형광검출 역상 액체크로마토그래피에 의한 Histamine의 정량

유희춘,김형룡,김상현,김대기,이영미,김형민,안년형,신태용 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

Histamine을 정확하고 신속하게 정량하기 위해 9.Fiuorenylmethyl chloroformate를 형광유도체화제로 하여 역상 HPLC법으로 정량하였다. 히스타민을 형광유도체화할 때 반응액의 pH, 반응시간, 형광유도체화제의 농도 등 최적 반응 조건을 검토하였다. 이 방법으로 히스타민을 분석한 결과 0.1~0.5ug/ml의 농도범위에서 상관계수가 0.922인 양호한 직선성을 나타내었으며 검출한계는 0.01??/ml였다. A rapid and simple method for the determination of histamine by reverse-phase high performance liquid chromatography with fluorescence detection was established. 9-Fluorenylmethyl chloroformate(FMOC) was used as fluorescent derivative reagent. The optimum conditions for the derivatiation such as pH, reaction time and he concentration of FMOC were investigated. Linearity of calibration curve was obtained between 0.1ug/ml/and 0.5ug/ml(r=0.922) and the limit of detection was 0.01ug/ml.

等誘電性 2成分溶媒系에서 鹽化알킬카르보닐의 加알코올 分解反應

柳俊夏,金良姬,成大東,朴現錫,嚴泰燮 東亞大學校 1990 東亞論叢 Vol.27 No.1

The nucleophilic substitution reactions of alkanecarbonyl chlorides with alchohols in the polar aprotic solventls have been studied by means of the conductimerical method. The results are as follows; 1. The order of magnitude of the second-order rate constants in the same substrate is acetyl carbonyl chloride>propionyl choride>X-valeryl iso-vareryl chloride. This is in full accord with the inductive effect by means of the polarizability effect that is due to connect with the σ-bond of alkyl radical to neigboring atom. 2. The reactionis proceeded through the S2 reaction mechanism from the analysis of the values of m and ℓwhich are obtained from the extended Grunwald-Winstein equation. 3. From the prediction on the More O'Ferrall plot the reaction mechanism is favored to the SN route. 4. As shown in the quantum mechanical model, the reaction mechanism is shown to favor an associative S2. 5. The reaction mechanism is in accord with an associative S2 reaction mechanism in consideration of the solvent effect exactly.

혈액투석중인 말기신부전 환자에서 Fludrocortisone acetate (FCA) 투여 후 혈청 칼륨 저하 효과

류봉관,강대웅,정지용,윤나라,신병철,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Background: Hyperkalemia is a commonly encountered problem in dialysis patients with end-stage renal disease. In this study we evaluated the effect of mineralocorticoid therapy (fludrocortisono acetate) on serum potassium level in the serum of hyperkalemic end-stage renal disease patients. Methods: Fourteen patients on hemodialysis receiving fludrocortisone acetate (FCA) 0.1 mg/day were observed for 2 months periods. Consecutive monthly biochemical profiles were compared for the druration of the pre-and post-treatment of FCA. Result: Fourteen patients with mean age (±SE) of 51.5 years (4 males and 10 females) and mean hemodialysis period of 51.9 months were studied. Mean serum potassium levels significantly fell (p<0.05) during the post-FCA period (5.2±0.66 mEq/L) compared with potassium levels during the pre-FCA (5.8±0.43 mEq/L) period. Pre-and post-FCA values were not different for sodium, chloride, protein, albumin, AST/ALT, glucose, blood nitrogen, creatinine, phosphate and calcium. Conclusions: FCA appears to decrease serum potassium value in patients with end-stage renal disease. These results suggested that FCA could be effective to treat hyperkalemia without any adverse effect in patients undergoing hemodialysis.

命令語水準竝列プロセッサなどに對するソフトウェアスケジュ-リングアルゴリズム

柳大熙 혜전대학 1999 出版文化硏究所論文集 Vol.1 No.-

In this paper, a scheduling algorithm for extracting instruction-level parallelism on instruction-level parallel processors is proposed. The algorithm schedules basic operations for parallel execution and removes pipeline hazards by examining data dependency and resource conflicts relations. For the purpose to evaluate the performance of this algorithm, by simulating various test programs, the validation of the proposed scheduling algorithm is shown.

신경교 세포 기원 종양의 조직 병리와 p53 Protein 발현과의 관계

류태희,최정목,강대영 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

The p53 gene is one of the most extensively investigated tumor suppressor genes. Several neoplasms have been thoroughly investigated for altered p53 gene expression, including lung, breast, and colorectal cancers, but the studies of neuroglial tumors are rare. Immunohistochemically, we demonstrated p53 protein expression in 40 cases of 156 central nervous system tumors, which were collected from Jan. 1989 to June 1993 at the department of anatomical pathology, Chungnam National University hospital. The results are as follows; 1. The incidence of gliomas(25.6%) was the highest in brain tumors, followed by meningomas(16.7%), pituitary adenomas(15.4%), neurilemomas(14.1%) and metastatic tumors(9.6%). 2. The incidence of gliomas in males was slightly higher than in females(M:F = 1.1: 1). Gliomas were distributed among all age groups, and the mean age was 35.3 years. 3. The positivity of p53 protein expression was the highest in glioblastoma multiforme(75.0%), followed by anaplastic astrocytoma(66.7%), low grade astrocytoma(30.0%), oligodendroglioma(20.0%), and ependymoma(16.1%). 4. The p53 index(No. of p53 protein positive cells/No. of total cells) was 68.7 in the glioblastomamultiforme in the original tumor, while 91.8 in the recurrent glioblastoma multiforme. The results suggest that there is some correlation between the degree of the histopathologic differentiation in neurogical tumors and the p53 protein expression. In addition, the p53 protein detection may provide a clue in the identification of malignant progression in neuroglial tumors.

부산사람들의 기질과 생활인식 : 2016년도‘부산의 하루’수강생 대상 설문조사 결과 분석

김대래(외 3명) 신라대학교 부산학연구센터 2016 부산연구 Vol.14 No.-

본연구는 2016년도‘부산의 하루’수강생과 타강좌 수강생 227명을 대상으로 한 설문조사 분석결과이다. 먼저, 응답자의 소속을 살펴보면 글로벌비즈니스대학 소속이 가장 많았고, 경영대학, 인문사회대학 순으로 나타났다. 그리고 1학년 재학생이 40.1%로 가장 많은 비중을 차지하였고 4학년 재학생이 14.1%로 가장 적게 포함되었다. 조사대상자의 성별은 남성이 54.2%로 나타나 성별의 분포가 비슷한 수준으로 나타났다. 현재 특정 종교를 갖고 있지 않는 응답자가 전체 조사대상자의 60%를 차지하였고, 불교가 27.8%로 높은 비중을 차지하고 있었다. 응답자의 부모 고향을 조사한 결과 아빠의 경우 부산출신이 47.2%로 가장 높았고, 경남/울산, 대구/경북 순으로 조사되었으며 엄마의 고향도 아빠와 유사한 분포를 나타내었다. 다음으로, 부산에 대한 교육을 받은 경험이 전무한 응답자가 80% 이상으로 높게 나타났으며, 대부분의 학생들이 아직도 부산을 큰 도시로 인지하고 있음을 알 수 있었다. 부산의 대표적인 음식에 대해서는 돼지국밥, 동래파전, 밀면, 생선회 순으로 조사되었다. 부산에 대한 자랑거리로 여기고 있고 외지인에게 구경시켜 주고 싶은 곳으로는 광안대교야경과 해운대가 가장 높은 것으로 나타났고, 특히 부산의 스포츠라 할 수 있는 야구에 대해 상당한 자긍심과 관심을 갖고 있는 것을 알 수 있다. 마지막으로, 부산시에서 새로 생겼으면 하는 것에 대해 공원이 27.4%로 가장 높게 나타났으며, 그 다음으로 연극공간, 공연장, 오페라 하우스 등 순으로 조사되었다. 마지막으로 요인분석을 통해 추출한 6개의 독립변인은 공중질서, 타인배려, 생활특성, 인간미, 기질, 성격이었다. 이 독립변인들을 부산의 이미지라는 종속변인과 다중회귀분석을 실시한 결과, 타인배려와 부산시민의 기질적 특성이 도시이미지에 유의한 영향을 미치는 것으로 나타났고, 특히 부산 시민 고유의 기질적 특성이 도시이미지에 상대적으로 큰 영향을 미치고 있음을 확인하였다.

Dabsyl Chlorides의 親核性 置換反應

成大東,朴現錫,柳俊夏,金良姬,李鍾八,嚴泰燮 東亞大學校 1990 東亞論叢 Vol.27 No.1

Kinetic studies of nuclsophilic substitution reaction of dabsyl chloride with pyridines have been investigated at 30℃ in a range of methanol-acetonitrile bianary solvent mixtures. The order of magnitude fo reactivity is β-picoline > pyridine > 1.5-N D A > α-picoline to react with dabsyl chloride, especially in case of α-picoline, the reactivity revealed lower than others, it is suggestd that nitrogen atom of pyfidine ring has a steric hinderance by the neightboring methyl group. The value of ρ(-0.96∼4.59) and β(0.36∼0.67) associated with a change of substituent in the nucleophile are large and indicate a realtively advanced bond formation in the transition state. Solvatochraomic correlations were predicted the importance of bond formation transition state, showing a greater contribution of polaritypolarizability (π*) lone paired to hydro-gen bond donar acidity (α). We conclude that the reaction of dabsyl chloride with pyridine proceed via S2 type reaction mechanism, as well as the reaction of dansyl chloride pyridine.

갑상선 분화암 환자의 경과 관찰에서 수술전·후 혈청 갑상선글로불린 측정의 유용성

이성진,원종철,김하영,한정희,이은주,김상욱,류진숙,문대혁,홍석준,안일민 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

^(131)I 전신스캔 음성 재발 분화 갑상선암에서 EDG PET의 임상적 의의 : ^(99m)Tc-MIBi Scintigraphy와 비교분석

원종철,이성진,이태윤,남궁일성,이시열,김하영,한정희,류진숙,문대혁,안일민 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

PRECISE ASYMPTOTICS IN LOGLOG LAW FOR ρ-MIXING RANDOM VARIABLES

Ryu, Dae-Hee The Honam Mathematical Society 2010 호남수학학술지 Vol.32 No.3

Let $X_1,X_2,\cdots$ be identically distributed $\rho$-mixing random variables with mean zeros and positive finite variances. In this paper, we prove $$\array{\lim\\{\in}\downarrow0}{\in}^2 \sum\limits_{n=3}^\infty\frac{1}{nlogn}P({\mid}S_n\mid\geq\in\sqrt{nloglogn}=1$$, $$\array{\lim\\{\in}\downarrow0}{\in}^2 \sum\limits_{n=3}^\infty\frac{1}{nlogn}P(M_n\geq\in\sqrt{nloglogn}=2 \sum\limits_{k=0}^\infty\frac{(-1)^k}{(2k+1)^2}$$ where $S_n=X_1+\cdots+X_n,\;M_n=max_{1{\leq}k{\leq}n}{\mid}S_k{\mid}$ and $\sigma^2=EX_1^2+ 2\sum\limits{^{\infty}_{i=2}}E(X_1,X_i)=1$.