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최석원,박하나,정승균 公州大學校 基礎科學硏究所 1997 自然科學硏究 Vol.6 No.-
지구정보시스템(GIS)을 이용하여 충청남도 부여군 서부지역의 산사태 발생 가능성을 분석하였다. 산사태 취약성 분석을 위하여 산사태 발생에 영향을 미치는 사면경사, 토양침식율, 지질, 토지이용도 등과 같은 환경지질학적 요인들을 선정한 후 산사태 발생지역에 대한 통계분석을 행하였다. 분석 결과를 이용하여 database를 구축하고 각각의 자료들을 중첩시켜 산사태 취약성 지수(LSI)를 산출한 다음 이 지수와 분포 면적에 대한 누적곡선을 작성하여 산사태 취약성도를 작성하였다. 산사태 취약성은 연구지역 남쪽과 북쪽 경계부, 그리고 은산면 중앙부 지역에 매우 높게 나타났으며, 은산면 북서쪽과 내산면 일대는 비교적 높은 산사태 취약성을 보였다. 그러나 규암면 일대와 구룡면, 옥산면을 잇는 수계하천을 따라서는 산사태 취약성이 매우 낮게 나타났다. This study used GIS to analyze the possibility of landslide occurrence in the western part of Puyeo-kun, Chung Nam Province. For the regional analysis of landslide, environmental and geological factors such as topographic slope, soil erodibility, geology, landuse which have influence on the landslide occurrence were extracted, and then analyzed statistically for the area of landslide occurrence. With the result obtained by statistical analysis, databases were constructed. LSI were calculated by overlapping each factor. Landslide susceptibility map was obtained by use of LSI and cumulative curve of area. The results of this study show that each border of the south and north regions and the center of Eunsan-myeon have the very high susceptibility and northwest of Eunsan-myeon and side area of drainage between Gurong-myeon and Oksan-myeon have the very low landslide susceptibility.
이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
Design and Implementation of WPAN Middle-ware for Combination between CDMA and Bluetooth
Na Seung-Won,Jeong Gu-Min,Lee Yang-Sun Korea Multimedia Society 2005 멀티미디어학회논문지 Vol.8 No.6
The Wireless Internet services widely spread out with the developments of CDMA(Code Division Multiple Access) networks and wireless units. In contrast to the telecommunication network, WPAN (Wireless Personal Area Network) enables to transmit data and voice in personal area. Although WPAN technologies are commercially utilized, the combined services with COMA network are not so poplar up to now. Various services can be provided using the combination between COMA and WPAN. This paper presents the practical and united model between COMA and WPAN. Specially, the main focus of this research lies on the design of the Middle-ware system of a handset which could be managing both COMA and WPAN. This system used Bluethooth by WPAN. For the devices with the proposed WPAN Middle-ware, service areas of the COMA network can be expanded to WPAN, various services can be realized by the transmission of data and voice, and consequently, the user computing environment could be improved.
Won Jin Kang,Seung-Hwan Yun,Hyun Kyung Kim,Hyun-Na Koo,Gil-Hah Kim 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
The two spotted mite, Tetranychus urticae Koch, is a global pest, and has developed severe resistance to several types of acaricides. This study compared the development in susceptible (S) and acequinocyl, bifenazate, pyridaben, abamectin and etoxazole-resistant (AcR, BR, PR, AbR and ER) strains of T. urticae by X-ray irradiation. When eggs were irradiated with 100 Gy, the egg hatching was completely inhibited in all strains. When nymphs were irradiated with 200 Gy, their hatching was completely inhibited in all strains. When adults were irradiated, the fecundity and egg hatching was decreased at 150 Gy and above, and hatchability of F1 generation was completely inhibited at 300 Gy in all strains. Adult longevity was slightly increase at 150 Gy and above. In addition, we performed quantitative real-time PCR on several genes. To examine the difference of all strains on radiation stress-induced gene expression, we performed quantitative RT-PCR (qPCR) of several known stress-induced genes.
Jin-Won Seo,Won Jin Kang,Min-Jun Kim,Jun-Won Park,Seung-Hwan Yun,Hyun-Na Koo,Gil-Hah Kim 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
In Korea, six mealybug species have been reported on pears. This study investigated the occurrence of mealybugs in 19 pear orchards from 2013 to 2014. Two species, Crisicoccus matsumotoi (Siraiwa) (Hemiptera: Pseudococcidae) and Pseudococcus comstocki (Kuwana) were mainly found. The dominant species was C. matsumotoi identified on 73% of infested fruit. Toxicities of 14 registered insecticides (7 single formulations and 7 mixed formulations) commonly used to control P. comstocki were evaluated to C. matsumotoi nymphs and adults at the recommended concentration. As a results, all insecticides exhibited strong insecticidal activity with 100% mortality of both nymphs and adults. These results indicate that the 14 insecticides can be used in control for C. matsumotoi in field.
Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma.
Shin, Won-Sik,Kwon, Junhye,Lee, Hae Won,Kang, Moon Chul,Na, Hye-Won,Lee, Seung-Taek,Park, Jong Ho Japanese Cancer Association 2013 CANCER SCIENCE Vol.104 No.8
<P>Esophageal squamous cell carcinoma (ESCC) is a common subtype of esophageal cancer that is particularly prevalent in East Asian countries. Our previous expression profile analysis showed that the gene encoding protein tyrosine kinase 7 (PTK7) is upregulated in ESCC tissues. Here, we aimed to validate PTK7 as a prognostic factor and a candidate target for molecular treatment of ESCC. Both RT-PCR and Western blot analysis of tissues from ESCC patients revealed that PTK7 was significantly upregulated in tumor tissue samples of ESCC. Immunohistochemical staining of PTK7 showed that increased expression of PTK7 was inversely correlated with overall survival (P = 0.021). In vitro knockdown of PTK7 inhibited proliferation, survival, wound healing, and invasion of ESCC cells. In addition, PTK7 knockdown decreased phosphorylation of Akt, Erk, and focal adhesion kinase (FAK), important determinants of cell proliferation, survival, and migration. Therefore, our findings suggest that PTK7 has potential as a prognostic marker for ESCC and might also be a candidate for targeted therapy in the treatment of ESCC.</P>