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KWON, SANGHOON,KIM, DONGBUM,PARK, BYOUNG KWON,WU, GUANG,PARK, MIN CHUL,HA, YANG-WHA,KWON, HYUNG-JOO,LEE, YOUNGHEE Spandidos Publications 2013 Oncology reports Vol.29 No.2
<P>The innovation of a peptide vaccine strategy may contribute to the development of efficacious and convenient cancer vaccines. Recently, we formulated an efficacious peptide vaccine without carriers using the natural phosphodiester bond CpG-DNA and a special liposome complex [Lipoplex(O)]. The peptide vaccine targeting a tumor antigen, transmembrane 4 superfamily member 5 protein (TM4SF5), was confirmed to have preventive and therapeutic effects in a mouse hepatocellular carcinoma (HCC) model. In this study, we demonstrated that the isotype-switched (IgM(-)IgD(-)) B cell population increased after immunization and that the functional memory response persisted for at least 70 days after the final immunization of mice. Delayed implantation of BNL-HCC cells significantly induced the peptide-specific IgG2a production in the immunized mice. Accordingly, tumor growth was inhibited and the survival rate increased. These results suggest that our peptide vaccine induces memory response, which is essential for cancer vaccine application.</P>
( Sanghoon Kwon ),( Young Eun Kim ),( Jeong A Park ),( Doo Sik Kim ),( Hyung Joo Kwon ),( Younghee Lee ) 생화학분자생물학회 2014 BMB Reports Vol.47 No.4
Molecular-targeted therapy has gained attention because of its high efficacy and weak side effects. Previously, we confirmed that transmembrane 4 superfamily member 5 protein (TM4SF5) can serve as a molecular target to prevent or treat hepatocellular carcinoma (HCC). We recently extended the application of the peptide vaccine, composed of CpG-DNA, liposome complex, and TM4SF5 peptide, to prevent colon cancer in a mouse model. Here, we first implanted mice with mouse colon cancer cells and then checked therapeutic effects of the vaccine against tumor growth. Immunization with the peptide vaccine resulted in robust production of TM4SF5-specific antibodies, alleviated tumor growth, and reduced survival rate of the tumor-bearing mice. We also found that serum levels of VEGF were markedly reduced in the mice immunized with the peptide vaccine. Therefore, we suggest that the TM4SF5-specific peptide vaccine has a therapeutic effect against colon cancer in a mouse model. [BMB Reports 2014; 47(4): 215-220]
ON THE SET OF CRITICAL EXPONENTS OF DISCRETE GROUPS ACTING ON REGULAR TREES
Kwon, Sanghoon Korean Mathematical Society 2019 대한수학회지 Vol.56 No.2
We study the set of critical exponents of discrete groups acting on regular trees. We prove that for every real number ${\delta}$ between 0 and ${\frac{1}{2}}\;{\log}\;q$, there is a discrete subgroup ${\Gamma}$ acting without inversion on a (q+1)-regular tree whose critical exponent is equal to ${\delta}$. Explicit construction of edge-indexed graphs corresponding to a quotient graph of groups are given.
Kwon, Sanghoon Korean Mathematical Society 2021 대한수학회논문집 Vol.36 No.4
We investigate the Möbius transformation action of PSL(2, ℝ) on the set of mutually distinct ordered triple points of ℝ ∪ {∞}.
IHARA ZETA FUNCTION OF DUMBBELL GRAPHS
Kwon, Sanghoon,Park, Jung-Hyeon The Kangwon-Kyungki Mathematical Society 2018 한국수학논문집 Vol.26 No.4
We study the Ihara zeta function of the dumbbell graph $D_{1,1,n}$ of type (1, 1, n) and $D_{1,2,n}$ of type (1, 2, n). Explicit formulas of the zeta functions of the graphs, their radius of convergence, and the connection with the number of closed cycles are given.
( Sanghoon Lee ),( Ji-hyun Lee ),( Doo-hoon Lee ),( Dong Hyun Sinn ),( Choon Hyuck David Kwon ),( Jeong-kwon Noh ),( In Keun Jang ),( Hey- Jung Park ),( Hee-hoon Yoon ),( Suk-koo Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Bioartificial liver (BAL) support offers a potential means of improving survival of acute liver failure (ALF) patients by providing partial liver function until a suitable donor liver is found or the native liver undergoes regeneration. Previous studies have suggested that ALF patients treated using BAL maintain a more stable medical condition, which may positively influence outcome after liver transplant (LT). This clinical trial was conducted to evaluate the safety and efficacy of the LifeLiver BAL system in ALF patients. Methods: Patients with evidence of acute liver failure exhibiting hepatic encephalopathy grade 2 or worse who were listed for deceased donor liver transplant were eligible for enrollment. Hepatocytes were harvested from 3~4 weeks old male pigs weighing 4 to 10 kg, raised in a sterile environment. The isolate hepatocytes were cultured to form spheroids and were then mixed with 1.5% alginate solution and placed in a high content/speed immobilization apparatus and dropped into 100mM calcium solution. The Ca-alginate-immobilized hepatocyte spheroid beads were packed within the bioreactor of the BAL system. BAL treatment was continued for up to 12 hours. Results: Six patients were given BAL treatment and were included in the safety analysis. Adverse events related to BAL treatment included coagulopathy (increased INR), pneumonia, sepsis and disease progression. One patient developed upper gastrointestinal tract bleeding and sepsis following BAL treatment and eventually died while waiting for transplant. No evidence of porcine endogenous retrovirus (PERV) were seen. Five patients completed the study per protocol and were included in the efficacy analysis. Four patients showed apparent decrease in serum ammonia levels and MELD scores during BAL treatment. Hepatic encephalopathy either decreased or remained stable throughout the BAL treatment period in 4 patients. Conclusions: The LifeLiver BAL support system showed safety and efficacy in ALF patients with hepatic encephalopathy. Two patients were successfully bridged to liver transplantation.
권상훈(Kwon Sanghoon),한혁수(Han Hyuksoo),우치수(Wu Chisu) 한국정보과학회 1995 한국정보과학회 학술발표논문집 Vol.22 No.2B
테스팅은 개발된 소프트웨어의 신뢰도를 나타내기 위해 수행되어야 하는 반드시 필요한 작업이다. 객체지향 방법은 적절한 모델링으로 소프트웨어 개발에 많은 향상을 가져 왔지만, 테스팅 작업에 있어서는 객체지향 방법의 특징으로 인하여 오히려 여러가지 문제점을 드러내고 있다. 즉, 기존의 소프트웨어를 위한 태스팅 방법이나, 전략들이 객체지향 소프트웨어를 테스트하기에는 적합하지 않은 것이다. 본 논문에서는 객체지향 소프트웨어의 테스팅을 위한 방법으로 ETMOS(Embeded Testing Model with Object oriented Strategy)를 제안 한다. 테스팅의 효율을 높이고 소프트웨어의 특성을 살리기 위해, ETMOS 는 객체지향적인 전략으로 이루어진 테스팅 모델이다.