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Laura Perezábad,Marta Reche,Teresa Valbuena,Rosina López-Fandiño,Elena Molina,Iván López-Expósito 대한천식알레르기학회 2017 Allergy, Asthma & Immunology Research Vol.9 No.1
Purpose: This study aimed to evaluate the safety and efficacy to induce clinical desensitization to cow’s milk (CM) of an oral immunotherapy (OIT) protocol in a pediatric population with cow’s milk allergy (CMA). In addition, the immune responses against β-casein, of peripheral blood mononuclear cells (PBMCs) from CMA patients, before and after the protocol were evaluated and compared to a nonallergic population. Methods: A group of 20 children with IgE-mediated CMA and 15 nonallergic children were recruited. Allergic subjects underwent an OIT protocol based on weekly doses of commercial semi-skimmed ultra-high temperature treated (UHT) CM, followed by a maintenance phase. Immune profiles and changes in all subjects were investigated by measuring Th1, Th2, and Treg cytokines, transcription factors, and specific IgE and IgG4 levels. Results: The CMOIT protocol enabled to desensitize 70% of the allergic patients. Successful OIT was accompanied by significant increases in casein-specific IgG4 levels, together with a reduction in the concentration of antigen-specific IgE and in IL-5, IL-13, and IL-10 production by β-casein-stimulated PBMCs. Baseline significant differences observed between allergic and nonallergic children in IL-13 and IL-5 levels were no longer found once the protocol had finished. Conclusions: The OIT protocol was safe and effective in inducing milk desensitization in 70% of the children with CMA, leading to alterations in their immune profiles toward a nonallergic phenotype.
Tania Perez-Perez,Arletty Funcada-Martinez,Ania Cabrera-Diaz,Luis E. Guerra-Diaz,Deny Oliva-Merencio,Zhenia Milan,Ileana Pereda-Reyes 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.5
Large pig farms generate enormous volumes of wastewater without proper treatment before discharge. High-rate anaerobic reactors as the expanded granular sludge bed (EGSB) are rarely reported for that purpose. In this study, an EGSB reactor with Cuban natural zeolite addition was evaluated for treating piggery wastewaters at lab scale. This study was conducted at different organic loading rate (OLR) ranging from 0.32 to 6.13 gCOD/Ld with a constant hydraulic retention time (HRT) of 12 h. The evolution of several control and operational parameters as the soluble chemical oxygen demand (COD) demonstrated a proper bioreactor performance to treat piggery wastewater. The results showed that the addition of natural zeolite at 40 gzeo/Lreactor in EGSB reactor results in COD efficiencies over 70%, despite of the fluctuations of fed wastewater characteristics. The kinetic study demonstrates that, the modified Stover-Kincannon model was found to be appropriate for EGSB reactor. The effluent soluble COD was predicted with high determination coefficient. The maximum removal rate constant (Umax) and saturation value constant (KB) were reported for a first time for the EGSB reactor with values of 10.2 and 11.8 gCOD/Ld, respectively. Methane yield for both, batch and continues experiments, were in the range from 214.5 to 299.8 mLCH4/gCOD.
( Marta Perez De Lis Novo ),( Emma Filgueira Davila ),( Julian Fernandez Martin ),( Jorge Pereira Tamayo ),( Candido Diaz Lagares ),( Alexandre Perez Gonzalez ),( Begona Machado ),( Roberto Perez Alva 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To analyze the clinical features, epidemiology, diagnosis and treatment of candidemia treated in a tertiary care hospital. Methods: From 2007 to 2013, patients with candidemia were identifi ed at a hospital in Spain.The medical records of all patients with bloodstream infections due to Candida species were retrospectively reviewed. Results: During the six-year period, a total of 104 episodes of candidemia were identifi ed, 70 men (67%) and 46 women (33%), with a mean age of 65 years (range 16- 83). risk factors for candidemia were: neoplasms (41%), diabetes (25%) and renal failure (16%). Candidemia was associated with the presence of invasive devices such as central venous catheter (52%), urinary catheter (48%) and the presence of previous antibiotic treatment (80%) and abdominal surgery (42%). The most frequent form of clinical presentation was sepsis in 67 patients (65.7%) and seven patients were diagnosed with endocarditis. C. albicans (46%) was the most common pathogen, followed by C. parapsilosis (24%) and C. glabrata (17%). (8%). Ninety-three patients (89%) received empirical antifungal therapy and in 72 (78%) was appropriate. Antifungal administered in order of frequency were: fi uconazole 68 patients (65%), caspofungin at 9 (9.5%), amphotericin B, 8 (7%) and voriconazole (2%). Mortality in the fi rst 30 days following the candidemia was 46% (n = 48). Risk factors that were associated with mortality were age> 60 years (p = 0.002), insuffi cient renal (p = 0.03), candidemia unknown focus, or abdominal focus (p = 0.008) and empirical treatment Inappropriate (p = 0.001). Conclusions: The mortality of candidemia in our country is high, and inappropriate treatment is the only factor improved prognosis. A high index of suspicion is essential for diagnosis. The existence of protocols and practice guidelines are necessary to improve the management of infection and prognosis.
( Marta Perez De Lis Novo ),( Alexandre Perez Gonzalez ),( Melania Estevez Gil ),( Emma Filgueira Davila ),( Julian Fernandez Martin ),( Roberto Perez Alvarez ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To analyse the epidemiological, clinical, diagnostic and therapeutic features related to the development of spondylodiscitis in a cohort of Spanish patients. Methods: A retrospective analysis of 75 cases of infectious spondylodiscitis diagnosed in university hospital between 2000 and 2013. Results: We studied 75 patients with a mean age of 63 + / - 20 years, of which 67% were male. Time average evolution of disease prior to consultation was 4.2 months. The main symptom was back pain or back pain (90%) The most frequent location was the lumbar spondylodiscitis (74%), 60% of patients had one or more associated diseases (Diabetes:20%; COPD: 18%; tumors: 17%). Furthermore, 50% of them suffered from heart disease, being the most frequently hypertensive. 23% of patients carried immunosuppressive therapy, mainly corticosteroids (90%). In 53 patients (70%) could be performed a certain diagnosis, with Staphylococcus aureus the most frequent (41%) followed by S. epidermidis (17%), and Streptococcus (15%). Blood cultures were positive in 60% of cases and surgical biopsy was performed in 37% of the patients. 8 cases had endocarditis criteria, 6 of which were fulfi lled by S. aureus. MRI was performed in 75% cases, being in all cases, pathological. The average length of treatment was 12 weeks, with the most commonly used antibiotics cloxacillin, vancomycin and ceftriaxone. 18% of patients underwent surgery, performed laminectomy and drainage of abscesses. During evolution 6 patients died. 10 patients (8%) had sequelae neurological. Conclusions: Spondylodiscitis is a rare disease in adults, but with high morbidity and mortality due to the diffi culty of diagnosis. Insidious development and the lack of specifi city of the symptoms it interferes with the diagnosis and treatment early, so a high index of suspicion is essential.
Vitamin D and its effects on cardiovascular diseases: a comprehensive review
( Nonanzit Perez-hernandez ),( Gad Aptilon-duque ),( Maria Cristina Nostroza-hernandez ),( Gilberto Vargas-alarcon ),( Jose Manuel Rodriguez-perez ),( Ruben Blachman-braun ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.6
Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.
Evaluation of Limestone -Based Remediation Technique in Sediments Affected by Mining Activities
Carmen Perez-Sirvent,M. Jose Martinez-Sanchez,M.luz Garcia-Lorenzo,Eva Gonzalez,Salvadora Martinez,Victor Perez,Lucia Martinez,Jose Molina,Carmen Hernandez,Jaume Bech,Manuel Hernandez-Cordoba 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6
( Marta Perez De Lis Novo ),( Roberto Perez Lvarez ),( Pilar Brito Zeron ),( Antoni Siso Almirall ),( Belchin Kostov ),( Mireia Marti Villalta ),( Albert Bove ),( Hoda Gheitasi ),( Soledad Retamozo ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To analyze the prevalence of SLE in the field of primary care and to evaluate the management of cardiovascular risk factors (CVRF) in comparison with a non-autoimmune control population. Methods: Analysis of the diagnostic accuracy of SLE by primary care physicians using medical record audit (EMR) in 3 health centers including a population of 44,184 inhabitants. The prevalence of CVRF and clinical cardiovascular disease (CVD) in the SLE population was evaluated and compared with a control population of patients without autoimmune disease matched for gender. Results: 145 patients were identifi ed as SLE. After a case-by-case audit, 112 (77%) patients were confirmed as having SLE, representing a prevalence of 0.25%: 92% were women, with a median follow-up of 11.3 years: death was recorded in 8.9%. The comparison of the main characteristics between SLE and the control group showed that SLE patients had a lower mean age (53.2 vs 60.5, p=0.001), a lower frequency of dyslipidemia (26% vs 47%, p=0.001), a lower mean total cholesterol (199.5 vs 211.3 mg/dL, p=0.023) and a lower mean systolic blood pressure (119 vs. 124.2 mmHg, p=0.043). In contrast, patients with SLE had a higher frequency of renal disease (32.1% vs 12.1, p<0.001), cerebrovascular disease (8.0% vs 1.6%, p=0.027) and non-fatal cardiovascular events (17.0% vs 4.8%, p=0.003). Conclusions: The level of diagnostic accuracy of SLE in our primary care area was high. We found a ‘cardiovascular paradox “: despite having a signifi cantly better degree of control of the main CVRF, and even being a younger population, a higher prevalence of CVD was observed in SLE patients, suggesting that this autoimmune disease is, per se, a cardiovascular risk factor.
( Marta Perez De Lis Novo ),( Roberto Perez Lyarez ),( Pilar Brito Zeron ),( Antoni Siso Almirall ),( Belchin Kostov ),( Mireia Marti Villalta ),( Albert Bove ),( Hoda Gheitasi ),( Soledad Retamozo ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Medical education for medical school graduates in Japan greatly changed after World War II. From 1948, the General Headquarters (GHQ), the Supreme Commander for the Allied Powers imposed internship medical school graduates as early clinical training, internal medicine for 5 months, surgery for a month, obstetrics and gynecology for a month, public health for a month, for initial year. This system was unpaid before the nation examination, and abolished in 1968 by the campus dispute spread throughout Japan. Subsequently became mainstream medical center by the universities and colleges, but did not develop the training of general practitioners and family doctors in Japan because of aiming for the priority of specialization by university faculty of medicine. Musashino Red Cross Hospital (MRCH) started comprehensive initial training for medical doctors since 1980. One of the reason is that The Japan Red Cross Society as the most important philosophy advocates disaster medicine and its realization in general medical education is very important. Methods: MRCH employed the intern doctors by general invitation examination, and educated them for two years. In principle mandatory training period within 2 years in internal medicine, surgery, pediatrics, obstetrics and gynecology training, psychiatry, and regional medical training. Results: From 1980 to now MRCH did general medical education to more than 200 doctors. These doctors are working around the world. In Japan, from 2004 Initial general medical training was compulsory to all new medical doctors for two years. Conclusions: Comprehensive initial training for medical doctors is very important in general medicine for all the generations and the disaster medicine. In Japan from the year 2020 general medicine training under the new medical program scheduled.
Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus
Munoz-Perez, Victor Manuel,Ortiz, Mario I.,Ponce-Monter, Hector A.,Monter-Perez, Vicente,Barragan-Ramirez, Guillermo The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4
The aim of this study was to evaluate the in vitro anti-inflammatory and utero-relaxant effect of ${\alpha}$-bisabolol on the pregnant human myometrium. Samples from the pregnant human myometrium were used in functional tests to evaluate the inhibitory effect of ${\alpha}$-bisabolol (560, 860, 1,200 and $1,860{\mu}M$) on spontaneous myometrial contractions. The intracellular cyclic adenosine monophosphate (cAMP) levels generated in response to ${\alpha}$-bisabolol in human myometrial homogenates were measured by ELISA. The anti-inflammatory effect of ${\alpha}$-bisabolol was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-${\alpha}$ ($TNF{\alpha}$) and interleukin $(IL)-1{\beta}$, and the anti-inflammatory cytokine IL-10, in pregnant human myometrial explants stimulated with lipopolysaccharide (LPS). Forskolin was used as a positive control to evaluate the cAMP and cytokine levels. ${\alpha}$-Bisabolol was found to induce a significant inhibition of spontaneous myometrial contractions at the highest concentration level (p<0.05). ${\alpha}$-Bisabolol caused a concentration-dependent decrease in myometrial cAMP levels (p<0.05) and a concentration-dependent decrease in LPS-induced $TNF{\alpha}$ and $IL-1{\beta}$ production, while IL-10 production did not increase significantly (p>0.05). The anti-inflammatory and utero-relaxant effects induced by ${\alpha}$-bisabolol were not associated with an increase in cAMP levels in pregnant human myometrial samples. These properties place ${\alpha}$-bisabolol as a potentially safe and effective adjuvant agent in cases of preterm birth, an area of pharmacological treatment that requires urgent improvement.
( Marta Perez De Lis Novo ),( Roberto Perez Alvarez ),( Soledad Retamozo ),( Pilar Brito Zeron ),( Xavier Bosch ),( Antoni Siso Almirall ),( Jaume Villalta ),( Ricardo Alvarez Vijande ),( Alfonso Lope 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To analyse the possible existence of features associated with IgG4-related disease (IgG4-RD) in patients diagnosed with retroperitoneal fi brosis or mesenteritis. Methods: Study cohort including patients diagnosed with retroperitoneal fi brosis and/ or mesenteritis by imaging studies (CT) in a university hospital during the last 20 years. Results: A total of 22 patients diagnosed with retroperitoneal fi brosis (15 patients) or mesenteritis (7 patients) are described (6 women and 16 men, with a mean age at diagnosis of 64.1 years, range: 46-82. The main clinical manifestations present at diagnosis were abdominal/back pain (n=14), general malaise/fever (n=7) and the presence of edema/thrombosis (n = 6); in one patient, diagnosis was made incidentally by imaging techniques. CT showed infl ammatory masses affecting retroperitoneal (n=17), mesenteric (n=7) and vascular structures, including iliac arteries (n=3), aorta (n=2), renal arteries (n=2) and cava (n=2). In 7 (32%) patients, involvement of other organs suggestive of IgG4-RD (liver/bile tract in 2 cases, periaortitis in 2 cases, pleura, lymph nodes and skin in 1 each, respectively) was found. Diagnosis was confi rmed by biopsy in 8 patients (36%); in any patient, studies to rule out IgG4-RD were performed. The main treatments included corticosteroids (n=17), immunosuppressive agents (azathioprine in 5, methotrexate in 1 and mycophenolate in 1), surgery (n = 5) and the placement of urinary catheters (n = 4). After a mean follow-up of 73 months, 7 patients died (32%) patients (4 of them due to septic shock). Conclusions: Ormond`s disease is a rare clinical entity but associated with a signifi cant morbidity and mortality. His recent inclusion in the clinical spectrum of IgG4-RD diffi cult their retrospective diagnosis, although this study and others recently published suggest that about half of the cases could correspond to IgG4-RD.