietary intake and the ratio of 4nutrients intake by animality and vegetability. The results of this study are as follows:...............

1994∼1995년 한국에서 발생한 가을철 열성질환에 대한 혈청역학적 연구

송기준,송진원,백락주,김상현,김세연,이용주 대한감염학회 1998 감염 Vol.30 No.4

목 적 : 최근 우리나라에서 발생했던 금성 열성질환의 전반적인 혈청역학적 양상의 분석을 위해 1994년부터 1995년까지 고려대학교 의과대학 미생물학교실, 바이러스병연구소에 급성 열성질환으로 검사가 의뢰된 환자혈청 5330건을 쯔쯔가무시병, 발진열, 신증후출혈열, 라임병 및 랩토스피라증에 대한 항체를 조사하였다. 방 법 : 1994년부터 1995년까지 2년간 고려대학교 의과대학 미생물학교실, 바이러스병 연구소에 검사가 의뢰된 환자혈청을 주 대상으로 간접면역형광항체법 검사로 쯔쯔가무시병, 발진열, 신증후출혈열 및 라임병에 대한 항체양성 유무를 검색하고 macroscopic agglutination법으로 렙토스피라증에 대한 항체를 조사하였다. 결 과 : 열성질환 환자 혈청 5330건을 대상으로 신증후출혈열, 쯔쯔가무시병, 발진열 및 라임병에 대한 항체검사 결과 쯔쯔가무시 항체양성자가 12% (640/5330)로 항체양성자 중 여자가 60%로 60대가 30% (192명)로 가장 많았다. 월별 분포에서는 대부분의 양성자 (89%)가 가을철에 집중되어 있었다. Richettsia, typhi에 대한 항체를 양성률을 보였다. 발진열 항체 양성자 중 남자가 60% (106/178)로 여자보다 많았으며, 모든 연령 층에서 발견되었으나 40∼50대가 57% (107명)로 가장 많았다. 대부분이 양성자 (44%)가 늦가을 (10∼12월)에 발생하였다. Macroscopic agglutination법에 의한 렙토스피라에 대한 항체률을 조사한 결과 1% (55/5330)의 항체 양성률을 보였으며 연도별로는 1994년 0.4% (11/2799), 1995년 1.7% (44/2531)로 1995년에 더 많은 항체 양성자가 발생하였다. 총 55건의 렙토스피라 항체양성자 중 남자가 71% 였으며, 연령별 분포에서는 60대가 47%로 가장 많았으며 20대 이상의 성인에서만 항체가 발견되었다. 대부분의 항체양성자 (78%)가 8∼10월에 집중되었다. 라임병은 총 5330건 중 항체양성자는 없었다. 결 론 : 1994∼1995년 우리나라에서 발생한 발열성질환환자 중 쯔쯔가무시병, 발진열, 신증후출혈열 및 렙토스피라증 환자가 전체의 29%였으며 항체 양성자수로는 신증후출혈열,쯔쯔가무시병,발진열,렙토스피라증 순이였다. 따라서 위의 4가지 질환이 우리나라에서 특히 가을철에 발생하는 급성열성질환의 주원이으로 생각되나 새로운 질병이나 신종 병원체에 의한 동일한 질환이 존재할 가능성이 매우 높으므로 지속적인 혈청역학적 조사가 수행되어야 할 것이다. Background :The principal acute febrile diseases reported in autumn, Korea, have been hemorrhagic fever with renal syndrome (HFRS), scrub typhus, murine typhus and leptospirosis. Methods : To evaluat the seroepidemiologic patterns of acute febrile illness in Korea, sera were collected from 5330 patients from 1994 to 1995, and examined for antibodies against Hantaan virus, Orientia tsutsugamushi, Rickettsia typhi, and Borrelia burgdorferi by indirect immunofluorescent antibidy technique (IFA) and by macroscopic agglutination test for Leptospira interogans. Results : Of 640 seropositive cases against O. tsutsugamushi, 60% were female; age group of the seventh decade occupied 30%; 89% were reported during October and November. By IFA test, the seropositive rate of murine typhus was 3.5% (18/5330) with high incidence rate (44%) in the period from October to December, and males in their forties and fifties were mostly affected. Cases seropositive for leptospirosis consisted 1% of 5330 acute febrile illness cases. Of 55 seropositive cases, 71% were male; 71% were in their sixties; 78% occurred during the period from August to October to January and males in the thirties were mostly infected. No seropositive case of Lyme disease was present. Conclusion : The above results indicate that hantavirus, O. tsutsugamushi, R. typhi, and L. interogans were the main causative agents of acute febrile diseases during autumn season in Korea.

Plyometric Training과 비타민 C 투여가 남고생의 체력, 혈중 젖산, 암모니아 및 젖산탈수소효소에 미치는 영향

장준원,김세종,이현미,서혜림,조현숙,고정림,염종우,예정복,백영호 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this was to examine the effect of plyometric training and vitamin C ingestion on physical fitness and fatigue substance....

아마릴 정(글리메피리드 2㎎)에 대한 글리메드 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,김세미,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tables, Amaryl^(?)(Handok/Aventis Pharm. Co., Ltd.) and Glimed (Kuhn Ⅱ Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The glimepiride release from the two glimepiride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB 80 into each dissolution medium). Twenty six healthy male subjects, 22.65±2.19 years in age and 66.55±8.85 kg in body weight, were divided into two groups and randomized 2×2 cross-over study was employed. After one tablet containing 2 ㎎ as glimepiride was orally administered, blood was taken at predetermined time intervals and the concentrations of glimepiride in serum were determined using HPLC method with UV detctor. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Amaryl were -3.70, -8.28 and 0.61% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.84)∼log(1.04) and log(0.82)∼log(1.03) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Glimed tablet and Amaryl tablet were bioequivalent.

비유피-4 정(염산프로피베린 20㎎)에 대한 건일염산프로피베린 정의 생물학적동등성

조혜영,박은자,강현아,백승희,김세미,박찬호,오인준,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

The purpose of the present study was to evaluate the bioequivalence of two propiverine hydrochloride tablets. BUP-4 (Jeil Pharm. Co., Ltd.) and Kuhnil Propiverine Hydrochloride (Kuhnil Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The propiverine release from the two propiverine hydrochloride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solutions, water and blend of polysorbate 80 into pH 6.8). Twenty six healthy male subjects, 23.73 ± 2.79 years in age and 67.04 ± 7.93 kg in body weight, were divided into two groups and a randomized 2 x 2 cross-over study was employed. After one tablet containing 20 mg as propiverine hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of propiverine in serum were determined using HPLC method with UV detector. The dis-solution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC" C _(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, C_(max), and untransformed T_(max). The results showed that the differences between two formulations based on the BUP-4 were 0.17%, 7.98% and 4.55% for AUC,, C_(max), and respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically trans-formed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.88)-log(l .12) and log(0.90)-log(l.15) for AUC, and _(max), respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kuhnil Propiverine Hydrochloride tablet was bioequivalent to BUP-4 tablet.

마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

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Inhibitory Effect of Fermented Tatary Buckwheat (Fagopyrum tataricum) on Adipocyte Differentiation

Hyun Jin Baek,Seon-A Jang,Chang Won Kim,Da Eun Lee,Dae Won Park,Se Min Jo,Hae Seong Song,Young Mi Cho,Yeji Lim,Jeong Yoon Lee,Hyun Mook Jung,Se Chan Kang 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

Korean Association for Clinical Oncology : Slide Session ; P-08 : Breast Cancer ; Prognostic Value of Axillary Nodal Ratio After Neoadjuvant Chemotherapy of AC Followed by Docetaxel: A Multicenter Retrospective Cohort Study

( Se Hyun Kim ),( Jee Hyun Kim ),( Tae Yong Kim ),( In Sil Choi ),( Yee Soo Chae ),( Sun Kyung Baek ),( Seok Yun Kang ),( In Hae Park ),( Yoon Ji Choi ),( Soo Hyeon Lee ),( Joo Hyuk Sohn ),( Yeon Hee 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The ratio of involved to retrieved lymph nodes (LNR) is suggested as a prognostic factor in operable breast cancer. However, there are confi icting results regarding its clinical signifi cance after neoadjuvant chemotherapy. We investigated the prognostic value of LNR with a thorough evaluation of potential prognostic factors in a large cohort constructed from Health Insurance Review and Assessment Service database of Korea. Methods: This retrospective analysis is based on the data of 814 patients with clinical stage II/III breast cancer treated with four cycles of adriamycin/cyclophosphamide followed by four cycles of docetaxel before surgery. We evaluated the clinical signifi - cance of the LNR (3 categories: Low, 0-0.20 vs. Intermediate, 0.21-0.65 vs. High, 0.66 -1.00) using Kaplan-Meier method, log-rank test, and Cox proportional hazard regression model. Results: A total of 799 patients underwent breast surgery (Median age 45, range 16- 74; Mastectomy 369, Lumpectomy 380, and Others 50). Axillary lymph node dissection was performed in 704 (88.1%) patients. Pathologic complete response (pCR) was achieved in 129 (16.1%) of 799 patients (HR+/HER2-, 34/373 [9.1%]; HER2+, 45/210 [21.4%]; TNBC 50/216 [23.1%]). The mean numbers of involved LN and retrieved LN were 2.70 (range 0-42) and 13.98 (range 1-64), respectively. The mean LNR was 0.17 (Low, 574 [71.8%]; Intermediate, 170 [21.3%]; High, 55 [6.9%]). In univariate analysis, LNR was signifi cantly associated with worse relapse-free survival (3-yr RFS rate 84.8% in low vs. 66.2% in intermediate vs. 54.3% in high; P <0.0001, log-rank test). In multivariate analysis, LNR was not signifi cantly associated with recurrence after adjustment of other clinical factors (Age, histologic grade, intrinsic subtype, ypT-stage, ypN-stage, lymphatic or vascular invasion, and pCR). Conclusions: LNR is not superior to ypN-stage in predicting clinical outcome of breast cancer after neoadjuvant chemotherapy.

Clinical Analysis of Internal Orbital Fractures in Children

Se Hyun Baek,Eui Young Lee 대한안과학회 2003 Korean Journal of Ophthalmology Vol.17 No.1

In order to describe the demographics, etiologic and clinical factors, and outcomes of orbital fractures in children, we have reviewed a case series of 17 patients under 18 years of age with internal orbital fractures (i.e., without involvement of the orbital rim) presenting to the Ghil hospital between March 2000 and June 2001. For 15 of the patients, we performed orbital wall reconstruction with Medpor?? barrier sheet implantation (thickness 1mm) through transconjunctival approach under endoscopic guidance, while maintaining mere observation on the other 2 patients. There were 14 male and 3 female patients. The most common cause of fractures was accident (7 cases). Inferior wall involvement was most commonly seen, and the trapdoor type fracture was the most common. Thirteen patients had extraocular muscle restriction, 9 had nausea/vomiting and 5 had bradycardia. Diplopia of 9 patients disappeared after 43±23 days. Nausea/vomiting and bradycardia disappeared rapidly after surgical intervention in all cases. These results suggest that trapdoor fractures with soft tissue entrapment are the most common in pediatric orbital wall fractures, and that most of them are associated with nausea/vomiting. We suggest that early diagnosis, and prompt surgical intervention are required for those patients with oculocardiac reflex.