결장직장암 환자의 임상적 고찰 : 조선대학교 부속병원의 10년 간의 결과

나은종,문성표,장정환,김권천,민영돈,김성환,조현진,김정용,김경종 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: The colorectal cancer rates 4th in the total cancer prevalence in Korea. The clinical patient demographics were considered with the incidence rate of the colon and rectal cancer. The clinicopathological factors were analyzed for the 5 year survival rate. Materials Methods: Of the 282 patients who were operated from Jan. 1, 1992 to Dec. 31, 2001 and diagnosed by pathological biopsy as colo-rectal cancer, 234 patients were followed up. The age, sex, location of the cancer, TNM stage, operation method, histopathological classification, metastatic region, complications after operation and the survival rate were investigated. Results: Of the 234 patients, male and female consisted of 120 cases (51.3%) and 114 cases (46.7%), with an average age of 61.6 years. The average follow up period was 52.3 months and the peri operative mortality was 5.6%. The site of the cancer was most frequent at the rectum with 127 cases (54.3%). The patients were classified according to the TNM stages with 38 cases of stage 1 (16.2%), 98 cases of II (41.9%), 72 cases of III (30.8%) and 26 cases of IV (11.1%). The 5 year survival rate in the age group older than 50 was 63.3 % and 73.5% in the group younger than 50. In regard to the operation type, the 5 year survival rate was 65.4% for elective operation and 65.8% for emergency operation. The 5 year survival rate for well differentiated, moderately differentiated, poorly differentiated cancer, and mucinous adenocarcinoma was 73.7%, 60.2%, 58.3%, and 92.6%, respectively. The 5 year survival rate of each of the TNM stage is 81.1%, 74.8%, 57.0%, and 11.5% for Classes I, II, III, and IV, respectively. Conclusion: The clinical factors were analyzed for the 5 year survival rate with no statistical significance for the age, sex, and location of the cancer. The TNM stage and histopathological differentiation were statistically significant. The colon cancer showed better prognosis compared to the rectal cancer.

文章題解決과 讀解力과의 關係에 관한 연구

宋煥龍,申卿子,羅炳昭 春川敎育大學 1987 論文集 Vol.27 No.-

정신분열병의 경과 중 발생하는 우울증

곽경환,박두병,최태영,민경준,이영식,기백석,나철 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.3

연구목적 : 정신분열병을 음성증상군과 양성증상군으로 나누어 두 군 사이에 우울증이 차이가 있는지를 조사하고 정신분열별의 증상과 우울증과의 연관과 정신분열병의 경과 중 보이는 우울증사의 특징에 대해서 알아보고자 하였다. 방 법 : 중앙대학병원에 입원한 총 31명(남자 13명, 여자 18명)의 정신분열병 환자를 대상으로 PANSS, BDI, HDRS와 Simpson Angus Scale을 시행하였다. 결 과 : 1) BDI 21점 이상을 기준으로 했을 때, 정신분열병의 경과 중 우울증이 발생한 환자는 총 18%였으며, 양성증상군과 음성증상군 간에 차이는 없었다. 2) 양성증상군과 음성증상군 간에 BDI, HDRS 그리고 PANSS-D 등의 점수의 차이는 없었다. 3) 주관척도인 BDI와 객관척도인 HDRS와 PANSS-D 사이의 연관은 없었다. 결 론 : 정신분열병의 우울증은 양성증상이나 음성증상의 한 부분으로 생각하기보다는 또 다른 영역으로 받아들여야 할 것으로 보인다. 임상적으로 정신분열병에서 우울증은 발생되는 비율의 정도를 고려할 대 다른 증상과 더불어 집중적인 관심이 필요하며 이와 함께 우울증으로 인한 결과와 예후의 심각성을 고려할 때 우울증에 대한 인식 및 진단과 치료에 더 많은 진전이 있어야 한다. Objective : The heterogeneity of symptomatology within the group of schizophrenias is still a major obstacle for defining clinically useful subgroups of these disorders. One of these symptoms is depression. Recently there is a growing evidence suggesting that depressive symptoms and related mood disturbances are important in treating schizophrenia. This so because of the improvement of such side effects as extraphramidal symptoms with increasing use of atypical antipsychotics. Althought depression is known to be a serious problems of many schizophrenic patients, the nature and course of depression in schizophrenia remain unknown. Methods : The author examined the depressive features in 31 patients with schizophrenia. Rating on the PANSS, BDI and HDRS were obtained. Eighteen percent of the total patients had BDI score above 21, considered depressed. Results : There were no difference in BDI, hDRS and PANSS-D between positive symptoms group and negative synptom group. There was also no correlation between subject scale(BDI) and objective scales(HDRS, PANSS-D). Conclusions : Depression in schizophrenia needs intensive studies. It is also considered as another hereogeneous domain beside negative or positive symptom domain. Out of respect for the high prevalence and serious outcome of depression in schizophrenia, a more differentiated assessment, analysis, and treatment of depressive symptom is recommended.

세라믹 브라켓의 제거 시 Er : YAG 레이저의 효능

서충환,장나영,채종문,조진형,김상철,강경화 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.4

본 연구에서는 세라믹 브라켓 제거에 Er:YAG 레이저 조사가 도움이 되는지 알아보고, 브라켓 제거에 적합한 레이저 조사 방법을 연구하였으며, 또 이렇게 적용된 레이저가 치수와 법랑질에 손상을 주는지도 알아보았다. 총 190개의 치아, 단결정 세라믹 브라켓(MISO), 다결정 세라믹 브라켓(Transcend series 6000)과 KEY Laser3를 사용하였다. 실험군은 세라믹 브라켓의 종류(단결정, 다결정)와 레이저의 에너지(140, 300, 450, 600 mJ)에 따라 분류하였으며, 레이저를 브라켓당 두 곳에 1펄스씩 조사하고, 전단 강도를 측정하였다. 대조군은 레이저를 조사하지 않는 군으로 하였다. 레이저 조사에 의한 열 효과는 브라켓 하방 법랑질과 치수강에서 측정하였으며, 전단 강도 측정 후 치면에 남아있는 접착제의 양을 접착제 잔류 지수(adhesive remnant index)를 이용하여 평가하였다. 레이저 조사로 인한 접착제의 파괴 양상과 법랑질 표면 변화를 주사전자현미경으로 관찰하였다. 모든 세라믹 브라켓군에서 레이저 에너지가 증가 할수록 전단 강도는 유의하게 감소하였다. 또한, 브라켓 하방 법랑질에서 최대 온도 변화는 평균 3.78˚C 상승에 그쳤으며, 치수강에서 최대 온도 변화는 평균 0.9˚C 상승에 그쳤다. 주사전자현미경을 이용한 법랑질과 접착제 단면 관찰에서 접착제 표면이 레이저에 의해 붕괴되어 분화구 모양의 구덩이로 관찰되었으며, 일부 시편에서 약 10 - 30μm의 법랑질 손상이 발견되었다. Transbond XT로 부착된 단결정 도재 브라켓(MISO)의 디본딩에 Er:YAG 레이저를 이용할 경우, 300 - 450 mJ의 레이저 에너지를, 그리고 다결정 도재 브라켓(Transcend series 6000)의 경우는 450 mJ 정도의 에너지를 사용하는 것이 효과적이고 안전할 것으로 생각된다. Objective: The aim of this study was to find out whether Er:YAG laser can aid in debonding ceramic brackets, and to see what kind of method will be the most appropriate for debonding. Methods: One hundred and ninety teeth, monocrystalline brackets (MISO, HT, Ansan-Si, Korea), polycrystalline brackets (TranscendTM series 6000, 3M Untek, Monrovia, CA, USA) and the KEY Laser3 (KavoDental, Biberach, Germany) were used. Experimental groups were classified according to the type of ceramic brackets, and the amount of laser energy (0, 140, 300, 450, 600 mJ). After applying laser on the bracket at two points at 1 pulse each, the shear bond strength was measured. The effect of heat caused by laser was measured at the enamel beneath the bracket and pulp chamber. After measuring the shear bond strength, adhesive residue was evaluated and enamel surface was investigated using SEM. Results: All ceramic bracket groups showed a significant decrease in shear bond strength as the laser energy increased. The greatest average temperature change was 3.78˚C on the enamel beneath the bracket and 0.9˚C on the pulp chamber. Through SEM, crater shape holes caused by the laser was seen on the enamel and adhesive surfaces. Conclusions: If laser is applied on ceramic brackets for debonding, 300 - 450 mJ of laser energy will be safe and efficient for monocrystalline brackets (MISO), and about 450 mJ for polycrystalline brackets (Transcend series 6000).

란크릭 캅셀(플루옥세틴 20mg)에 대한 프로작 캅셀의 생물학적 동등성 시험

심상범,조요나,오한석,류재환,이경태,김남재,서성훈 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Bioequivalence of two flouxetine capsule, ProzacR (Lilly kora Ltd.) and LanclicR (Samsung Pharm. IND. Co.), was evalated according to the guideline of KFDA. Twenty four healthy male volunteers (21-26 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After 60mg of fluoxetine was orally administered, blood was taken at 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24, 32, 48 and 72 hours after administration and just before administration. Plasma was analyzed for fluoxetine and internal standard (clomipramine) by a sensitive and validated HPLC assay. The pharmaco kinetic parameters (AUCt, Cmax and Tmax) wre calculated and ANOVA test was used for the statistical analysis of parameters. Differences in (AUCt, Cmax and Tmax between two capsules were -0.90, 3.46 and -14.08% respectively. All powers (1-β) for AUGt, Cmax and Tmax were more than 0.9. Detectable differences (Δ) and confidence interval were all less than ±20%. All the parameters above met the criteria of KFDA for bioequivalence and indicated that LanclicR capsules are bioequivalent to ProzacR capsules.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Autonomic Dysfunction in Normal Tension Glaucoma: The Short-term Heart Rate Variability Analysis

Na, Kyung-Sun,Lee, Na Young,Park, Sung-Hwan,Park, Chan Kee Lippincott Williams Wilkins, Inc. 2010 Journal of glaucoma Vol.19 No.6

INTRODUCTION: The purpose of this study was to investigate the dysfunction of autonomic control that may be a contributing factor in normal tension glaucoma (NTG) by showing the short-term heart rate variability in NTG patients. MATERIALS AND METHODS: Newly diagnosed NTG patients and an age-matched normal control group were enrolled in this prospective study. Blood pressure was obtained and the electrocardiogram was monitored for 5 minutes after 30-minute rest in a supine position. Electrocardiographic signals were transferred to a heart rate analyzer. The time and frequency domain parameters of heart rate variability were analyzed between two groups. RESULT: In all, 77 NTG patients and 30 healthy controls were included in the study. There were no significant differences between NTG and controls with respect to age, sex, and a hypertensive history, heart rate, systolic pressure, and diastolic pressure. NTG patients showed a significant reduction in the standard deviation of the mean of qualified normal-to-normal intervals in comparison with controls (27.64±10.90 vs. 36.22±10.21, P=0.041). Low-frequency values in NTG patients were statistically lower than in healthy controls (P=0.001) and the low-frequency/high-frequency ratio was significantly higher in the NTG group (P=0.000). DISCUSSION: Our study results showed that the dysfunction of an autonomic control is associated with NTG patients.

고농도 수소 검출을 위한 팔라듐 나노갭 가스 센서 칩

나경환(Kyung Hwan Na),남구현(Koo Hyun Nam),임시형(Si-Hyung Lim) 한국가스학회 2016 한국가스학회 학술대회논문집 Vol.2016 No.6

Myriocin induces apoptotic lung cancer cell death via activation of DR4 pathway

Choi, Kyung Eun,Jung, Young Suk,Kim, Dea Hwan,Song, Ju Kyung,Kim, Ji Young,Jung, Yu Yeon,Eum, So Young,Kim, Joo Hwan,Yoon, Na Young,Yoo, Hwan Soo,Han, Sang-Bae,Hong, Jin Tae 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4

It has been known that myriocin inhibits melanoma growth. However, the effects and action mechanisms of myriocin on lung cancer cell growth have not been reported. In this study, we examined whether myriocin isolated from Mycelia sterilia inhibits cell growth of lung cancer cells (A549 and NCI-H460) as well as possible signaling pathways involved in cell growth inhibition. Different concentrations of myriocin inhibited the growth of lung cancer cells through the induction of apoptotic cell death. Consistent with cancer cell growth inhibition, myriocin induced the expression of death receptors (DRs) as well as p-JNK and p-p38 in both cell lines. Moreover, the combination of myriocin with DR4 ligand TRAIL, and other well known anti-tumor drugs (docetaxel and cisplatin) synergistically inhibited cancer cell growth, and induced DR4 expression. These results showed that myriocin inhibits lung cancer cells growth through apoptosis via the activation of DR4 pathways, and enhanced anticancer effects with well known drugs. Thus, our study indicates that myriocin could be effective for lung cancer cells as an anti-cancer drug and/or a conjunction agent with well known anti-cancers.

삼중 덕티드 팬 비행체 운동모델링 및 리아푸노프 제어를 이용한 안정화

나경석(Kyung Seok Na),원대희(Dae Hee Won),윤석환(Seok Hwan Yoon),성상경(Sang Kyung Sung),류민형(Min Hyoung Ryu),조진수(Jin Soo Cho),이영재(Young Jae Lee) 한국항공우주학회 2012 韓國航空宇宙學會誌 Vol.40 No.7

로터를 이용한 무인비행체는 노출된 블레이드로 운용 시 위험이 따른다. 반면 덕티드팬은 블레이드 주위를 덕트로 감싸 위험요소를 줄여주고, 동일 동력 하중을 사용한 로터보다 향상된 추력성능을 보인다. 본 논문에서는 덕티드 팬의 장점을 적용하고자 세 개의 덕티드 팬으로 구성된 삼중 덕티드 팬 비행체 형상을 제안한다. 크기가 동일한 두 개의 덕티드 팬과, 크기가 다른 한 개의 덕티드 팬으로 구성되며 3개의 덕티드 팬 중 하나는 추력 방향 조절을 통해 신속한 자세 제어가 가능하다. 삼중 덕티드 팬 비행체의 운동방정식을 유도 하였고, 리아푸노프 함수를 적용하여 시스템을 안정하게 하는 제어 입력을 도출하였다. 그리고 비행체 초기모델의 파라미터를 적용하여 비선형 모델 시뮬레이션을 통해 안정한 자세각이 출력됨을 확인하고 결과를 분석하였다. Because of the exposed blade, the UAV using the rotors entail the risks during operation. While a wrapped duct around the fan blades reduces risks, it is a higher thrust performance than the same power load rotor. In this paper, for applying advantages of a ducted fan, the tri-ducted fan air vehicle configuration is proposed. The vehicle has three ducted fans. Two of them are the same shape and size and the third one is the smaller. It is possible to control a rapid attitude stability using thrust vector control. The equations of motion of the tri-ducted fan were derived. Lyapunov control input was applied to the system and stable inputs were derived. A nonlinear simulation was fulfilled by using parameters of a prototype vehicle. It verified a stable attitude and analyzed results.