http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
C -11 및 F - 18 표지 콜린의 합성과 체내동태에 관한 연구
전권수,유국현,김상욱,임상무,홍성운,서용섭,양승대,안순혁,허민구 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.3
Objectives: Recently, [methyl-(11)^C]-(β-Hydroxyethyl)trimethylammonium ([(11)^C]choline) has been discovered to be a very effective tracer in imaging various human tumors using positron emission tomography. Because of the short half-life of C-11, it is very difficult to use in a routine imaging procedure and needs a frequent synthesis of [(11)^]choline. This can be supplemented by the substitution of [(11)^Ccholine with [methyS-18]fluorocholine. Here, we would like to report cell uptake and biodistribution of [(11)^Ccholine and [(18)^F]fluorocholine as a basic study. Methods [(11)^C]Choline was prepared by the treatment of [(11)^C]CHzI with N,N-dimethylaminoethanol and [18F]fluorocholine was synthesized from reaction of CHzBr[18F]F with N,N-dimethylaminoethanol. The radiochemical purity was checked by high performance liquid chromatography (HPLC). The biodistribution of [(11)^C]choline and [(18)^F]fluorocholine was determined in balb/c mouse at 5 min, 20 min, 40 min and 80 min. The cell uptake wa measured using glioma (9L) and colon adeocarcinoma (SW620). Results: The radiochemical purity was more than 98% after purification. In the liver, uptake did not change over time the uptake was 20/ID/g for [C]choline and 13%ID/g for [(18)^F]fluorocholine. In the kidney, radioactivity decreased over tirne the uptake was 15%1D/g for [(11)^Ccholine and 20%ID/g for [(18)^F]fluorocholine, 80 min post-injection. The cell uptake of [(11)^Ccholine was 4.93% for glioma (9L) and 18.69F for colon adenocarcinoma (SW620). For [(18)^F]fluorocholine, 1.77% for glioma (9L) and 2.77% for colon adenocarcinoma (SW620). Conclusion: [(11)^CCholine and [(18)^F]fluorocholine showed a different cell uptake tendency, depending on cancer cell line. (Korean J Nucl Med 200135:185-191)
갑상선 결절에 대한 세침흡입 세포검사에서 반복적인 비진단적 검체의 원인에 대한 분석
최영근<SUP>1<.SUP>,윤찬석,고승상,허민희,강성수,이지현,전이경<SUP>2<.SUP>,박지영<SUP>2<.SUP>,이해경,Young Gun Choi,<SUP>1<.SUP>,Chan Seok Yoon,Seung Sang Ko,Min Hee Hur,Sung Soo Kang,Jee Hyun Lee,Yi Kyeong Chun,<SUP>2<.SUP>,Ji Y 대한갑상선-내분비외과학회 2006 The Koreran journal of Endocrine Surgery Vol.6 No.1
Kim, Min-Kyeong,Song, Ji-Yang,Koh, Dong-In,Kim, Jin Young,Hatano, Masahiko,Jeon, Bu-Nam,Kim, Min-Young,Cho, Su-Yeon,Kim, Kyung-Sup,Hur, Man-Wook American Society for Biochemistry and Molecular Bi 2019 The Journal of biological chemistry Vol.294 No.1
<P>Even in the face of physiological DNA damage or expression of the tumor suppressor protein p53, B cell CLL/lymphoma 6 (BCL6) increases proliferation and antagonizes apoptotic responses in B cells. BCL6 represses <I>TP53</I> transcription and also appears to inactivate p53 at the protein level, and additional findings have suggested negative mutual regulation between BCL6 and p53. Here, using <I>Bcl6</I><SUP>−/−</SUP> knockout mice, HEK293A and HCT116 <I>p53</I><SUP>−/−</SUP> cells, and site-directed mutagenesis, we found that BCL6 interacts with p53 and thereby inhibits acetylation of Lys-132 in p53 by E1A-binding protein p300 (p300), a modification that normally occurs upon DNA damage–induced cellular stress and whose abrogation by BCL6 diminished transcriptional activation of p53 target genes, including that encoding caspase-1. Conversely, we also found that BCL6 protein is degraded via p53-induced, caspase-mediated proteolytic cleavage, and the formation of a BCL6–p53–caspase-1 complex. Our results suggest that p53 may block oncogenic transformation by decreasing BCL6 stability via caspase-1 up-regulation, whereas aberrant BCL6 expression inactivates transactivation of p53 target genes, either by inhibiting p53 acetylation by p300 or repressing <I>TP53</I> gene transcription. These findings have implications for B cell development and lymphomagenesis.</P>
Relativistic channeling of a linearly polarized laser pulse in overdense plasma
Hur, Min Sup,Kim, Young-Kuk,Kulagin, Victor V.,Suk, Hyyong Cambridge University Press 2012 Laser and particle beams Vol.30 No.3
<B>Abstract</B><P>We investigated a dynamic procedure for relativistic channeling by a linearly polarized ultraintense laser pulse in overdense plasma, subsequently determining a phenomenological formula for the channel-digging speed. Channeling of the linearly polarized pulse usually results in a sharp-cut (non-adiabatic) pulse front, since the pulse is continuously reflected on the transparency-opacity interface during the channeling process. Using the novel formula for the channel-digging speed, it was possible to analytically predict where such a sharp-cut occurs longitudinally.</P>
Jang, Dogeun,Uhm, Han Sup,Jang, Donggyu,Hur, Min Sup,Suk, Hyyong IOP 2016 Plasma sources science & technology Vol.25 No.6
<P>Inductively-coupled plasmas (ICP) in the high electron density regime of the order of 10<SUP>13</SUP> cm<SUP>−3</SUP> are generated and their electron density characteristics are investigated by the terahertz time-domain spectroscopy (THz-TDS) method. In this experiment, the plasma was produced by RF (13.56 MHz) with an applied RF power of 300–550 W and the argon gas pressure was in the range of 0.3–1.1 Torr. We generated the THz wave by focusing a femtosecond laser pulse in air with a DC electric field. As a plasma diagnostic tool, the THz-TDS method is found to successfully provide the plasma density information in the high-density regime, where other available plasma diagnostic tools are very limited. In addition, the analytical model based on the ambipolar diffusion equation is compared with experimental observations to explain the behavior of the electron density in the ICP source, where the plasma density is shown to be related to the applied RF power and gas pressure. The analytical result from the model is found to be in good agreement with the THz-TDS result.</P>
Hur Yang Rok,Song Woo Sup,Kim Kyung Min,Hwang Ki Hun 대한뇌신경재활학회 2022 뇌신경재활 Vol.15 No.2
The need for a comprehensive nursing care service ward (CNCW) is emerging, but few studies have investigated its medical validity. This study aimed to assess the effect of hospitalization on functional recovery and fall incidence in poststroke patients. This retrospective study enrolled 354 patients with subacute stroke between July 2017 and April 2020. CNCW provided full caregiving and nursing to the patient. Baseline demographic and hospital data, including fall occurrence, were collected. Functional outcomes, including the Medical Research Council (MRC), Korean version of the Modified Barthel Index (K-MBI), and Korean version of the Mini-Mental State Examination (K-MMSE), were evaluated upon admission and discharge. One hundred seventy-two patients were hospitalized in CNCW among the 354 stroke patients. Initial and final K-MMSE and K-MBI were significantly higher in the CNCW group. The K-MMSE score gain was significantly lower in the CNCW group (p < 0.05). The fall occurrence was significantly higher in the CNCW group (p < 0.01). Hospitalization in CNCW adversely affected cognitive function after stroke. Falls were detected more frequently and reported in CNCW.
ZBTB2 increases PDK4 expression by transcriptional repression of <i>RelA/p65</i>
Kim, Min-Young,Koh, Dong-In,Choi, Won-Il,Jeon, Bu-Nam,Jeong, Deok-yoon,Kim, Kyung-Sup,Kim, Kunhong,Kim, Se-Hoon,Hur, Man-Wook Oxford University Press 2015 Nucleic acids research Vol.43 No.3
<P>The NF-κB is found in almost all animal cell types and is involved in a myriad of cellular responses. Aberrant expression of NF-κB has been linked to cancer, inflammatory diseases and improper development. Little is known about transcriptional regulation of the NF-κB family member gene <I>RelA/p65</I>. Sp1 plays a key role in the expression of the <I>RelA/p65</I> gene. ZBTB2 represses transcription of the gene by inhibiting Sp1 binding to a Sp1-binding GC-box in the <I>RelA/p65</I> proximal promoter (bp, −31 to −21). Moreover, recent studies revealed that <I>RelA/p65</I> directly binds to the peroxisome proliferator-activated receptor-γ coactivator1α (PGC1α) to decrease transcriptional activation of the PGC1α target gene <I>PDK4</I>, whose gene product inhibits pyruvate dehydrogenase (PDH), a key regulator of TCA cycle flux. Accordingly, we observed that <I>RelA/p65</I> repression by ZBTB2 indirectly results in increased PDK4 expression, which inhibits PDH. Consequently, in cells with ectopic ZBTB2, the concentrations of pyruvate and lactate were higher than those in normal cells, indicating changes in glucose metabolism flux favoring glycolysis over the TCA cycle. Knockdown of ZBTB2 in mouse xenografts decreased tumor growth. ZBTB2 may increase cell proliferation by reprogramming glucose metabolic pathways to favor glycolysis by upregulating PDK4 expression via repression of <I>RelA/p65</I> expression.</P>
효율적인 네트워크 자원 관리를 위한 호스트의 접속 유형 판별에 관한 연구
허민(Min Hur),김명섭(Myung-Sup Kim) 한국통신학회 2012 韓國通信學會論文誌 Vol.37 No.11B
최근 스마트 디바이스 사용이 대중화 되고 업무 환경 또한 PC중심에서 스마트 디바이스로 확대되어 가면서 무선 트래픽 양이 급격하게 증가 되고 있다. Enterprise 네트워크 에서 무선 IP 대역과 무선 트래픽 대역폭 관리는 중요한 사항이 되고 있다. 네트워크 설계 시 단말 호스트들의 네트워크 접속 유형 판별은 효율적인 네트워크 설계와 관리에 큰 이점이 된다. 또한 판별된 단말 호스트의 지속적인 관리를 통해 효과적인 네트워크 운용이 가능하고, 접속 유형의 변화를 통해 NAT 사용 호스트를 판별 할 수 있다. 본 논문에서는 Enterprise 네트워크의 인터넷 접속점에서 수집된 트래픽의 RTT(Round-Trip-Time) 값을 이용하여 단말 호스트의 접속 유형을 판별하는 방법론을 제안한다. 또한, 실제 학내 망을 대상으로 제안하는 방법의 타당성을 증명한다. As the use of smart devices has become popular, the number of smart devices connected to network has increased and the amount of traffic from them has grown rapidly. The management of mobile traffic and IP address for smart devices in an enterprise network is crucial problem for efficient operation of network. The information about connection type of a terminal host to the network will be very useful for stable and efficient management of an enterprise network. Also, this information might be used to identify NAT device. In this paper, we propose a methodology to identify the connection type of a terminal host using RTT (Round-Trip-Time) value extracted from captured packets. We prove the feasibility of our proposed method in a target campus network.