http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5
Jeong Ji-Hoon,Park Seung-Ho,Kim Hyunhee,Nam Hae Yun,Kim Sung-Hak,Jeong Minseok,Kong Min-Jeong,Son Jihyun,Jeong Ji-Eun,Song Ji-Hye,Kim Seong Who,Choi Kyung-Chul 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Glioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor prognosis. Although patients with GBM are treated with surgery, chemotherapy, and radiation therapy, GBM is highly resistant to treatment, making it difficult and expensive to treat. In this study, we analyzed the Gene Expression Profiling Interactive Analysis dataset, the Cancer Genome Atlas dataset, and Gene Expression Omnibus array data. ZBTB7A (also called FBI1/POKEMON/LRF) was found to be highly expressed in low-grade glioma but significantly downregulated in patients with GBM. ZBTB7A is a transcription factor that plays an important role in many developmental stages, including cell proliferation. The activation of epithelial-mesenchymal transition (EMT) is a key process in cancer progression and metastasis. Erythrocyte membrane protein band 4.1 like 5 (EPB41L5) is an essential protein for EMT progression and metastasis in various types of cancer. We found that ZBTB7A depletion in U87 cells induced GBM progression and metastasis. Based on RNA sequencing data, ZBTB7A directly binds to the promoter of the EPB41L5 gene, reducing its expression and inhibiting GBM progression. We demonstrated that ZBTB7A dramatically inhibits GBM tumor growth through transcriptional repression of EPB41L5. Thus, both ZBTB7A and EPB41L5 may be potential biomarkers and novel therapeutic targets for GBM treatment. Overall, we discovered the role of a novel tumor suppressor that directly inhibits GBM progression (ZBTB7A) and identified EPB41L5 as a therapeutic target protein for patients with GBM.
Recent Trend of Residual Pesticides in Korean Feed
Jeong, Jin Young,Kim, Minseok,Baek, Youl-Chang,Song, Jaeyong,Lee, Seul,Kim, Ki Hyun,Ji, Sang Yun,Lee, Hyun-Jeong,Oh, Young Kyun,Lee, Sung Dae The Korean Society of Grassland and Forage Science 2018 한국초지조사료학회지 Vol.38 No.3
Pesticide application in agriculture provides significant benefits such as protection from disease, prevention of harmful insects, and increased crop yields. However, accurate toxicological tests and risk assessments are necessary because of many related adverse effects associated with pesticide use. In this review, we discuss and analyze residual pesticides contained in livestock feed in Korea. A pesticide residue tolerance standard for livestock feed has not been precisely established; so, risk assessments are required to ensure safety. Standards and approaches for animal criteria and appropriate methods for evaluating residual pesticides are discussed and analyzed based on technology related to animal product safety in Korea. The safety of livestock feed containing pesticides is assessed to establish maximum residue limits relative to pesticides. Analysis of residual pesticides in milk, muscle, brain, and fat was performed with a livestock residue test and safety evaluation of the detected pesticide was performed. Efficacy of organic solvent extraction and clean-up of feed was verified, and suitability of the instrument was examined to establish if they are effective, rapid, and safe. This review discussed extensively how pesticide residue tolerance in livestock feed and hazard evaluation may be applied in future studies.
여성의원은 여성을 대표하는가? 제19대 국회 여성법안 발의를 중심으로
정민석 ( Jeong Minseok ),이현우 ( Lee Hyeon-woo ) 한국의회발전연구회 2020 의정연구 Vol.26 No.1
제17대 국회에 비례대표 후보 여성할당제가 도입된 이후로, 국회 내 여성의원의 수는 지속적으로 증가해 왔다. 본 연구는 비례대표 여성할당제가 제도적 효과를 달성하고 있는지, 즉 국회에서의 여성의 기술적 대표성 증대가 실질적 대표성의 증대로 이어지는가를 확인하기 위해 제19대 국회의원을 대상으로 여성법안 발의에 있어서 남녀의원의 성차를 분석했다. 분석 결과, 지역구 의원의 경우 여성의원이 남성의원에 비해 여성법안을 통계적으로 유의미하게 많이 발의하는 것으로 나타났다. 그러나 비례대표 의원의 경우에는 남녀의원의 성차가 통계적 유의미성을 띠지 않았다. 이에 따라 본 연구는 비례대표 의원 내에서 기술적 대표성이 실질적 대표성으로 이어지지 않는 현상을 극복하기 위해, 비례대표 후보 여성할당제를 넘어서 지역구에서 선출된 여성의원이 많아지도록 정당의 역할과 함께 제도 개선이 요구된다는 함의를 제공한다. Since gender quota was adopted in the 17<sup>th</sup> National Assembly (2004), the number of women in Korean legislative branch has been increasing constantly. This study analyses the influence of representatives’ gender differences on proposing gender bills to measure the effectiveness of gender quota, in other word, link between descriptive and substantive representation. As a result, among the district representatives, female legislators introduce statistically significantly more gender bills than male representatives. However, in case of proportional representatives, there are no statistically significant difference between female and male legislatives. Consequently, this study implies that political parties’ effort to make more female district representatives are required to overcome the disconnection between descriptive and substantive representation in proportional representatives, beyond gender quota.
STFT와 DMD를 이용한 GH₂/GO₂ 로켓 연소기의 연소불안정성 분석
곽민석(Minseok Kwak),Hung Truyen Luong,한희선(Hee Sun Han),손채훈(Chae Hoon Sohn),정승민(Seung-Min Jeong),최정열(Jeong-Yeol Choi) 한국연소학회 2019 한국연소학회지 Vol.24 No.4
The post-processing analysis tools, Short Time Fourier Transform (STFT) and Dynamic Mode Decomposition (DMD) were applied to analyze dynamic characteristics of the GH₂/GO₂ rocket model combustor. The STFT analysis was performed with pressure data in the chamber to exhibit the appearance of frequency components at instant time. The STFT results indicate resonant frequencies of signal through their amplitudes. DMD analysis was conducted with the planar pressure data to extract the resonant frequencies and damping coefficients of acoustic modes. The damping coefficient is a parameter to evaluate the stability of a certain pressure oscillation in a dynamic system. By combining the results of STFT and DMD, the appearance of the resonant frequencies causing unstable combustion can be determined.
Characterizing Milk Production Related Genes in Holstein Using RNA-seq
Seo, Minseok,Lee, Hyun-Jeong,Kim, Kwondo,Caetano-Anolles, Kelsey,Jeong, Jin Young,Park, Sungkwon,Oh, Young Kyun,Cho, Seoae,Kim, Heebal Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.3
Although the chemical, physical, and nutritional properties of bovine milk have been extensively studied, only a few studies have attempted to characterize milk-synthesizing genes using RNA-seq data. RNA-seq data was collected from 21 Holstein samples, along with group information about milk production ability; milk yield; and protein, fat, and solid contents. Meta-analysis was employed in order to generally characterize genes related to milk production. In addition, we attempted to investigate the relationship between milk related traits, parity, and lactation period. We observed that milk fat is highly correlated with lactation period; this result indicates that this effect should be considered in the model in order to accurately detect milk production related genes. By employing our developed model, 271 genes were significantly (false discovery rate [FDR] adjusted p-value<0.1) detected as milk production related differentially expressed genes. Of these genes, five (albumin, nitric oxide synthase 3, RNA-binding region (RNP1, RRM) containing 3, secreted and transmembrane 1, and serine palmitoyltransferase, small subunit B) were technically validated using quantitative real-time polymerase chain reaction (qRT-PCR) in order to check the accuracy of RNA-seq analysis. Finally, 83 gene ontology biological processes including several blood vessel and mammary gland development related terms, were significantly detected using DAVID gene-set enrichment analysis. From these results, we observed that detected milk production related genes are highly enriched in the circulation system process and mammary gland related biological functions. In addition, we observed that detected genes including caveolin 1, mammary serum amyloid A3.2, lingual antimicrobial peptide, cathelicidin 4 (CATHL4), cathelicidin 6 (CATHL6) have been reported in other species as milk production related gene. For this reason, we concluded that our detected 271 genes would be strong candidates for determining milk production.
Suh Minseok,Ryoo Hyun Gee,Kang Keon Wook,Jeong Jae Min,Jeong Chang Wook,Kwak Cheol,Cheon Gi Jeong 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.9
Objective: 68Ga-NGUL is a novel prostate-specific membrane antigen (PSMA)-targeting tracer based on Glu-Urea-Lys derivatives conjugated to a 1,4,7-triazacyclononane-N,N’,N’’-triacetic acid (NOTA) chelator via a thiourea-type short linker. This phase I clinical trial of 68Ga-NGUL was conducted to evaluate the safety and radiation dosimetry of 68Ga-NGUL in healthy volunteers and the lesion detection rate of 68Ga-NGUL in patients with prostate cancer. Materials and Methods: We designed a prospective, open-label, single-arm clinical trial with two cohorts comprising six healthy adult men and six patients with metastatic prostate cancer. Safety and blood test-based toxicities were monitored throughout the study. PET/CT scans were acquired at multiple time points after administering 68Ga-NGUL (2 MBq/kg; 96–165 MBq). In healthy adults, absorbed organ doses and effective doses were calculated using the OLINDA/EXM software. In patients with prostate cancer, the rates of detecting suspicious lesions by 68Ga-NGUL PET/CT and conventional imaging (CT and bone scintigraphy) during the screening period, within one month after recruitment, were compared. Results: All 12 participants (six healthy adults aged 31–32 years and six prostate cancer patients aged 57–81 years) completed the clinical trial. No drug-related adverse events were observed. In the healthy adult group, 68Ga-NGUL was rapidly distributed, with the highest uptake in the kidneys. The median effective dose coefficient was calculated as 0.025 mSv/MBq, and cumulative activity in the bladder had the highest contribution. In patients with metastatic prostate cancer, 229 suspicious lesions were detected using either 68Ga-NGUL PET/CT or conventional imaging. Among them, 68Ga-NGUL PET/CT detected 199 (86.9%) lesions and CT or bone scintigraphy detected 114 (49.8%) lesions. Conclusion: 68Ga-NGUL can be safely applied clinically and has shown a higher detection rate for the localization of metastatic lesions in prostate cancer than conventional imaging. Therefore, 68Ga-NGUL is a valuable option for prostate cancer imaging.