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Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering
Molina, Eric R.,Smith, Brandon T.,Shah, Sarita R.,Shin, Heungsoo,Mikos, Antonios G. Elsevier 2015 Journal of controlled release Vol.219 No.-
<P><B>Abstract</B></P> <P>The immune system plays a crucial role in the success of tissue engineering strategies. Failure to consider the interactions between implantable scaffolds, usually containing cells and/or bioactive molecules, and the immune system can result in rejection of the implant and devastating clinical consequences. However, recent research into mesenchymal stem cells, which are commonly used in many tissue engineering applications, indicates that they may play a beneficial role modulating the immune system. Likewise, direct delivery of bioactive molecules involved in the inflammatory process can promote the success of tissue engineering constructs. In this article, we will review the various mechanisms in which modulation of the immune system is achieved through delivered bioactive molecules and cells and contextualize this information for future strategies in tissue engineering.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications
Madhurakkat Perikamana, Sajeesh Kumar,Lee, Jinkyu,Lee, Yu Bin,Shin, Young Min,Lee, Esther J.,Mikos, Antonios G.,Shin, Heungsoo American Chemical Society 2015 Biomacromolecules Vol.16 No.9
<P>Current advances in biomaterial fabrication techniques have broadened their application in different realms of biomedical engineering, spanning from drug delivery to tissue engineering. The success of biomaterials depends highly on the ability to modulate cell and tissue responses, including cell adhesion, as well as induction of repair and immune processes. Thus, most recent approaches in the field have concentrated on functionalizing biomaterials with different biomolecules intended to evoke cell- and tissue-specific reactions. Marine mussels produce mussel adhesive proteins (MAPs), which help them strongly attach to different surfaces, even under wet conditions in the ocean. Inspired by mussel adhesiveness, scientists discovered that dopamine undergoes self-polymerization at alkaline conditions. This reaction provides a universal coating for metals, polymers, and ceramics, regardless of their chemical and physical properties. Furthermore, this polymerized layer is enriched with catechol groups that enable immobilization of primary amine or thiol-based biomolecules via a simple dipping process. Herein, this review explores the versatile surface modification techniques that have recently been exploited in tissue engineering and summarizes polydopamine polymerization mechanisms, coating process parameters, and effects on substrate properties. A brief discussion of polydopamine-based reactions in the context of engineering various tissue types, including bone, blood vessels, cartilage, nerves, and muscle, is also provided.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2015/bomaf6.2015.16.issue-9/acs.biomac.5b00852/production/images/medium/bm-2015-00852b_0006.gif'></P>
Lee, Esther J.,Huh, Beom Kang,Kim, Se Na,Lee, Jae Yeon,Park, Chun Gwon,Mikos, Antonios G.,Choy, Young Bin Elsevier 2017 Progress in materials science Vol.89 No.-
<P><B>Abstract</B></P> <P>The plentiful assortment of natural and synthetic materials can be leveraged to accommodate diverse wound types, as well as different stages of the healing process. An ideal material is envisioned to promote tissue repair with minimal inconvenience for patients. Traditional materials employed in the clinical setting often invoke secondary complications, such as infection, pain, foreign body reaction, and chronic inflammation. This review surveys the repertoire of surgical sutures, wound dressings, surgical glues, orthopedic fixation devices and bone fillers with drug eluting capabilities. It highlights the various techniques developed to effectively incorporate drugs into the selected material or blend of materials for both soft and hard tissue repair. The mechanical and chemical attributes of the resultant materials are also discussed, along with their biological outcomes <I>in vitro</I> and/or <I>in vivo</I>. Perspectives and challenges regarding future research endeavors are also delineated for next-generation wound repair materials.</P>
Effective Environmental Regimes in East Asia for Climate Change and Environmental Security
Miko Maekawa 사단법인 한국평화연구학회 2014 평화학연구 Vol.15 No.6
The purpose of this paper is to examine the role of the United Nations (UN) and regional collaboration in tackling climate change and environmental security in East Asia. East Asia plays critical roles in both climate change mitigation and adaptation. In order to seek environmental sustainability, the aspect of so-called planetary boundaries also should be taken into consideration, by assessing the thresholds of climate change, biodiversity loss, nitrogen cycle, and others. However, compared to the active economic regional integration, transboundary cooperation in environmental management is rather weak. Despite the regional environmental agreements, the actual implementation and the impacts are quite limited. In East Asia, regional environmental initiatives did not evolve into formal institutions. Cases of the Montreal Protocol and Mekong River transboundary management are examined to draw concrete lessons for effective regional frameworks. Elements for success are to embrace scientific rigor and flexible legal framework for implementation, trade provisions, give support to developing countries through multilateral processes, including the UN and the broader framework for cooperation, including not only the environment, but also socio and economic bargaining. The participation of the super powers in the agreement is also crucial. The environmental concerns should be reflected in the existing regional trade and economic frameworks in the region.
Miko Andi WARDANA,I Ketut RAHYUDA,I Putu Gde SUKAATMADJA,I Gusti Ayu Ketut GIANTARI 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.4
The aim of the study was to examine the effect of trust, awareness, attitude, subjective norms, and behavioural control on intention and examine the mediating role of trust in the relationship between awareness and attitude. The population was Muslims in Bali Province, with a sample of 150 respondents. Quantitative analysis is used based on multivariate analysis using the SEM model with a variance-based PLS. The results are as follows: (1) knowledge has a significant positive effect on attitude. (2) Awareness has no significant effect on attitude. (3) Awareness has a significant positive effect on trust. (4) Trust has a significant positive effect on attitude. (5) Attitude has no significant effect on intention. (6) Subjective norm has a significant positive effect on intention. (7) Behaviour control has a significant positive effect on intention. (8) The role of trust is a conscious mediation that impacts attitude. The study provides insight into Islamic bank managers to meet prospective customers’ expectations and identify their intention to become customers through managing trust, awareness, attitude, subjective norms, behavioural control, and intention in one unified whole as internal resource. This study enriches empirical evidence on the Theory of Planned Behaviour, which examines knowledge, awareness, and belief.
Alfan Miko,Delmira Syafrini,Jendrius 숙명여자대학교 아시아여성연구원 2024 Asian Women Vol.40 No.1
This study discusses the shifting patterns of care for elderly women in the changing matrilineal society of Minangkabau, West Sumatra, Indonesia. The Minangkabau are the most populous matrilineal culture in the world. One crucial characteristic of Minangkabau society is its communal and woman-centered family structure and women have special rights that protect them within the family and the community. However, this traditional ideal must be questioned, given the current tendency for women of advanced age to be placed in care homes for the elderly. Why are the special rights of women in their communities seemingly not applicable to the elderly? This study finds that the increased use of elderly care homes is a logical consequence of a significant transformation in the matrilineal culture of the Minangkabau. Changes in power relations, social categorization, and social structures justify the placing of elderly women in care homes. The traditional infrastructure has eroded over time, and the values and symbols of the past are no longer protected. In other words, placing elderly women in care homes is a logical consequence of unavoidable structural changes.