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Park Yeong-Ju,Hwang Unsik,Park Suyeon,Sim Sol,Jeong Soyeon,Park Misun,Kang Minji,Lee Youngsoo,Song Youngju,Park Hoon,Suh Hee-Jae 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.1
Compound K (CK; 20-O-β-(d-glucopyranosyl)-20(S)-protopanaxadiol) is one of the metabolites of ginsenosides contained in red ginseng (RG) and is known to have high bioavailability. This study aimed to establish the optimal conditions for enzyme treatment to convert ginsenosides from RG extract to CK, and to prove the characteristics of bioconverted red ginseng (BRG) extract. CK was not detected in unenzyme-treated RG extract, and in the single-step enzyme treatment, it was produced at less than 4.58 mg/g only in treatment group with Pyr-flo or Sumizyme AC (at 50 °C for 48 h). The highest yield of CK (14.32 mg/g) was obtained by Ultimase MFC treatment at 50 °C for 48 h after treatment with a mixture of Pyr-flo and Rapidase at 50 °C for 24 h. Total polyphenol, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) (ABTS) radical scavenging activity were higher in BRG than in RG (p < 0.5). High-fat diet (HD) rat fed 1% BRG had significantly lower body weight, heart weight, fat pads (periosteal fat, epididymal fat), serum glucose levels, and hepatic triglyceride levels than those HD rat fed 1% RG (p < 0.05). In conclusion, the sequential enzymatic bioconversion was produces higher CK in RG root extract than single-step enzyme treatment.
Doping effects of multiferroic manganitesYMn0.9X0.1O3(X=Al, Ru, and Zn)
Park, Junghwan,Kang, Misun,Kim, Jiyeon,Lee, Seongsu,Jang, Kwang-Hyun,Pirogov, A.,Park, J.-G.,Lee, Changhee,Park, S.-H.,Kim, Hyoung Chan American Physical Society 2009 Physical review. B, Condensed matter and materials Vol.79 No.6
One-Nanometer-Scale Size-Controlled Synthesis of Monodisperse Magnetic Iron Oxide Nanoparticles
Park, Jongnam,Lee, Eunwoong,Hwang, Nong-Moon,Kang, Misun,Kim, Sung Chul,Hwang, Yosun,Park, Je-Geun,Noh, Han-Jin,Kim, Jae-Young,Park, Jae-Hoon,Hyeon, Taeghwan WILEY-VCH Verlag 2005 Angewandte Chemie Vol.44 No.19
<B>Graphic Abstract</B> <P>Accurate to size: Monodisperse magnetic iron oxide nanoparticles with a continuous size spectrum of 6–13 nm have been synthesized by a procedure similar to seed-mediated growth and characterized by transmission electron microscopy (see picture) and magnetic measurements. This method yields monodisperse nanoparticles directly without a size-selection process. <img src='wiley_img/14337851-2005-44-19-ANIE200461665-content.gif' alt='wiley_img/14337851-2005-44-19-ANIE200461665-content'> </P>
( Misun Yun ),( Hee Eun Jo ),( Namhee Kim ),( Hyo Kyeong Park ),( Young Seo Jang ),( Ga Hee Choi ),( Ha Eun Jo ),( Jeong Hyun Seo ),( Ji Ye Mok ),( Sang Min Park ),( Hak-jong Choi ) 한국미생물생명공학회 2024 Journal of microbiology and biotechnology Vol.34 No.4
Excessive alcohol consumption can have serious negative consequences on health, including addiction, liver damage, and other long-term effects. The causes of hangovers include dehydration, alcohol and alcohol metabolite toxicity, and nutrient deficiency due to absorption disorders. Additionally, alcohol consumption can slow reaction times, making it more difficult to rapidly respond to situations that require quick thinking. Exposure to a large amount of ethanol can also negatively affect a person’s righting reflex and balance. In this study, we evaluated the potential of lactic acid bacteria (LAB) to alleviate alcohol-induced effects and behavioral responses. Two LAB strains isolated from kimchi, Levilactobacillus brevis WiKim0168 and Leuconostoc mesenteroides WiKim0172, were selected for their ethanol tolerance and potential to alleviate hangover symptoms. Enzyme activity assays for alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) were then conducted to evaluate the role of these bacteria in alcohol metabolism. Through in vitro and in vivo studies, these strains were assessed for their ability to reduce blood alcohol concentrations and protect against alcohol-induced liver damage. The results indicated that these LAB strains possess significant ethanol tolerance and elevate ADH and ALDH activities. LAB administration remarkably reduced blood alcohol levels in rats after excessive alcohol consumption. Moreover, the LAB strains showed hepatoprotective effects and enhanced behavioral outcomes, highlighting their potential as probiotics for counteracting the adverse effects of alcohol consumption. These findings support the development of functional foods incorporating LAB strains that can mediate behavioral improvements following alcohol intake.