우리 나라 都市와 農村地方의 母乳授乳 實態에 關한 調査硏究 : 全南地方을 中心으로

文松洙,具光鍊,金成宜,韓圭炯,羅昌洙 朝鮮大學校 附設 醫學硏究所 1983 The Medical Journal of Chosun University Vol.8 No.1

Human milk is the best source of nutrients for the human infant, and its nutritional and immunologic benefits are now established, In spite of these advantages, the incidence and duration of breast feeding- is decreasing in many part of the world. The purpose of the study is to collect the data on breast feeding practice in rural and urban area of Chullanamdo, Korea and to follow the trend toward breast feeding in fuutre. Between July 1981 and January 1982, 674 mothers with the children under 2 years of age have been interviewed at Out-Patient Department. The breast feeding situation at the time of interviewed was recorded. The percentage of wholly breast-fed in the age group of 0~1, 1-2, 2~3 ,3~4, 4~5, 5~6, 6-12 and 12~24 months were 61.8%, 50.0%, 51.6%, 65.2%, 50.0%, 45.7%, 23.0% and 17.3% respectively. And the percentage of partially breast-fed in the age group of 0~1, 1~2, 2~3, 3~4, 4~5, 5~6, 6~12, and 12~24 months were 29.4%, 33.3%, 25.8%, 17.4%, 34.2%, 39.1%, 8.6% and 80.0% respectively, In the incidence of wholly breast feeding, there was no correlation between deliveries in hospital and deliveries at home attended by midwives or traditional midwives. The most frequent reasons for partially breast-fed in the age group of 0~1, 1~2, 2~3, and 3~4 months were not enough breast milk.

韓國 中小企業의 問題와 高度化方案 : 製造業을 中心으로

宋文圭 全北大學校 商科大學 附設 産業開發硏究所 1976 상과대학論文集 Vol.6 No.-

小兒 急性絲述體腎炎에 있어서 血淸 免疫글로불린에 關한 硏究

文松洙,韓圭炯,明槿哲,文炅來,羅昌洙 조선의대 1984 The Medical Journal of Chosun University Vol.9 No.1

제주 차귀도 연안해역 미생물 분포 및 이화학적 특성

문영건,김만철,이준백,송춘복,여인규,김종만,박근태,손홍주,최우봉,허문수 한국환경과학회 2006 한국환경과학회지 Vol.15 No.3

심상성 루프스에서 Nested-Primer Gene Amplification Assay에 의한 결핵균 DNA의 검출

신문석,전효진,김병천,이규석,김재룡,권호준,송준영 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Lupus vulgaris, which is a progressive form of postprimary tuberculosis in patients with a moderate to high degree of immunity and tuberculin sensitivity, is the most common, most serious, and most variable type of cutaneous and mucous membrane tuberculosis. Domonstration of M.tuberculosis directly or in culture in some of these eruptions can be difficult. It is essential to demonstrate the presence of M.tuberculosis in a clinical sample for a definitive diagnosis of tuberculosis. With the discovery of the polymerase chain reaction (PCR), the DNA diagnostic approach for infection has developed in a short period. With the dual purpose of definitive and rapid diagnosis of tuberculosis, this study examined the usefulness of a nested PCR for detection of M. turberculosis. Compared with a single-step PCR, the two-step PCR was able to enhance sensitivity approximately 1,000-fold on the basis of bacterial counts and DNA quantity. We concluded that two-step nested PCR appeared to be the most useful PCR protocol for early and sensitive diagnostic method detecting M.tuberculosis in acid-fast stain negative specimens.

성인간호학회지 논문(1989-2000)의 내용과 경향 분석

서문자,김소선,송미순,이명선,오의금,신경림,김옥수,이숙자,이영자,오효숙,정재심,김철규 성인간호학회 2001 성인간호학회지 Vol.13 No.4

"Journal of Korean Academy of Adult Nursing" has been published since 1989 and more than 330 articles have been published up 2000. We reviewed all the articles published in this journal to analyze the contents and trend of published articles and to find out the way of improvement both in quantity and quality of studies in this area. The results are as follows : 1) Ninety percent of articles were quantitative studies. Experimental design was used in 16.1% and quasi-experimental design was adapted in 73.6% of articles. Qualitative research were 10.3% of total articles reviewed. 2) Only 5.1% of articles described theoretical framework and 73.6% of experimentally designed articles included research hypotheses. 3) Among experimental studies, only one was true experimental studie design. Eighty nine point three persent had descriptive survey method among non-experimental studies. Amog the thirty four qualitative studies, phenomenologic(73.5%), grounded theory(14.7%), and ethnographic (11.8%) design were used. 4) Most of research subject were patients and few healthy people, healthcare worker, and patient family. 5) Psychosocial data collection method which used questionnaire were 53.7% and interview. physical measurement, observation were used in 22.8%. 8.2% 5.4% of articles respectively. 6) Total number of keywords were 692, and average number of key words per article was 2.2. Health-related keyword was the most frequently used according to four metaparadigm of nursing (human, health, nursing, and environment). Environment related keyword was rarely appeared. The number and quality of nursing research in "Journal of Korean Academy of Adult Nursing" have been improved continuously. It is difficult to find out special trend or characteristics which is unique in this journal because of relatively short history of adult nursing studies. This review study was performed to analyze adult nursing studies only in the view of quantitative aspect, but it is needed to analyse qualitatively to find philosophical or theoretical trend in nursing.

7개 대학 병원에서 조사한 지역사회 폐렴의 원인균

정문현,김성민,강문원,최희정,정희진,이경원,한성우,송재훈,신형식,김의종,최강원,김민자,박승철,배현주,정윤섭,김준명,백경란,신완식,이규만,김양리 대한감염학회 1997 감염 Vol.29 No.5

목 적 : 폐렴은 많이 발생하면서 사망률이 크게 줄지 않는 질환이며, 이를 적절히 치료하기 위해서는 원인균의 상대적 빈도, 기저 질환에 따른 변화, 항균제 내성률, 사망에 관련된 인자들을 알아야 한다. 원인균의 빈도는 지역마다 차이가 있고 국내에서는 항균제 내성률이 높아 지역사회에서 발생한 폐렴을 치료하기 위한 경험적 항균제 선택에 도움이 되기 위해 서울 소재 6개 대학 병원과 천안의 1개 대학 병원이 참여하여 위의 사항들에 대해 조사를 하였다. 방 법 : 1995년에 내과에 입원했던 16세 이상 환자를 대상으로 했다. 퇴원 진단명이 폐렴 또는 폐결핵인 병록지을 찾았고, 이중에서 병원 감염을 제외하였다. 특이도를 높이기 위해, 이들 중에서 호흡기 증상이 있고 발열이나 저체온이 있으면서 흉부 X-선에서 이상 음영이 있는 환자만을 대상으로 했다. 폐결핵은 위의 기준에 입원 초기에 항균제 치료를 하고 입원 7일 이후에야 항결핵제가 투여된 경우만을 폐렴의 원인균으로 하였다. 혈액 배양에서 양성, 객담에서 항상균이나 M. tuberculosis가 증명된 경우, 혈청학적으로 항체가가 4배 이상 증가된 경우, 조직에서 원인균이 진단된 경우는 확정(definitive) 원인균으로 하였고, 객담에서 배양된 균이 그람 도말과 일치할때, 항결액제에 대한 반응으로 진단한 폐결핵, 단일 항체가 양성이고 이에 대해 항균제를 사용했을 때는 가능(probable) 원인균으로 정의하였다. 다세균 감염균은 각각 다 른 원인균으로 처리하였다. 임상 조사와 함께 임상병리과에서 S. pneumoniae, H. influenzae, M. catarrhalis, mycoplasma, 항상균에 대해 검사 의뢰 건수, 배양 양성수, 항균제 감수성 결과를 조사하였다. 결 과 : 폐렴의 증례 정의에 부합하지 않은 135명과 폐결핵의 정의에 해당하지 않는 230명을 제외하고 남은 246명의 평균 나이는 58.2세이고 남성이 142명(58.2%) 이었고, 71%의 환자에서 기저 질환이 있었다. 진단 방법의 시행 횟수는 혈액 배양 77.6%, 혈청 검사 18.3%, 기관지경 검사는 4.1%였고, 세균의 항원 검사를 한 예는 없었다. 원인균이 밝혀진 예는 77명(31.3%)이었다. 다세균 감염이 4명에서 있었고, 원인균의 상대적 빈도는 결핵 20명(확정 17, 가능 3: 6개 병원 자료), 폐렴구균 18(확정8 가능 10)명과 폐렴구균이 아닌 Streptococcus 3명 (모두 확정), H. influenzae 11명(모두 가능), 그람음성간균 11명(확정 7, 가능 4) (K. pneumoniae 8건), Mycoplasma 5명(확정 1, 가능 4), S. aureus 4명(확정 2, 가능 2), mucormycosis 1명(확정)이었다. 평균 입원 기간은 19일이고, 중환자실 입원률과 인공 호흡기 사용율은 각각 18%와 9.3%였다. 사망률은 13.8%였고 사망까지 평균 기간은 14.6일 이었다. 다변량 분석에서 사망을 예측할 수 있는 인자는 저체온과 빈호흡이었다. 임상병리과에서 배양되었던 모든 폐렴구균의 Penicillin 내성률은 서울 3개 병원에서 82-88%, 천안에서 72%였다. 폐렴 환자의 혈액에서 배양된 7주는 모두 Penicillin에 감수성이 있었다. K. pneumoniae 8주 모두 cefotaxime과 gentamicin에 감수성을 보였다. 결 론 : 후향적 조사이고 병원마다 원인균 진단에 차이가 있지만, 원인이 밝혀진 경우에는 결핵과 폐렴균이 흔하였고, 무균 부위에서 배양된 폐렴구균의 항균제 내성률은 낮았다. 원인이 밝혀지지 않은 경우가 많고, 혈청검사로 진단되는 원인균이 드물며, 분리균주가 적어 항균제 내성 정도를 추정하기 어려워, 이를 밝히기 위한 전향적 조사가 필요하다. Background : Community-acquired pneumonia (CAP) is one of the leading causes of mortality and morbidity, but its management is still challenging. The limitation of diagnostic methods to identify etiologic agents rapidly make it necessary to use empiric antibiotics in almost all patients, and furthermore the discovery of new respiratory pathogens and the emergence of antibiotic-resistant organisms pose difficulties to the selection of an empiric regimen. To clarify the factors necessary for the optimal choice of empirical antibiotics, such as the frequency of etiologic agents, the attributable rates to death and antimicrobial resistance rates in the community, six university hospitals in Seoul and one university hospital in Cheonan were participating in this study. Methods : medical records of adults (>15 years of age) hospitalized for CAP or pulmonary tuberculosis between April 1995 and March 1996, were reviewed. Patients who satisfied all of the following criteria were included in the study: (1) fever or hypothermia; (2) respiratory symptoms; and (3) pulmonary infiltrates on chest roentgenogram. To exclude cases of pulmonary tuberculosis whose roentgenographic features were so typical that it could be easily differentiated from conventional pneumonia, two additional criteria were required for inclusion: antibiotic treatment during the first week of hospital admission and initiation of anti-tuberculosis medications thereafter. Organisms isolated from sterile body sites, acid-fast bacilli or Mycobacterium tuberculosis isolated from sputum, pathogens diagnosed by a 4-fold rising titer of antibodies to “atypical”pathogens, or pathogens revealed by histopathology were defined as definitive cause of pneumonia; isolates from sputum withcompatible Gram stain, pathogens diagnosed by a single diagnostic titer plus use of a specific antimicrobial agent, or tuberculosis diagnosed by clinucal response to anti- tuberculosis medications were considered probable cause of pneumonia. The records of the clinical microbiology were reviewed for isolates of S. pneumoniae, H. influenzae, M. catarrhalis, Mycobacterium or acid-fast bacilli, and Mycoplasma. Then the frequency of these agents, antimicrobial resistance rates of resiratory pathogens from all body sites, and their clinical significance were evaluated. Results: After excluding 365 patients (230 with pulmonary tuberculosis and 135 with CAP) who were screened for inclusion but did not meet the inclusion criteria,246 persons were enrolled in this study. Their mean age was 58.2 years old with slight male predominance (58.2%), and 171(71%) patients had underlying illnesses. Blood cultures were performed on 191 (77.6%) patients and serologic tests on 44(18.3%) patients. The etiologic agents were identified in 31.3%, and the list of individual agents, in decreasing order, was pulmonary tuberculosis (17 definite and 3 probable: data of six hospitals), S. pneumoniae (8 definite and 10 probable), non-pneumococci (3 definite), aerobic gram-negative bacilli (7 definite and 4 probable), Haemophilus spp. (11 probable), mycoplasma (1 definite and 4 probable), polymicrobial infections (2 definite and 2 probable: E. coli and S. agalactiae, M. tuberculosis and S. aureus, S. pneumoniae and H. influenzae and A. baumannii and K. pneumonias), S. aureus (2 definite and 2 probable) , and mucormycosis (1 definite). Among gram-negative bacilli, K. pneumoniae was the most common agent (8isolates). therates of admission to the intensive care unitand of using assisted ventilation were 18% and 9.3%, respectively. The mortality was 13.8% and logistic regression analysis showed that hypothermia and tachypnea were associated with death. Hospital stay averaged 19 days. Susceptible rates of S. pneumoniae isolated from all body sites to penicillin ranged from 8% to 28% but seven isolated from blood of patients with pneumonia were susceptible to penicillin. Also all 8 isolated of k> pneumoniae from patients with pneumonia were susceptible to cefotaxime and gentamicin. Conclusion: In Korea, in addition to S. pneumoniae, M. tuberculosis is an important agent causing community-acquired pneumonia. The low incidence of etiologic diagnosis is probably related to infrequent requesting of test "atypical" pathogens and does not represent the true incidence of infections by "atypical" pathogens, which well be answered by a prospective study. The antimicrobial resistance rates of major respiratory pathogens from sterile body sites are low, however, because of a small number of the isolates this result needs confirmation by a nationwide surveillance of antimicrobial resistance.

레반다이어트 식품섭취가 비만여성의 신체구성성분, 혈중 렙틴 및 지질수준에 미치는 영향

이규성,유병렬,정락희,김문희,송봉준,이길자 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

This study was to varify the effects of levan diet administration on body composition, blood leptin level and lipids components (TC, TG, LDL-C, HDL-C) in obese women during 8 weeks. The subjects of study were divided into 20-29year group (n=15) and 30-39year group (n=15) randomly selected. Administration of Levan Diet in this study was 2 times (breakfast, lunch or dinner) per day, 11tablets per 1times. Statistical method for data processing produced mean and SD of total variable. To analyze difference between groups and periods had executed 2? ANOVA. This study was given conclusion as follows: First, systolic blood pressure showed decrease after administration of levan diet in 30-39years, but it was not statistically significant. Second, body weight and %fat gradually decreased according to the application period of levan diet administration in 20-29years and 30-39years, and it was statistically significant (p<.05). Third, blood leptin level and blood lipid levels (TC, TG, LDL-C) showed decrease after administration of levan diet in 20-29years and 30-39years, but it was not statistically significant. In conclusion, this study shows that the administration of levan diet play a positive role as assistant diet. Therfore, levan diet administration should be recommended as ergogenic aids for these who do obese adults.

환자이탈군 특성요인과 이탈환자 예측모형에 관한 연구

민경진,송규문,김광환 한국의료QA학회 2002 한국의료질향상학회지 Vol.9 No.1

Background : We developed a model for predicting premature discharge and identifying related factors. Methods : Prediction model was developed by data mining techniques. Basic data were collected from the total discharge data base of a university hospitals in Chungnam province during the period from July 1, 1999 to June 30, 2000. Results : 1. Among 22,873 patients, the number of patients discharge with usual discharge orders were 21,695 or 94.8%. The number of the prematurely discharged patients were 1,178 or 5.2%. 2. The primary reason for unusal discharge was transfer to other hospital. Move to a local hospital closer to their home and burdensome medical expenses were main reasons. 3. Predictability of each model was tested using the top 10 percent of patients with the highest probabilities of premature discharge. The neural network model was chosen as the most appropriate model for predicting prematurely discharged patients. 4. Ten percent of the total number of patients had been selected randomly to test the effectiveness of the neural network model. We have chosen the threshold of the neural network model as 0.7. The number of patients who were expected to discharge prematurely was 312. Among them, 241 had been discharged prematurely(77.2%). Conclusion : of the several data mining techniques used, the neural network model was the most effective, It can be used to identify and manage the patients who are expected to discharge prematurely.

精神分裂症의 生物學的 硏究 : 液體 크로마토그라프와 放財酵素法에 依한 Catecholamines 微量定量 A Rapid Microassay of Catecholamines by High Performance Liquid Chromatography-Radioenzymatic Method

고병학,송옥헌,임규,황병두,백문기 中央醫學社 1983 中央醫學 Vol.45 No.4

A direct rapid radioenzymatic assay in combination with high performance liquid chromatography (HPLC) for measuring simultaneously picogram quantities of nore pinephrine, epinephrine and dopamine has been developed, and the relationship of changes in cerebrospinal fluid (CSF) norepinephrine concentration during haloperidol treatment to changes in psychosis rating of twelve schizophrenic patients has been investigated. The three catecholamines in 20?l of CSF are converted to their 0-methylated ana-logues by catechol-0-methyltransferase in the presence of S-adenosyl-L-1{methyl-3H} methionine. After the addition of tetraphenylborate, these derivatives are extracted. with diethylether at pH 8.2 followed by re-extraction with 0.1N HCI and then isol-ated by HPLC using, ?Bondapak C18column and 0.17 M acetic acid-60% methanol- 0.02 M Na2SO4 as solvent. Manual collection of each fraction is started two seconds after in appeared mark. The HPLC fraction of norepinephrine and epinephrine deri-vatives are oxidized to vanillin followed by extracting the vanillin with toluene, and dopamine derivatives fraction is extracted with toluene/isoamylalcohol and then re-extracted with 0.1N HCl. Internal standard curve shows a good linearity from 5 to 30 picogram per samples, and incorporated radioactivity of norepinephrine, epinephrine and dopamine derivatives are 163±11.4, 125±10.5 and 112±3.9cpm per picogram and calculated sensitivities are 0.4, 0.3 and 1 picogram, respectively. 3H-Normetanephrine, 3H-metanephrine and 3H-methoxytytamine are well separated by HPLC, and each retention times are 3.52, 4.08 and 5.62 minutes and yields are 75.6?0.9, 76.1?0.8 and 70.1?0.4%. Separation of the methylated derivatives by HLPC are performed within 8 minutes, and thus enabled us to complete the differential analysis of 15 samples (30 tubes) in a day. CSF norepinephrine concentration in schizophrenic patients show rostral-caudal gradient and haloperidol induced decreases of norepinephrine and the decreases correlated significantly with psychosis rating, From the above rsults, it is suggested that this method is more excellent than any others in sensitivity, accuracy, reproducibility and specificity of the differential assay, and CSF norepinephrine can be used for evaluation of neuroleptics treatment of schizophrenia by this method.