Slide Session : OS-END-17 ; Endocrinology : Metabolic Syndrome Among Diabetic and Hypertensive Patients in Hadhramout

( Rasheed Mohammed Bamekhlah ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors: diabetes, hyperlipidemia and high blood pressure. People with MetS are twice as likely to die from and three times as likely to have a heart attack or stroke compared with people without. Our objective was to observe the frequency of MetS in patients with type 2 diabetes mellitus (DM) and with hypertension. Methods: A cross-sectional study conducted at lbnseena Hospital, Mukalla, Hadhramout, Republic of Yemen from 04/2012 to 02/2013. Two hundreds of type 2 DM and 200 hypertensive cases were included; MetS was estimated according to International Diabetes Federation (IDF) criteria. Results: diabetic patients, 92 were males and 108 females, hypertensive patients 109 were males and 91 females. In diabetics, 130 (65%) had MetS (58.2±10.4years), 57 were males and 73 females. In hypertensive cases, 109 (54.5%) had MetS (57.9±9.2 years), 56 were males and 57 females. Waist circumference was 98.7±6.7 cm in diabetics and 98.7±6.7 cm in hypertensive. In MetS Triglycerides was 152±13.4mg/ dl in diabetics and 154±13.2mg/dl in hypertensive and both were significantly higher in MetS patients. Serum HDL-C was significantly lower in MetS cases, 40.3±8.5mg/ dl in diabetics and 40.9±8.4mg/dl in hypertensive. Increased waist circumference was present in all MetS cases, hypertension in 81.5% in diabetics and DM in 92.7% of hypertensive. Low HDL-C in 62.3% of diabetics and 66.1% of hypertensive, high triglycerides in 57.7% of diabetics and 54.1% of hypertensive. 24.6% of diabetics and 11% of hypertensive were having three criteria, 48.5% of diabetics and 58.7 of hypertensive with four, and 26.9% of diabetics and 30.3% of hypertensive with all criteria.. Conclusions: Metabolic syndrome is common among type 2 diabetic and hypertensive patients in our province; Hadhramout. Most patients were having more than three IDF criteria.

Identity-Exchange based Privacy Preserving Mechanism in Vehicular Networks

Rasheed Hussain(후세인 라쉬드),Heekuck Oh(오희국) 한국정보보호학회 2014 정보보호학회논문지 Vol.24 No.6

차량과 통신기술의 발전으로 임시네트워크를 이용한 지능형 교통 시스템이 실현되었다. VANET은 지능형 교통 시스템의 한 예로써, 현재 배포단계를 눈앞에 두고 있다. 하지만 지능형 교통 시스템의 많은 장점에도 불구하고, 보안과 프라이버시 문제로 아직 대다수 차량에 설치되지 못하고 있다. 사용자들은 주변 차량이나 기반시설과의 통신을 위해 자신들의 프라이버시가 노출되는 것을 원치 않기 때문이다. 따라서 지능형 교통 시스템의 대중화를 위해 프라이버시 문제는 선결되어야 한다. 일반적인 임시네트워크나 VANET과 같은 특정 상황에서 프라이버시 문제를 해결하기 위한 여러 가지 기법들이 제안되었다. 대표적으로 다중 익명성을 이용한 기법이 있지만, 이를 비콘 메시지에 적용하더라도 공격자는 사용자를 특정 지을 수 있다. 따라서 임시네트워크에서 프라이버시를 보호하기 위한 새로운 기법이 필요하다. 본 논문에서는 VANET 환경에서 프라이버시를 조건부로 보장하는 신원교환 기법을 제안한다. 사용자는 자신의 가명을 이웃과 교환하고 메시지를 보낼 땐 이웃의 가명을 이용하여 보낸다. 제안하는 기법은 분쟁이 발생하는 경우 (권한이 있는) 기관이 메시지 송신자의 익명성을 철회할 수 있게 만듦으로써 프라이버시를 조건부로 제공한다. Intelligent transportation system (ITS) is realized through a highly ephemeral network, i.e. vehicular ad hoc network (VANET) which is on its way towards the deployment stage, thanks to the advancements in the automobile and communication technologies. However, it has not been successful, at least to date, to install the technology in the mass of vehicles due to security and privacy challenges. Besides, the users of such technology do not want to put their privacy at stake as a result of communication with peer vehicles or with the infrastructure. Therefore serious privacy measures should be taken before bringing this technology to the roads. To date, privacy issues in ephemeral networks in general and in VANET in particular, have been dealt with through various approaches. So far, multiple pseudonymous approach is the most prominent approach. However, recently it has been found out that even multiple pseudonyms cannot protect the privacy of the user and profilation is still possible even if different pseudonym is used with every message. Therefore, another privacy-aware mechanism is essential in vehicular networks. In this paper, we propose a novel identity exchange mechanism to preserve conditional privacy of the users in VANET. Users exchange their pseudonyms with neighbors and then use neighbors’ pseudonyms in their own messages. To this end, our proposed scheme conditionally preserves the privacy where the senders of the message can be revoked by the authorities in case of any dispute.

Ultrasensitive colorimetric detection of NF-κB protein at picomolar levels using target-induced passivation of nanoparticles

Rasheed, P. Abdul,Lee, Jae-Seung Springer-Verlag 2018 Analytical and Bioanalytical Chemistry Vol.410 No.4

<P>We developed a highly sensitive and selective sensor based on the nanoprobe conjugates of catalytic nanoparticles and double-stranded DNA (dsDNA) for the colorimetric detection of NF-kappa B protein. The sensing mechanism takes advantage of the catalytic activity of nanoparticle surfaces and the specific binding of NF-kappa B to a dsDNA sequence. In the presence of NF-kappa B, the highly selective interactions between dsDNA and NF-kappa B lead to the passivation of the catalytic nanoparticle surfaces, impeding the sodium borohydride-mediated reduction rate of 4-nitrophenol. The correlation between the NF-kappa B concentration and the visualized reduction rate of 4-nitrophenol from yellow to colorless clearly demonstrates the highly quantitative nature of the sensor. Importantly, this sensor can conclusively detect concentrations as low as 6.39 pM of NF-kappa B, which to best of our knowledge is the lowest limit of detection for a colorimetric NF-kappa B detection system. The excellent sensitivity of this sensor relies on the high binding constant of NF-kappa B to dsDNA and the catalytic activity of nanoparticle surfaces for the signal amplification. This sensor allows visual detection without the need for any spectrometric instrumentation. We also determined the various parameters such as the pH, temperature, incubation time, and salt concentration for optimal NF-kappa B-dsDNA interactions. Finally, we demonstrated the performance of the sensor with simulated sample analysis.</P>

Formulation, standardization and pharmacological evaluation of a poly herbal traditional remedy -Ashwagandharishtam

Rasheed, Arun,Roja, C.,Reddy, G. Avinash Kumar,Reddy, B. Sravya 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.1

Ayurvedic formulations were considered the best and safer alternatives for synthetic drugs. But the demand to such products is diminishing due to lack of standardization. Ashwagandharishtam, a fermented kind of ayurvedic formulation, is used to treat epilepsy, nervous disorders, skin diseases, immune disorders and rheumatism. In the present study, the standardization of Ashwagandharishtam using sophisticated techniques were attempted for assessing the quality and safety of herbal products involved in it. It was formulated according to a working formula and its physicochemical, pharmacological and biological parameters were determined. The results of physicochemical studies showed that the values were under acceptable limits as per the Ayurvedic Pharmacopoeial specifications. FTIR studies of formulation revealed the presence of functional groups similar to Ashwagandha powder. The heavy metal content in the formulation is determined using Atomic Absorption Spectroscopy. HPTLC reports proved the presence of biomarker, withanolide-A in ashwagandharishtam which helped in its chemical standardization. The anti-epileptic activity of ashwagandharishtamwas evaluated by Maximal electro shock (MES) method in rats. It exhibited a dose dependent significant (P<0.001) reduction in various phases of epileptic seizures when compared with that of standard phenytoin. It was also assessed for its anti inflammatory activity in carrageen induced paw edema method which showed a good activity comparable to standard thus making it biologically standardized.

Molecular detection of Leishmania tropica in field caught Phlebotomus sand flies (Diptera: Psychodidae) from cutaneous leishmaniasis endemic focus of Pakistan

Rasheed Syed Basit,Shah Muhammad Zahir 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.4

Cutaneous Leishmaniasis is endemic in tribal district Khyber for last more than one decade. The causative agent Leishmania tropica is known but sand fly species responsible for the transmission of disease still needs to be investigated. A total of 2647 Phlebotomus females belonging to 11 species were divided into 435 batches and subjected to PCR for detection of Leishmania in sand flies. A total of 50 batches belonging to three species i.e. Phlebotomus Phlebotomus sergenti, Phlebotomus papatasi and Phlebotomus alexandri were detected positive for Leishmania tropica. Overall minimum infection rate was 1.89% (50/2647). Highest minimum infection rate of 2.11% (39/ 1710) was observed for Phlebotomus sergenti followed by 1.21% (8/661) for Phlebotomus paptasi and 1.82% (3/ 165) for Phlebotomus alexandri. Both blood fed (38%) and unfed (62%) sand flies were detected positive for the parasite DNA. Positive specimens were collected throughout the active season, from all collection sites of the study area. Detection of Leishmania parasite in multiple species of Phlebotomus indicates the possible role of these species as vector of disease in the tribal district Khyber of Pakistan. It also indicates the probable complex transmission cycle of the disease involving multiple vector species in the study area. Devising a control strategy by focusing on these vector species, may reduce the disease burden in the cutaneous leishmaniasis endemic tribal district Khyber.

A Secure and Privacy-Aware Route Tracing and Revocation Mechanism in VANET-based Clouds

Rasheed Hussain(후세인 라쉬드),Heekuck Oh(오희국) 한국정보보호학회 2014 정보보호학회논문지 Vol.24 No.5

많은 연구 끝에 VANET의 상용화를 눈앞에 두고 있다. VANET은 차량용 애드혹 네트워크의 약자로서, Cloud와 융합하는 방향으로 연구가 진행되고 있다. 하지만 놀랍게도 VANET 기반 클라우드로 진화한데 가장 큰 역할을 한 것은 차량과 통신기술의 발달이다. 이러한 기술이 확산되는 단계에서 연구자들은 항상 보안과 프라이버시에 대해 고민해 왔다. 게다가 VANET처럼 프라이버시, 익명철회, 경로추적 등 상반된 보안 이슈들이 서로 얽힌 상황은 연구자들을 더욱 고민에 빠지게 했다. 최근 Hussain 등은 VANET 기반 클라우드 프레임워크인 VuC (VANET using Clouds)를 제안하였다. VuC는 VANET과 클라우드가 VANET 사용자(서비스 가입자)에게 서비스를 제공하기 위해 협력하는 환경을 말한다. 본 논문은 Hussain 등이 제안한 VANET 기반 클라우드 프레임워크인 VuC에 초점을 두고 있으며, 특히 앞서 말한 프라이버시, 익명철회, 경로추적에 대한 문제를 다루고 있다. 제안하는 기법은 다중 익명화를 통해 프라이버시를 보호한다. 또한 비컨(Beacon)메시지를 클라우드에 저장하여 경로추적과 익명 철회에 활용한다. 익명철회 권한을 가진 기관들은 연합하여 사용자 노드가 선택한 경로를 특정 시간 동안 추적할 수 있으며, 필요한 경우 신원을 확인할 수 있다. 제안된 기법은 안전하고 조건부 익명성을 보장하며 기존의 기법에 비해 연산량이 적다 Vehicular Ad hoc Network (VANET) has gone through a rich amount of research and currently is making its way towards the deployment. However, surprisingly it evolved to rather more applications and services-rich breed referred to as VANET-based clouds due to the advancements in the automobile and communication technologies. Security and privacy have always been the challenges for the think tanks to deploy this technology on mass scale. It is even worse that some security issues are orthogonally related to each other such as privacy, revocation and route tracing. In this paper, we aim at a specific VANET-based clouds framework proposed by Hussain et al. namely VANET using Clouds (VuC) where VANET and cloud infrastructure cooperate with each other in order to provide VANET users (more precisely subscribers) with services. We specifically target the aforementioned conflicted privacy, route tracing, and revocation problem in VANET-based clouds environment. We propose a multiple pseudonymous approach for privacy reasons and leverage the beacons stored in the cloud infrastructure for both route tracing and revocation. In the proposed scheme, revocation authorities after colluding, can trace the path taken by the target node for a specified timespan and can also revoke the identity if needed. Our proposed scheme is secure, conditional privacy preserved, and is computationally less expensive than the previously proposed schemes.

Antibacterial Acativity of Camellia sinensis Extracts Against Dental Caries

Rasheed, Azmat,Haider, Mujtaba The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.3

Different bacteria wwere seperated from saliva and teeth of cariogenic patients and identified by a variety of morphological and biochemical tests. Extracts of green tea strongly inhibited Escherichia coli, Streptococcus salivarius and Streptococcus mutans. The antibacterial effect of green and black tea extracts were compared with those of amoxicillin, cephradine and eugenol.

The Exchange-Correlation Field Effect over the Magnetoacoustic-Gravitational Instability in Plasmas

Rasheed, A.,Jamil, M.,Jung, Young-Dae,Sahar, A.,Asif, M. De Gruyter 2017 Zeitschrift für Naturforschung. A, A journal Vol.72 No.10

<P>Jeans instability with magnetosonic perturbations is discussed in quantum dusty magnetoplasmas. The quantum and smaller thermal effects are associated only with electrons. The quantum characteristics include exchange-correlation potential, recoil effect, and Fermi degenerate pressure. The multifluid model of plasmas is used for the analytical study of this problem. The significant contribution of electron exchange is noticed on the threshold value of wave vector and Jeans instability. The presence of electron exchange and correlation effects reduce the time to stabilise the phenomenon of self-gravitational collapse of massive species. The results of Jeans instability by magnetosonic perturbations at quantum scale help to disclose the details of the self-gravitating dusty magnetoplasma systems.</P>

Allelic Variation and Composition of HMW-GS in Advanced Lines Derived from D-genome Synthetic Hexaploid / Bread Wheat ($Triticum$ $aestivum$ L.)

Rasheed, Awais,Mahmood, Tariq,Kazi, Alvina Gul,Ghafoor, Abdul,Mujeeb-Kazi, Abdul 한국작물학회 2012 Journal of crop science and biotechnology Vol.15 No.1

The objective of this study was to identify allelic variations at $Glu-1$ loci of wheat ($Triticum$ $aestivum$ L.) advanced lines derived from hybridization of bread wheat and synthetic hexaploid wheats (2n = 6x = 42; AABBDD). Locally adapted wheat genotypes were crossed with synthetic hexaploid wheats. From the 134 different cross combinations made, 202 $F_8$ advanced lines were selected and their HMW-GS composition was studied using SDS-PAGE. In total, 24 allelic variants and 68 HMW-GS combinations were observed at $Glu-A1$, $Glu-B1$, and $Glu-D1$ loci. In bread wheat, the $Glu-D1$ locus is usually characterized by subunits 1Dx2+1Dy12 and 1Dx5+1Dy10 with the latter having a stronger effect on bread-making quality. The subunit 1Dx5+1Dy10 was predominantly observed in these advanced lines. The inferior subunit 1Dx2+1Dy12, predominant in adapted wheat germplasm showed a comparative low frequency in the derived advanced breeding lines. Its successful replacement is due to the other better allelic variants at the $Glu-D1$ locus inherited in these synthetic hexaploid wheats from $Aegilops$ $tauschii$ (2n = 2x = 14; DD).

Constrained ICA Based Ballistocardiogram and Electro-Oculogram Artifacts Removal from Visual Evoked Potential EEG Signals Measured Inside MRI

Rasheed, T.,In, M. H.,Lee, Y.-K.,Lee, S.,Lee, S. Y.,Kim, T.-S. SPRINGER-VERLAG 2006 Lecture Notes in Computer Science Vol.4232 No.-